Research Topics
Species | P K PetersonSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
A preliminary placebo-controlled crossover trial of fludrocortisone for chronic fatigue syndromeP K Peterson
Department of Medicine, Hennepin County Medical Center, Minneapolis, Minn 55415, USA
Arch Intern Med 158:908-14. 1998..To provide a preliminary assessment of the efficacy and safety of fludrocortisone acetate treatment of chronic fatigue syndrome...- The opioid-cytokine connectionP K Peterson
Neuroimmunobiology and Host Defense Laboratory, Minneapolis Medical Research Foundation, MN 55404, USA
J Neuroimmunol 83:63-9. 1998..The importance of opiate addiction in the AIDS epidemic means that gaining a better understanding of the mechanisms of opioid-induced immunomodulation is of more than academic interest... - Endomorphin-1 potentiates HIV-1 expression in human brain cell cultures: implication of an atypical mu-opioid receptorP K Peterson
Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, MN 55404, USA
Neuropharmacology 38:273-8. 1999..They also provide evidence, for the first time, that an endogenous mu-opioid peptide has neuroimmunomodulatory activity... - Human cytomegalovirus replication and modulation of apoptosis in astrocytesJ R Lokensgard
Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, Minnesota 55404, USA
J Hum Virol 2:91-101. 1999..To characterize replication patterns and cytopathic effects during human cytomegalovirus (HCMV) infection of brain cells... - Robust expression of TNF-alpha, IL-1beta, RANTES, and IP-10 by human microglial cells during nonproductive infection with herpes simplex virusJ R Lokensgard
Neuroimmunology Laboratory, Minneapolis Medical Research Foundation, Minneapolis, Minnesota 55404, USA
J Neurovirol 7:208-19. 2001..These results suggest that IP-10 possesses direct antiviral activity in neurons and support a role for microglia in both antiviral defense of the brain as well as amplification of immune responses during neuroinflammation... - Orphan opioid receptor oligonucleotides inhibit HIV-1 expression in human brain cellsC C Chao
Neuroimmunobiology and Host Defense Laboratory, Minneapolis Medical Research Foundation MN 55404, USA
Adv Exp Med Biol 437:83-90. 1998..These findings indicate that while human brain cells constitutively express mRNA for OR, antisense oligonucleotides to OR non-specifically inhibit acute HIV-1 infection... - Diazepam inhibits HIV-1 Tat-induced migration of human microgliaJ R Lokensgard
Neuroimmunology Laboratory, Minneapolis Medical Research Foundation, Minneapolis, Minnesota 55404, USA
J Neurovirol 7:481-6. 2001..These data support the notion that through their effects on microglia, peripheral BDZ receptor ligands could alter the neuropathogenesis of HIV-1... - Inhibition of microglial cell RANTES production by IL-10 and TGF-betaS Hu
Neuroimmunobiology and Host Defense Laboratory, Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, MN 55404, USA
J Leukoc Biol 65:815-21. 1999..These results may have important therapeutic implications for inflammatory diseases of the brain... - WIN55,212-2 inhibits production of CX3CL1 by human astrocytes: involvement of p38 MAP kinaseW S Sheng
Department of Medicine, The Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota Medical School, Minneapolis, MN 55455, USA
J Neuroimmune Pharmacol 4:244-8. 2009..Our results support the concept that synthetic cannabinoids have anti-inflammatory properties and that these agents may have therapeutic potential for certain neuroinflammatory disorders... - Cytokine expression in the mouse brain in response to immune activation by Corynebacterium parvumW S Sheng
Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, and the University of Minnesota Medical School, NeuroImmunology Lab D 305, 914 South 8th St, Minneapolis, MN 55404, USA
Clin Diagn Lab Immunol 8:446-8. 2001.... - Effect of thalidomide on chemokine production by human microgliaJ R Lokensgard
Minneapolis Medical Research Foundation, Minneapolis, MN 55404, USA
J Infect Dis 182:983-7. 2000..These results suggest thalidomide could have a therapeutic role in acute bacterial meningitis through inhibition of IL-8-mediated neutrophil chemotaxis... - Cytomegalovirus induces cytokine and chemokine production differentially in microglia and astrocytes: antiviral implicationsM C Cheeran
Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, Minneapolis, Minnesota 55404, USA
J Neurovirol 7:135-47. 2001..The host defense function of microglial cells may be directed in part by chemokines, such as MCP-1, produced by infected astrocytes... - U50488 inhibits HIV-1 expression in acutely infected monocyte-derived macrophagesC C Chao
Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, Hennepin County Medical Center and the University of Minnesota Medical School, Minneapolis, MN 55404, USA
Drug Alcohol Depend 62:149-54. 2001..Taken together, these in vitro findings support the anti-HIV-1 property of U50488, and suggest that KOR ligands may have therapeutic potential for treating patients with acquired immunodeficiency syndrome... - Kappa-opioid receptor agonist suppression of HIV-1 expression in CD4+ lymphocytesP K Peterson
Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, 914 South 8th Street, Minneapolis, MN 55404, USA
Biochem Pharmacol 61:1145-51. 2001..The results of this study broaden understanding of the antiviral properties of KOR ligands to include cells outside of the nervous system and suggest a potential role for these agents in the treatment of HIV-1 infection... - Naltrexone potentiates anti-HIV-1 activity of antiretroviral drugs in CD4+ lymphocyte culturesG Gekker
Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, Hennepin County Medical Center and the University of Minnesota Medical School, Minneapolis, MN 55404, USA
Drug Alcohol Depend 64:257-63. 2001..Also, based upon naltrexone's safety profile and its synergistic activity in vitro, these findings suggest clinical trials should be considered of naltrexone as an adjunctive therapy of HIV-1 infection... - Transcriptional response of human microglial cells to interferon-gammaR B Rock
Department of Medicine, Division of Infectious Diseases and International Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
Genes Immun 6:712-9. 2005..In sum, our results provide a foundation for the molecular mechanisms of the microglial response to IFN-gamma-a key to understanding cell-mediated immunity of the CNS... - CCL5 evokes calcium signals in microglia through a kinase-, phosphoinositide-, and nucleotide-dependent mechanismC R Shideman
Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA
J Neurosci Res 83:1471-84. 2006..Because changes in [Ca(2+)](i) affect chemotaxis, secretion, and gene expression, pharmacologic modulation of this pathway may alter inflammatory and degenerative processes in the CNS... - Severe sepsis in the emergency department and its association with a complicated clinical courseS W Smith
Department of Emergency Medicine, Hennepin County Medical Center, and the University of Minnesota Medical School, Minneapolis 55415, USA
Acad Emerg Med 5:1169-76. 1998..The objective of the study was to use modified criteria to determine the clinical course associated with three levels of infection severity in infected patients admitted from the ED... - Cannabinoids and morphine differentially affect HIV-1 expression in CD4(+) lymphocyte and microglial cell culturesP K Peterson
Minneapolis Medical Research Foundation, 914 S Eighth Street, Minneapolis, MN 55404, USA
J Neuroimmunol 147:123-6. 2004..These in vitro findings support the notion that pharmacologic factors need to be considered in epidemiological studies and animal models that pertain to HIV-1 infection... - kappa opioid receptors in human microglia downregulate human immunodeficiency virus 1 expressionC C Chao
Neuroimmunobiology and Host Defense Laboratory, Minneapolis Medical Research Foundation and University of Minnesota Medical School, 55404, USA
Proc Natl Acad Sci U S A 93:8051-6. 1996..These findings suggest that kappa opioid agonists have immunomodulatory activity in the brain, and that these compounds could have potential in the treatment of HIV-1-associated encephalopathy... - Activation of human microglial cells by HIV-1 gp41 and Tat proteinsW S Sheng
Department of Pharmacology, Institute for Brain and Immune Disorders, Minneapolis, Minnesota, 55404, USA
Clin Immunol 96:243-51. 2000..The results of this study suggest that HIV-1 Tat and gp41 proteins impact several key functions of microglial cells which could contribute to the neuropathogenesis of HIV-1... - Tumor necrosis factor-alpha mediates the release of bioactive transforming growth factor-beta in murine microglial cell culturesC C Chao
Minneapolis Medical Research Foundation, Department of Medicine, Hennepin County Medical Center, Minnesota, USA
Clin Immunol Immunopathol 77:358-65. 1995..Exogenous TGF-beta, on the other hand, suppressed LPS-stimulated TNF-alpha release. These findings suggest an autoregulation of microglial cell TNF-alpha production by TGF-beta which may limit inflammation-associated brain injury...