Research Topics
| Carol PrescottSummaryAffiliation: University of Southern California Country: USA Publications
Research Grants
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Detail Information
Publications
Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4C A Prescott
Department of Psychology, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, USA
Mol Psychiatry 11:603-11. 2006..The results of this study suggest the importance of genetic variation in chromosome 4 in the etiology and severity of alcoholism in Caucasian populations...- Challenges in genetic studies of the etiology of substance use and substance use disorders: introduction to the special issueCarol A Prescott
Department of Psychology, University of Southern California, SGM 501, Los Angeles, CA, 90036, USA
Behav Genet 36:473-82. 2006.... - Twin pair resemblance for psychiatric hospitalization in the Swedish Twin Registry: a 32-year follow-up study of 29,602 twin pairsCarol A Prescott
Department of Psychology, University of Southern California, 3620 S McClintock Ave, SGM 501, Los Angeles, CA 90089 1061, USA
Behav Genet 37:547-58. 2007..The present report updates the prior results by using 17 additional years of follow-up, including members of opposite-sex twin pairs, and addressing biases arising from cohort effects and from excluding pairs with unknown zygosity... - Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twinsKenneth S Kendler
Virginia Institute for Psychiatric and Behavioral Genetics, USA
Am J Psychiatry 160:687-95. 2003..Data on use and misuse of six classes of illicit substances by male twin pairs were used to examine whether genetic and shared environmental risk factors for substance use disorders are substance-specific or -nonspecific in their effect... - Longitudinal modeling of genetic and environmental influences on self-reported availability of psychoactive substances: alcohol, cigarettes, marijuana, cocaine and stimulantsNathan A Gillespie
Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219 1534, USA
Psychol Med 37:947-59. 2007..Although an obvious environmental factor influencing drug use, the sources of individual differences in drug availability (DA) are unknown... - Lifestyle risk and delaying factorsMargaret Gatz
Department of Psychology, University of Southern California, 3620 McClintock Avenue, Los Angeles, CA 90089 1061, USA
Alzheimer Dis Assoc Disord 20:S84-8. 2006..Such findings point to the importance of taking a life-course perspective to designing interventions to delay or to prevent dementia... - Predictors of illicit substance dependence among individuals with alcohol dependenceNicole D Sintov
Department of Psychology, University of Southern California, Los Angeles, California 90089 1061, USA
J Stud Alcohol Drugs 70:269-78. 2009..The goal of this cross-sectional study was to identify factors associated with drug dependence among individuals with AD... - The structure of genetic and environmental risk factors for anxiety disorders in men and womenJohn M Hettema
Virginia Institute for Psychiatry and Behavioral Genetics and Department of Psychiatry, Virginia Commonwealth University, Richmond, USA
Arch Gen Psychiatry 62:182-9. 2005..The anxiety disorders exhibit high levels of lifetime comorbidity with one another. Understanding the underlying causes of this comorbidity can provide insight into the etiology of the disorders and inform classification and treatment... - Genetic and environmental influences on alcohol, caffeine, cannabis, and nicotine use from early adolescence to middle adulthoodKenneth S Kendler
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical School of Virginia Virginia Commonwealth University, Richmond, VA 23298 0126, USA
Arch Gen Psychiatry 65:674-82. 2008..While both environmental and genetic factors are important in the etiology of psychoactive substance use (PSU), we know little of how these influences differ through development... - The temporal relationship of the onsets of alcohol dependence and major depression: using a genetically informative study designPo Hsiu Kuo
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
Psychol Med 36:1153-62. 2006..In this longitudinal study, we used a genetically informative population-based twin sample to examine the age-at-onset distributions and the temporal relationship of AD and MD... - A twin study of early cannabis use and subsequent use and abuse/dependence of other illicit drugsArpana Agrawal
Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Department of Human Genetics, Richmond, VA 23298 0003, USA
Psychol Med 34:1227-37. 2004..Gateway and common liabilities models have been employed to explain this relationship. We sought to examine this association using a combination of the discordant twin design and modeling methods... - Genetic and environmental sources of covariation between generalized anxiety disorder and neuroticismJohn M Hettema
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
Am J Psychiatry 161:1581-7. 2004..Because women have higher levels of neuroticism and twice the risk of lifetime generalized anxiety disorder of men, gender-specific effects were also explored... - Empirically defined subtypes of alcohol dependence in an Irish family sampleNicole D Sintov
Department of Psychology, University of Southern California, Los Angeles, CA 90089, USA
Drug Alcohol Depend 107:230-6. 2010..These findings are consistent with the affective regulation and behavioral disinhibition subtypes of alcoholism, and are in line with prior work suggesting familial influences on subtype etiology... - The subtypes of major depression in a twin registryPatrick F Sullivan
Virginia Commonwealth University, Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, P O Box 980126, Richmond VA 23298 0126, USA
J Affect Disord 68:273-84. 2002..The subtypes of major depression (MD) remain incompletely understood. While there is consensus about the existence of MD with 'typical' vegetative features, further data are required to evaluate the existence of MD with atypical features... - Using the Mplus computer program to estimate models for continuous and categorical data from twinsCarol A Prescott
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0126
Behav Genet 34:17-40. 2004.... - Sex differences in the genetic and environmental influences on the development of antisocial behaviorKristen C Jacobson
Virginia Institute for Psychiatric and Behavioral Genetics, USA
Dev Psychopathol 14:395-416. 2002..We speculate that sex differences in timing of puberty may account for the earlier presence of genetic effects among females... - Mood-related drinking motives mediate the familial association between major depression and alcohol dependenceKelly C Young-Wolff
Department of Psychology, University of Southern California, Los Angeles, California 90089 1061, USA
Alcohol Clin Exp Res 33:1476-86. 2009..This study investigated whether mood-related drinking motives mediate the association between major depression and alcohol dependence, and what the genetic and environmental bases are for this relationship... - Dimensions of religiosity and their relationship to lifetime psychiatric and substance use disordersKenneth S Kendler
Virginia Institute for Psychiatry and Behavioral Genetics and Department of Psychiatry and Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
Am J Psychiatry 160:496-503. 2003..This study used data from a general population sample to clarify the dimensions of religiosity and the relationships of these dimensions to risk for lifetime psychiatric and substance use disorders... - The Washington University Twin Study of alcoholismCarol A Prescott
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
Am J Med Genet B Neuropsychiatr Genet 134:48-55. 2005..Power to test other sources of heterogeneity was limited, but the results suggest no evidence for higher heritability for male early onset alcoholism or for alcoholism with comorbid antisocial personality... - A twin study of genetic and environmental influences on tobacco initiation, regular tobacco use and nicotine dependenceHermine H Maes
Departments of Human Genetics and Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0003, USA
Psychol Med 34:1251-61. 2004..As the development of ND requires regular tobacco use (RTU) which in turn requires TI, a conditional approach is necessary... - The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and womenKenneth S Kendler
Virginia Institute for Psychiatry and Behavioral Genetics and the Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0126, USA
Arch Gen Psychiatry 60:929-37. 2003..The pattern of lifetime comorbidity of common psychiatric and substance use disorders results largely from the effects of genetic risk factors... - Cannabis and other illicit drugs: comorbid use and abuse/dependence in males and femalesArpana Agrawal
Department of Human Genetics, Medical College of Virginia of Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, Virginia 23298, USA
Behav Genet 34:217-28. 2004..Overall, our results suggest that the use and abuse/dependence of cannabis and other illicit drugs are strongly linked via common risk factors that jointly influence their individual liabilities... - A population-based twin study of the relationship between neuroticism and internalizing disordersJohn M Hettema
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, P O Box 980126, Richmond, VA 23298 0126, USA
Am J Psychiatry 163:857-64. 2006..The authors examined how genetic and environmental factors shared by the personality trait neuroticism and seven internalizing disorders may help explain this comorbidity... - Specificity of genetic and environmental risk factors for symptoms of cannabis, cocaine, alcohol, caffeine, and nicotine dependenceKenneth S Kendler
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Medical School, Richmond, VA 23298 0126, USA
Arch Gen Psychiatry 64:1313-20. 2007..Although genetic risk factors have been found to contribute to dependence on both licit and illicit psychoactive substances, we know little of how these risk factors interrelate... - A population based twin study of sex differences in depressive symptomsArpana Agrawal
Department of Human Genetics, Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond 23298, USA
Twin Res 7:176-81. 2004..Our analyses suggest that while there may be mean differences in the levels of depressive symptoms across sexes, the genetic and environmental factors that predispose males and females to depressive symptoms are not different... - Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol DependencePo Hsiu Kuo
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA
Alcohol Clin Exp Res 30:1807-16. 2006..The goal of this study was to identify genomic regions containing susceptibility loci for alcohol-related traits... - Is risk for alcoholism mediated by individual differences in drinking motivations?Carol A Prescott
Virginia Institute of Psychiatric and Behavioral Genetics, Departments of Psychiatry and Psychology, Virginia Commonwealth University, Richmond, Virginia, USA
Alcohol Clin Exp Res 28:29-39. 2004.... - Gender differences in the symptoms of major depression in opposite-sex dizygotic twin pairsAmir A Khan
Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
Am J Psychiatry 159:1427-9. 2002..Gender differences in the symptoms of major depression have received limited research attention. The aim of this study was to explore these differences in male-female twin pairs... - The Irish Affected Sib Pair Study of Alcohol Dependence: study methodology and validation of diagnosis by interview and family historyCarol A Prescott
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA
Alcohol Clin Exp Res 29:417-29. 2005.... - Sex differences in the relationship between social support and risk for major depression: a longitudinal study of opposite-sex twin pairsKenneth S Kendler
Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298-0126, USA
Am J Psychiatry 162:250-6. 2005..Clarification of the nature of the causal links between low social support and depression in women is needed... - The differential impact of risk factors on illicit drug involvement in femalesArpana Agrawal
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Dept of Human Genetics, Richmond, VA, USA
Soc Psychiatry Psychiatr Epidemiol 40:454-66. 2005..Are there risk factors that associate with illicit drug use or illicit drug abuse/dependence? Is the magnitude of the association the same for use and abuse/dependence? Does this pattern of association differ across categories of drugs?.. - A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorderKenneth S Kendler
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Alcohol Clin Exp Res 30:1972-7. 2006..Are the susceptibility genes underlying this peak specific for AD or do they increase risk for externalizing disorders more generally? Can we, in the IASPSAD, replicate prior evidence for linkage to conduct disorder (CD)?.. - Factor and item-response analysis DSM-IV criteria for abuse of and dependence on cannabis, cocaine, hallucinogens, sedatives, stimulants and opioidsNathan A Gillespie
Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, VA 23219 1534, USA
Addiction 102:920-30. 2007.... - Unraveling the molecular mechanisms of alcohol dependenceGursharan Kalsi
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, PO Box 980424, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
Trends Genet 25:49-55. 2009.... - A genome-wide linkage analysis for the personality trait neuroticism in the Irish affected sib-pair study of alcohol dependencePo Hsiu Kuo
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23298 0126, USA
Am J Med Genet B Neuropsychiatr Genet 144:463-8. 2007..These results, together with prior studies, indicate several potential regions for quantitative trait loci for neuroticism that warrant further study... - The etiology of phobias: an evaluation of the stress-diathesis modelKenneth S Kendler
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E Leigh St, Box 980126, Richmond, VA 23298-0126, USA
Arch Gen Psychiatry 59:242-8. 2002..The stress-diathesis model may not be an appropriate paradigm for phobic disorders... - Major depression and associated impairment: same or different genetic and environmental risk factors?Debra L Foley
Virginia Institute for Psychiatric and Behavioral Genetics, Departments of Human Genetics and Psychiatry, Virginia Commonwealth University, USA
Am J Psychiatry 160:2128-33. 2003..The addition of associated functional impairment as a criterion for the diagnosis of major depression not only lowers prevalence estimates but also introduces a small set of new etiological factors into the diagnosis of major depression... - Mixed-effects variance components models for biometric family analysesJohn J McArdle
Department of Psychology, University of Southern California, Los Angeles, CA 90089, USA
Behav Genet 35:631-52. 2005.... - Sex differences in the genetic risk for alcoholismCarol A Prescott
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Adult Twin Study of Psychiatric and Substance Use Disorders, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia, USA
Alcohol Res Health 26:264-73. 2002..However, the genetic epidemiology research conducted to date on this issue has several limitations, some of which may be resolved by future molecular genetic studies... - A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom countsGursharan Kalsi
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, USA
Hum Mol Genet 19:2497-506. 2010..Haplotype-specific expression measurements in post-mortem tissue samples suggested a functional role for DKK2. This evidence notwithstanding, replication is needed before confidence can be placed in these findings... - The differential heritability of regular tobacco use based on method of administrationJ Eric Schmitt
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298-0126, USA
Twin Res Hum Genet 8:60-2. 2005..Thus, the genetic influences on the liability for regular tobacco use appear to vary based on tobacco type. The causes for the use of different forms of tobacco are complex and worthy of further study... - Level of family dysfunction and genetic influences on smoking in womenKenneth S Kendler
Department of Psychiatry, Medical College of Virginia/Virginia Commonwealth University, Richmond, VA 23298-0126, USA
Psychol Med 34:1263-9. 2004..The hypothesis that genetic effects for psychiatric and drug-use disorders become stronger in more adverse environments is not universally true... - Low extraversion and high neuroticism as indices of genetic and environmental risk for social phobia, agoraphobia, and animal phobiaO Joseph Bienvenu
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Meyer 115, 600 North Wolfe St, Baltimore, MD 21287, USA
Am J Psychiatry 164:1714-21. 2007.... - Personality and comorbidity of common psychiatric disordersAmir A Khan
Mental Health and Behavioral Sciences Service, Providence VA Medical Center, 830 Chalkstone Ave, Providence, RI 02908, USA
Br J Psychiatry 186:190-6. 2005..We know little about the degree to which comorbidity, socommonly seen among psychiatric disorders, arises from variation in normal personality... - The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replicationKenneth S Kendler
Virginia Institute for Psychiatry and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298, USA
Arch Gen Psychiatry 62:529-35. 2005..Prior evidence from twin studies suggested genetic moderation of the depressogenic effects of stressful life events (SLEs). Can the specific genes involved in this effect be identified?.. - Toward a comprehensive developmental model for major depression in womenKenneth S Kendler
Department of Psychiatry, PO Box 980126, Medical College of Virginia, Richmond, VA 23298 0126, USA
Am J Psychiatry 159:1133-45. 2002..The authors used structural equation modeling to generate a developmental model for the etiology of major depression in women... - Genetic and environmental influences on illicit drug use and tobacco use across birth cohortsKenneth S Kendler
Virginia Institute for Psychiatry and Behavioral Genetics and Department of Psychiatry, Medical College of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
Psychol Med 35:1349-56. 2005..One theory, which postulates that heritability of deviant traits increases in permissive environments, predicts a positive relationship across cohorts between prevalence and heritability of substance use... - Toward a comprehensive developmental model for major depression in menKenneth S Kendler
Virginia Institute for Psychiatry and Behavioral Genetics and the Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
Am J Psychiatry 163:115-24. 2006..In 2002, the authors presented a developmental model for major depression in women. Based on similar methods, they here present an analogous model for men... - Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxietyKenneth S Kendler
Virginia Institute for Psychiatry and Behavioral Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, USA
Arch Gen Psychiatry 60:789-96. 2003..The event dimensions that preceded mixed MD-GAS episodes were largely the sum of those that preceded pure MD and pure GAS episodes... - Effects of genetic and procedural variation on measurement of alcohol sensitivity in mouse inbred strainsJohn C Crabbe
Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, 97239, USA
Behav Genet 36:536-52. 2006..In certain instances, substrain seems to matter little, while in others, substrains differed a great deal. These data are generally encouraging about the stability of genetic differences... - Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) samplePo Hsiu Kuo
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital 138, National Cheng Kung University, Sheng Li Road, Tainan 704, Taiwan
Alcohol Clin Exp Res 32:785-95. 2008..The present study examined evidence for the association of alcohol metabolism genes with AD in the Irish Affected Sib Pair Study of alcohol dependence... - Sex influences on shared risk factors for bulimia nervosa and other psychiatric disordersTracey D Wade
School of Psychology, Flinders University, Adelaide, Australia
Arch Gen Psychiatry 61:251-6. 2004..The examination of opposite-sex and same-sex dizygotic twins allows us to explore the sex-specific comorbidity of psychiatric disorders. To date, this question has not been explored in eating disorders... - Creating a social world: a developmental twin study of peer-group devianceKenneth S Kendler
Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University Medical School, VA 23298 0126, USA
Arch Gen Psychiatry 64:958-65. 2007..Peer-group deviance is strongly associated with externalizing behaviors. We have limited knowledge of the sources of individual differences in peer-group deviance... - Forms of cannabis and cocaine: a twin studyArpana Agrawal
Department of Human Genetics, Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia 23298 0003, USA
Am J Med Genet B Neuropsychiatr Genet 129:125-8. 2004..These findings also reinforce the validity of composite variables in epidemiological and genetic research... - The types of regular cigarette smokers: a latent class analysisHelena Furberg
Department of Genetics, University of North Carolina at Chapel Hill, School of Medicine 27599 7264, USA
Nicotine Tob Res 7:351-60. 2005.... - The impact of generalized anxiety disorder and stressful life events on risk for major depressive episodesJohn M Hettema
Virginia Institute for Psychiatry and Behavioral Genetics and Department of Psychiatry, Virginia of Virginia Commonwealth University, Richmond, VA 23298 0126, USA
Psychol Med 36:789-95. 2006..In this study, we sought to analyze the joint effects of prior history of GAD and recent SLEs on risk for major depressive episodes, comparing these in men and women... - Genomewide linkage survey of nicotine dependence phenotypesPatrick F Sullivan
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
Drug Alcohol Depend 93:210-6. 2008..We sought to identify genomic regions that might contain etiologically-relevant loci using genomewide univariate and bivariate linkage analyses...
Research Grants
- MEDIATION AND MODERATION OF GENETIC RISK FOR ALCOHOLISMCarol Prescott; Fiscal Year: 2002..To facilitate this, the candidate will obtain training in behavioral pharmacology and molecular genetics. ..
- An Irish Affected Sib Pair Study of Alcohol DependenceCarol Prescott; Fiscal Year: 2004..To conduct this project we have assembled a team of experts in clinical assessment, statistical genetics and molecular genetics...