Sean P Pitroda

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi MUC1-associated proliferation signature predicts outcomes in lung adenocarcinoma patients
    Dhara M Macdermed
    The Scripps Research Institute and Scripps Translational Science Institute, 3344 N Torrey Pines Court Ste, 300, La Jolla, CA 92037, USA
    BMC Med Genomics 3:16. 2010
  2. ncbi STAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effect
    Sean P Pitroda
    Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL 60637, USA
    BMC Med 7:68. 2009
  3. ncbi Ad.Egr-TNF and local ionizing radiation suppress metastases by interferon-beta-dependent activation of antigen-specific CD8+ T cells
    Yuru Meng
    Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, Illinois, USA
    Mol Ther 18:912-20. 2010
  4. ncbi MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment
    Sean P Pitroda
    Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 106:5837-41. 2009
  5. ncbi MUC1-induced transcriptional programs associated with tumorigenesis predict outcome in breast and lung cancer
    Nikolai N Khodarev
    Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, Illinois 60637, USA
    Cancer Res 69:2833-7. 2009
  6. ncbi Radioresistance of Stat1 over-expressing tumour cells is associated with suppressed apoptotic response to cytotoxic agents and increased IL6-IL8 signalling
    Elena V Efimova
    Department of Radiation and Cellular Oncology, The University of Chicago, Illinois 60637, USA
    Int J Radiat Biol 85:421-31. 2009
  7. ncbi STAT1 pathway mediates amplification of metastatic potential and resistance to therapy
    Nikolai N Khodarev
    Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 4:e5821. 2009

Collaborators

  • Ralph R Weichselbaum
  • Lei Huang
  • Mitchell C Posner
  • Vera Levina
  • Nikolai N Khodarev
  • Dhara M Macdermed
  • Donald W Kufe
  • Thomas E Darga
  • Michael A Beckett
  • Yuru Meng
  • Helena J Mauceri
  • Elena V Efimova
  • Darrin C Edwards
  • Charles A Pelizzari
  • Mara G Beveridge
  • Anna Lokshin
  • Harold G Sutton
  • Ravi F Sood
  • Michael Y Shao
  • Daniel W Golden
  • Paul Roach
  • Edwardine Labay
  • Mihir Bhayani
  • Hua Liang
  • Bernard Roizman

Detail Information

Publications7

  1. ncbi MUC1-associated proliferation signature predicts outcomes in lung adenocarcinoma patients
    Dhara M Macdermed
    The Scripps Research Institute and Scripps Translational Science Institute, 3344 N Torrey Pines Court Ste, 300, La Jolla, CA 92037, USA
    BMC Med Genomics 3:16. 2010
    ..The cytoplasmic domain of MUC1 (MUC1-CD) induces tumorigenesis and resistance to DNA-damaging agents. We characterized MUC1-CD-induced transcriptional changes and examined their significance in lung cancer patients...
  2. ncbi STAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effect
    Sean P Pitroda
    Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL 60637, USA
    BMC Med 7:68. 2009
    ....
  3. ncbi Ad.Egr-TNF and local ionizing radiation suppress metastases by interferon-beta-dependent activation of antigen-specific CD8+ T cells
    Yuru Meng
    Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, Illinois, USA
    Mol Ther 18:912-20. 2010
    ..These findings support a model in which treatment of tumors with Ad.Egr-TNF and IR is mediated by local and distant immune-mediated antitumor effects that suppress the development of metastases...
  4. ncbi MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment
    Sean P Pitroda
    Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 106:5837-41. 2009
    ..These findings indicate that (i) MUC1 regulates cholesterol and fatty acid metabolism, and (ii) activation of these pathways in ER(+) breast cancers predicts failure to tamoxifen treatment...
  5. ncbi MUC1-induced transcriptional programs associated with tumorigenesis predict outcome in breast and lung cancer
    Nikolai N Khodarev
    Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, Illinois 60637, USA
    Cancer Res 69:2833-7. 2009
    ..The data show that the MUC1 oncoprotein contributes to the regulation of genes that are highly predictive of clinical outcome in breast and lung cancer patients...
  6. ncbi Radioresistance of Stat1 over-expressing tumour cells is associated with suppressed apoptotic response to cytotoxic agents and increased IL6-IL8 signalling
    Elena V Efimova
    Department of Radiation and Cellular Oncology, The University of Chicago, Illinois 60637, USA
    Int J Radiat Biol 85:421-31. 2009
    ..To determine the mechanisms of Signal Transducer and Activator of Transcription 1 (Stat1)-associated radioresistance developed by nu61 tumour selected in vivo by fractionated irradiation of the parental radiosensitive tumour SCC61...
  7. ncbi STAT1 pathway mediates amplification of metastatic potential and resistance to therapy
    Nikolai N Khodarev
    Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 4:e5821. 2009
    ....