Research Topics
Species | Zhilin QuSummaryAffiliation: University of California Country: USA Publications
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Publications
Effects of Na(+) channel and cell coupling abnormalities on vulnerability to reentry: a simulation studyZhilin Qu
Department of Medicine, Cedars Sinai Research Institute, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Am J Physiol Heart Circ Physiol 286:H1310-21. 2004..In remodeled hearts with altered Na(+) channel properties and cellular uncoupling, dynamic instabilities arising from electrical restitution exert important influences on the VW for reentry...- Coordination of cell growth and cell division: a mathematical modeling studyZhilin Qu
Cardiovascular Research Laboratory, University of California, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
J Cell Sci 117:4199-207. 2004..The model also accounts for the cell cycle delay seen in restriction point experiments performed in HeLa cells... - Nonlinear dynamics of cardiac excitation-contraction coupling: an iterated map studyZhilin Qu
Cardiovascular Research Laboratory, Department of Medicine Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Phys Rev E Stat Nonlin Soft Matter Phys 75:011927. 2007.... - Effects of Na(+) and K(+) channel blockade on vulnerability to and termination of fibrillation in simulated normal cardiac tissueZhilin Qu
David Geffen School of Medicine at UCLA, 47 123 CHS, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
Am J Physiol Heart Circ Physiol 289:H1692-701. 2005..Our findings help illuminate, from a theoretical perspective, the possible underlying mechanisms of termination of different types of fibrillation by antiarrhythmic drugs... - Critical mass hypothesis revisited: role of dynamical wave stability in spontaneous termination of cardiac fibrillationZhilin Qu
Department of Medicine Cardiology, David Geffen School of Medicine at UCLA, 47 123 CHS, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
Am J Physiol Heart Circ Physiol 290:H255-63. 2006..Therefore, in addition to tissue mass and geometry, dynamical instability is an important factor influencing the maintenance of cardiac fibrillation... - Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 2: multiple extrasystolesZhilin Qu
Department of Medicine Cardiology, David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
Biophys J 91:805-15. 2006..The equivalent dispersion of refractoriness created dynamically in homogeneous tissue by spatially discordant alternans is more likely to cause conduction block than a comparable degree of preexisting dispersion in heterogeneous tissue... - Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 1: single extrasystolesZhilin Qu
Department of Medicine Cardiology, David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
Biophys J 91:793-804. 2006..g., an epicardial extrasystole versus an endocardial extrasystole)... - The effects of cascade length, kinetics and feedback loops on biological signal transduction dynamics in a simplified cascade modelZhilin Qu
Department of Medicine Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Phys Biol 6:016007. 2009..Likewise, the feedback strength required to generate oscillations changes (again with power-law characteristics) inversely with the length of the cascade... - Dynamics and cardiac arrhythmiasZhilin Qu
Department of Medicine Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Cardiovasc Electrophysiol 17:1042-9. 2006.... - Dynamical effects of diffusive cell coupling on cardiac excitation and propagation: a simulation studyZhilin Qu
David Geffen School of Medicine at UCLA, 47 123 CHS, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
Am J Physiol Heart Circ Physiol 287:H2803-12. 2004..These effects are brought about by the modulation of ionic current activation and inactivation... - Dynamics of the cell cycle: checkpoints, sizers, and timersZhilin Qu
Cardiovascular Research Laboratory, Departments of Medicine Cardiology and Physiology, David Geffen School of Medicine at University of California, Los Angeles, California 90095, USA
Biophys J 85:3600-11. 2003..This model successfully reproduces sizer, timer, and the restriction point features of the eukaryotic cell cycle, in addition to other experimental findings... - Multi-scale modeling in biology: how to bridge the gaps between scales?Zhilin Qu
Department of Medicine Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Prog Biophys Mol Biol 107:21-31. 2011..We then discuss the gaps between different modeling methodologies and between scales, and discuss potential methods for bridging the gaps between scales... - Regulation of the mammalian cell cycle: a model of the G1-to-S transitionZhilin Qu
Cardiovascular Research Laboratory, Department of Medicine, University of California, Los Angeles, California 90095, USA
Am J Physiol Cell Physiol 284:C349-64. 2003..In addition, we found that multisite phosphorylation of CDC25A, Rb, and CKI was critical for the generation of dynamics required for cell cycle progression... - Chaos in the genesis and maintenance of cardiac arrhythmiasZhilin Qu
Department of Medicine Cardiology, David Geffen School of Medicine at University of California, 650 Charles E Young Drive South, Los Angeles, CA 90095, USA
Prog Biophys Mol Biol 105:247-57. 2011.... - Increased susceptibility of aged hearts to ventricular fibrillation during oxidative stressNorishige Morita
Translational Arrhythmia Research Laboratory and Cardiovascular Research Laboratory, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, USA
Am J Physiol Heart Circ Physiol 297:H1594-605. 2009..We conclude that in aged ventricles exposed to oxidative stress, fibrosis facilitates the ability of cellular EADs to emerge and generate TA, VT, and VF at the tissue level... - Vulnerability to re-entry in simulated two-dimensional cardiac tissue: effects of electrical restitution and stimulation sequenceDiana X Tran
Cardiovascular Research Laboratories, Department of Physiological Science, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California 90095, USA
Chaos 17:043115. 2007..When APD restitution is even steeper, the vulnerable window is reduced due to collision of the spiral tips... - Dynamic origin of spatially discordant alternans in cardiac tissueHideki Hayashi
Division of Cardiology, Cedars Sinai Medical Center, Los Angeles, California, USA
Biophys J 92:448-60. 2007..Our results support the viewpoint that spatially discordant alternans in the heart can be formed via a dynamical pattern formation process which does not require tissue heterogeneity... - From pulsus to pulseless: the saga of cardiac alternansJames N Weiss
Department of Medicine Cardiology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Circ Res 98:1244-53. 2006..These insights have illuminated the mechanistic basis underlying the clinical association of cardiac alternans (eg, T wave alternans) with arrhythmia risk, which may lead to novel therapeutic approaches to avert sudden cardiac death... - Modifying L-type calcium current kinetics: consequences for cardiac excitation and arrhythmia dynamicsAman Mahajan
UCLA Cardiovascular Research Laboratory, Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Biophys J 94:411-23. 2008..These findings provide a proof-of-concept test that I(Ca,L) can be targeted to increase dynamic wave stability without depressing contractility, which may have promise as an antifibrillatory strategy... - A simulation study of the effects of cardiac anatomy in ventricular fibrillationFagen Xie
Department of Medicine (Cardiology, Cardiovascular Research Laboratory, University of California, Los Angeles (UCLA, Los Angeles, California 90095-1679, USA
J Clin Invest 113:686-93. 2004..Thus, interventions that promote dynamical wave stability show promise as an antifibrillatory strategy in this more realistic setting... - Intracellular Ca dynamics in ventricular fibrillationChikaya Omichi
Division of Cardiology, Cedars-Sinai Medical Center and Center for Health Sciences, University of California-Los Angeles Cardiovascular Research Laboratory, David Geffen School of Medicine, UCLA, Los Angeles, California 90095-1760, USA
Am J Physiol Heart Circ Physiol 286:H1836-44. 2004..Cai is closely associated with Vm closely during pacing and VT but not during VF. These findings suggest that during VF, non-voltage-gated Cai release events occur and may influence wavebreak by altering Vm and APD locally... - Intracellular Ca alternans: coordinated regulation by sarcoplasmic reticulum release, uptake, and leakLai Hua Xie
Cardiovascular Research Laboratory, Department of Medicine Cardiology, David Geffen School of Medicine at the University of California, Los Angeles, California 90095, USA
Biophys J 95:3100-10. 2008..Thus, BayK8644 promotes, whereas Ad-SERCA2a overexpression, ryanodine, and FK506 suppress, Ca(i) alternans under AP clamp conditions... - Protective role of transient pore openings in calcium handling by cardiac mitochondriaPaavo Korge
Cardiovascular Research Laboratory, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
J Biol Chem 286:34851-7. 2011..We found that transient mPTP openings also stimulated reactive oxygen species production, which may engage reactive oxygen species-dependent cardioprotective signaling... - Cardiac alternans induced by fibroblast-myocyte coupling: mechanistic insights from computational modelsYuanfang Xie
Department of Medicine Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Am J Physiol Heart Circ Physiol 297:H775-84. 2009..Thus, through their coupling with myocytes, fibroblasts alter repolarization and Ca(i) cycling alternans at both the cellular and tissue scales, which may play important roles in arrhythmogenesis in diseased cardiac tissue with fibrosis... - Spark-induced sparks as a mechanism of intracellular calcium alternans in cardiac myocytesRobert Rovetti
Department of Mathematics, Loyola Marymount University, Los Angeles, Calif, USA
Circ Res 106:1582-91. 2010..Intracellular calcium (Ca) alternans has been widely studied in cardiac myocytes and tissue, yet the underlying mechanism remains controversial... - A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart ratesAman Mahajan
UCLA Cardiovascular Research Laboratory, Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Biophys J 94:392-410. 2008.... - So little source, so much sink: requirements for afterdepolarizations to propagate in tissueYuanfang Xie
University of California Los Angeles Cardiovascular Research Laboratory, Departments of Medicine Cardiology, Physiology and Integrative Biology and Physiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Biophys J 99:1408-15. 2010..Structural and electrophysiological remodeling decrease these numbers significantly but still require synchronization mechanisms for EADs and DADs to overcome the robust protective effects of source-sink mismatch... - Irregularly appearing early afterdepolarizations in cardiac myocytes: random fluctuations or dynamical chaos?Daisuke Sato
Department of Medicine Cardiology, David Geffen School of Medicine at University of California, Los Angeles, California, USA
Biophys J 99:765-73. 2010..We conclude that the irregular dynamics of EADs is intrinsically chaotic, with random fluctuations playing a nonessential, auxiliary role potentiating the complex dynamics... - Action potential duration restitution and ventricular fibrillation due to rapid focal excitationMoshe Swissa
Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
Am J Physiol Heart Circ Physiol 282:H1915-23. 2002..In this model of focal source VF, the VT-to-VF transition occurred due to a wave break outside the aconitine site, and drugs that flattened the APD restitution slope converted VF to VT despite continuous activation from aconitine site... - Genesis of phase 3 early afterdepolarizations and triggered activity in acquired long-QT syndromeMitsunori Maruyama
Krannert Institute of Cardiology and the Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Circ Arrhythm Electrophysiol 4:103-11. 2011..Both phase 2 and phase 3 early afterdepolarizations (EADs) occur in long-QT syndromes, but their respective roles in generating arrhythmias in intact cardiac tissue are incompletely understood... - Effects of fibroblast-myocyte coupling on cardiac conduction and vulnerability to reentry: A computational studyYuanfang Xie
Department of Medicine Cardiology, David Geffen School of Medicine at University of California, Los Angeles, California 90095, USA
Heart Rhythm 6:1641-9. 2009.... - Bifurcation and chaos in a model of cardiac early afterdepolarizationsDiana X Tran
Department of Medicine, Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Phys Rev Lett 102:258103. 2009..During period pacing, chaos always occurs at the transition from no EAD to EADs as the stimulation frequency decreases, providing a distinct explanation for the irregular EAD behavior frequently observed in experiments... - Hysteresis and cell cycle transitions: how crucial is it?Zhangang Han
Cardiovascular Research Laboratory, Department of Medicine (Cardiology, David Geffen School of Medicine at the University of California, Los Angeles, California 90095, USA
Biophys J 88:1626-34. 2005..Thus, although a hysteretic response is neither necessary nor sufficient, it is in general a much more robust mechanism for generating cell cycle dynamics than nonhysteretic mechanisms... - The dynamics of cardiac fibrillationJames N Weiss
Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 1760, USA
Circulation 112:1232-40. 2005..As global properties, rather than local electrophysiological characteristics, dynamic factors represent an attractive target for novel therapies to prevent ventricular fibrillation... - Dispersion of refractoriness and induction of reentry due to chaos synchronization in a model of cardiac tissueYuanfang Xie
Department of Medicine Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Phys Rev Lett 99:118101. 2007..These regions of increased refractoriness create localized conduction block, which induces spiral wave reentry... - The pinwheel experiment revisited: effects of cellular electrophysiological properties on vulnerability to cardiac reentryMing Jim Yang
Cardiovascular Research Laboratory, David Geffen School of Medicine, University of California, Los Angeles 90095, USA
Am J Physiol Heart Circ Physiol 293:H1781-90. 2007..We derive an analytical treatment that shows good agreement with numerical simulation results... - Short-term cardiac memory and mother rotor fibrillationAli Baher
David Geffen School of Medicine at UCLA, Division of Cardiology, 47 123 CHS, 10833 LeConte Ave, Los Angeles, CA 90095 1679, USA
Am J Physiol Heart Circ Physiol 292:H180-9. 2007..This was due to progressive acceleration and stabilization of rotors as accumulation of memory shortened APD and flattened APD restitution slope nonuniformly throughout the tissue... - Multisite phosphorylation and network dynamics of cyclin-dependent kinase signaling in the eukaryotic cell cycleLing Yang
Departments of Medicine (Cardiology) and Physiology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095, USA
Biophys J 86:3432-43. 2004..In summary, our findings suggest that multisite phosphorylation of proteins is a critical biological mechanism in generating the essential dynamics and ensuring robust behavior of the cell cycle... - Synchronization of chaotic early afterdepolarizations in the genesis of cardiac arrhythmiasDaisuke Sato
Cardiovascular Research Laboratory, Department of Medicine Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 106:2983-8. 2009..This mechanism explains how collective cellular behavior integrates at the tissue scale to generate lethal cardiac arrhythmias over a wide range of heart rates... - Anisotropic conduction block and reentry in neonatal rat ventricular myocyte monolayersCarlos de Diego
Cardiovascular Research Laboratory, Department of Medicine Cardiology and Physiology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095, USA
Am J Physiol Heart Circ Physiol 300:H271-8. 2011.... - Increased vulnerability to inducible atrial fibrillation caused by partial cellular uncoupling with heptanolToshihiko Ohara
Division of Cardiology, Cedars-Sinai Research Institute, Department of Medicine, University of California of Los Angeles School of Medicine, Los Angeles, California 90048, USA
Am J Physiol Heart Circ Physiol 283:H1116-22. 2002..The effects of heptanol were reversible. We conclude that partial cellular uncoupling by heptanol without changing atrial active membrane properties promotes wavebreak, reentry, and AF during rapid pacing... - Early afterdepolarizations and cardiac arrhythmiasJames N Weiss
UCLA Cardiovascular Research Laboratory, Departments of Medicine Cardiology, Physiology and Integrative Biology and Physiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Heart Rhythm 7:1891-9. 2010.... - Bidirectional ventricular tachycardia: ping pong in the His-Purkinje systemAlex A Baher
Cardiovascular Research Laboratory, Department of Medicine Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Heart Rhythm 8:599-605. 2011..Evidence from human and animal studies attributes BVT to alternating ectopic foci originating from the distal His-Purkinje system in the left and/or right ventricle, respectively... - Acceleration of cardiac tissue simulation with graphic processing unitsDaisuke Sato
Cardiovascular Research Laboratory, Department of Medicine Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Med Biol Eng Comput 47:1011-5. 2009..These results demonstrate that a commodity personal computer is able to perform a whole heart simulation of electrical wave conduction within times that enable the investigators to interact more easily with their simulations... - Nonlinear dynamics of paced cardiac cellsYohannes Shiferaw
Division of Cardiology, David Geffen School of Medicine at UCLA, University of California-Los Angeles, Los Angeles, CA 90095, USA
Ann N Y Acad Sci 1080:376-94. 2006..We explain the development and properties of these maps, and show that they provide a fruitful framework to understand dynamical instabilities of voltage and calcium in paced cardiac cells... - Glycolytic oscillations in isolated rabbit ventricular myocytesJun Hai Yang
Cardiovascular Research Laboratory, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1760, USA
J Biol Chem 283:36321-7. 2008.... - Linking flickering to waves and whole-cell oscillations in a mitochondrial network modelMelissa Nivala
Department of Medicine Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California, USA
Biophys J 101:2102-11. 2011..These simulation results may provide mechanistic insight into the transition from random mitochondrial flickering to the waves and whole-cell oscillations observed in many experimental studies... - Suppression of re-entrant and multifocal ventricular fibrillation by the late sodium current blocker ranolazineNorishige Morita
Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
J Am Coll Cardiol 57:366-75. 2011..The purpose of this study was to test the hypothesis that the late Na current blocker ranolazine suppresses re-entrant and multifocal ventricular fibrillation (VF)... - Electrical refractory period restitution and spiral wave reentry in simulated cardiac tissueFagen Xie
Cardiovascular Research Laboratory and Division of Cardiology, Department of Medicine, University of California, Los Angeles, California 90095, USA
Am J Physiol Heart Circ Physiol 283:H448-60. 2002..Thus ERP restitution, which is easier to measure clinically than APD restitution, is a reliable determinant of spiral wave stability in simulated atrial and ventricular tissue... - Electrical restitution and cardiac fibrillationJames N Weiss
Department of Medicine, UCLA School of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90095 1760, USA
J Cardiovasc Electrophysiol 13:292-5. 2002..Developing therapies that favorably alter these cardiac electrical restitution properties are a promising new approach to preventing fibrillation... - Signal transduction network motifs and biological memoryZhangang Han
Department of Medicine Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Theor Biol 246:755-61. 2007.... - Linking cell division to cell growth in a spatiotemporal model of the cell cycleLing Yang
Department of Medicine (Cardiology, Cardiovascular Research Laboratory, University of California, David Geffen School of Medicine at UCLA, 47-123 CHS, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
J Theor Biol 241:120-33. 2006.... - Deducing topology of protein-protein interaction networks from experimentally measured sub-networksLing Yang
Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California 90095, USA
BMC Bioinformatics 9:301. 2008..However, whether topological information reaped from these experimentally-measured sub-networks can be extrapolated to complete protein-protein interaction networks is unclear... - Period-doubling bifurcation in an array of coupled stochastically excitable elements subjected to global periodic forcingXiaohua Cui
Department of Physiological Science, University of California, Los Angeles, California 90095, USA
Phys Rev Lett 103:044102. 2009..Using a mean-field representation, we show that this macroscopic bifurcation behavior is caused by interactions between the random excitation, the refractory period, and recruitment (spatial cooperativity) of the excitable elements... - Chronic nicotine in hearts with healed ventricular myocardial infarction promotes atrial flutter that resembles typical human atrial flutterMizuho Miyauchi
Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA
Am J Physiol Heart Circ Physiol 288:H2878-86. 2005..Chronic nicotine in hearts with MI promotes AFL that closely resembles typical human AFL. Increased atrial interstitial fibrosis and flattened electrical restitution are important substrates for the AFL... - Alternans and arrhythmias: from cell to heartJames N Weiss
Department of Medicine, University of California at Los Angeles, 90095, USA
Circ Res 108:98-112. 2011..Throughout, we emphasize the qualitatively novel properties that emerge at each new scale of integration... - Bi-stable wave propagation and early afterdepolarization-mediated cardiac arrhythmiasMarvin G Chang
Department of Medicine Cardiology, David Geffen School of Medicine at University of California, Los Angeles, California 90095, USA
Heart Rhythm 9:115-22. 2012..However, it has not been shown whether the same tissue can exhibit both the I(Na)-mediated and the I(Ca,L)-mediated conduction... - Mechanism for spiral wave breakup in excitable and oscillatory mediaJunzhong Yang
Department of Medicine (Cardiology, University of California, Los Angeles, 90095, USA
Phys Rev Lett 91:148302. 2003..The difference in phenomenology is due to the asymptotic behavior of the modulation mode... - Mitochondrial oscillations and waves in cardiac myocytes: insights from computational modelsLing Yang
Department of Medicine Cardiology, David Geffen School of Medicine at University of California, Los Angeles, California, USA
Biophys J 98:1428-38. 2010..Our observations provide mechanistic insights into the spatiotemporal dynamics underlying RIRR-induced PsiM oscillations and waves observed experimentally in cardiac myocytes... - Arrhythmogenic consequences of myofibroblast-myocyte couplingThao P Nguyen
UCLA Cardiovascular Research Laboratory, Division of Cardiology, Department of Medicine, Los Angeles, CA, USA
Cardiovasc Res 93:242-51. 2012.... - Systems biology approaches to metabolic and cardiovascular disorders: network perspectives of cardiovascular metabolismJames N Weiss
Cardiovascular Research Laboratory, Departments of Medicine Cardiology and Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Lipid Res 47:2355-66. 2006..We speculate how this state of "metabolic fibrillation" leads to cell death if not corrected and discuss the implications for cardioprotection... - Shaping a new Ca²? conductance to suppress early afterdepolarizations in cardiac myocytesRoshni V Madhvani
Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095 7115, USA
J Physiol 589:6081-92. 2011..We propose that modifying the biophysical properties of I(Ca,L) has potential as a powerful therapeutic strategy for suppressing EADs and EAD-mediated arrhythmias... - Understanding biological complexity: lessons from the pastJames N Weiss
The UCLA Cardiovascular Research Laboratory, and Department of Medicine Cardiology, UCLA School of Medicine, Los Angeles, California 90095 1760, USA
FASEB J 17:1-6. 2003..When combined, they are highly synergistic in analyzing the mechanisms underlying the behavior of complex biological systems. Their effective integration will be essential for unraveling the physical basis of the mysteries of life... - T-wave Alternans and Arrhythmogenesis in Cardiac DiseasesZhilin Qu
Department of Medicine Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095
Front Physiol 1:1-15. 2010..In this review, we summarize the cellular mechanisms of alternans arising from these different mechanisms, and discuss their roles in arrhythmogenesis in the setting of cardiac disease... - The chicken or the egg? Voltage and calcium dynamics in the heartZhilin Qu
Am J Physiol Heart Circ Physiol 293:H2054-5. 2007 - Inferring the cellular origin of voltage and calcium alternans from the spatial scales of phase reversal during discordant alternansDaisuke Sato
Biophys J 92:L33-5. 2007..These results show that experimentally accessible measurements of Ca(i) and V(m) in cardiac tissue can be used to shed light on the cellular origin of alternans... - Spatially discordant alternans in cardiac tissue: role of calcium cyclingDaisuke Sato
Department of Physics and Center for Interdisciplinary Research on Complex Systems, Northeastern University, Boston, Mass, USA
Circ Res 99:520-7. 2006..Finally, we address the experimental relevance of these findings and suggest physiological conditions under which these patterns can be observed... - Effects of the excitation-contraction uncouplers diamine monoxime (DAM) and cytochalasin D (CytoD) on induced arrhythmias in the rabbit ventricleJames N Weiss
J Cardiovasc Electrophysiol 14:331-2; author reply 332-4. 2003 - Mother rotors and the mechanisms of D600-induced type 2 ventricular fibrillationTsu Juey Wu
Cardiovascular Center, Taichung Veterans General Hospital and Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan
Circulation 110:2110-8. 2004..Type 1 VF is characterized by the presence of multiple, wandering wavelets, whereas type 2 VF shows local spatiotemporal periodicity. We hypothesized that a single mother rotor underlies type 2 VF... - Nonlinear dynamic control of irregular cardiac rhythmsZhilin Qu
J Cardiovasc Electrophysiol 15:1186-7. 2004 - [Estimation of transition probability in diameter grade transition model of forest population]Zhilin Qu
Northeast Forestry University, Harbin 150040, China
Ying Yong Sheng Tai Xue Bao 17:2307-10. 2006..The results of case studies showed that both of the two methods had the characteristics of easy operation and high practicability, and the importance of theoretical guidance and practical application in forest management...