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| Thomas F PattersonSummaryAffiliation: University of Texas Health Science Center Country: USA Publications
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Publications
Simple method for detecting fluconazole-resistant yeasts with chromogenic agarT F Patterson
Department of Medicine, University of Texas Health Science Center at San Antonio 78284, USA
J Clin Microbiol 34:1794-7. 1996..This screening method appears to be rapid and sensitive for detection of fluconazole-resistant yeasts...- Risk stratification for invasive aspergillosis: early assessment of host susceptibilityThomas F Patterson
The University of Texas Health Science Center at San Antonio, and the South Texas Veterans Health Care System, San Antonio, Texas 78229 3900, USA
Med Mycol 47:S255-60. 2009.... - The role of antifungal susceptibility testing in the management of patients with invasive mycosesS Perea
Department of Medicine, Div Infectious Diseases, University of Texas, Health Science Center at San Antonio, Texas, USA
Rev Iberoam Micol 16:180-6. 1999..It can be anticipated that the development, standardization and validation of in vitro antifungal susceptibility testing will guide clinicians in the management of patients with invasive mycoses... - Invasive aspergillosis. Disease spectrum, treatment practices, and outcomes. I3 Aspergillus Study GroupT F Patterson
Division of Infectious Diseases, University of Texas Health Science Center, San Antonio 78284 7881, USA
Medicine (Baltimore) 79:250-60. 2000..New approaches and new therapies are needed to improve the outcome of invasive aspergillosis in high-risk patients... - Strategy of following voriconazole versus amphotericin B therapy with other licensed antifungal therapy for primary treatment of invasive aspergillosis: impact of other therapies on outcomeThomas F Patterson
Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
Clin Infect Dis 41:1448-52. 2005..In that trial, treatment with voriconazole or amphotericin B deoxycholate could be followed with other licensed antifungal therapies (OLAT). Here, we report the impact of OLAT on the outcome of patients with invasive aspergillosis... - The future of animal models of invasive aspergillosisT F Patterson
Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
Med Mycol 43:S115-9. 2005.... - Fungal susceptibility testing: where are we now?T F Patterson
University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
Transpl Infect Dis 4:38-45. 2002..While susceptibility testing of all fungal isolates is not necessary and not recommended, the judicious use of these tests and the role of the mycology laboratory in assisting in management of invasive fungal infection is also evaluated... - Advances and challenges in management of invasive mycosesThomas F Patterson
Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
Lancet 366:1013-25. 2005..This Seminar reviews the changing epidemiology of invasive mycoses, new diagnostic methods, and recent therapeutic options and current management strategies for these opportunistic pathogens... - Role of newer azoles in surgical patientsT F Patterson
Department of Medicine, The University of Texas Health Science Center at San Antonio, 78229 3900, USA
J Chemother 11:504-12. 1999..Other new azoles with expanded activity are still in the early phases of development. In this review, strategies for optimizing use of the clinically available new azoles and the potential for new agents are discussed... - Clinical utility and development of biomarkers in invasive aspergillosisThomas F Patterson
The University of Texas Health Science Center at San Antonio, Department of Medicine Division of Infectious Diseases, 7703 Floyd Curl Drive, MSC 7881, San Antonio, TX 78229 3900, USA
Trans Am Clin Climatol Assoc 122:174-83. 2011.... - Comparative evaluation of macrodilution and chromogenic agar screening for determining fluconazole susceptibility of Candida albicansT F Patterson
Department of Medicine, University of Texas Health Science Center at San Antonio 78284, USA
J Clin Microbiol 34:3237-9. 1996..This agar dilution methods appears to highly correlate with NCCLS macrobroth methods for detection of C. albicans and may be an effective screen for fluconazole susceptibility... - Approaches to fungal diagnosis in transplantationT F Patterson
Department of Medicine, University of Texas Health Science Center at San Antonio, 78229 3900, USA
Transpl Infect Dis 1:262-72. 1999..Prompt recognition of fungal infection combined with intensive antifungal therapy is needed for successful therapy... - Assessment of Aspergillus fumigatus burden in pulmonary tissue of guinea pigs by quantitative PCR, galactomannan enzyme immunoassay, and quantitative cultureAna C Vallor
The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, TX 78229 3900, USA
Antimicrob Agents Chemother 52:2593-8. 2008..02). Confirmation of fungal tissue burden by two or more methods should provide a more precise account of the burden, allowing improved assessment of diagnostic and therapeutic strategies in invasive pulmonary aspergillosis... - Loss of in vitro resistance in Candida glabrata following discontinuation of fluconazole prophylaxis in a hematopoietic stem cell transplantation patientSteven D Westbrook
Department of Dental Diagnostic Sciences, Division of General Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Med Mycol 48:557-60. 2010..Transcription analysis demonstrated constitutive expression of genes encoding efflux pumps in the isolate recovered on fluconazole prophylaxis and transient expression in those isolates collected after fluconazole was discontinued... - Replacement of Candida albicans with C. dubliniensis in human immunodeficiency virus-infected patients with oropharyngeal candidiasis treated with fluconazoleMarcos Martinez
Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, 78245, USA
J Clin Microbiol 40:3135-9. 2002..dubliniensis. C. dubliniensis in this setting may be underestimated due to lack of identification and may occur due to the impact of fluconazole on the ecology of oral yeast species... - Candida glabrata is an emerging cause of oropharyngeal candidiasis in patients receiving radiation for head and neck cancerSpencer W Redding
Department of General Dentistry, University of Texas Health Science Center at San Antonio, South Texas Veterans Healthcare System, TX 78229 3900, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:47-52. 2004..As with systemic infection, previous fluconazole use appears to be a risk factor for this infection, but not with all patients... - Antifungal combinations against Candida albicans biofilms in vitroStefano P Bachmann
Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
Antimicrob Agents Chemother 47:3657-9. 2003..Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP... - Efficacy of caspofungin alone and in combination with voriconazole in a Guinea pig model of invasive aspergillosisWilliam R Kirkpatrick
Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, TX 78229 3900, USA
Antimicrob Agents Chemother 46:2564-8. 2002..The combinations of CAS plus VRC were highly effective in this model and should be further evaluated for use against invasive aspergillosis... - Antifungal susceptibilities among different serotypes of Cryptococcus gattii and Cryptococcus neoformansGeorge R Thompson
Department of Internal Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
Antimicrob Agents Chemother 53:309-11. 2009..Isavuconazole, posaconazole, and voriconazole demonstrated excellent potency against each isolate and serotype, including isolates with reduced fluconazole susceptibilities... - Factors associated with mortality in transplant patients with invasive aspergillosisJohn W Baddley
Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, AL 35294 0006, USA
Clin Infect Dis 50:1559-67. 2010..The purpose of this study was to evaluate factors associated with mortality in transplant patients with IA... - Oropharyngeal candidiasis in the era of antiretroviral therapyGeorge R Thompson
Division of Infectious Diseases, Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:488-95. 2010..Current knowledge of the epidemiology, pathogenesis, clinical presentation, treatment, and mechanisms of antifungal resistance observed in OPC are important in managing patients with this infection and are the focus of this review... - In vitro interaction of caspofungin acetate with voriconazole against clinical isolates of Aspergillus sppSofia Perea
Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
Antimicrob Agents Chemother 46:3039-41. 2002..0 to 2.0, was found in 8.3% of the interactions. No antagonism was observed. Animal models are required to validate the in vivo significance of these in vitro data presented for the combination of caspofungin and voriconazole... - Evaluation of Etest method for determining isavuconazole MICs against Cryptococcus gattii and Cryptococcus neoformansGeorge R Thompson
Department of Internal Medicine, Division of Infectious Diseases, UTHSCSA, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Antimicrob Agents Chemother 52:2959-61. 2008..8% agreement was found between these methods, without major discrepancies (>2-well dilution difference). Our findings support the use of the Etest methodology as a reliable method for the determination of MICs against Cryptococcus spp... - Oropharyngeal candidiasis caused by non-albicans yeast in patients receiving external beam radiotherapy for head-and-neck cancerMarta C Dahiya
Department of Radiation Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Int J Radiat Oncol Biol Phys 57:79-83. 2003..To characterize non-albicans Candida oral infections in patients with head-and-neck cancer receiving external beam radiotherapy (EBRT) with or without concurrent chemotherapy... - Assessment of serum (1->3)-beta-D-glucan concentration as a measure of disease burden in a murine model of invasive pulmonary aspergillosisNathan P Wiederhold
The University of Texas at Austin College of Pharmacy, Austin, Texas, USA
Antimicrob Agents Chemother 52:1176-8. 2008..Serum (1-->3)-beta-D-glucan was detected early during the course of infection, and reductions in this biomarker were associated with improved survival in animals treated with antifungal agents... - Efficacy of posaconazole as treatment and prophylaxis against Fusarium solaniNathan P Wiederhold
University of Texas at Austin College of Pharmacy, Austin, Texas, USA
Antimicrob Agents Chemother 54:1055-9. 2010..In this model high dosages of posaconazole were effective as treatment and prophylaxis against disseminated fusariosis caused by F. solani... - Development of caspofungin resistance following prolonged therapy for invasive candidiasis secondary to Candida glabrata infectionGeorge R Thompson
Department of Internal Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Antimicrob Agents Chemother 52:3783-5. 2008..Pre- and posttreatment isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed an F659V substitution within the FKS2 region of the glucan synthase complex... - In vitro activity of caspofungin against Candida albicans biofilmsStefano P Bachmann
Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
Antimicrob Agents Chemother 46:3591-6. 2002..albicans. Together these findings indicate that caspofungin displays potent activity against C. albicans biofilms in vitro and merits further investigation for the treatment of biofilm-associated infections... - Combination therapy with terbinafine and amphotericin B in a rabbit model of experimental invasive aspergillosisWilliam R Kirkpatrick
Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, Texas 78229 3900, USA
Antimicrob Agents Chemother 49:4751-3. 2005..Terbinafine was evaluated with AmB to assess antagonism or synergy in a rabbit model of invasive aspergillosis. Terbinafine had relatively little activity but did not demonstrate antagonism against AmB in our model... - Sequential or combination antifungal therapy with voriconazole and liposomal amphotericin B in a Guinea pig model of invasive aspergillosisWilliam R Kirkpatrick
The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, TX 78229 3900, USA
Antimicrob Agents Chemother 50:1567-9. 2006..Simultaneous VRC and L-AMB was most effective, although VRC monotherapy was also effective. These regimens as well as sequential L-AMB followed by VRC were more effective than L-AMB alone or VRC followed by L-AMB... - Candida krusei sepsis secondary to oral colonization in a hemopoietic stem cell transplant recipientSteven D Westbrook
Department of Dental Diagnostic Sciences, The University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
Med Mycol 45:187-90. 2007..We report on an autologous hemopoietic stem cell transplant recipient who developed Candida krusei sepsis from pre-existing oral colonization... - In vitro activity of caspofungin (MK-0991) against Candida albicans clinical isolates displaying different mechanisms of azole resistanceStefano P Bachmann
Department of Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, South Texas Centers for Biology in Medicine, San Antonio, Texas 78245, USA
J Clin Microbiol 40:2228-30. 2002.... - Antifungal susceptibility testing of micafungin against Candida glabrata isolatesErica R Oliveira
Department of General Dentistry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:457-9. 2008..glabrata was performed to evaluate the hypothesis that micafungin may be a suitable alternative in treating those patients whose infections are from C. glabrata and have developed resistance to fluconazole... - Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001-2006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) DatabaseDimitrios P Kontoyiannis
The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Clin Infect Dis 50:1091-100. 2010..The incidence and epidemiology of invasive fungal infections (IFIs), a leading cause of death among hematopoeitic stem cell transplant (HSCT) recipients, are derived mainly from single-institution retrospective studies... - Screening for drug-resistant Candida yeasts with chromogenic agarWilliam R Kirkpatrick
Department of Medicine, South Texas Veterans Health Care System, San Antonio, TX, USA
Med Mycol 48:807-16. 2010..However, the determination of resistance or non-susceptibility in yeasts may be more problematic, and may be species dependent... - Antifungal resistance in pathogenic fungiSofia Perea
Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Clin Infect Dis 35:1073-80. 2002.... - Comparison of lateral flow technology and galactomannan and (1->3)-beta-D-glucan assays for detection of invasive pulmonary aspergillosisNathan P Wiederhold
University of Texas at Austin College of Pharmacy, Austin, Texas, USA
Clin Vaccine Immunol 16:1844-6. 2009..The lateral flow device became positive earlier (day 3) than the (1-->3)-beta-D-glucan and galactomannan assays (day 5), with all samples positive by each assay on day 7... - Inhaled voriconazole for prevention of invasive pulmonary aspergillosisJustin A Tolman
The University of Texas at Austin College of Pharmacy, Austin, Texas, USA
Antimicrob Agents Chemother 53:2613-5. 2009..Inhaled voriconazole significantly improved survival and limited the extent of invasive disease, as assessed by histopathology, compared to control and amphotericin B treatments... - Combination antifungal therapyThomas F Patterson
University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
Pediatr Infect Dis J 22:555-6. 2003 - New guinea pig model of Cryptococcal meningitisWilliam R Kirkpatrick
The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, San Antonio, TX 78229 3900, USA
Antimicrob Agents Chemother 51:3011-3. 2007..Disease was monitored by serial cerebrospinal fluid (CSF) cultures and quantitative organ cultures. Our model produces disseminating central nervous system disease and responds to antifungal therapy... - In vitro activity of isavuconazole against Trichosporon, Rhodotorula, Geotrichum, Saccharomyces and Pichia speciesGeorge R Thompson
Department of Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
J Antimicrob Chemother 64:79-83. 2009..These organisms can be resistant or refractory to existing antifungal agents. We sought to evaluate the activity of the new triazole isavuconazole against these difficult pathogens... - Voriconazole use and pharmacokinetics in combination with interferon-gamma for refractory cryptococcal meningitis in a patient receiving low-dose ritonavirNatalie E Nierenberg
Department of Internal Medicine, Division of General Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Med Mycol 48:532-6. 2010.... - Cost advantage of voriconazole over amphotericin B deoxycholate for primary treatment of invasive aspergillosisJames S Lewis
Department of Pharmacy, University of Texas Health Science Center at San Antonio, University Health System, San Antonio, Texas, USA
Pharmacotherapy 25:839-46. 2005.... - Molecular mechanisms of fluconazole resistance in Candida dubliniensis isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasisSofia Perea
Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, 78245, USA
Antimicrob Agents Chemother 46:1695-703. 2002..dublinensis clinical isolates from HIV-infected patients treated with FLC is mediated by multiple molecular mechanisms of resistance, similar to the observations found in the case of C. albicans... - Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patientsS Perea
Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
Antimicrob Agents Chemother 45:2676-84. 2001..These results may help in the development of new strategies to overcome the problem of resistance as well as new treatments for this condition... - Multiple patterns of resistance to fluconazole in Candida glabrata isolates from a patient with oropharyngeal candidiasis receiving head and neck radiationSpencer W Redding
Department of General Dentistry, The University of Texas Health Science Center and The South Texas Veterans Healthcare System, San Antonio, Texas 78229 3900, USA
J Clin Microbiol 41:619-22. 2003..In conclusion, development of resistance to fluconazole by C. glabrata is a highly varied process involving multiple molecular mechanisms... - Caspofungin dose escalation for invasive candidiasis due to resistant Candida albicansNathan P Wiederhold
The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
Antimicrob Agents Chemother 55:3254-60. 2011..These data suggest that caspofungin dose escalation for invasive candidiasis may not be consistently effective against resistant C. albicans isolates, and this may be associated with the virulence of the strain... - The C-terminal antibody binding domain of Candida albicans mp58 represents a protective epitope during candidiasisAngel Viudes
Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, South Texas Centers for Biology in Medicine, Texas Research Park, 15355 Lambda Dr, San Antonio, TX 78245, USA
FEMS Microbiol Lett 232:133-8. 2004..Together, these observations indicate the carboxy-terminal antibody binding domain of C. albicans mp58 represents a protective epitope during candidiasis... - Candida glabrata oropharyngeal candidiasis in patients receiving radiation treatment for head and neck cancerSpencer W Redding
Department of General Dentistry, Division of Infectious Diseases, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
J Clin Microbiol 40:1879-81. 2002.... - Investigation of multidrug efflux pumps in relation to fluconazole resistance in Candida albicans biofilmsGordon Ramage
Department of Microbiology, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
J Antimicrob Chemother 49:973-80. 2002.... - A randomized study of the use of fluconazole in continuous versus episodic therapy in patients with advanced HIV infection and a history of oropharyngeal candidiasis: AIDS Clinical Trials Group Study 323/Mycoses Study Group Study 40Mitchell Goldman
Indiana University School of Medicine, Division of Infectious Diseases, Wishard Memorial Hospital, Indianapolis, IN 46202, USA
Clin Infect Dis 41:1473-80. 2005..However, concerns exist with regard to the use of fluconazole prophylaxis and the risk of development of fluconazole treatment-refractory infections... - Aspergillus fumigatus stimulates leukocyte adhesion molecules and cytokine production by endothelial cells in vitro and during invasive pulmonary diseaseLisa Y Chiang
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, Torrance, CA 90502, USA
Infect Immun 76:3429-38. 2008..fumigatus could enhance the host defense against this organism by contributing to the recruitment of activated leukocytes to sites of angioinvasion... - Salivary anticandidal activity and saliva composition in an HIV-infected cohortA L Lin
Department of Dental Diagnostic Science, University of Texas Health Science Center at San Antonio, USA
Oral Microbiol Immunol 16:270-8. 2001..This study shows reduced anticandidal activity and salivary flow rate in HIV-infected patients. These alterations may contribute to their increased incidence of oral candidal infections... - Prophylactic efficacy of single dose pulmonary administration of amphotericin B inhalation powder in a guinea pig model of invasive pulmonary aspergillosisWilliam R Kirkpatrick
The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
J Antimicrob Chemother 67:970-6. 2012..We evaluated the prophylactic efficacy of single dose administration of ABIP in a guinea pig model of invasive pulmonary aspergillosis... - A noninvasive renal fungus ball caused by Rhizopus--a previously unreported manifestation of zygomycosisFederico Palacio-Bedoya
Departments of Internal Medicine, Division of Hospital Medicine, Fungus Testing Laboratory University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
Med Mycol 48:866-9. 2010..The therapy was changed to posaconazole with subsequent clinical, mycologic, and radiographic improvement and the patient has remained free of recurrence 5 years after diagnosis... - Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteriaBrahm H Segal
Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Clin Infect Dis 47:674-83. 2008..We also discuss potential pitfalls in assessing outcome, such as conflicting clinical, radiological, and/or mycological data and gaps in knowledge... - Pulmonary aspergillosisGeorge R Thompson
Division of Infectious Diseases, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
Semin Respir Crit Care Med 29:103-10. 2008..Diagnosis is often difficult because existing tests lack desired sensitivity or specificity... - Invasive Aspergillus infections in hematologic malignancy patientsSofia Perea
Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, 78229-3900, USA
Semin Respir Infect 17:99-105. 2002..Targeted antifungal prophylaxis for hematologic patients who are at high risk for developing invasive fungal infections is not currently standardized... - Growth competition between Candida dubliniensis and Candida albicans under broth and biofilm growing conditionsW R Kirkpatrick
Departments of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
J Clin Microbiol 38:902-4. 2000..dubliniensis in broth culture and under biofilm growing conditions; however, with the presence of a supporting structure for biofilm formation, C. dubliniensis was able to better withstand the competitive pressures from C. albicans... - Investigation and control of aspergillosis and other filamentous fungal infections in solid organ transplant recipientsJ E Patterson
Department of Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, 78284 7881, USA
Transpl Infect Dis 2:22-8. 2000..Ongoing surveillance and continuing intervention is needed for prevention of infection in high-risk solid organ transplant patients... - Candida dubliniensis in radiation-induced oropharyngeal candidiasisS W Redding
Department of General Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, Tex 78229 3900, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:659-62. 2001..To our knowledge, this is the first described case of C dubliniensis contributing to oropharyngeal candidiasis in this patient population... - Efficacy of voriconazole in a guinea pig model of disseminated invasive aspergillosisW R Kirkpatrick
Departments of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
Antimicrob Agents Chemother 44:2865-8. 2000..VRC treatment regimens improved survival and significantly reduced tissue colony counts compared with those of controls... - Epidemiology of oropharyngeal Candida colonization and infection in patients receiving radiation for head and neck cancerS W Redding
Department of General Dentistry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284 7881, USA
J Clin Microbiol 37:3896-900. 1999..One patient, however, did show the acquisition of a new strain. With this high rate of infection (27%), prophylaxis to prevent infection should be evaluated for these patients... - Therapeutic and prophylactic efficacy of aminocandin (IP960) against disseminated candidiasis in miceL K Najvar
Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
Clin Microbiol Infect 14:595-600. 2008..These results demonstrate that single doses of aminocandin are effective as treatment and prophylaxis, and suggest that extended interval dosing may be a useful strategy for treating invasive candidiasis... - Candida glabrata sepsis secondary to oral colonization in bone marrow transplantationS W Redding
Department of General Dentistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
Med Mycol 42:479-81. 2004..We report on a bone marrow transplant patient who developed Candida glabrata sepsis from pre-existing oral colonization... - Comparison of antifungal susceptibilities to fluconazole and voriconazole of oral Candida glabrata isolates from head and neck radiation patientsA K Burn
Department of General Dentistry, University of Texas Health Science Center San Antonio, San Antonio, TX 78229, USA
J Clin Microbiol 42:5846-8. 2004..Oral C. glabrata isolates for which the fluconazole MICs are elevated are commonly those for which the voriconazole MICs are elevated, but these increases may be transient for voriconazole, as they are for fluconazole... - In vitro interaction of posaconazole and caspofungin against clinical isolates of Candida glabrataE R Oliveira
Department of General Dentistry, University of Texas Health Science Center at San Antonio, Mail Code 7914, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Antimicrob Agents Chemother 49:3544-5. 2005..Synergy was seen in 18% of all isolates and in 4% of fluconazole-resistant isolates at 48 h without evidence of antagonism. This antifungal combination may have utility against this organism... - Interpretation of trailing endpoints in antifungal susceptibility testing by the National Committee for Clinical Laboratory Standards methodS G Revankar
University of Texas Health Science Center at San Antonio, 78284 7881, USA
J Clin Microbiol 36:153-6. 1998..In addition, with isolates for which trailing endpoints are observed, reading the endpoint for the NCCLS method at 24 h may be more appropriate... - Efficacy of SCH56592 in a rabbit model of invasive aspergillosisW R Kirkpatrick
Departments of Medicine, San Antonio, Texas 78284, USA
Antimicrob Agents Chemother 44:780-2. 2000..from tissues. Compared with controls, SCH regimens reduced mortality, improved survival, and significantly reduced tissue colony counts... - Distinct patterns of gene expression associated with development of fluconazole resistance in serial candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasisJ L Lopez-Ribot
Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284 7881, USA
Antimicrob Agents Chemother 42:2932-7. 1998..Additional studies are needed to estimate the frequency and clinical impact of these mechanisms of resistance... - Fluconazole versus Candida albicans: a complex relationshipJ R Graybill
Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
Antimicrob Agents Chemother 42:2938-42. 1998..albicans isolates is associated with increasing fluconazole MICs in some cases but not in others and shows that these low-virulence strains may not consistently cause infection... - Multiple resistant phenotypes of Candida albicans coexist during episodes of oropharyngeal candidiasis in human immunodeficiency virus-infected patientsJ L Lopez-Ribot
Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
Antimicrob Agents Chemother 43:1621-30. 1999.... - False-positive Gen-Probe direct Mycobacterium tuberculosis amplification test results for patients with pulmonary M. kansasii and M. avium infectionsJ H Jorgensen
Departments of Pathology, The University of Texas Health Science Center, San Antonio, Texas 78284, USA
J Clin Microbiol 37:175-8. 1999..It remains to be determined if the enhanced MTD test (MTD 2) recently released by Gen-Probe will provide greater specificity than that observed in this report with its first-generation test... - Low levels of antigenic variability in fluconazole-susceptible and -resistant Candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasisJ L Lopez-Ribot
Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284 7881, USA
Clin Diagn Lab Immunol 6:665-70. 1999.... - Efficacy of ravuconazole (BMS-207147) in a guinea pig model of disseminated aspergillosisWilliam R Kirkpatrick
Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, TX 78229 3900, USA
J Antimicrob Chemother 49:353-7. 2002..All three doses of ravuconazole improved survival and also reduced the tissue burden of ASPERGILLUS: In this model of invasive aspergillosis, ravuconazole showed significant activity and may be a useful compound in human disease... - Overview of antifungal agentsGeorge R Thompson
Department of Internal Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Clin Chest Med 30:203-15, v. 2009..Emphasis is placed on pharmacodynamics and kinetics, drug interactions, adverse events, and evidence for their use. Selected clinical trials demonstrating the efficacy of these agents are also reviewed... - Immune reconstitution inflammatory syndrome after cessation of the tumor necrosis factor alpha blocker adalimumab in cryptococcal pneumoniaJose Cadena
Department of Medicine, University of Texas Health Science Center at San Antonio, 78229, USA
Diagn Microbiol Infect Dis 64:327-30. 2009..We describe the 1st case of IRIS secondary to cryptococcal pneumonia after cessation of adalimumab... - Human p38 mitogen-activated protein kinase inhibitor drugs inhibit Plasmodium falciparum replicationMichael J Brumlik
Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, 2040 Babcock Rd, Suite 201, San Antonio, TX 78229, USA
Exp Parasitol 128:170-5. 2011..These results suggest that pyridinylimidazoles and pyrrolobenzimidazoles designed to inhibit human p38 MAPK activation can be developed to treat malaria... - Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET)Peter G Pappas
Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham Medical Center, Birmingham, Alabama 35294 0006, USA
Clin Infect Dis 50:1101-11. 2010..Invasive fungal infections (IFIs) are a major cause of morbidity and mortality among organ transplant recipients. Multicenter prospective surveillance data to determine disease burden and secular trends are lacking... - Strain-dependent variation in 18S ribosomal DNA Copy numbers in Aspergillus fumigatusM L Herrera
Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
J Clin Microbiol 47:1325-32. 2009..These results suggest that while the ribosomal genes are excellent targets for enumeration by qPCR, the copy number should be determined prior to using them as targets for quantitative analysis... - In vivo analysis of Aspergillus fumigatus developmental gene expression determined by real-time reverse transcription-PCRFabrice N Gravelat
Department of Microbiology and Immunology, McGill University, Duff Medical Building, Room 502, Montreal, Quebec H3A 2B4, Canada
Infect Immun 76:3632-9. 2008..These results highlight the importance of the evaluation of putative virulence factors expressed by competent hyphae and analysis of gene expression levels during invasive infection rather than in vitro alone... - Early use of antifungal therapy in high-risk patientsThomas F Patterson
Curr Opin Infect Dis 15:561-3. 2002 - Nosocomial outbreak of Exophiala jeanselmei fungemia associated with contamination of hospital waterMarcio Nucci
Mycology Laboratory, Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, 21941 590 Rio de Janeiro, Brazil
Clin Infect Dis 34:1475-80. 2002..RAPD typing showed that isolates from case patients and isolates from the pharmacy water were highly related, whereas the patterns of isolates recovered from the 2 other sources of water were distinct... - Voriconazole versus amphotericin B for primary therapy of invasive aspergillosisRaoul Herbrecht
Département d Hématologie et d Oncologie, Hopital de Hautepierre, Strasbourg, France
N Engl J Med 347:408-15. 2002..Voriconazole is a broad-spectrum triazole that is active against aspergillus species. We conducted a randomized trial to compare voriconazole with amphotericin B for primary therapy of invasive aspergillosis... - New agents for treatment of invasive aspergillosisThomas F Patterson
Clin Infect Dis 35:367-9. 2002 - Micafungin (FK463), alone or in combination with other systemic antifungal agents, for the treatment of acute invasive aspergillosisDavid W Denning
Education and Research Centre, Wythenshawe Hospital and University of Manchester, Academic Department of Medicine and Surgery, Southmoor Road, Manchester M23 9LT, UK
J Infect 53:337-49. 2006..This study evaluated the safety and efficacy of micafungin in patients with proven or probable invasive aspergillosis (IA)... - Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin productionRobert A Cramer
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
Eukaryot Cell 5:972-80. 2006..This result suggests that gliotoxin is not required for virulence in an immunosuppressed host with an invasive pulmonary infection... - Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatusWilliam J Steinbach
Department of Pediatrics, Division of Pediatric Infectious Diseases, Box 3499, Duke University Medical Center, Durham, North Carolina 27710, USA
Eukaryot Cell 5:1091-103. 2006..Our findings reveal that calcineurin appears to play a globally conserved role in the virulence of several pathogenic fungi and yet plays specialized roles in each and can be an excellent target for therapeutic intervention... - Standardization of an experimental murine model of invasive pulmonary aspergillosisDonald C Sheppard
McGill University, Department of Microbiology and Immunology, Montreal, Quebec, Canada
Antimicrob Agents Chemother 50:3501-3. 2006.... - Multicenter, noncomparative study of caspofungin in combination with other antifungals as salvage therapy in adults with invasive aspergillosisJohan Maertens
Department of Hematology, University Hospital Gasthuisberg, Leuven, Belgium
Cancer 107:2888-97. 2006..Interest remains as to whether caspofungin, in combination with other antifungal classes, can improve the efficacy against IA... - Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trialThomas J Walsh
Immunocompromised Host Section, National Cancer Institute, Bethesda, MD 20892, USA
Clin Infect Dis 44:2-12. 2007..Current treatments provide limited benefit. Posaconazole is an extended-spectrum triazole with in vitro and in vivo activity against Aspergillus species... - Imaging findings in acute invasive pulmonary aspergillosis: clinical significance of the halo signReginald E Greene
Massachusetts General Hospital, Boston, MA 02114, USA
Clin Infect Dis 44:373-9. 2007.... - Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of AmericaThomas J Walsh
Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
Clin Infect Dis 46:327-60. 2008 - Polymerase chain reaction detection of aspergillus DNA in experimental models of invasive aspergillosisJuergen Loeffler
Medizinische Klinik Abteilung II, University of Tuebingen, Otfried Mueller Strasse 10, 72076 Tuebingen, Germany
J Infect Dis 185:1203-6. 2002..Quantitative PCR analysis of blood samples showed a fungus load of 10(1)-10(2) cfu/mL of blood. The data confirm the superior sensitivity of PCR for the diagnosis of experimental Aspergillus infections... - Efficacy and safety of caspofungin for treatment of invasive aspergillosis in patients refractory to or intolerant of conventional antifungal therapyJohan Maertens
University Hospital, Gasthuisberg, Leuven, Belgium
Clin Infect Dis 39:1563-71. 2004..Two patients discontinued caspofungin therapy because of drug-related adverse events. Drug-related nephrotoxicity and hepatotoxicity occurred infrequently. CONCLUSION: Caspofungin demonstrated usefulness in the salvage treatment of IA... - Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) CBen de Pauw
Department of Blood Transfusion Service and Transplant Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Clin Infect Dis 46:1813-21. 2008..Clarity and uniformity in defining these infections are important factors in improving the quality of clinical studies. A standard set of definitions strengthens the consistency and reproducibility of such studies... - Should the consensus guidelines' specific criteria for the diagnosis of invasive fungal infection be changed?Ben E de Pauw
University Medical Center, Nijmegen, The Netherlands
Clin Infect Dis 41:S377-80. 2005..This combination of factors has urged researchers to reconsider the continuing appropriateness of the current definitions...
Research Grants
- Detection and Significance of Antifungal Resistance in Oropharyngeal CandidiasisThomas F Patterson; Fiscal Year: 2010..This research is aimed at developing rapid molecular tests to detect yeasts which are resistant to antifungal agents in order to allow early use of more effective therapy. ..
- FLUCONAZOLE RESISTANCE IN OROPHARYNGEAL CANDIDIASISThomas Patterson; Fiscal Year: 2000....
- Detection and Significance of Antifungal Resistance in Oropharyngeal CandidiasisThomas Patterson; Fiscal Year: 2009..This research is aimed at developing rapid molecular tests to detect yeasts which are resistant to antifungal agents in order to allow early use of more effective therapy. ..