Research Topics
| Jonathan E RosenbergSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Second-line chemotherapy for hormone-refractory prostate cancer: has the time come?Jonathan E Rosenberg
University of California at San Francisco, Comprehensive Cancer Center, San Francisco, CA 94115, USA
Clin Prostate Cancer 3:122-4. 2004..Finding new agents that are active in the second-line setting and identifying relevant outcome variables and predictive pretreatment variables are crucial in improving survival and quality of life for this patient population...- A phase II trial of R115777, an oral farnesyl transferase inhibitor, in patients with advanced urothelial tract transitional cell carcinomaJonathan E Rosenberg
Department of Medicine, University of California, San Francisco, California 94115, USA
Cancer 103:2035-41. 2005..R115777 is a potent farnesyl transferase inhibitor and has significant antitumor effects in vitro and in vivo... - Update on chemotherapy for advanced bladder cancerJonathan E Rosenberg
Department of Medicine, University of California San Francisco, San Francisco, California, USA
J Urol 174:14-20. 2005..Recent years have seen several advances in the treatment of locally advanced and metastatic bladder cancer. We summarize the current state of the art for advanced bladder cancer treatment... - A retrospective evaluation of second-line chemotherapy response in hormone-refractory prostate carcinoma: second line taxane-based therapy after first-line epothilone-B analog ixabepilone (BMS-247550) therapyJonathan E Rosenberg
Division of Hematology Oncology, University of California San Francisco, San Francisco, California 94115, USA
Cancer 106:58-62. 2006..Clinical cross-resistance of ixabepilone and taxanes in HRPC is unknown... - Phase II study of bortezomib in patients with previously treated advanced urothelial tract transitional cell carcinoma: CALGB 90207J E Rosenberg
Division of Hematology and Oncology, University of California, San Francisco Cancer Center, San Francisco, CA 94115, USA
Ann Oncol 19:946-50. 2008..Response rates to second-line chemotherapy for advanced UC are low and response duration is short. Bortezomib is a proteasome inhibitor with preclinical activity against UC... - Current status of neoadjuvant and adjuvant chemotherapy for muscle-invasive bladder cancerJonathan E Rosenberg
UCSF Comprehensive Cancer Center, 1600 Divisadero Street, Box 1711, San Francisco, CA 94115, USA
Expert Rev Anticancer Ther 7:1729-36. 2007..Neoadjuvant strategies are a potent tool for research and should be employed to test new agents for the treatment of transitional cell carcinoma... - Activity of second-line chemotherapy in docetaxel-refractory hormone-refractory prostate cancer patients : randomized phase 2 study of ixabepilone or mitoxantrone and prednisoneJonathan E Rosenberg
Department of Medicine, University of California at San Francisco, Comprehensive Cancer Center, San Francisco, California, USA
Cancer 110:556-63. 2007..This randomized, noncomparative, multicenter, clinical trial evaluated ixabepilone or mitoxantrone/prednisone (MP) as second-line chemotherapy for taxane-refractory, hormone-refractory, prostate cancer (HRPC)... - A phase I trial of docetaxel/estramustine/imatinib in patients with hormone-refractory prostate cancerAmy M Lin
UCSF Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
Clin Genitourin Cancer 5:323-8. 2007..Imatinib inhibits the platelet-derived growth factor receptor that is expressed in prostate cancer and is synergistic with taxanes in preclinical prostate cancer models... - Phase I study of ixabepilone, mitoxantrone, and prednisone in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel-based therapy: a study of the department of defense prostate cancer clinical trials consortiumJonathan E Rosenberg
Department of Medicine, University of California San Franscisco, Helen Diller Family Comprehensive Cancer Center, 1600 Divisadero St, Box 1711, San Francisco, CA 94115, USA
J Clin Oncol 27:2772-8. 2009..Mitoxantrone plus prednisone and ixabepilone each have modest activity as second-line chemotherapy in docetaxel-refractory castration-resistant prostate cancer (CRPC) patients. Clinical noncrossresistance was previously observed... - A phase 1 study of everolimus and sorafenib for metastatic clear cell renal cell carcinomaAndrea L Harzstark
Department of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143 1711, USA
Cancer 117:4194-200. 2011.... - Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapyCharles J Ryan
Urologic Oncology Program, University of California, San Francisco, San Francisco, CA 94115, USA
J Clin Oncol 28:1481-8. 2010..This phase I dose-escalation study of abiraterone acetate evaluated safety, pharmacokinetics, and effects on steroidogenesis and prostate-specific antigen (PSA) levels in men with CPRC with or without prior ketoconazole therapy... - Evaluation and significance of circulating epithelial cells in patients with hormone-refractory prostate cancerJorge A Garcia
Department of Medicine, University of California San Francisco, San Francisco, CA, USA
BJU Int 99:519-24. 2007.... - A phase II trial of imatinib mesylate in patients with biochemical relapse of prostate cancer after definitive local therapyAmy M Lin
University of California/San Francisco, San Francisco, CA 94115, USA
BJU Int 98:763-9. 2006.... - A phase I study of a 2-day lapatinib chemosensitization pulse preceding nanoparticle albumin-bound Paclitaxel for advanced solid malignanciesAmy J Chien
Department of Medicine, University of California San Francisco, San Francisco, California 94143 0875, USA
Clin Cancer Res 15:5569-75. 2009..This study investigates the clinical relevance of this approach... - Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinomaBrian I Rini
Department of Solid Tumor Oncology and Urology, Cleveland Clinic Taussig Cancer Institute, 9500 Euclid Avenue, Desk R35, Cleveland, OH 44195, USA
J Clin Oncol 26:3743-8. 2008..To assess the safety and efficacy of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma (mRCC) and explore biomarkers for sunitinib response... - Patients with metastatic renal cell carcinoma with long-term disease-free survival after treatment with sunitinib and resection of residual metastasesBrian I Rini
Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Center, OH 44195, USA
Clin Genitourin Cancer 5:232-4. 2006..Herein, we report 2 cases of patients with cytokine-refractory metastatic RCC who received sunitinib and achieved sufficient decrease in tumor burden to permit subsequent surgical resection, resulting in long-term CR...