Research Topics
Species | EDWARD ROSLONIECSummaryAffiliation: University of Tennessee Country: USA Publications
Research Grants
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Detail Information
Publications
Analog peptides of type II collagen can suppress arthritis in HLA-DR4 (DRB1*0401) transgenic miceYoshihiko Sakurai
Department of Medicine, University of Tennessee, 956 Court Avenue, Memphis, TN 38163, USA
Arthritis Res Ther 8:R150. 2006..These experiments represent the first description of an analog peptide of CII recognized by T cells in the context of HLA-DR4 that can suppress autoimmune arthritis...- HLA-DR1 (DRB1*0101) and DR4 (DRB1*0401) use the same anchor residues for binding an immunodominant peptide derived from human type II collagenEdward F Rosloniec
Veterans Affairs Medical Center, Research Service 151, 1030 Jefferson Avenue, Memphis, TN 38104, USA
J Immunol 168:253-9. 2002.... - Second-generation peptidomimetic inhibitors of antigen presentation effectively treat autoimmune diseases in HLA-DR-transgenic mouse modelsEdward F Rosloniec
Research Service, Veterans Affairs Medical Center, Memphis, TN 38104, USA
J Autoimmun 27:182-95. 2006..Selected compounds of this series are shown to inhibit antigen presentation in vivo, as well as effectively treat collagen induced arthritis and experimental autoimmune encephalomyelitis in HLA-DR transgenic mouse models... - Paradoxical roles of IFN-gamma in models of Th1-mediated autoimmunityEdward F Rosloniec
VA Medical Center, Research Service 151, Memphis, Tennessee, USA
Arthritis Res 4:333-6. 2002.... - Collagen-induced arthritis mediated by HLA-DR1 (*0101) and HLA-DR4 (*0401)Edward F Rosloniec
Veterans Affairs Medical Center and the Department of Medicine, University of Tennessee, Memphis, Tennessee 38104, USA
Am J Med Sci 327:169-79. 2004..In all, these studies demonstrate that DR1 and DR4 are capable of binding peptides derived from human type II collagen (hCII) and support the hypothesis that autoimmune responses to hCII play a role in the pathogenesis of RA... - Ex vivo characterization of the autoimmune T cell response in the HLA-DR1 mouse model of collagen-induced arthritis reveals long-term activation of type II collagen-specific cells and their presence in arthritic jointsKary A Latham
Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
J Immunol 174:3978-85. 2005.... - Molecular characterization of an arthritogenic collagen peptide interacting with I-ArYoshihiko Sakurai
Department of Medicine, University of Tennessee, Memphis, TN 38163, USA
Immunology 117:136-42. 2006..Identification of the molecular interactions involved in T-cell recognition of CII should lead to antigen-specific means of inhibiting autoimmune arthritis... - Peptide-induced suppression of collagen-induced arthritis in HLA-DR1 transgenic miceLinda K Myers
University of Tennessee, Memphis, USA
Arthritis Rheum 46:3369-77. 2002..These experiments represent the first description of an analog peptide of CII recognized by T cells in the context of a human major histocompatibility complex molecule that can suppress autoimmune arthritis... - Estradiol treatment redirects the isotype of the autoantibody response and prevents the development of autoimmune arthritisKary A Latham
Veterans Affairs Medical Center, Memphis, TN 38104, USA
J Immunol 171:5820-7. 2003.... - Immunopathogenesis of collagen arthritisDavid D Brand
Veterans Affairs Medical Center, Research Service (151, 130 Jefferson Avenue, Memphis, TN 38104, USA
Springer Semin Immunopathol 25:3-18. 2003..In recent years, the pathogenesis of this model has been studied extensively and the CIA model is proving to be a valuable asset for the design of new immunotherapeutics for the potential treatment of RA and other autoimmune diseases... - An autoantigen-specific, highly restricted T cell repertoire infiltrates the arthritic joints of mice in an HLA-DR1 humanized mouse model of autoimmune arthritisZhaohui Qian
Veterans Affairs Medical Center, Memphis, TN 38104, USA
J Immunol 185:110-8. 2010..In addition, this model may be very useful for studying the function in situ and the mechanism by which autoimmune T cells are recruited to the site of inflammation... - T cell immunity to type II collagen in the biobreeding rat: the identification and characterization of RT1u-restricted T cell epitopes on alpha 1(II)Michael A Cremer
Research Service of Veterans Affairs Medical Center, Memphis, TN 38104, USA
J Immunol 173:1795-801. 2004..This motif is similar to one recognized by collagen-induced arthritis-susceptible HLA-DR1- and HLA-DR4-transgenic mice... - MHC class II derived recombinant T cell receptor ligands protect DBA/1LacJ mice from collagen-induced arthritisJianya Huan
Neuroimmunology Research, Veterans Affairs Medical Center, Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland 97201, USA
J Immunol 180:1249-57. 2008..This is the first report demonstrating effective prevention of joint inflammation and clinical signs of CIA with an I-Aq-derived RTL, thus supporting the possible clinical use of this approach for treating rheumatoid arthritis in humans... - Collagen-induced arthritisDavid D Brand
Research Service, Veterans Affairs Medical Center, Memphis, Tennessee 38104, USA
Nat Protoc 2:1269-75. 2007..The total time for the preparation of reagents and the immunization of ten mice is about 1.5 h... - Detection of early changes in autoimmune T cell phenotype and function following intravenous administration of type II collagen in a TCR-transgenic modelDavid D Brand
Veterans Affairs Medical Center, 1030 Jefferson Avenue, Memphis, TN 38104, USA
J Immunol 168:490-8. 2002.... - The mouse model of collagen-induced arthritisDavid D Brand
Department of Medicine, University of Tennessee Health Sciences Center, Memphis, USA
Methods Mol Med 102:295-312. 2004.... - Crystallographic structure of a rheumatoid arthritis MHC susceptibility allele, HLA-DR1 (DRB1*0101), complexed with the immunodominant determinant of human type II collagenEdward F Rosloniec
Veterans Affairs Medical Center, Memphis, TN 38104, USA
J Immunol 177:3884-92. 2006..Comparison of the DR1-CII structure to a DR1-hemagglutinin peptide structure revealed that the binding of these two peptides generates significantly different interfaces for the interaction with their respective Ag-specific TCRs... - An analog peptide that suppresses collagen-induced arthritisLinda K Myers
Department of Pediatrics and Medicine, University of Tennessee, and from the Research Service of the Veterans Affairs Medical Center, Memphis, Tennessee, USA
Am J Med Sci 327:212-6. 2004..An analog peptide of CII recognized by T cells in the context of a human major histocompatibility complex molecule should have therapeutic significance for autoimmune arthritis... - T cell receptors recognizing type II collagen in HLA-DR-transgenic mice characterized by highly restricted V beta usageXiaowen He
Research Service, Memphis Veterans Affairs Medical Center, and University of Tennessee, 38104, USA
Arthritis Rheum 50:1996-2004. 2004..To determine the T cell receptor (TCR) structure recognizing type II collagen (CII) in HLA-DR-transgenic mice, and to examine the role of T cells with certain V(beta)-chains in collagen-induced arthritis (CIA)... - Collagen-induced arthritisEdward F Rosloniec
Veterans Affairs Medical Center, and University of Tennessee Health Science Center, Memphis, Tennessee, USA
Curr Protoc Immunol . 2010.... - Class II major histocompatibility complex-peptide tetramer staining in relation to functional avidity and T cell receptor diversity in the mouse CD4(+) T cell response to a rheumatoid arthritis-associated antigenMichael T Falta
University of Colorado Health Sciences Center, and National Jewish Medical and Research Center, Denver, Colorado 80262, USA
Arthritis Rheum 52:1885-96. 2005..We undertook this study to better understand the parameters for specific binding of this tetramer... - A single-chain class II MHC-IgG3 fusion protein inhibits autoimmune arthritis by induction of antigen-specific hyporesponsivenessLi Zuo
Division of Rheumatology, Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
J Immunol 168:2554-9. 2002..Such fusion proteins may be useful to study novel therapeutic approaches for T cell-mediated autoimmune diseases...
Research Grants
- MECHANISMS OF AUTOIMMUNE ARTHRITISEDWARD ROSLONIEC; Fiscal Year: 2001..These recombinant DR molecules will be tested for their ability to alter T-cell responses to hCII in vitro, and prevent the development of autoimmune arthritis in the DR transgenic mice. ..