Research Topics
| SCOTT KLINE POWERSSummaryAffiliation: University of Florida Country: USA Publications
Research Grants
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Publications
Loss of exercise-induced cardioprotection after cessation of exerciseShannon L Lennon
Department of Exercise and Sport Sciences, University of Florida, Gainesville, Florida 32611, USA
J Appl Physiol 96:1299-305. 2004..Therefore, other cytoprotective molecules are responsible for providing protection during I/R...- Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force productionScott K Powers
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA
Physiol Rev 88:1243-76. 2008..Ongoing research continues to probe the mechanisms by which oxidants influence skeletal muscle contractile properties and to explore interventions capable of protecting muscle from oxidant-mediated dysfunction... - Corticosteroid effects on ventilator-induced diaphragm dysfunction in anesthetized rats depend on the dose administeredKaren Maes
Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
Respir Res 11:178. 2010..This may be important for patients undergoing mechanical ventilation and receiving corticosteroids... - Exercise-induced cardioprotection against myocardial ischemia-reperfusion injuryScott K Powers
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
Free Radic Biol Med 44:193-201. 2008..Understanding the molecular basis for exercise-induced cardioprotection will provide the required knowledge base to develop therapeutic approaches to protect the heart during an IR insult... - Reactive oxygen and nitrogen species as intracellular signals in skeletal muscleScott K Powers
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
J Physiol 589:2129-38. 2011..We will conclude with a discussion of unanswered questions in redox signalling in skeletal muscle in the hope of promoting additional research interest in this field... - Exercise-induced oxidative stress in humans: cause and consequencesScott K Powers
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
Free Radic Biol Med 51:942-50. 2011.... - Dietary antioxidants and exerciseScott K Powers
Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
J Sports Sci 22:81-94. 2004..Furthermore, it is currently unclear whether regular vigorous exercise increases the need for dietary intake of antioxidants. Clearly, additional research that analyses the antioxidant requirements of individual athletes is needed... - Aging, exercise, and cardioprotectionScott K Powers
Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
Ann N Y Acad Sci 1019:462-70. 2004..Understanding the molecular basis for exercise-induced cardioprotection is important in developing exercise paradigms to protect the heart during an I-R insult... - Ischemia-reperfusion-induced cardiac injury: a brief reviewScott K Powers
Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
Med Sci Sports Exerc 39:1529-36. 2007..Finally, in hopes of stimulating future research, this review will also identify important gaps in our knowledge of IR-induced myocardial injury... - Mechanisms of disuse muscle atrophy: role of oxidative stressScott K Powers
Department of Applied Physiology and Kinesiology, PO Box 118225, University of Florida, Gainesville, FL 32611, USA
Am J Physiol Regul Integr Comp Physiol 288:R337-44. 2005..By discussing unresolved issues and suggesting topics for future research, it is hoped that this review will serve as a stimulus for the expansion of knowledge in this exciting field... - Prolonged mechanical ventilation alters diaphragmatic structure and functionScott K Powers
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
Crit Care Med 37:S347-53. 2009..To review current knowledge about the impact of prolonged mechanical ventilation on diaphragmatic function and biology... - Reactive oxygen species are signalling molecules for skeletal muscle adaptationScott K Powers
Department of Applied Physiology and Kinesiology, University of Florida, Room 25, Florida Gym, Gainesville, FL 32611, USA
Exp Physiol 95:1-9. 2010..e. exercise training) and during prolonged periods of muscular inactivity (i.e. immobilization). In an effort to stimulate further research, we conclude with a discussion of unanswered questions about redox signalling in skeletal muscle... - Oxidative stress and disuse muscle atrophyScott K Powers
Department of Applied Physiology and Kinesiology, PO Box 118205, University of Florida, Gainesville, FL 32611, USA
J Appl Physiol 102:2389-97. 2007..By presenting unresolved issues and suggesting topics for future research, it is hoped that this review will serve as a stimulus for the expansion of knowledge in this exciting field... - Pressure support ventilation attenuates ventilator-induced protein modifications in the diaphragmScott K Powers
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32608, USA
Crit Care 12:191. 2008..Therefore, developing methods to protect against mechanical ventilation-induced diaphragmatic weakness is important... - Exercise protects against doxorubicin-induced oxidative stress and proteolysis in skeletal muscleAshley J Smuder
Dept of Applied Physiology and Kinesiology, Univ of Florida, Gainesville, FL 32611, USA
J Appl Physiol 110:935-42. 2011..Together, these novel results demonstrate that muscular exercise is a useful countermeasure that can protect skeletal muscle against Dox treatment-induced oxidative stress and protease activation in skeletal muscles... - Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weaknessScott K Powers
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
Crit Care Med 39:1749-59. 2011..Therefore, identifying the site(s) of mechanical ventilation- induced reactive oxygen species production in the diaphragm is important... - Exercise-induced changes in diaphragmatic bioenergetic and antioxidant capacityScott K Powers
Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville 32611, USA
Exerc Sport Sci Rev 30:69-74. 2002..These exercise-induced changes in oxidative and antioxidant capacity occur rapidly after the onset of training and are associated with reduced oxidative injury and improved diaphragmatic endurance... - Exercise, heat shock proteins, and myocardial protection from I-R injuryS K Powers
Department of Exercise and Sport Sciences and Physiology, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
Med Sci Sports Exerc 33:386-92. 2001..This is an important area for future research... - Analysis of cellular responses to free radicals: focus on exercise and skeletal muscleS K Powers
Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville 32611, USA
Proc Nutr Soc 58:1025-33. 1999..Also, training-induced upregulation of antioxidant enzymes is limited to highly-oxidative skeletal muscles. The effects of endurance training on non-enzymic antioxidants remain a relatively uninvestigated area... - Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophyKisuk Min
Dept of Applied Physiology and Kinesiology, Univ of Florida, PO Box 118206, Gainesville, FL 32611
J Appl Physiol 111:1459-66. 2011.... - Antioxidant and Vitamin D supplements for athletes: sense or nonsense?Scott Powers
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611 8208, USA
J Sports Sci 29:S47-55. 2011.... - Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief reviewS K Powers
Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville 32611, USA
Med Sci Sports Exerc 31:987-97. 1999..It seems plausible that increased cellular concentrations of these antioxidants will reduce the risk of cellular injury, improve performance, and delay muscle fatigue... - Antioxidants and exerciseS K Powers
Department of Exercise and Sport Sciences, University of Florida, Gainesville, USA
Clin Sports Med 18:525-36. 1999..This is an important area for future research... - Mechanistic links between oxidative stress and disuse muscle atrophyScott K Powers
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, 32611, USA
Antioxid Redox Signal 15:2519-28. 2011..Finally, by presenting unresolved issues related to oxidative stress and muscle atrophy, we hope that this review will serve as a stimulus for new research in this exciting field... - Myosin phenotype and bioenergetic characteristics of rat respiratory musclesS K Powers
Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville 32611, USA
Med Sci Sports Exerc 29:1573-9. 1997..These differences in biochemical properties provide the muscles of the respiratory pump with great versatility in functional properties... - Exercise and cardioprotectionScott K Powers
Department of Exercise and Sport Sciences and Physiology, Center for Exercise Science, University of Florida, Gainesville, 32611, USA
Curr Opin Cardiol 17:495-502. 2002..Improving our understanding of the molecular basis for exercise-induced cardioprotection will play an important role in developing optimal exercise interventions to protect the heart from ischemic injury... - Mechanical ventilation results in progressive contractile dysfunction in the diaphragmScott K Powers
Department of Exercise and Sport Sciences, University of Florida, Gainesville 32611, USA
J Appl Physiol 92:1851-8. 2002..These data support the hypothesis that relatively short-term MV impairs diaphragmatic contractile function and that the magnitude of MV-induced force deficit increases with time on the ventilator... - Mechanical ventilation-induced oxidative stress in the diaphragmMurat A Zergeroglu
Department of Execise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville, FL 32601, USA
J Appl Physiol 95:1116-24. 2003..We conclude that MV results in a rapid onset of oxidative injury in the diaphragm and that insoluble proteins are primary targets of MV-induced protein oxidation... - Increased temperature, not cardiac load, activates heat shock transcription factor 1 and heat shock protein 72 expression in the heartJessica L Staib
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA
Am J Physiol Regul Integr Comp Physiol 292:R432-9. 2007..Collectively, these data suggest that HSF1 activation and HSP72 gene transcriptional competence during simulated exercise are linked to elevated heart temperature and are not a direct function of increased cardiac workload... - Mechanical ventilation-induced diaphragmatic atrophy is associated with oxidative injury and increased proteolytic activityR Andrew Shanely
Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville, Florida 32611, USA
Am J Respir Crit Care Med 166:1369-74. 2002..These data support the hypothesis that MV is associated with atrophy of all diaphragmatic fiber types, increased diaphragmatic protease activity, and augmented diaphragmatic oxidative stress... - Exercise induces a cardiac mitochondrial phenotype that resists apoptotic stimuliAndreas N Kavazis
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
Am J Physiol Heart Circ Physiol 294:H928-35. 2008..Furthermore, these results are consistent with the concept that exercise-induced mitochondrial adaptations contribute to exercise-induced cardioprotection... - Mechanical ventilation depresses protein synthesis in the rat diaphragmR Andrew Shanely
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville 32611, USA
Am J Respir Crit Care Med 170:994-9. 2004..Further, the decline in myosin heavy chain protein synthesis does not appear to be associated with a decrease in myosin heavy chain messenger ribonucleic acid... - Selective downregulation of ubiquitin conjugation cascade mRNA occurs in the senescent rat soleus muscleKeith C DeRuisseau
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
Exp Gerontol 40:526-31. 2005..Furthermore, the decline in E2(14k) and MuRF1 mRNA levels may contribute to altered substrate degradation by the UCC in the soleus muscle of senescent rats... - Exercise, antioxidants, and HSP72: protection against myocardial ischemia/reperfusionKaryn L Hamilton
Department of Exercise and Sport Science, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
Free Radic Biol Med 34:800-9. 2003.... - Reloading the diaphragm following mechanical ventilation does not promote injuryDarin Van Gammeren
Department of Applied Psychology, Center for Exercise Science, University of Florida, Room 25 FLG, Gainesville, FL 32611, USA
Chest 127:2204-10. 2005..CONCLUSION: We conclude that the return to spontaneous breathing following 24 h of controlled MV does not exacerbate MV-induced diaphragm contractile dysfunction or result in fiber membrane damage, but increases neutrophil infiltration... - Xanthine oxidase contributes to mechanical ventilation-induced diaphragmatic oxidative stress and contractile dysfunctionMelissa A Whidden
Dept of Applied Physiology and Kinesiology, Univ of Florida, Gainesville, FL 32611, USA
J Appl Physiol 106:385-94. 2009..Nonetheless, the failure of XO inhibition to completely prevent MV-induced diaphragmatic oxidative damage suggests that other sources of oxidant production are active in the diaphragm during prolonged MV... - Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragmMelissa A Whidden
Department of Applied Physiology and Kinesiology, University of Florida, PO Box 118205, Gainesville, FL 32611, USA
J Appl Physiol 108:1376-82. 2010.... - Trolox attenuates mechanical ventilation-induced diaphragmatic dysfunction and proteolysisJenna L Betters
Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
Am J Respir Crit Care Med 170:1179-84. 2004..Our findings suggest that antioxidant therapy could be beneficial during prolonged mechanical ventilation... - Diaphragmatic proteasome function is maintained in the ageing Fisher 344 ratAndreas N Kavazis
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
Exp Physiol 92:895-901. 2007.... - Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72Andreas N Kavazis
Applied Physiology and Kinesiology, University of Florida, USA
Am J Physiol Heart Circ Physiol 299:H1515-24. 2010..Finally, our data are consistent with the concept that increases in cardiac mitochondrial antioxidant enzymes may contribute to exercise-induced cardioprotection... - Elevated MnSOD is not required for exercise-induced cardioprotection against myocardial stunningShannon L Lennon
Department of Exercise and Sport Science, University of Florida, Gainesville, FL 32611, USA
Am J Physiol Heart Circ Physiol 287:H975-80. 2004..Therefore, we conclude that different mediators are responsible for exercise-induced cardioprotection against myocardial stunning and infarction... - Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant productionAndreas N Kavazis
Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
Free Radic Biol Med 46:842-50. 2009..In conclusion, these results are consistent with the concept that diaphragmatic inactivity promotes an increase in mitochondrial ROS emission, mitochondrial oxidative damage, and mitochondrial respiratory dysfunction... - Experimental guidelines for studies designed to investigate the impact of antioxidant supplementation on exercise performanceScott K Powers
Dept of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
Int J Sport Nutr Exerc Metab 20:2-14. 2010.... - Apocynin attenuates diaphragm oxidative stress and protease activation during prolonged mechanical ventilationJoseph M McClung
Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL, USA
Crit Care Med 37:1373-9. 2009..To investigate whether apocynin protects the diaphragm from wasting and oxidative stress during mechanical ventilation (MV)... - Overexpression of antioxidant enzymes in diaphragm muscle does not alter contraction-induced fatigue or recoveryJoseph M McClung
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
Exp Physiol 95:222-31. 2010..Finally, the transgenic overexpression of independent endogenous antioxidants alters diaphragm skeletal muscle morphology, and these changes may also contribute to the diminished specific force production observed in these animals... - Exercise training induces a cardioprotective phenotype and alterations in cardiac subsarcolemmal and intermyofibrillar mitochondrial proteinsAndreas N Kavazis
Applied Physiology and Kinesiology, Proteomics Division, University of Florida, Gainesville, FL 32611, USA
Am J Physiol Heart Circ Physiol 297:H144-52. 2009..Importantly, based on our findings, pharmacological or other interventions could be used to develop a strategy of protecting the myocardium during an ischemic attack... - Alteration of contractile force and mass in the senescent diaphragm with beta(2)-agonist treatmentWesley N Smith
Department of Exercise and Sport Sciences, University of Florida, Gainesville, Florida 32611, USA
J Appl Physiol 92:941-8. 2002..05) in type IIb MHC and a decrease in type I, IIa, and IIx MHC in both young and old animals. These data support the hypothesis that CB treatment can restore the age-associated decline in both diaphragmatic-specific P(o) and muscle mass... - Adaptation of upper airway muscles to chronic endurance exerciseHeather K Vincent
Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
Am J Respir Crit Care Med 166:287-93. 2002..It seems possible that this exercise-mediated adaptation is related to the recruitment of these muscles as stabilizers of the upper airway... - Cumulative effects of aging and mechanical ventilation on in vitro diaphragm functionDavid S Criswell
Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
Chest 124:2302-8. 2003..Since aging increases skeletal muscle susceptibility to atrophy and injury, we tested the hypothesis that MV-induced diaphragmatic contractile dysfunction would be exacerbated in aging rats... - Diaphragm unloading via controlled mechanical ventilation alters the gene expression profileKeith C DeRuisseau
Department of Applied Physiology and Kinesiology, University of Florida, Room 25, Florida Gym, Gainesville, Florida 32611, USA
Am J Respir Crit Care Med 172:1267-75. 2005..However, the impact of controlled mechanical ventilation on global mRNA alterations in the diaphragm remains unknown... - Ischemia-reperfusion-induced calpain activation and SERCA2a degradation are attenuated by exercise training and calpain inhibitionJoel P French
Dept. of Applied Physiology and Kinesiology, Center for Exercise Science, Univ. of Florida, Gainesville, FL 32611, USA
Am J Physiol Heart Circ Physiol 290:H128-36. 2006.... - Moderate caloric restriction increases diaphragmatic antioxidant enzyme mRNA, but not when combined with lifelong exerciseKeith C DeRuisseau
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA
Antioxid Redox Signal 8:539-47. 2006..085). In summary, although CR elevated the mRNA of key antioxidant enzymes in the diaphragm, lifelong CR alone or in combination with voluntary exercise did not alter diaphragm CS activity, antioxidant protein quantity, or GSH levels... - Mechanical ventilation induces alterations of the ubiquitin-proteasome pathway in the diaphragmKeith C DeRuisseau
Center for Exercise Science, Univ. of Florida, Rm 25 FLG, Gainesville, FL 32611, USA
J Appl Physiol 98:1314-21. 2005.... - Short-term exercise does not increase ER stress protein expression in cardiac muscleZsolt Murlasits
Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA
Med Sci Sports Exerc 39:1522-8. 2007..Hence, these experiments tested the hypothesis that exercise training is associated with an increase in ER stress proteins in the heart... - MnSOD antisense treatment and exercise-induced protection against arrhythmiasKaryn L Hamilton
Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida Gainesville, FL 32611, USA
Free Radic Biol Med 37:1360-8. 2004..The mechanism by which MnSOD provides protection does not appear to be linked to protein nitrosylation or oxidation... - Diaphragm contractile dysfunction in MyoD gene-inactivated miceJessica L Staib
Department of Exercise and Sport Sciences, University of Florida, Gainesville, Florida 32611, USA
Am J Physiol Regul Integr Comp Physiol 283:R583-90. 2002..Hence, MyoD plays an important role in determining diaphragmatic contractile properties... - Diaphragmatic nitric oxide synthase is not induced during mechanical ventilationDarin Van Gammeren
Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, Florida 32611, USA
J Appl Physiol 102:157-62. 2007..Collectively, these data reveal that MV-induced oxidative stress in the diaphragm is not due to increases in nitric oxide production by NOS... - Exercise-induced protection against myocardial apoptosis and necrosis: MnSOD, calcium-handling proteins, and calpainJoel P French
Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, Florida, USA
FASEB J 22:2862-71. 2008..These results suggest that MnSOD provides cardioprotection by attenuating IR-induced oxidation and calpain-mediated degradation of myocardial Ca(2+)-handling proteins, thereby preventing myocardial apoptosis and necrosis... - Correction of the enzymatic and functional deficits in a model of Pompe disease using adeno-associated virus vectorsThomas J Fraites
Powell Gene Therapy Center, University of Florida College of Medicine, Gainesville, Florida 32610, USA
Mol Ther 5:571-8. 2002.... - Exercise-induced HSP-72 elevation and cardioprotection against infarct and apoptosisJohn C Quindry
Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, Florida, USA
J Appl Physiol 103:1056-62. 2007.... - Increased temperature and protein oxidation lead to HSP72 mRNA and protein accumulation in the in vivo exercised rat heartJessica L Staib
Department of Applied Physiology and Kinesiology, University of Florida, PO Box 118225, Gainesville, FL 32611, USA
Exp Physiol 94:71-80. 2009.... - Short-duration mechanical ventilation enhances diaphragmatic fatigue resistance but impairs force productionR Andrew Shanely
Department of Exercise and Sport Sciences, University of Florida, Gainesville, FL 32601, USA
Chest 123:195-201. 2003..05) absolute specific force throughout the fatigue protocol. CONCLUSIONS: These data indicate that 18 h of MV enhances diaphragmatic fatigue resistance but impairs diaphragmatic specific tension... - Caspase-3 regulation of diaphragm myonuclear domain during mechanical ventilation-induced atrophyJoseph M McClung
Department of Applied Physiology and Kinesiology, University of Florida, Room 25, Florida Gym, Gainesville, FL 32611, USA
Am J Respir Crit Care Med 175:150-9. 2007..Unloading the diaphragm via mechanical ventilation (MV) results in rapid diaphragmatic fiber atrophy. It is unknown whether the myonuclear domain (cytoplasmic myofiber volume/myonucleus) of diaphragm myofibers is altered during MV... - Mechanical ventilation-induced oxidative stress in the diaphragm: role of heme oxygenase-1Darin J Falk
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
Chest 139:816-24. 2011..We tested the hypothesis that HO-1 acts as a pro-oxidant in the diaphragm during prolonged MV... - Use of anabolic steroids to attenuate the effects of glucocorticoids on the rat diaphragmJane M Eason
Louisiana State University Health Sciences Center, Department of Physical Therapy, 1900 Gravier St, New Orleans, LA 70112, USA
Phys Ther 83:29-36. 2003..The purpose of this study was to assess the effects of simultaneous administration of testosterone and glucocorticoids on morphological and contractile properties of the rat diaphragm... - Age and attenuation of exercise-induced myocardial HSP72 accumulationHaydar A Demirel
Department of Sports Medicine, School of Medicine, Hacettepe University, Ankara, Turkey
Am J Physiol Heart Circ Physiol 285:H1609-15. 2003..These data demonstrate that aging is associated with diminished exercise-induced myocardial HSP72 expression. Mechanisms other than HSF-1 activation and transcription of HSP72 mRNA are responsible for this age-related impairment... - Elevation of body temperature is an essential factor for exercise-increased extracellular heat shock protein 72 level in rat plasmaYuji Ogura
Institute of Health and Sports Science and Medicine, Juntendo University, Inba, Chiba, Japan
Am J Physiol Regul Integr Comp Physiol 294:R1600-7. 2008..In addition, the possible role of body temperature elevation is displayed when the exercise stressor is combined with it... - Effects of vitamin E deficiency on fatigue and muscle contractile propertiesJeff S Coombes
School of Human Movement Studies, Rm 520, Connell Building, University of Queensland, St Lucia, QLD 4072, Australia
Eur J Appl Physiol 87:272-7. 2002..05). These data support the hypothesis that VE deficiency impairs muscular endurance and alters muscle contractile properties following a prolonged series of contractions... - Changes in PKB/Akt and calcineurin signaling during recovery in atrophied soleus muscle induced by unloadingTakao Sugiura
Department of Exercise and Health Sciences, Faculty of Education, Yamaguchi University, Japan
Am J Physiol Regul Integr Comp Physiol 288:R1273-8. 2005..Our data support the concept that CaN is involved in muscle remodeling during the later phases of recovery from disuse muscle atrophy... - High intensity exercise increases expression of matrix metalloproteinases in fast skeletal muscle fibresEli Carmeli
Department of Physical Therapy, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
Exp Physiol 90:613-9. 2005.... - Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humansSanford Levine
Department of Surgery, University of Pennsylvania, USA
N Engl J Med 358:1327-35. 2008..The combination of complete diaphragm inactivity and mechanical ventilation (for more than 18 hours) elicits disuse atrophy of myofibers in animals. We hypothesized that the same may also occur in the human diaphragm... - Estrogen administration attenuates immobilization-induced skeletal muscle atrophy in male ratsTakao Sugiura
Department of Exercise and Health Sciences, Yamaguchi University, Yamaguchi, 753 8513 Japan
J Physiol Sci 56:393-9. 2006..These results support the postulate that estrogen attenuates the rate of disuse muscle atrophy, partly because of reductions in immobilization-induced calcium-activated protease levels... - Infusions of rocuronium and cisatracurium exert different effects on rat diaphragm functionDries Testelmans
Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, O and N 1, bus 706, Herestraat 49, 3000, Leuven, Belgium
Intensive Care Med 33:872-9. 2007..The aim of our study was to compare the effects of 24 h infusion of rocuronium or cisatracurium on the diaphragm in mechanically ventilated rats...
Research Grants
- Mechanical ventilation, oxidative stress, and diaphragmatic atrophyScott Powers; Fiscal Year: 2009..Our long-term goal is to develop methods for the prevention of MV-induced diaphragmatic weakness based on an understanding of the cellular mechanisms responsible for MV-induced diaphragmatic atrophy and contractile dysfunction. ..
- Mechanical Ventilation and Diaphragmatic Oxidant InjuryScott Powers; Fiscal Year: 2007..abstract_text> ..
- Exercise, Antioxidants, and I-R InjuryScott Powers; Fiscal Year: 2006..abstract_text> ..
- MECHANICAL VENTILATION AND RESPIRATORY MUSCLESScott Powers; Fiscal Year: 2004..The long-term goal of our experiments is to provide the knowledge required to develop clinical strategies to oppose the deleterious effects of MV on respiratory muscles. ..
- Mechanical ventilation, oxidative stress, and diaphragmatic atrophySCOTT KLINE POWERS; Fiscal Year: 2010..Our long-term goal is to develop methods for the prevention of MV-induced diaphragmatic weakness based on an understanding of the cellular mechanisms responsible for MV-induced diaphragmatic atrophy and contractile dysfunction. ..