E Albert Reece

..There remains, however, a great deal of controversy over when to begin screening for hyperglycemia in pregnancy and at what level of hyperglycemia should aggressive intervention be initiated...

..Based on what we know about the molecular pathophysiology of diabetic embryopathy, our laboratory and others are developing interventions against to key molecular targets in this multifactorial disease process...

....

..The PBIC program continues to challenge our faculty members to attain their highest potential while rewarding them accordingly...

..Judging by the speed of its progression and the toll it is taking, obesity can truly be called America's newest and fastest-growing epidemic...

..In addition, the article offers recommendations for facilitating the broader scale implementation of evidence-based approaches to preventing obesity, particularly among pregnant women...

..The apoptosis is triggered by caspase 8, which activates members of the Bcl-2 and caspase families, such as Bid and caspase 3. Whether PKC?2 regulates caspase 8-induced apoptosis remains to be addressed...

..These data suggest that caspase-8 may control diabetic embryopathy-associated apoptosis via regulation of the Bid-stimulated mitochondrion/caspase-9 pathway...

..To establish a link between oxidative stress signaling and diabetic embryopathy, levels of phosphorylated-p66Shc (which is a key signaling molecule that mediates oxidative stress-induced apoptosis) were evaluated...

..In addition, during embryopathy, teratogen such as hyperglycemia is associated with concomitant injury to the yolk sac and embryo...

..Therefore, it is recommended that all women with diabetes of childbearing age be advised of the importance of seeking preconception care, which includes attainment of optimal glucose control and the use of contraception...

..Activation of cPLA(2) was also decreased, suggesting that PKCs mediate the hyperglycemic effects through the cPLA(2)-phospholipid peroxidation pathway...

..The purpose of this study was to examine the effects of self-monitoring of blood glucose (SMBG) on feelings of self-efficacy, dietary compliance, and pregnancy outcomes in women with diet-controlled gestational diabetes mellitus (GDM)...

..Maternal diabetes adversely impacts embryonic vasculogenesis, which results in embryonic vasculopathy. The purpose of our study is to determine whether hypoxia inducible factor (HIF)-1? plays a role in diabetic embryonic vasculopathy...

..We tested whether mitigating oxidative stress, using superoxide dismutase 1 (SOD1) transgenic (Tg) mice, would block hyperglycemia-induced specific protein kinase C (PKC) isoform activation and its downstream cascade...

..In addition, KLF4-siRNA inhibits PKC?-dependent p21(Cip1) promoter activity. PKC? increases KLF4 expression leading to enhanced KLF4 interaction with the GC-rich elements in the p21(Cip1) promoter to activate transcription...

..These findings are informative as they suggest an essential role for selected PKC and MAPK cascade enzymes in mediating a range of end responses to a range of differentiation stimuli in keratinocytes...

..JNK activation itself is sufficient to induce embryonic anomalies, and thus mimics the teratogenic effect of hyperglycemia...

..The ultimate goal is to develop multi-nutrient dietary supplements to eliminate embryonic abnormalities induced by maternal diabetes...

..The objective was to test the hypothesis that hyperglycemia-induced injury of yolk sac cell membranes is associated with disruption of cellular apoptotic signaling pathways...

..The supplementation of polyunsaturated fatty acid arachidonic acid, and antioxidant vitamin E rescued conceptuses from diabetic embryopathy by triggering a restoration of normal membrane signaling pathways...

..However, the role of nicotine in embryonic malformations has not been addressed, and the mechanisms by which nicotine affects embryonic development remain to be delineated...

..This article reviews the existing data on pregnancies complicated by type 2 diabetes and the implications for management and prevention...

..Because unplanned pregnancy is common among diabetic women, they should be counseled early for the importance of preconception care in the progression of this disease...

....

..The purpose of this study was to examine associations between diabetes mellitus and 39 birth defects...

..In addition, these data also demonstrate that hyperglycemia induces altered gene expression, resulting in aberrant cell signaling, morphogenesis, and embryopathy...

..Biophysical profile could prove to be a clinically useful adjunctive tool in the assessment of fetal well-being in labor...

..With new laboratory methods and improved precision, we sought to re-evaluate the correctness of this approach...

....

..This study, conducted by the Institute of Medicine's Clinical Research Roundtable (CRR), sought to learn about the perceptions by medical and nursing school deans of these challenges or the efforts and strategies needed to address them...

..The described ANGELS model encourages replication among other programs that wish to improve perinatal regionalization attempts in their service areas...

..Collectively, the response and proposed strategies can serve as a roadmap to improve clinical research funding and training, evidence-based medical practice, and health care quality...

..More intensive investigation regarding the safety and feasibility of oral agents in pregnancies complicated by type 2 diabetes is necessary...

..All participants in the US health care delivery system must come together to focus on system-wide improvements that will benefit the public...

..During the upcoming grant period, we anticipate the planning and funding of the UM Clinical and Translational Science Center. ..

..In this second funding cycle, the UAMS GCRC will continue expanding campus-wide clinical investigation. Support from all three sister institutions will continue to ensure GCRC success. ..

..During the upcoming grant period, we anticipate the planning and funding of the UM Clinical and Translational Science Center. ..

..During the upcoming grant period, we anticipate the planning and funding of the UM Clinical and Translational Science Center. ..

..The results of the study will provide information that will serve as a basis for future development of therapeutic interventions to prevent maternal diabetes-associated birth defects. ..

....

..The proposed project, which will be co-financed by an $1,165,000 contribution from the State of Maryland, is therefore, considered instrumental for sustaining the stature of the MPRC in schizophrenia researc ..

..The proposed project, which will be co-financed by contributions from the State of Maryland, therefore, considered instrumental for sustaining the stature of the MPRC in schizophrenia research. ..

..abstract_text> ..

..Biostatisticians will assist investigators in designing clinical studies and analyzing data. Combined, the resources provided through the GCRC will sustain and improve the clinical research efforts at UAMS and the VAMC. ..

....

..WVU has a different organizational structure, a different information technology network, and different human subjects research emphasis from the University of Maryland School of Medicine. ..

..The results of the study will provide information that will serve as a basis for future development of therapeutic interventions to prevent maternal diabetes-associated birth defects. ..