Richmond T Prehn

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Immunostimulation and immunoinhibition of premalignant lesions
    Richmond T Prehn
    Department of Pathology, University of Washington, Seattle, WA 98118, USA
    Theor Biol Med Model 4:6. 2007
  2. ncbi Does the immune reaction cause malignant transformation by disrupting cell-to-cell or cell-to-matrix communications?
    Richmond T Prehn
    Department of Pathology, University of Washington, Seattle, WA 98118, USA
    Theor Biol Med Model 4:16. 2007
  3. ncbi Whipsaw cancer treatments: the role of hormesis in endocrine and immune therapies
    Richmond T Prehn
    Department of Pathology, University of Washington, Seattle, WA, USA
    Semin Oncol 33:708-10. 2006
  4. ncbi An immune reaction may be necessary for cancer development
    Richmond T Prehn
    Theor Biol Med Model 3:6. 2006
  5. ncbi The epigenetic instruction manual for the operation of the genome
    R T Prehn
    University of Washington, Seattle, Washington, USA
    Med Hypotheses 58:177-81. 2002
  6. ncbi The paradoxical effects of splenectomy on tumor growth
    Richmond T Prehn
    Department of Pathology, University of Washington, Seattle, WA, USA
    Theor Biol Med Model 3:23. 2006
  7. ncbi The flip side of immune surveillance: immune dependency
    Richmond T Prehn
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98118, USA
    Immunol Rev 222:341-56. 2008
  8. ncbi Immunologgical self-tolerance in allophenic and embryo-aggregated mice
    Richmond T Prehn
    Dept of Pathology, University of Washington, 5433 South Hudson St, Seattle, WA 98118, USA
    Theor Biol Med Model 7:38. 2010

Collaborators

Detail Information

Publications8

  1. ncbi Immunostimulation and immunoinhibition of premalignant lesions
    Richmond T Prehn
    Department of Pathology, University of Washington, Seattle, WA 98118, USA
    Theor Biol Med Model 4:6. 2007
    ..The immune reaction may be either stimulatory or inhibitory to tumor growth, depending upon the local ratio of immune reactants to tumor cells...
  2. ncbi Does the immune reaction cause malignant transformation by disrupting cell-to-cell or cell-to-matrix communications?
    Richmond T Prehn
    Department of Pathology, University of Washington, Seattle, WA 98118, USA
    Theor Biol Med Model 4:16. 2007
    ..There is even some evidence suggesting that transformation in vivo may seldom occur in the absence of immunostimulation of the premalignant lesion. Positive selection by the immune reaction may be the reason that tumors are immunogenic...
  3. ncbi Whipsaw cancer treatments: the role of hormesis in endocrine and immune therapies
    Richmond T Prehn
    Department of Pathology, University of Washington, Seattle, WA, USA
    Semin Oncol 33:708-10. 2006
    ..We suggest that the phenomenon of hormesis might be used to keep a tumor under hormonal and/or immunologic environments that are inimical to its growth and well-being...
  4. ncbi An immune reaction may be necessary for cancer development
    Richmond T Prehn
    Theor Biol Med Model 3:6. 2006
    ..Instead, the higher level of immune response in a normal animal, even if it does not rise to tumor-inhibitory levels, probably gives less positive support to tumor growth. This seems more than a semantic distinction...
  5. ncbi The epigenetic instruction manual for the operation of the genome
    R T Prehn
    University of Washington, Seattle, Washington, USA
    Med Hypotheses 58:177-81. 2002
    ..The increasing concentration after puberty might tend to activate the genome in reverse order and thus contribute to senescence...
  6. ncbi The paradoxical effects of splenectomy on tumor growth
    Richmond T Prehn
    Department of Pathology, University of Washington, Seattle, WA, USA
    Theor Biol Med Model 3:23. 2006
    ..Sometimes splenectomy seems to inhibit tumor growth, but in other cases it seems, paradoxically, to facilitate both oncogenesis and the growth of established tumors...
  7. ncbi The flip side of immune surveillance: immune dependency
    Richmond T Prehn
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98118, USA
    Immunol Rev 222:341-56. 2008
    ..This knowledge may help to explain some clinical observations concerning the relationships among tumor types and the organ distribution of metastases...
  8. ncbi Immunologgical self-tolerance in allophenic and embryo-aggregated mice
    Richmond T Prehn
    Dept of Pathology, University of Washington, 5433 South Hudson St, Seattle, WA 98118, USA
    Theor Biol Med Model 7:38. 2010
    ....