Research Topics
Genomes and Genes
| Arshad RahmanSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
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Detail Information
Publications
Blocking NF-?B: an inflammatory issueArshad Rahman
Department of Pediatrics, Box 850, Lung Biology and Disease Program, University of Rochester School of Medicine, Rochester, New York 14642, USA
Proc Am Thorac Soc 8:497-503. 2011....- cAMP targeting of p38 MAP kinase inhibits thrombin-induced NF-kappaB activation and ICAM-1 expression in endothelial cellsArshad Rahman
Department of Pediatrics, University of Rochester School of Medicine, Rochester, New York 14642, USA
Am J Physiol Lung Cell Mol Physiol 287:L1017-24. 2004.... - Hug tightly and say goodbye: role of endothelial ICAM-1 in leukocyte transmigrationArshad Rahman
Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Antioxid Redox Signal 11:823-39. 2009..This review summarizes our current understanding of the "ICAM-1 paradigm" of TEM with an emphasis on the signaling events mediating ICAM-1 expression and activated by ICAM-1 engagement in endothelial cells... - Activation of Syk by protein kinase C-delta regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65Kaiser M Bijli
Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
J Biol Chem 283:14674-84. 2008.... - Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cellsMohd Minhajuddin
Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Biol Chem 284:4052-61. 2009..Thus, these data reveal an important role of PKC-delta and PI3K/Akt pathways in activating mTOR as an endogenous modulator to ensure a tight regulation of NF-kappaB signaling of ICAM-1 expression in endothelial cells... - Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cellsFabeha Fazal
Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Biol Chem 284:21047-56. 2009..Together, these data show that cofilin-1 occupies a central position in RhoA-actin pathway mediating nuclear translocation of RelA/p65 and expression of ICAM-1 in endothelial cells... - Inhibition of mammalian target of rapamycin potentiates thrombin-induced intercellular adhesion molecule-1 expression by accelerating and stabilizing NF-kappa B activation in endothelial cellsMohd Minhajuddin
Department of Pediatrics, University of Rochester School of Medicine, Rochester, New York 14642, USA
J Immunol 174:5823-9. 2005..These data define a novel role of mTOR in down-regulating thrombin-induced ICAM-1 expression in endothelial cells by controlling a delayed and transient activation of NF-kappaB... - Cigarette-smoke-induced oxidative/nitrosative stress impairs VEGF- and fluid-shear-stress-mediated signaling in endothelial cellsIndika Edirisinghe
Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York 14642, USA
Antioxid Redox Signal 12:1355-69. 2010.... - Evidence for actin cytoskeleton-dependent and -independent pathways for RelA/p65 nuclear translocation in endothelial cellsFabeha Fazal
Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Biol Chem 282:3940-50. 2007.... - c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cellsKaiser M Bijli
Department of Pediatrics, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 292:L396-404. 2007..These data implicate an important role of c-Src in phosphorylating RelA/p65 to promote the transcriptional activity of NF-kappaB and thereby ICAM-1 expression in endothelial cells... - RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of I kappa B kinase beta and phosphorylation of RelA/p65Khandaker N Anwar
Department of Pediatrics, University of Rochester School of Medicine, Rochester, NY 14642, USA
J Immunol 173:6965-72. 2004.... - VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunctionIndika Edirisinghe
Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
FASEB J 22:2297-310. 2008..This explains the mechanism of endothelial dysfunction in smokers and has implications in understanding the pathogenesis of pulmonary and cardiovascular diseases... - GPR56 Regulates VEGF production and angiogenesis during melanoma progressionLiquan Yang
Departments of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14612, USA
Cancer Res 71:5558-68. 2011..We propose that components of the GPR56-mediated signaling pathway may serve as new targets for antiangiogenic treatment of melanoma... - Nitric oxide stimulates macrophage inflammatory protein-2 expression in sepsisRandal A Skidgel
Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
J Immunol 169:2093-101. 2002..Thus, NO production in high quantities may be important in the mechanism of amplification of the lung inflammatory response associated with sepsis... - Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-alpha -induced NF-kappa B activation and intercellular adhesion molecule-1 expression in endothelial cellsJie Fan
Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
J Biol Chem 277:3404-11. 2002..Thus, oxidant signaling by the PMN NAD(P)H oxidase complex is an important determinant of TNFalpha-induced NF-kappaB activation and ICAM-1 expression in endothelial cells... - Galpha(q) and Gbetagamma regulate PAR-1 signaling of thrombin-induced NF-kappaB activation and ICAM-1 transcription in endothelial cellsArshad Rahman
Department of Pharmacology, College of Medicine, The University of Illinois, Chicago, Ill 60612 7343, USA
Circ Res 91:398-405. 2002..These results support a model in which ligation of PAR-1 induces NF-kappaB activation and ICAM-1 transcription by the engagement of parallel Galphaq/PKC-delta and Gbetagamma/PI3-kinase pathways that converge at Akt... - Tumor necrosis factor-alpha induces early-onset endothelial adhesivity by protein kinase Czeta-dependent activation of intercellular adhesion molecule-1Kamran Javaid
Department of Pharmacology, University of Illinois College of Medicine, 835 S Wolcott Ave, Chicago, Ill 60612, USA
Circ Res 92:1089-97. 2003..The rapid ICAM-1 expression represents a novel mechanism for promoting the stable adhesion of PMN to endothelial cells that is needed to facilitate the early-onset transendothelial migration of PMN... - Regulation of lung neutrophil recruitment by VE-cadherinJanie Orrington-Myers
Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
Am J Physiol Lung Cell Mol Physiol 291:L764-71. 2006..These results suggest that disassembly of VE-cadherin junctions serves as a negative signal for limiting transendothelial PMN migration secondary to decreased ICAM-1 expression in the mouse model of LPS-induced sepsis... - Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cellsRandall S Frey
Department of Pharmacology and Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, Illinois 60612, USA
J Biol Chem 281:16128-38. 2006..Thus, PI3Kgamma lies upstream of PKCzeta in the endothelium, and its activation is crucial in signaling NADPH oxidase-dependent oxidant production and subsequent NF-kappaB activation and ICAM-1 expression... - E. coli pneumonia induces CD18-independent airway neutrophil migration in the absence of increased lung vascular permeabilityEvan S Ong
Dept of Pharmacology, College of Medicine, Univ of Illinois, 835 S Wolcott Ave, Chicago, IL 60612 7343, USA
Am J Physiol Lung Cell Mol Physiol 285:L879-88. 2003..The massive CD11/CD18-independent airway PMN influx occurring in the absence of lung vascular injury is indicative of an efficient host-defense response elicited by E. coli pneumonia... - Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727Shahab Uddin
Section of Hematology Oncology, Department of Medicine, University of Illinois at Chicago and West Side Veterans Administration Medical Center, Chicago, Illinois 60607, USA
J Biol Chem 277:14408-16. 2002..Altogether, these findings indicate that PKC-delta functions as a serine kinase for Stat1 and an upstream regulator of the p38 MAP kinase and plays an important role in the induction of Type I IFN-biological responses... - Time-dependent reversal of sepsis-induced PMN uptake and lung vascular injury by expression of CD18 antagonistNing Xu
Department of Pharmacology, College of Medicine, The University of Illinois, 835 S Wolcott Avenue, Chicago, IL 60612, USA
Am J Physiol Lung Cell Mol Physiol 282:L796-802. 2002..The results support the model that initial engagement of CD18 integrins enables the further recruitment of additional PMN into lung tissues such that PMN continue to sequester and migrate after E. coli challenge... - Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: studies in p47phox-/- and gp91phox-/- miceXiao Pei Gao
Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
J Immunol 168:3974-82. 2002.... - PKCzeta regulates TNF-alpha-induced activation of NADPH oxidase in endothelial cellsRandall S Frey
Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612-7343, USA
Circ Res 90:1012-9. 2002..These data demonstrate a novel function of PKCzeta in signaling oxidant generation in endothelial cells by the activation of NADPH oxidase, which may be important in mediating endothelial activation responses... - Activation of protein kinase C delta by IFN-gammaDilip K Deb
Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Chicago, IL 60611, USA
J Immunol 171:267-73. 2003..Thus, PKCdelta is activated during engagement of the IFN-gamma receptor and plays an important role in IFN-gamma signaling by mediating serine phosphorylation of Stat1 and facilitating transcription of IFN-gamma-stimulated genes... - Inhibition of activator protein-1 transcription factor activation by omega-3 fatty acid modulation of mitogen-activated protein kinase signaling kinasesTricia A Babcock
Department of Surgery, University of Illinois at Chicago, 60612, USA
JPEN J Parenter Enteral Nutr 27:176-80; discussion 181. 2003..These results provide further evidence for the transcriptional level regulation in the elaboration of proinflammatory cytokines by omega-3 FA in this Mphi model... - Tumor necrosis factor-alpha induces nuclear factor-kappaB-dependent TRPC1 expression in endothelial cellsBiman C Paria
Department of Pharmacology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
J Biol Chem 278:37195-203. 2003..The augmented Ca2+ entry secondary to TRPC1 expression may be an important mechanism of endothelial injury induced by TNF-alpha...
Research Grants
- G-protein-induced Signaling of PMN-mediated Lung InjuryArshad Rahman; Fiscal Year: 2005....
- G-protein-induced Signaling of PMN-mediated Lung InjuryArshad Rahman; Fiscal Year: 2007..These studies may provide future directions for development of therapeutic strategies for inflammatory disease states such as Acute Respiratory Distress Syndrome (ARDS). ..
- G-protein-induced Signaling of PMN-mediated Lung InjuryArshad Rahman; Fiscal Year: 2010..These studies may provide future directions for development of therapeutic strategies for inflammatory disease states such as Acute Respiratory Distress Syndrome (ARDS). ..