LENORE PALMA PEREIRA

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Cytomegalovirus infection in the human placenta: maternal immunity and developmentally regulated receptors on trophoblasts converge
    L Pereira
    Department of Cell and Tissue Biology, School of Dentistry, University of California San Francisco, 513 Parnassus, C 734, Box 0640, San Francisco, 94143, USA
    Curr Top Microbiol Immunol 325:383-95. 2008
  2. ncbi Patterns of human cytomegalovirus infection in term placentas: a preliminary analysis
    Susan McDonagh
    Department of Cell and Tissue Biology, University of California San Francisco, UCSF Box 0640, San Francisco, CA 94143, USA
    J Clin Virol 35:210-5. 2006
  3. ncbi Human cytomegalovirus transmission from the uterus to the placenta correlates with the presence of pathogenic bacteria and maternal immunity
    Lenore Pereira
    Departments of Stomatology, University of California San Francisco, San Francisco, California 94143 0512, USA
    J Virol 77:13301-14. 2003
  4. ncbi Viral and bacterial pathogens at the maternal-fetal interface
    Susan McDonagh
    Department of Stomatology, University of California, San Francisco, San Francisco, California 94143 0512, USA
    J Infect Dis 190:826-34. 2004
  5. ncbi Insights into viral transmission at the uterine-placental interface
    Lenore Pereira
    Department of Cell and Tissue Biology, University of California San Francisco, UCSF Box 0422, San Francisco, California, CA 94143, USA
    Trends Microbiol 13:164-74. 2005
  6. ncbi Maternal antibodies enhance or prevent cytomegalovirus infection in the placenta by neonatal Fc receptor-mediated transcytosis
    Ekaterina Maidji
    Department of Cell and Tissue Biology, School of Dentistry, University of California San Francisco, 513 Parnassus, San Francisco, San Francisco, CA 94143-0512, USA
    Am J Pathol 168:1210-26. 2006
  7. ncbi Cytomegalovirus-specific, high-avidity IgG with neutralizing activity in maternal circulation enriched in the fetal bloodstream
    Naoki Nozawa
    Department of Cell and Tissue Biology, University of California San Francisco, 94122, United States
    J Clin Virol 46:S58-63. 2009
  8. ncbi Antibody treatment promotes compensation for human cytomegalovirus-induced pathogenesis and a hypoxia-like condition in placentas with congenital infection
    Ekaterina Maidji
    Department of Cell and Tissue Biology, School of Dentistry, University of California San Francisco, San Francisco, CA 94143, USA
    Am J Pathol 177:1298-310. 2010
  9. ncbi Human cytomegalovirus interleukin-10 downregulates metalloproteinase activity and impairs endothelial cell migration and placental cytotrophoblast invasiveness in vitro
    Takako Yamamoto-Tabata
    Department of Stomatology, University of California San Francisco, San Francisco, California 94143 0512, USA
    J Virol 78:2831-40. 2004
  10. ncbi Developmental regulation of human cytomegalovirus receptors in cytotrophoblasts correlates with distinct replication sites in the placenta
    Ekaterina Maidji
    Department of Cell and Tissue Biology, School of Dentistry, University of California San Francisco, 513 Parnassus, San Francisco, CA 94143, USA
    J Virol 81:4701-12. 2007

Research Grants

  1. FETAL CMV INFECTION: ROLE OF THE HUMAN PLACENTA
    Lenore Pereira; Fiscal Year: 2007
  2. FETAL CMV INFECTION: ROLE OF THE HUMAN PLACENTA
    Lenore Pereira; Fiscal Year: 2004
  3. Human Placental CMV Infection: Global Gene Expression
    Lenore Pereira; Fiscal Year: 2003
  4. ROLE OF CMV ENVELOPE GLYCOPROTEINS IN POLARIZED CELLS
    Lenore Pereira; Fiscal Year: 2003
  5. FETAL CMV INFECTION: ROLE OF THE HUMAN PLACENTA
    LENORE PALMA PEREIRA; Fiscal Year: 2010

Collaborators

  • Susan Fisher
  • S P Adler
  • Natali Aziz
  • Maurizio M Anceschi
  • Giovanni Nigro
  • Giuseppe Gerna
  • Ekaterina Maidji
  • Susan McDonagh
  • Takako Tabata
  • Hsin-Ti Chang
  • Naoki Nozawa
  • Hsin Ti Chang
  • June Fang-Hoover
  • Virginia D Winn
  • Olga Genbacev
  • Takako Yamamoto-Tabata
  • Stephen Shiboski
  • Stefania Muci
  • Keiko Sakai
  • Dean Sheppard
  • Motohiko Aiba
  • Takao Sakai
  • Hisaaki Kawakatsu
  • Agnes C Paquet
  • Kui-Tzu V Feng
  • Kui Tzu V Feng
  • Andrej Sali
  • Ronit Haimov-Kochman
  • M S Madhusudhan
  • Matthew Gormley
  • Y Jean Yang
  • David A Bernlohr
  • Wenge Ma
  • Elena Percivalle

Detail Information

Publications14

  1. ncbi Cytomegalovirus infection in the human placenta: maternal immunity and developmentally regulated receptors on trophoblasts converge
    L Pereira
    Department of Cell and Tissue Biology, School of Dentistry, University of California San Francisco, 513 Parnassus, C 734, Box 0640, San Francisco, 94143, USA
    Curr Top Microbiol Immunol 325:383-95. 2008
    ..Reduced invasiveness of infected cells could impair remodeling of the uterine vasculature, restrict maternal blood flow and access of the fetus to nutrients causing intrauterine growth restriction...
  2. ncbi Patterns of human cytomegalovirus infection in term placentas: a preliminary analysis
    Susan McDonagh
    Department of Cell and Tissue Biology, University of California San Francisco, UCSF Box 0640, San Francisco, CA 94143, USA
    J Clin Virol 35:210-5. 2006
    ..These preliminary results suggest that the incidence of asymptomatic congenital CMV infection might be higher than currently estimated...
  3. ncbi Human cytomegalovirus transmission from the uterus to the placenta correlates with the presence of pathogenic bacteria and maternal immunity
    Lenore Pereira
    Departments of Stomatology, University of California San Francisco, San Francisco, California 94143 0512, USA
    J Virol 77:13301-14. 2003
    ..These results suggest that the outcome of cytomegalovirus infection depends on the presence of other pathogens and coordinated immune responses to viral replication at the maternal-fetal interface...
  4. ncbi Viral and bacterial pathogens at the maternal-fetal interface
    Susan McDonagh
    Department of Stomatology, University of California, San Francisco, San Francisco, California 94143 0512, USA
    J Infect Dis 190:826-34. 2004
    ..Analyses of immunoglobulin G isolated from the placenta support the hypothesis that immune responses suppress CMV reactivation in the presence of pathogenic bacteria at the maternal-fetal interface...
  5. ncbi Insights into viral transmission at the uterine-placental interface
    Lenore Pereira
    Department of Cell and Tissue Biology, University of California San Francisco, UCSF Box 0422, San Francisco, California, CA 94143, USA
    Trends Microbiol 13:164-74. 2005
    ..Infection of villus explants and differentiating and/or invading cytotrophoblasts offers an in vitro model for studying viruses associated with prenatal infections...
  6. ncbi Maternal antibodies enhance or prevent cytomegalovirus infection in the placenta by neonatal Fc receptor-mediated transcytosis
    Ekaterina Maidji
    Department of Cell and Tissue Biology, School of Dentistry, University of California San Francisco, 513 Parnassus, San Francisco, San Francisco, CA 94143-0512, USA
    Am J Pathol 168:1210-26. 2006
    ..These findings could explain the efficacy of hyperimmune IgG for treatment of primary CMV infection during gestation and support vaccination...
  7. ncbi Cytomegalovirus-specific, high-avidity IgG with neutralizing activity in maternal circulation enriched in the fetal bloodstream
    Naoki Nozawa
    Department of Cell and Tissue Biology, University of California San Francisco, 94122, United States
    J Clin Virol 46:S58-63. 2009
    ..Whether CMV reaches the fetus and disseminates depends on the level of high-avidity antibodies in the maternal circulation and the passive immunity of the fetus...
  8. ncbi Antibody treatment promotes compensation for human cytomegalovirus-induced pathogenesis and a hypoxia-like condition in placentas with congenital infection
    Ekaterina Maidji
    Department of Cell and Tissue Biology, School of Dentistry, University of California San Francisco, San Francisco, CA 94143, USA
    Am J Pathol 177:1298-310. 2010
    ..Taken together the results indicate that antibody treatment can suppress HCMV replication and prevent placental dysfunction, thus improving fetal outcome...
  9. ncbi Human cytomegalovirus interleukin-10 downregulates metalloproteinase activity and impairs endothelial cell migration and placental cytotrophoblast invasiveness in vitro
    Takako Yamamoto-Tabata
    Department of Stomatology, University of California San Francisco, San Francisco, California 94143 0512, USA
    J Virol 78:2831-40. 2004
    ..Reduced MMP activity early in placental development could impair cytotrophoblast remodeling of the uterine vasculature and eventually restrict fetal growth in affected pregnancies...
  10. ncbi Developmental regulation of human cytomegalovirus receptors in cytotrophoblasts correlates with distinct replication sites in the placenta
    Ekaterina Maidji
    Department of Cell and Tissue Biology, School of Dentistry, University of California San Francisco, 513 Parnassus, San Francisco, CA 94143, USA
    J Virol 81:4701-12. 2007
    ....
  11. ncbi Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production
    Takako Tabata
    Department of Cell and Tissue Biology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0640, USA
    Am J Pathol 172:1127-40. 2008
    ..Our results suggest that activation of TGF-beta1 by integrin alphavbeta6 contributes to pathological changes and may impair endothelial cell functions in tissues that are chronically infected with CMV...
  12. ncbi Recent advances in the prevention and treatment of congenital cytomegalovirus infections
    Stuart P Adler
    Department of Pediatrics, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, VA 23298, USA
    Semin Perinatol 31:10-8. 2007
    ..This plus the reversibility of many manifestations of congenital infection in the fetus and newborn indicate that congenital CMV disease is in part a syndrome of placental insufficiency...
  13. ncbi Transmission of human cytomegalovirus from infected uterine microvascular endothelial cells to differentiating/invasive placental cytotrophoblasts
    Ekaterina Maidji
    Department of Servizio di Virologia, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, 27100, Pavia, Italy
    Virology 304:53-69. 2002
    ..In turn, these cells could infect endovascular cytotrophoblasts, one possible initiation point of a cascade that results in retrograde placental CMV infection...
  14. ncbi Gene expression profiling of the human maternal-fetal interface reveals dramatic changes between midgestation and term
    Virginia D Winn
    Reproductive Science, University of Colorado Health Sciences Center, 12800 East 19th Avenue, P O Box 6511, Aurora, CO 80045, USA
    Endocrinology 148:1059-79. 2007
    ....

Research Grants15

  1. FETAL CMV INFECTION: ROLE OF THE HUMAN PLACENTA
    Lenore Pereira; Fiscal Year: 2007
    ..Understanding these processes is the first step in the design of novel approaches to block viral spread and enhance the barrier function of the placenta to prevent damage caused by this important human pathogen in congenital disease. ..
  2. FETAL CMV INFECTION: ROLE OF THE HUMAN PLACENTA
    Lenore Pereira; Fiscal Year: 2004
    ..The results could offer the first molecular evidence regarding the route of transmission and lead to strategies to prevent infection of the fetus. ..
  3. Human Placental CMV Infection: Global Gene Expression
    Lenore Pereira; Fiscal Year: 2003
    ..abstract_text> ..
  4. ROLE OF CMV ENVELOPE GLYCOPROTEINS IN POLARIZED CELLS
    Lenore Pereira; Fiscal Year: 2003
    ....
  5. FETAL CMV INFECTION: ROLE OF THE HUMAN PLACENTA
    LENORE PALMA PEREIRA; Fiscal Year: 2010
    ..abstract_text> ..