Research Topics
| M J PlewaSummaryAffiliation: University of Illinois Country: USA Publications
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Detail Information
Publications
The use of single cell gel electrophoresis and flow cytometry to identify antimutagens from commercial soybean by-productsM J Plewa
College of Agricultural, Consumer and Environmental Sciences, Department of Crop Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Mutat Res 402:211-8. 1998..These data indicate that agronomic crops such as soybean may yield a wealth of commercially available antimutagenic agents that may be suitable as chemoprotective food supplements...- Antimutagenic activity of chemical fractions isolated from a commercial soybean processing by-productM J Plewa
Department of Crop Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana Champaign, USA
Teratog Carcinog Mutagen 19:121-35. 1999..These data indicate that commercial soybean products and by-products may be a source of chemoprotective food additives... - Isolating antigenotoxic components and cancer cell growth suppressors from agricultural by-productsM J Plewa
Department of Crop Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana Champaign, 364 NSRC MC 635, 1101 West Peabody Drive, Urbana, IL 61801, USA
Mutat Res 480:109-20. 2001..This research may lead to the isolation of novel chemoprotectants from agronomic commercial processing products and by-products... - Mammalian cell cytotoxicity and genotoxicity analysis of drinking water disinfection by-productsMichael J Plewa
Department of Crop Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana Champaign, 61801, USA
Environ Mol Mutagen 40:134-42. 2002..The microplate CHO cell cytotoxicity and genotoxicity assays were well suited for the analysis of DBPs, especially when the quantity of test material is limited... - Analysis of mutagens with single cell gel electrophoresis, flow cytometry, and forward mutation assays in an isolated clone of Chinese hamster ovary cellsE D Wagner
College of Agricultural, Consumer and Environmental Sciences, Department of Crop Sciences, University of Illinois at Urbana Champaign, Urbana, USA
Environ Mol Mutagen 32:360-8. 1998..With UV, only the SCGE assay and flow cytometry were correlated. Agent-specific variations in the intragenomic distribution of DNA damage for each mutagen was measured in the SCGE assay... - Mutagenic synergy between paraoxon and mammalian or plant-activated aromatic aminesE D Wagner
Department of Crop Sciences, University of Illinois at Urbana Champaign 61801 4723, USA
Environ Mol Mutagen 30:312-20. 1997..S. population tested positive for OP insecticide residues... - Cytotoxicity of organophosphorus ester (OP) insecticides and cytotoxic synergism of 2-acetoxyacetylaminofluorene (2AAAF) in Chinese hamster ovary (CHO) cellsE D Wagner
Department of Crop Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana-Champaign, 366 NSRC MC-635, 1101 West Peabody Drive, Urbana, IL 61801, USA
Bull Environ Contam Toxicol 75:329-34. 2005 - Comparative quantitative analysis of agricultural chemicals using a microplate mammalian cell cytotoxicity assayK C Sorensen
Department of Natural Resources and Environmental Sciences, University of Illinois at Urbana-Champaign, W-321 Turner Hall, 1102 South Goodwin, Urbana, IL 61801, USA
Bull Environ Contam Toxicol 70:1083-8. 2003 - Evidence that hydrogen sulfide is a genotoxic agentMatias S Attene-Ramos
Department of Animal Sciences, University of Illinois, Urbana, IL, USA
Mol Cancer Res 4:9-14. 2006..These data indicate that given a predisposing genetic background that compromises DNA repair, H2S may lead to genomic instability or the cumulative mutations found in adenomatous polyps leading to colorectal cancer... - Evaluation of the nuclear DNA Diffusion Assay to detect apoptosis and necrosisTomas Gichner
Institute of Experimental Botany, Academy of Sciences of Czech Republic, Na Karlovce 1a, 160 00 Prague 6, Czech Republic
Mutat Res 586:38-46. 2005.... - Modulation of the cytotoxicity and genotoxicity of the drinking water disinfection byproduct lodoacetic acid by suppressors of oxidative stressEduardo Cemeli
Department of Biomedical Sciences, University of Bradford, Bradford, West Yorkshire, BD7 1DP, UK
Environ Sci Technol 40:1878-83. 2006..5 and 42%, respectively. These results support the hypothesis that oxidative stress is involved in the induction of genotoxicity and mutagenicity by iodoacetic acid... - Haloacetonitriles vs. regulated haloacetic acids: are nitrogen-containing DBPs more toxic?Mark G Muellner
College of Agricultural, Consumer and Environmental Sciences, Department of Crop Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
Environ Sci Technol 41:645-51. 2007..The toxicity of N-DBPs may become a health concern because of the increased use of alternative disinfectants, such as chloramines, which may enhance the formation of N-DBPs, including HANs... - Hydrogen sulfide induces direct radical-associated DNA damageMatias S Attene Ramos
Department of Animal Sciences, Institute for Genomic Biology, University of Illinois at Urbana Champaign, 364 NSRC, 1101 West Peabody Drive, Urbana, IL 61801, USA
Mol Cancer Res 5:455-9. 2007..These observations highlight the possible role of sulfide as an environmental insult that, given a predisposing genetic background, may lead to genomic instability or the cumulative mutations characteristic of colorectal cancer... - Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for researchSusan D Richardson
National Exposure Research Laboratory, US Environmental Protection Agency, Athens, GA 30605, USA
Mutat Res 636:178-242. 2007..The categories of DBPs described here, the identified data gaps, and the emerging role of dermal/inhalation exposure provide guidance for drinking water and public health research... - Modulation of the genotoxicity of pesticides reacted with redox-modified smectite clayKara C Sorensen
Department of Natural Resources and Environmental Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
Environ Mol Mutagen 46:174-81. 2005..These data introduce a new paradigm on the interaction between redox-modified clays and pesticide-related environmental genotoxicity... - Chemical and biological characterization of newly discovered iodoacid drinking water disinfection byproductsMichael J Plewa
College of Agricultural, Consumer and Environmental Sciences, Department of Crop Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
Environ Sci Technol 38:4713-22. 2004..Ultimately, it will be important to know the levels at which these iodoacids occur in drinking water in order to assess the potential for adverse environmental and human health risks... - Halonitromethane drinking water disinfection byproducts: chemical characterization and mammalian cell cytotoxicity and genotoxicityMichael J Plewa
Department of Crop Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana Champaign, 1101 West Peabody Drive, Urbana, Illinois 61801, USA
Environ Sci Technol 38:62-8. 2004..The halonitromethanes are potent mammalian cell cytotoxins and genotoxins and may pose a hazard to the public health and the environment... - Evaluation of EMS-induced DNA damage in the single cell gel electrophoresis (Comet) assay and with flow cytometric analysis of micronucleiElizabeth D Wagner
University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
Teratog Carcinog Mutagen . 2003..These data indicate that using molecular and computer technologies, the genotoxic impact of toxic and environmental agents can be rapidly and comprehensively evaluated in mammalian cell systems... - Tribromopyrrole, brominated acids, and other disinfection byproducts produced by disinfection of drinking water rich in bromideSusan D Richardson
National Exposure Research Laboratory, U S Environmental Protection Agency, Athens, Georgia 30605, USA
Environ Sci Technol 37:3782-93. 2003..2,3,5-Tribromopyrrole also induced acute genomic damage, with a genotoxic potency (299 microM) similar to that of MX... - The comet assay: genotoxic damage or nuclear fragmentation?Mark S Rundell
Department of Crop Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
Environ Mol Mutagen 42:61-7. 2003..These data support the conclusion that mutagen-induced DNA damage is the principal cause of the damage measured in the comet assay... - Modulation of the mutagenicity of heterocyclic amines by organophosphate insecticides and their metabolitesElizabeth D Wagner
Department of Crop Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana Champaign, 366 NSRC MC 635, 1101 West Peabody Drive, Urbana, IL 61801, USA
Mutat Res 536:103-15. 2003..Under real world conditions where people are exposed to a multitude of agents, the results of this study raise a concern about the environmental and public health impacts of OP insecticides... - Analysis of the cytotoxicity and mutagenicity of drinking water disinfection by-products in Salmonella typhimuriumYahya Kargalioglu
Department of Crop Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
Teratog Carcinog Mutagen 22:113-28. 2002..This information is critical when conducting quantitative structure-function analysis of these hazardous agents... - Occurrence, synthesis, and mammalian cell cytotoxicity and genotoxicity of haloacetamides: an emerging class of nitrogenous drinking water disinfection byproductsMichael J Plewa
College of Agricultural, Consumer and Environmental Sciences, Department of Crop Sciences, University of Illinois at Urbana Champaign, 1101 West Peabody Drive, Urbana, Illinois 61801, USA
Environ Sci Technol 42:955-61. 2008..Log P was not a factor for monohaloacetamides but may play a role in the genotoxicity of trihaloacetamides and possible activation of dihaloacetamides by intracellular GSH and -SH compounds... - Alteration of mammalian-cell toxicity of pesticides by structural iron(II) in ferruginous smectiteKara C Sorensen
Department of Natural Resources and Environmental Sciences University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
Environ Sci Technol 38:4383-9. 2004..The Fe oxidation state of clay minerals should, therefore, be taken into account in pesticide management programs... - Mutant spectra analysis at hisG46 in Salmonella typhimurium strain YG1029 induced by mammalian S9- and plant-activated aromatic aminesYoung H Ju
Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
Teratog Carcinog Mutagen . 2003..These data show that the plant-activated and mammalian-activated aromatic amine products inflicted different types or distributions of DNA lesions that were reflected in the resulting induced mutant spectra...