Research Topics
| M RubenfireSummaryAffiliation: University of Michigan Country: USA Publications
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Detail Information
Publications
Lipoprotein (a): perspectives from a lipid-referral programMelvyn Rubenfire
Division of Cardiovascular Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, PO Box 322, Ann Arbor, MI 48188, USA
J Clin Lipidol 6:66-73. 2012..Lipoprotein (a) [Lp(a)] has a strong association with coronary disease (CHD). We evaluated the implications of implementing a niacin strategy in persons above low risk by the Framingham risk score (FRS)...- How to manage primary pulmonary hypertension. Giving hope to patients with a life-threatening illnessM J Ricciardi
Division of Cardiology, Northwestern University Medical School, Chicago, USA
Postgrad Med 105:45-8, 51-6. 1999..It has markedly improved quality of life and extended survival in patients with the condition, and it has changed the physician's role from providing emotional support to dying patients to providing management of a chronic disease... - Carotid artery reactivity to isometric hand grip exercise identifies persons at risk and with coronary diseaseMelvyn Rubenfire
Division of Cardiology, Department of Internal Medicine, University of Michigan Health System, P O Box 363, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106 0363, USA
Atherosclerosis 160:241-8. 2002..We designed a study to determine the CA diameter (CA(d)) response to exercise (IHG), whether the response is influenced by coronary risk, and compare it with the BAO(cclR) method... - Anaerobic dental flora and the acute coronary syndromeMelvyn Rubenfire
Division of Cardiovascular Medicine and Department of Internal Medicine, School of Dentistry, Center for Human Growth and Development, University of Michigan, Ann Arbor, Michigan 48106 0363, USA
Coron Artery Dis 18:111-6. 2007..Evidence exists that coronary heart disease is influenced by anaerobic bacterial flora and gingival inflammation. We assessed the association of periodontal bacteria, coronary artery disease, and acute coronary events... - Transition from IV epoprostenol to subcutaneous treprostinil in pulmonary arterial hypertension: a controlled trialMelvyn Rubenfire
University of Michigan, 24 Frank Lloyd Wright Dr, Ann Arbor, MI 48106 0363, USA
Chest 132:757-63. 2007..We determined the relative efficacy of subcutaneous (SC) treprostinil in stable World Health Organization class II and III patients transitioned from IV epoprostenol... - Pulmonary hypertension in the critical care setting: classification, pathophysiology, diagnosis, and managementMelvyn Rubenfire
Division of Cardiovascular Medicine and Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48106 0363, USA
Crit Care Clin 23:801-34, vi-vii. 2007..We review the physiology, definitions, classification, pathogenesis, diagnostic tools, and algorithms for diagnosis and specific treatments for the various causes of PH as seen in the critical care setting... - Evaluating health-related quality of life, work ability, and disability in pulmonary arterial hypertension: an unmet needMelvyn Rubenfire
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA
Chest 136:597-603. 2009..We also discuss the impact of PAH on work ability and the need for provisions to address medical disability status and Social Security benefit status... - Treating mixed hyperlipidemia and the atherogenic lipid phenotype for prevention of cardiovascular eventsMelvyn Rubenfire
Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Mich 48106, USA
Am J Med 123:892-8. 2010.... - Carotid artery vasoreactivity in response to sympathetic stress correlates with coronary disease risk and is independent of wall thicknessM Rubenfire
Department of Internal Medicine, University of Michigan, Ann Arbor, USA
J Am Coll Cardiol 36:2192-7. 2000..We designed a study to determine the carotid artery (CA) response to sympathetic activity and to determine whether the response correlates with coronary risk and is independent of wall thickness (IMT)... - The metabolic fitness program: lifestyle modification for the metabolic syndrome using the resources of cardiac rehabilitationMelvyn Rubenfire
Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
J Cardiopulm Rehabil Prev 31:282-9. 2011..To describe and assess the effectiveness of a lifestyle intervention program (Met Fit) designed to treat the metabolic syndrome (MetSyn) in a cardiac rehabilitation setting... - Usefulness of brachial artery reactivity to isometric handgrip exercise in identifying patients at risk and with coronary artery diseaseM Rubenfire
Department of Internal Medicine, University of Michigan, Ann Arbor, USA
Am J Cardiol 86:1161-5. 2000..5% for IHG vs 71.6% for occlusion and release, p = 0.086). BA response to IHG may be useful for identifying risk factors, patients at risk and with preclinical CAD, and the assessment of treatment strategies... - Safety and compliance with once-daily niacin extended-release/lovastatin as initial therapy in the Impact of Medical Subspecialty on Patient Compliance to Treatment (IMPACT) studyMelvyn Rubenfire
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, 48109 0363, USA
Am J Cardiol 94:306-11. 2004..Niacin extended-release/lovastatin 1,000/40 mg, dosed as initial therapy, was associated with good compliance and safety and had very low incidences of increased liver and muscle enzymes... - Oxygen desaturation on the six-minute walk test and mortality in untreated primary pulmonary hypertensionG Paciocco
Dept of Internal Medicine, University of Michigan, Ann Arbor, USA
Eur Respir J 17:647-52. 2001..The six-minute walk distance and exercise oxygen saturation may be helpful in selecting patients with primary pulmonary hypertension for whom transplant listing is appropriate... - Life-threatening acute and chronic thromboembolic pulmonary hypertension and subclavian vein thrombosisMark A Meier
Division of Cardiology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Clin Cardiol 29:103-6. 2006..We then review the mechanism, clinical presentation, diagnosis, and available therapeutic modalities... - Association between self-reported physical activity and vascular reactivity in postmenopausal womenR McKechnie
Department of Internal Medicine, Division of Cardiology, The University of Michigan Medical Center, Ann Arbor, MI, USA
Atherosclerosis 159:483-90. 2001.... - Abnormal brachial artery flow-mediated vasodilation in young adults with major depressionS Rajagopalan
Department of Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
Am J Cardiol 88:196-8, A7. 2001..Further studies are needed to define the mechanisms that underlie these observations... - Usefulness of visceral obesity (waist/hip ratio) in predicting vascular endothelial function in healthy overweight adultsR D Brook
Division of Hypertension, University of Michigan, Ann Arbor, Michigan, USA
Am J Cardiol 88:1264-9. 2001.... - Potential clinical and economic effects of homocyst(e)ine loweringB K Nallamothu
Division of General Medicine, University of Michigan Medical Center, 3116 Taubman Center, Ann Arbor, MI 48109 0376, USA
Arch Intern Med 160:3406-12. 2000..However, the benefits expected from lowering homocyst(e)ine levels with folic acid and vitamin B(12) supplementation have yet to be demonstrated in clinical trials... - A negative carotid plaque area test is superior to other noninvasive atherosclerosis studies for reducing the likelihood of having underlying significant coronary artery diseaseRobert D Brook
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA
Arterioscler Thromb Vasc Biol 26:656-62. 2006..Although each test may enhance risk stratification, their comparative abilities to screen for underlying coronary stenoses in individual patients is less established... - Effect of statin use in patients with acute coronary syndromes and a serum low-density lipoprotein<or=80 mg/dlThomas T Tsai
Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
Am J Cardiol 96:1491-3. 2005..0% vs 9.5%, p=0.005). These results suggest that patients who have an acute coronary syndrome and a low-density lipoprotein cholesterol level<or=80 mg/dl in the absence of statin therapy may benefit from such therapy at discharge... - Perceived quality of care and lifestyle counseling among patients with heart diseaseElizabeth A Jackson
Department of Internal Medicine, University of Michigan Health System, Ann Arbor, USA
Clin Cardiol 33:765-9. 2010..To examine patients' perceived quality of care and reported receipt of information on diet and exercise related to cardiovascular disease prevention... - Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: a randomized controlled clinical trialVallerie V McLaughlin
University of Michigan Health System, CVC Cardiovascular Medicine, Ann Arbor, Michigan 48109 5853, USA
J Am Coll Cardiol 55:1915-22. 2010..This study assessed the efficacy and safety of inhaled treprostinil in pulmonary arterial hypertension (PAH) patients receiving therapy with either bosentan or sildenafil... - Behavioral medicine: the challenge of integrating psychological and behavioral approaches into primary carePeter C Trask
Behavioral Medicine Program, University of Michigan, Ann Arbor 48108-0757, USA
Eff Clin Pract 5:75-83. 2002 - The lipid management nutrition outcomes project: perspectives from a national experience in protocol implementation and nutrition outcomes trackingKatherine S Rhodes
Division of Cardiovascular Medicine, Preventive Cardiology, University of Michigan Health System, Ann Arbor, MI 48106 0363, USA
J Am Diet Assoc 108:332-9. 2008..7+/-16.5 weeks with 3.0+/-1.4 RD visits. The Lipid Management Nutrition Outcomes Project highlights frustrations and values of outcomes monitoring in actual practice and identifies areas for practice advancement... - Usefulness of low-density lipoprotein particle size measurement in cardiovascular disease preventionRobert D Brook
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA
Clin Cardiol 28:534-7. 2005.... - The effect of St John's Wort on the pharmacodynamic response of clopidogrel in hyporesponsive volunteers and patients: increased platelet inhibition by enhancement of CYP3A4 metabolic activityWei C Lau
Cardiovascular Center, Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109 5861, USA
J Cardiovasc Pharmacol 57:86-93. 2011..0002) and increased platelet inhibition (23% ± 11% vs. 41% ± 16%, P = 0.002). SJW may be a future therapeutic option to increase CYP metabolic activity and antiplatelet effect of clopidogrel in hyporesponders... - Frequency of negative coronary arteriographic findings in patients with chest pain is related to community practice patternsPeter M Farrehi
Department of Internal Medicine, University of Michigan, Ann Arbor, USA
Am J Manag Care 8:643-8. 2002..Cardiology self-referral and personal gain does not seem to be a major factor in selection of patients for invasive studies... - Potential effect of an apoprotein B-based algorithm on management of new patients with hypertriglyceridemia referred to a specialty lipid clinicRobert D Brook
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA
Clin Cardiol 32:251-5. 2009..In patients with hypertriglyceridemia, non-high density lipoprotein cholesterol (nonHDL-C) is a targeted goal. However, apoprotein B100 (apoB) may be superior in predicting cardiovascular risk so we assessed the utility of an apoB-based... - The prognostic role of the ECG in primary pulmonary hypertensionEduardo Bossone
Division of Cardiology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48106-0363, USA
Chest 121:513-8. 2002.... - Electron-beam computed tomography in the diagnosis of coronary artery disease: a meta-analysisB K Nallamothu
B1F245, Division of General Medicine, University Hospital, Ann Arbor, MI 48109 0022, USA
Arch Intern Med 161:833-8. 2001..Before its clinical use is justified, however, the overall accuracy of EBCT must be better defined... - Unexplained exertional limitation: characterization of patients with a mitochondrial myopathyK R Flaherty
Dyspnea and Pulmonary Hypertension Clinics, University of Michigan Health System, Ann Arbor, Michigan, USA
Am J Respir Crit Care Med 164:425-32. 2001..We conclude that mitochondrial myopathies are more prevalent than previously reported. The characteristic physiological profile may be useful in the diagnostic evaluation of mitochondrial myopathy... - Utility of C-reactive protein measurement in risk stratification during primary cardiovascular disease preventionRobert L Bard
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA
Am J Cardiol 95:1378-9. 2005..Because hs-CRP evaluation significantly altered the cardiovascular risk strata of most intermediate-risk patients, it may therefore be a useful test during primary cardiovascular disease prevention... - Balloon atrial septostomy in end-stage pulmonary hypertension guided by a novel intracardiac echocardiographic transducerM Moscucci
Division of Cardiology, Department of Medicine, University of Michigan Health System, Ann Arbor, Michigan 48108, USA
Catheter Cardiovasc Interv 52:530-4. 2001..5--10 MHz transducer with spectral and color-flow Doppler capabilities was used to assist a balloon atrial septostomy and to obtain hemodynamic data in a patient with end-stage pulmonary hypertension... - Antioxidant nutrient supplementation and brachial reactivity in patients with coronary artery diseaseRonald McKechnie
Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, Ann Arbor, MI, USA
J Lab Clin Med 139:133-9. 2002..These data should be confirmed in larger-scale trials and examined in studies evaluating individual dietary antioxidant supplementation... - Altered cutaneous microvascular responses to reactive hyperaemia in coronary artery disease: a comparative study with conduit vessel responsesQurratul Aine Shamim-Uzzaman
Department of Internal Medicine, and Section of Vascular Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109-0273, USA
Clin Sci (Lond) 103:267-73. 2002..However, a time to peak response of >10 s as measured by laser Doppler imaging offers superior specificity for the diagnosis of CAD compared with brachial FMD... - Effect of carotid atherosclerosis screening on risk stratification during primary cardiovascular disease preventionRobert L Bard
Division of Cardiovascular Medicine, Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
Am J Cardiol 93:1030-2. 2004..These tests adjust the risk strata of >/=63% of patients deemed as having intermediate risk by Framingham scores... - Lung and heart-lung transplant practice patterns in pulmonary hypertension centersE J Pielsticker
Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor 48106-0363, USA
J Heart Lung Transplant 20:1297-304. 2001..CONCLUSIONS: Physicians and patients should be aware of the considerable variability in practice patterns for transplantation in pulmonary hypertension, despite published guidelines... - Cardiovascular risk factors in ethnic minority women aged < or =30 yearsLatha Palaniappan
Division of Cardiology, Department of Internal Medicine, Ann Arbor, Michigan, USA
Am J Cardiol 89:524-9. 2002..The tendency toward peripheral insulin insensitivity and increased body fat in this age group of African-American women suggests diet and exercise may reduce the risk of subsequent CHD... - The impact of time and day on the presentation of acute coronary syndromesTroy LaBounty
Michigan Cardiovascular Outcomes Research and Reporting Program, Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical Center, University of Michigan, Ann Arbor, Michigan 48106-0363, USA
Clin Cardiol 29:542-6. 2006..Consideration should be given to these findings when developing clinical care paradigms, health care staffing needs, and when comparing new treatment outcomes in patients with ACS... - Addition of sildenafil to long-term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: a randomized trialGerald Simonneau
Service de Pneumologie, Hopital Antoine Beclere, Universite Paris Sud, Clamart, France
Ann Intern Med 149:521-30. 2008..Oral sildenafil and intravenous epoprostenol have independently been shown to be effective in patients with pulmonary arterial hypertension... - Latent pulmonary hypertension: looking beyond the sceneEduardo Bossone
Chest 134:469-70. 2008 - The interpretation of the electrocardiogram in patients with pulmonary hypertension: the need for clinical correlationEduardo Bossone
National Research Council, Lecce, and Institute of Respiratory Disease, University of Milan, IRCCS Ospedale Maggiore, Milan, Italy
Ital Heart J 4:850-4. 2003..The aim of the study was to determine the importance of clinical information in providing an accurately edited electrocardiographic system... - Psychosocial aspects of pulmonary hypertension: a reviewJohn M Wryobeck
University of Toledo Health Science Campus, Department of Psychiatry, Toledo, OH 43614, USA
Psychosomatics 48:467-75. 2007.... - Outcome after cardiopulmonary resuscitation in patients with pulmonary arterial hypertensionMarius M Hoeper
Dept of Respiratory Medicine, Hannover Medical School, 30623 Hannover, Germany
Am J Respir Crit Care Med 165:341-4. 2002..Our data indicate that CPR for circulatory arrest in patients with PAH is rarely successful unless the cause of the cardiopulmonary decompensation can be corrected... - Cardiovascular response to exercise in elite ice hockey playersEduardo Bossone
Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore, Milan, Italy
Can J Cardiol 20:893-7. 2004..High-performance ice hockey requires unique strength and endurance, which are facilitated by training... - Defining appropriate outcome measures in pulmonary arterial hypertension related to systemic sclerosis: a Delphi consensus study with cluster analysisOliver Distler
University Hospital Zurich, Zurich, Switzerland
Arthritis Rheum 59:867-75. 2008..The aim of the present study was to establish an expert consensus regarding which outcome measures are most appropriate for clinical trials in PAH-SSc...