Research Topics
| R K ReinscheidSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
The Orphanin FQ / Nociceptin receptor as a novel drug target in psychiatric disordersRainer K Reinscheid
Department of Pharmacology, University of California Irvine, 360 Med Surge II, 92697 4625, USA
CNS Neurol Disord Drug Targets 5:219-24. 2006..This paper will summarize current developments and highlight the scientific achievements that have been made to elucidate the functions of OFQ/N with respect to psychiatric disorders...- Neuropeptide S as a novel arousal promoting peptide transmitterRainer K Reinscheid
Department of Pharmacology, University of California, Irvine, CA 92697 4625, USA
FEBS J 272:5689-93. 2005..NPS appears to possess a unique pharmacological profile in producing both anxiolytic-like and hypervigilant effects... - Neuropeptide S and its receptor: a newly deorphanized G protein-coupled receptor systemRainer K Reinscheid
Department of Pharmacology, University of California, Irvine, 92697 4625, USA
Neuroscientist 11:532-8. 2005..This unique pharmacological profile of NPS offers significant potential for developing new drugs for the treatment of sleep and/or anxiety disorders... - Phylogenetic appearance of neuropeptide S precursor proteins in tetrapodsRainer K Reinscheid
Pharmaceutical Sciences, University of California Irvine, 360 Med Surge 2, Irvine, CA 92697, USA
Peptides 28:830-7. 2007..Together, these data show that NPS is a relatively recent gene in vertebrate evolution whose appearance might coincide with its specialized physiological functions in terrestrial vertebrates... - The orphanin FQ/nociceptin knockout mouse: a behavioral model for stress responsesR K Reinscheid
Department of Pharmacology, UC Irvine, 101 Theory, Irvine, CA, 92612, USA
Neuropeptides 36:72-6. 2002..Availability of a selective small molecule OFQ/N antagonist might help clarify this discrepancy... - Neuropeptide S: anatomy, pharmacology, genetics and physiological functionsRainer K Reinscheid
Program in Pharmaceutical Sciences, Department of Pharmacology, University of California Irvine, Irvine, CA 92697 4625, USA
Results Probl Cell Differ 46:145-58. 2008..Further studies about interactions of the NPS system with other transmitter systems might help to discover additional functions of NPS and define its role within complex neural networks... - The orphanin FQ/nociceptin gene: structure, tissue distribution of expression and functional implications obtained from knockout miceR K Reinscheid
Department of Pharmacology, College of Medicine, 354 Med Surge II, University of California Irvine, 92697 4625, Irvine, CA, USA
Peptides 21:901-6. 2000..This review will summarize recent findings on the molecular biology of the OFQ/N precursor and relate it to possible physiological functions of this newly discovered neuropeptide system... - Pharmacological characterization of human and murine neuropeptide s receptor variantsRainer K Reinscheid
Department of Pharmacology, University of California at Irvine, 360 Med Surge II, Irvine, CA 92697 4625, USA
J Pharmacol Exp Ther 315:1338-45. 2005.... - Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effectsYan Ling Xu
Department of Pharmacology, University of California Irvine, Irvine, Irvine, California 92697, USA
Neuron 43:487-97. 2004..These results indicate that NPS could be a new modulator of arousal and anxiety. They also show that the LC region encompasses distinct nuclei expressing different arousal-promoting neurotransmitters... - Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptorsO Civelli
Department of Pharmacology, University of California Irvine, 369 MedSurge II, Irvine, CA 92612, USA
Trends Neurosci 24:230-7. 2001..One nucleotide-sugar derivative and six peptides or peptide families identified through this strategy are novel and have already enriched our understanding of various brain functions... - Neuropeptide S: a novel modulator of stress and arousalNaoe Okamura
Department of Pharmacology, University of California, Irvine, CA 92697, USA
Stress 10:221-6. 2007..NPS might interact with other hypothalamic neuropeptide systems that are known to be involved in stress and appetite control and thus might be a valuable target for development of a new class of drugs to treat anxiety disorders... - Orphan receptors, novel neuropeptides and reverse pharmaceutical researchO Civelli
Department of Pharmacology, University of California, Irvine, CA 92697 4625, USA
Brain Res 848:63-5. 1999.... - Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptorNaoe Okamura
Department of Pharmaceutical Sciences, University of California Irvine, Irvine, CA 92697 4625, USA
J Pharmacol Exp Ther 325:893-901. 2008..Therefore, SHA 68 could be a useful tool to characterize physiological functions and pharmacological parameters of the NPS system in vitro and in vivo... - Neuropeptide S: a new player in the modulation of arousal and anxietyRainer K Reinscheid
Department of Pharmacology, University of California Irvine, Irvine, CA 92697-4625, USA
Mol Interv 5:42-6. 2005..It also enhances our understanding of the neurobiological mechanisms of sleep/wakefulness regulation and the neuronal processing of stress... - Orphan GPCRs and their ligandsOlivier Civelli
Department of Pharmacology and Department of Developmental and Cell Biology, University of California, Irvine, Med Surge II Room 369, Irvine, CA 92697 4625, USA
Pharmacol Ther 110:525-32. 2006..This review aims at describing the history of the orphan GPCRs and their impact on our understanding of biology... - Importance of extracellular loop one of the neuropeptide S receptor for biogenesis and functionStewart D Clark
Pharmaceutical Sciences, University of California, Irvine, 147 Biological Sciences Administration, Irvine, CA 92697, USA
Peptides 31:130-8. 2010..Our studies suggest that N-linked glycosylation is not important for receptor biogenesis or function, and that residue D105 might be critical for receptor binding... - Behavioral phenotyping of neuropeptide S receptor knockout miceDee M Duangdao
Department of Pharmaceutical Sciences, University of California Irvine, 360 Med Surge 2, Irvine, CA 92697 4625, USA
Behav Brain Res 205:1-9. 2009..Together, these data indicate that the endogenous NPS system might be involved in setting or maintaining behavioral arousal thresholds and that the NPS system might have other yet undiscovered physiological functions... - In-depth activation of channelrhodopsin 2-sensitized excitable cells with high spatial resolution using two-photon excitation with a near-infrared laser microbeamSamarendra K Mohanty
Beckman Laser Institute, University of California, Irvine, California, USA
Biophys J 95:3916-26. 2008.... - Orphanin FQ/nociceptin interacts with the basolateral amygdala noradrenergic system in memory consolidationBenno Roozendaal
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
Learn Mem 14:29-35. 2007..These findings indicate that endogenously released OFQ/N interacts with noradrenergic activity within the BLA in modulating memory consolidation... - Gender-specific association of a functional coding polymorphism in the Neuropeptide S receptor gene with panic disorder but not with schizophrenia or attention-deficit/hyperactivity disorderNaoe Okamura
Department of Pharmacology, University of California Irvine, 360 Med Surge 2, Irvine, CA 92697, USA
Prog Neuropsychopharmacol Biol Psychiatry 31:1444-8. 2007..These results provide evidence for a gender-specific effect of NPSR in the pathogenesis of panic disorder... - Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonistH P Nothacker
Department of Pharmacology, University of California at Irvine, Irvine, California, USA
Mol Pharmacol 58:1601-8. 2000..Moreover, we have identified BAY u9773 as a CysLT(2) selective agonist, which could prove to be of immediate use in understanding the functional roles of the CysLT(2) receptor... - Distribution of neuropeptide S receptor mRNA and neurochemical characteristics of neuropeptide S-expressing neurons in the rat brainYan Ling Xu
Department of Pharmacology, University of California Irvine, Irvine, California 92697, USA
J Comp Neurol 500:84-102. 2007..These data suggest that the NPS system may play a key role in modulating a variety of physiological functions, especially arousal, anxiety, learning and memory, and energy balance... - Neuropeptide S attenuates neuropathological, neurochemical and behavioral changes induced by the NMDA receptor antagonist MK-801Naoe Okamura
Department of Pharmaceutical Sciences, University of California, Irvine, CA 92697, USA
Neuropharmacology 58:166-72. 2010..Our study suggests that NPS may have protective effects against the neurotoxic and behavioral changes produced by NMDA receptor antagonists and that NPS receptor agonists may elicit antipsychotic effects... - Endogenous orphanin FQ/nociceptin is involved in the development of morphine toleranceShinjae Chung
Department of Pharmacology, Program in Pharmaceutical Sciences, University of California, 360 Med Surge II, Irvine, CA 92697-4625, USA
J Pharmacol Exp Ther 318:262-7. 2006..Furthermore, it suggests that OFQ/N antagonists could provide a novel therapeutic strategy to attenuate morphine tolerance development... - Salusin beta is a surrogate ligand of the mas-like G protein-coupled receptor MrgA1Zhiwei Wang
Department of Pharmacology, University of California, Irvine, CA 92697, USA
Eur J Pharmacol 539:145-50. 2006..Our results show that human salusin beta is a surrogate ligand of the mouse MrgA1 and raises a cautionary flag for experiments that analyze the pharmacological profiles of mas-like G protein-coupled receptors from different species... - High-throughput real-time monitoring of Gs-coupled receptor activation in intact cells using cyclic nucleotide-gated channelsRainer K Reinscheid
Department of Pharmacology, University of California Irvine, 101 Theory Dr, Irvine, CA 92612, USA
Eur J Pharmacol 478:27-34. 2003.... - Neuropeptide S stimulates dopaminergic neurotransmission in the medial prefrontal cortexWei Si
Department of Pharmaceutical Sciences, University of California Irvine, Irvine, California 92697, USA
J Neurochem 115:475-82. 2010..Dopamine release in the mPFC has been previously linked to modulation of anxiety states and fear extinction. The present results may thus provide a physiological and anatomical basis for the reported effects of NPS on these behaviors... - Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdalaKay Jüngling
Institute of Physiology I Neurophysiology, Westfälische Wilhelms University Münster, Robert Koch Strasse 27a, D 48149 Munster, Germany
Neuron 59:298-310. 2008..These results identify mechanisms of NPS in the brain, a key role of intercalated neurons in the amygdala for fear extinction, and a potential pharmacological avenue for treating anxiety disorders... - Synthesis and biological activity of human neuropeptide S analogues modified in position 2Valeria Camarda
Department of Experimental and Clinical Medicine, Section of Pharmacology and Italian Institute of Neuroscience, University of Ferrara, via Fossato di Mortara 19, Ferrara, Italy
J Med Chem 51:655-8. 2008.... - Effect of orphanin FQ/nociceptin (OFQ/N) and isoflurane on the prolactin secretory response in OFQ/N knockout miceKelly L Zullig
Center for Neuroscience, Department of Zoology, 212 Pearson Hall, Miami University, Oxford, OH 45056, USA
Peptides 28:1611-4. 2007..This is the first report that exogenously administered OFQ/N stimulates prolactin secretion in mice and that brief isoflurane exposure does not significantly affect this response... - Conformation-activity relationship of neuropeptide S and some structural mutants: helicity affects their interaction with the receptorTeodorico Tancredi
Istituto di Chimica Biomolecolare, CNR, Via Campi Flegrei 34, I 80078 Pozzuoli, Italy
J Med Chem 50:4501-8. 2007..The identification of hNPSR partial agonists heralds the possibility of designing pure NPS receptor antagonists... - Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson's diseaseMatteo Marti
Department of Experimental and Clinical Medicine, Neuroscience Center, University of Ferrara, 44100 Ferrara, Italy
J Neurosci 25:9591-601. 2005..Based on these data, we propose that NOP receptor antagonists may represent a novel approach for combined (symptomatic and neuroprotective) therapy of Parkinson's disease... - Normal sensitivity to acute pain, but increased inflammatory hyperalgesia in mice lacking the nociceptin precursor polypeptide or the nociceptin receptorUlrike B Depner
Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Universitat Erlangen Nurnberg, Fahrstrasse 17, 91054 Erlangen, Germany
Eur J Neurosci 17:2381-7. 2003..Among the three types of mutant mice nociceptive behaviour was nearly identical, indicating that the lack of other potential ppN/OFQ products in the ppN/OFQ-/- mice was apparently without effect on the nociceptive phenotype... - Orphanin FQ/nociceptin interactions with the immune system in vivo: gene expression changes in lymphoid organs and regulation of the cytokine response to staphylococcal enterotoxin AYael Goldfarb
Department of Psychology, Tel Aviv University, Tel Aviv, Israel
J Neuroimmunol 176:76-85. 2006..Overall, this suggests that the OFQ/N system can influence immune function and is itself influenced by immune stimuli... - Delayed epileptogenesis in nociceptin/orphanin FQ-deficient miceAnna Binaschi
Department of Clinical and Experimental Medicine, Section of Pharmacology, and Neuroscience Center, University of Ferrara, Via Fossato di Mortara 17 19, 44100 Ferrara, Italy
Neuroreport 14:825-7. 2003..These data indicate that N/OFQ is involved in the development of kindling and that it may play a pro-epileptogenic role... - The opioid peptide nociceptin/orphanin FQ mediates prostaglandin E2-induced allodynia, tactile pain associated with nerve injuryEmiko Okuda-Ashitaka
Department of Medical Chemistry, Kansai Medical University, 10 15 Fumizono, Moriguchi 570 8506, Japan
Eur J Neurosci 23:995-1004. 2006..N/OFQ immunoreactive puncta were colocalized with EP4. Taken together, these results demonstrate that PGE(2) induced allodynia by stimulation of N/OFQ release in the spinal cord via EP4 receptor subtypes... - Involvement of NMDA receptors in alcohol-mediated behavior: mice with reduced affinity of the NMDA R1 glycine binding site display an attenuated sensitivity to ethanolFalk Kiefer
Department of Psychiatry, University Hospital of Hamburg, Hamburg, Germany
Biol Psychiatry 53:345-51. 2003....
Research Grants
- Natural ligands for 2 endothelin-like orphan receptorsRainer Reinscheid; Fiscal Year: 2004..Identification of the natural ligands will enable us to study the physiological functions of these two orphan GPCRs under normal and pathological conditions. ..
- Physiological Functions of Neuropeptide SRainer Reinscheid; Fiscal Year: 2009..We will study the pharmacology of the mutant receptor isoforms which may help to understand the physiological consequences of the mutation in human airway tissue. ..