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Genomes and GenesSpecies | Andrew T ParsaSummaryAffiliation: University of California Country: USA Publications
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Publications
Soluble factors secreted by glioblastoma cell lines facilitate recruitment, survival, and expansion of regulatory T cells: implications for immunotherapyCourtney A Crane
Corresponding Author A T Parsa, MD, PhD, Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, M779, San Francisco, CA 94143
Neuro Oncol 14:584-95. 2012....- Immunological considerations of modern animal models of malignant primary brain tumorsMichael E Sughrue
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA
J Transl Med 7:84. 2009..As this review demonstrates, many of these models have inherent immune system limitations, and the impact of these limitations on studies on the influence of pre-clinical therapeutics testing warrants further attention... - Endocrinologic, neurologic, and visual morbidity after treatment for craniopharyngiomaMichael E Sughrue
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94117, USA
J Neurooncol 101:463-76. 2011..4%, P = 0.11). Given the difficulty in obtaining class 1 data regarding the treatment of this tumor, this study can serve as an estimate of expected outcomes for these patients, and guide decision making until these data are available... - Factors influencing overall survival rates for patients with pineocytomaAaron J Clark
Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94117, USA
J Neurooncol 100:255-60. 2010..Gross total resection is the most appropriate treatment for pineocytoma. The potential benefit of conventional radiotherapy for the treatment of these lesions is unproven, and little evidence supports its use at present... - Primary gliosarcoma: key clinical and pathologic distinctions from glioblastoma with implications as a unique oncologic entitySeunggu J Han
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94117, USA
J Neurooncol 96:313-20. 2010..Clinical and pathologic characteristics distinct from GBM suggest that they may warrant specific treatment, separate from conventional GBM therapy... - Giant thoracic schwannoma presenting with abrupt onset of abdominal pain: a case reportIsaac Yang
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
J Med Case Reports 3:88. 2009..We report the case of a patient with a giant thoracic schwannoma presenting unusually with acute abdominal pain and with delayed neurological impairment... - The complement cascade as a mediator of tissue growth and regenerationMartin J Rutkowski
Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94143, USA
Inflamm Res 59:897-905. 2010..Here, we describe the complement cascade as a mediator of tissue growth and regeneration... - Prognostic significance of intracranial dissemination of glioblastoma multiforme in adultsAndrew T Parsa
Department of Neurological Surgery, School of Medicine, University of California at San Francisco, California 94143, USA
J Neurosurg 102:622-8. 2005..The objective in the present study was to assess the prognostic significance of disseminated intracranial GBM in adults at presentation and at the time of tumor progression... - Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in gliomaAndrew T Parsa
Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Avenue, M 779, San Francisco, California 94143, USA
Nat Med 13:84-8. 2007..These data identify a previously unrecognized mechanism linking loss of the tumor suppressor PTEN with immunoresistance, mediated in part by B7-H1... - Spinal cord and intradural-extraparenchymal spinal tumors: current best care practices and strategiesAndrew T Parsa
Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
J Neurooncol 69:291-318. 2004..Advances in many disciplines including neuroradiology, neurosurgery, neurooncology, and neuropathology have contributed to expediting diagnosis and improving outcomes... - Autologous adjuvant linked fibroblasts induce anti-glioma immunity: implications for development of a glioma vaccineAndrew T Parsa
Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
J Neurooncol 64:77-87. 2003..In this study we describe an in vitro model of active immunotherapy using autologous fibroblasts as immunogen. Correlative results from glioma patients immunized with autologous fibroblasts are also described... - Gamma interferon-mediated superinduction of B7-H1 in PTEN-deficient glioblastoma: a paradoxical mechanism of immune evasionSeunggu J Han
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94117, USA
Neuroreport 20:1597-602. 2009..The combination of PTEN loss and gamma-interferon exposure in glioblastoma patients results in an exceptionally immunoresistant phenotype that may negate adaptive immunity through induction of T-cell apoptosis... - Management of recurrent intracranial hemangiopericytomaMartin J Rutkowski
Brain Tumor Research Center, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
J Clin Neurosci 18:1500-4. 2011..This multimodality approach also appears to outperform GKS in extending time to second recurrence. Accordingly, when safe and feasible, surgical resection of recurrent HPC with adjuvant EBRT should be the first steps in management... - Results with judicious modern neurosurgical management of parasagittal and falcine meningiomas. Clinical articleMichael E Sughrue
Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California, USA
J Neurosurg 114:731-7. 2011..The present study aims to address surgical outcomes in a focused cohort of these patients for which there is not clinical equipoise between radiosurgery and transcranial resection... - Secondary gliosarcoma after diagnosis of glioblastoma: clinical experience with 30 consecutive patientsSeunggu J Han
Department of Neurological Surgery, University of California, San Francisco, California 94117, USA
J Neurosurg 112:990-6. 2010..The authors present a large series of histologically confirmed SGSs, with follow-up to describe the clinical and radiological presentation, pathological diagnosis, and treatment outcomes... - Implications for immunotherapy of tumor-mediated T-cell apoptosis associated with loss of the tumor suppressor PTEN in glioblastomaJames S Waldron
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94123, USA
J Clin Neurosci 17:1543-7. 2010..In addition, our results raise the possibility of combining T-cell based immunotherapy protocols with clinical inhibitors of the PI3K/Akt/mTOR pathway... - A novel PTEN-dependent link to ubiquitination controls FLIPS stability and TRAIL sensitivity in glioblastoma multiformeAmith Panner
Brain Tumor Research Center, Department of Neurological Surgery and University of California San Francisco Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94158 9001, USA
Cancer Res 69:7911-6. 2009..These results define the PTEN-Akt-AIP4 pathway as a key regulator of FLIP(S) ubiquitination, FLIP(S) stability, and TRAIL sensitivity and also define a novel link between PTEN and the ubiquitin-mediated control of protein stability... - Differentiation of recurrent glioblastoma multiforme from radiation necrosis after external beam radiation therapy with dynamic susceptibility-weighted contrast-enhanced perfusion MR imagingRamon F Barajas
Department of Radiology, Neuroradiology Section, University of California, San Francisco, CA 94143, USA
Radiology 253:486-96. 2009.... - The relevance of Simpson Grade I and II resection in modern neurosurgical treatment of World Health Organization Grade I meningiomasMichael E Sughrue
Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
J Neurosurg 113:1029-35. 2010.... - A comprehensive analysis of hearing preservation after radiosurgery for vestibular schwannomaIsaac Yang
Department of Neurological Surgery, University of California at San Francisco, California 94117, USA
J Neurosurg 112:851-9. 2010..Their aim was to objectively characterize the prognostic factors that contribute to hearing preservation after GKS, as well as methodically summarize the reported literature describing hearing preservation after GKS for VS... - Surgical technique of temporary arterial occlusion in the operative management of spinal hemangioblastomasAaron J Clark
Department of Neurological Surgery, University of California, San Francisco, California, USA
World Neurosurg 74:200-5. 2010..Although benign, their highly vascular nature makes resection challenging. A major difficulty involves intraoperative differentiation of vessels supplying the tumor from those supplying the spinal cord... - Clinical characteristics and outcomes for a modern series of primary gliosarcoma patientsSeunggu J Han
Department of Neurological Surgery, University of California, San Francisco, CA, USA
Cancer 116:1358-66. 2010..In the current study, the authors present a modern series of confirmed PGS cases treated in the era of magnetic resonance imaging (MRI), after the accepted glioblastoma management of resection, radiation, and temozolomide... - Intracranial hemangiopericytoma: clinical experience and treatment considerations in a modern series of 40 adult patientsMartin J Rutkowski
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA
Cancer 118:1628-36. 2012..Intracranial hemangiopericytoma (HPC) is a malignant meningothelial tumor. Because of its rarity, few guidelines exist for optimal management... - Risk factors for the development of serious medical complications after resection of meningiomas. Clinical articleMichael E Sughrue
Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California, USA
J Neurosurg 114:697-704. 2011..The authors performed a review of 834 patients who underwent craniotomy for meningioma at their institution and analyzed the rate of major cardiac, pulmonary, renal, and hepatic complications... - Impact of bevacizumab chemotherapy on craniotomy wound healingAaron J Clark
Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
J Neurosurg 114:1609-16. 2011..Phase II trials reported 4%-6% impaired wound healing for bevacizumab initiated postoperatively. The effect of preoperative bevacizumab on subsequent craniotomy healing has not been addressed... - A critical evaluation of cystic features in primary glioblastoma as a prognostic factor for survivalGurvinder Kaur
Department of Neurological Surgery, University of California, San Francisco, California, USA
J Neurosurg 115:754-9. 2011.... - A meta-analysis of tumor control rates and treatment-related morbidity for patients with glomus jugulare tumorsMichael E Ivan
Department of Neurological Surgery, University of California, San Francisco, California, USA
J Neurosurg 114:1299-305. 2011..In this study, the authors assessed data collected from 869 patients with glomus jugulare tumors from the published literature to identify treatment variables that impacted clinical outcomes and tumor control rates... - Lack of B7 expression, not human leukocyte antigen expression, facilitates immune evasion by human malignant gliomasRichard C E Anderson
Department of Neurological Surgery, The Neurological Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Neurosurgery 60:1129-36; discussion 1136. 2007..Lack of human leukocyte antigens and costimulatory molecules have been suggested as mechanisms by which human malignant gliomas avoid immune recognition and elimination... - Extent of resection and the long-term durability of vestibular schwannoma surgeryMichael E Sughrue
Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
J Neurosurg 114:1218-23. 2011..In this prospective study, the authors evaluated 772 patients who underwent microsurgical resection of VSs to analyze the association between total tumor resection and the tumor recurrence rate... - The value of intraoperative facial nerve electromyography in predicting facial nerve function after vestibular schwannoma surgeryMichael E Sughrue
Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94143, USA
J Clin Neurosci 17:849-52. 2010..In conclusion, while facial nerve EMG is a critical adjunct for locating the facial nerve intraoperatively, its predictive value for facial nerve function remains to be determined... - Outcome and survival following primary and repeat surgery for World Health Organization Grade III meningiomasMichael E Sughrue
Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, California 94143, USA
J Neurosurg 113:202-9. 2010..The authors present the largest case series to date dealing with these tumors, providing analysis of 63 patients... - Tumor control after surgery and radiotherapy for pineocytomaAaron J Clark
Department of Neurological Surgery, University of California, San Francisco, California 94117, USA
J Neurosurg 113:319-24. 2010..Therefore, the authors performed a systematic review of the literature on tumor control after surgery for pineocytoma to determine the relative benefits of aggressive resection and postoperative adjuvant radiotherapy... - Non-audiofacial morbidity after Gamma Knife surgery for vestibular schwannomaMichael E Sughrue
Department of Neurological Surgery, University of California, San Francisco, California 94117, USA
Neurosurg Focus 27:E4. 2009..For this reason, the authors conducted a systematic review of the literature for non-audiofacial-related morbidity after the treatment of vestibular schwannoma with radiosurgery... - Craniopharyngioma: a comparison of tumor control with various treatment strategiesIsaac Yang
Department of Neurological Surgery, University of California, San Francisco, California, USA
Neurosurg Focus 28:E5. 2010..Here, the authors summarize the published literature regarding rates of tumor control with various treatment modalities for craniopharyngiomas... - Factors associated with preservation of facial nerve function after surgical resection of vestibular schwannomaOrin Bloch
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA
J Neurooncol 102:281-6. 2011..Residual disease can be followed and controlled with radiosurgery if interval growth is noted... - Epidermal growth factor module-containing mucin-like receptor 2 is a newly identified adhesion G protein-coupled receptor associated with poor overall survival and an invasive phenotype in glioblastomaMartin J Rutkowski
Brain Tumor Research Center, Department of Neurological Surgery, University of California, 505 Parnassus Ave, San Francisco, CA 94143, USA
J Neurooncol 105:165-71. 2011..The invasive phenotype conferred by EMR2 correlates with clinical data demonstrating poor survival in glioblastoma patients who express high levels of EMR2 in their tumor... - Facial nerve preservation after vestibular schwannoma Gamma Knife radiosurgeryIsaac Yang
Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94143, USA
J Neurooncol 93:41-8. 2009..In this study, we report the results of an objective analysis of reported facial nerve outcomes after the treatment of vestibular schwannomas with Gamma Knife radiosurgery... - Predictors of mortality following treatment of intracranial hemangiopericytomaMartin J Rutkowski
Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California, USA
J Neurosurg 113:333-9. 2010..A systematic review of the published literature was performed to ascertain predictors of death following treatment for intracranial HPC... - Adjuvant radiation therapy and chondroid chordoma subtype are associated with a lower tumor recurrence rate of cranial chordomaBrian J Jian
Department of Neurological Surgery, University of California at San Francisco, 505, Parnassus Ave, San Francisco, CA 94143, USA
J Neurooncol 98:101-8. 2010..Our data suggests that younger patients with chondroid type cranial chordoma treated with both surgery and radiation may have improved rates of tumor recurrence in the treatment of these tumors... - Postoperative seizures following the resection of convexity meningiomas: are prophylactic anticonvulsants indicated? Clinical articleMichael E Sughrue
Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California, USA
J Neurosurg 114:705-9. 2011..Given the paucity of tumor-type and site-specific data, the authors evaluated the incidence of postoperative seizures in patients with convexity meningiomas and no prior seizures... - Functional mapping-guided resection of low-grade gliomas in eloquent areas of the brain: improvement of long-term survival. Clinical articleEdward F Chang
Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California, USA
J Neurosurg 114:566-73. 2011..Given the lack of long-term survival data, the prognostic significance of eloquent brain tumor location and the role of functional mapping during resective surgery in presumed eloquent brain regions are unknown... - Clinical and surgical considerations for cerebellopontine angle meningiomasAri J Kane
Department of Neurological Surgery, Brain Tumor Research Center, University of California at San Francisco, San Francisco, CA 94143, USA
J Clin Neurosci 18:755-9. 2011..Caution must be used when attempting to resect tumor extensions into the jugular foramen given the high rates of lower CN complications... - Anatomic location is a risk factor for atypical and malignant meningiomasAri J Kane
Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143, USA
Cancer 117:1272-8. 2011..Hence, the authors have reviewed a large series of their patients to determine risk factors for higher-grade pathology, with particular interest paid to tumor location... - mTOR-independent translational control of the extrinsic cell death pathway by RalAAmith Panner
UCSF Cancer Center, 2340 Sutter St, Rm N219, San Francisco, CA 94115-0875, USA
Mol Cell Biol 26:7345-57. 2006.... - A critical evaluation of vestibular schwannoma surgery for patients younger than 40 years of ageMichael E Sughrue
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143, USA
Neurosurgery 67:1646-53; discussion 1653-4. 2010..There are few published prospective data sets specifically focusing on patients younger than 40 years old undergoing microsurgery for vestibular schwannoma... - Increased expression of the glioma-associated antigen ARF4L after loss of the tumor suppressor PTEN. Laboratory investigationJohn H Chi
Department of Neurological Surgery, Brain Tumor Research Center, University of California, San Francisco, California 94143, USA
J Neurosurg 108:299-303. 2008..The authors investigated the relationship between PTEN status and the expression of a glioma-associated antigen, adenosine diphosphate-ribosylation factor 4-like (ARF4L) protein... - Incidence, risk factors, and outcome of venous infarction after meningioma surgery in 705 patientsMichael E Sughrue
Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, P O Box 0112, San Francisco, California 94143, USA
J Clin Neurosci 18:628-32. 2011..9%, ?(2)p<0.05). We demonstrated that the most important factor determining the risk of venous infarction is the approach used to access the tumor... - Implications of cystic features in vestibular schwannomas of patients undergoing microsurgical resectionBrian J Jian
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA
Neurosurgery 68:874-80; discussion 879-80. 2011..Cystic vestibular schwannomas (VSs) are described as being more aggressive than solid tumors... - Changes in transcranial motor evoked potentials during intramedullary spinal cord tumor resection correlate with postoperative motor functionAlfredo Quinones-Hinojosa
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
Neurosurgery 56:982-93; discussion 982-93. 2005..In this study, we hypothesized that changes in the intraoperative MEPs during tumor resection correlate with postoperative motor function deficits... - A prospective study of hearing preservation in untreated vestibular schwannomasMichael E Sughrue
Department of Neurological Surgery, University of California, San Francisco, 94143, USA
J Neurosurg 114:381-5. 2011..In this paper the authors present an analysis of prospectively collected outcomes in patients with untreated VS from their institution that confirms their previous findings... - Factors affecting outcome following treatment of patients with cavernous sinus meningiomasMichael E Sughrue
Department of Neurological Surgery, University of California at San Francisco, California 94143, USA
J Neurosurg 113:1087-92. 2010..The authors performed a meta-analysis of reported tumor control and survival rates of patients described in the published literature, with an emphasis on specific prognostic factors... - Preoperative prognostic classification system for hemispheric low-grade gliomas in adultsEdward F Chang
Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
J Neurosurg 109:817-24. 2008..As a result, the objective in the present study was to design a preoperative scoring system to prognosticate long-term outcomes in patients with LGGs... - Prevalence of previous extracranial malignancies in a series of 1228 patients presenting with meningiomaMichael E Sughrue
Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
J Neurosurg 113:1115-21. 2010..The authors present an analysis of the prevalence of previously diagnosed extracranial malignancies at the time of meningioma diagnosis in 1228 patients evaluated at a single institution... - An extent of resection threshold for newly diagnosed glioblastomasNader Sanai
Brain Tumor Research Center, University of California, San Francisco, California, USA
J Neurosurg 115:3-8. 2011..The authors attempt to define these values for the patient with newly diagnosed GBM in the modern neurosurgical era... - Hearing preservation after stereotactic radiosurgery for vestibular schwannoma: a systematic reviewIsaac Yang
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, California 94143, USA
J Clin Neurosci 16:742-7. 2009..2 months. Our data suggest that an overall hearing preservation rate of about 57% can be expected after radiosurgical treatment, and patients treated with 12.5 Gy were more likely to have preserved hearing... - The long-term postsurgical prognosis of patients with pineoblastomaMatthew Tate
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0350, USA
Cancer 118:173-9. 2012..For this report, the authors comprehensively summarized the existing literature on patients with pineoblastoma and identified the variables and treatments that had an impact patient on outcomes... - Post-radiation reactive changes in a single vertebral body mimicking metastatic pineoblastomaMatthew C Tate
Departments of Neurological Surgery, University of California San Francisco, California, USA
J Neurosurg Pediatr 4:479-83. 2009..To the authors' knowledge this is the first reported case of reactive changes mimicking metastasis in a single vertebral body following standard therapy for resected primary pineoblastoma... - A comprehensive analysis of intracranial chordoma and survival: a systematic reviewBrian J Jian
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA
Br J Neurosurg 25:446-53. 2011..Here, we perform a systematic review of the literature to evaluate across multiple institutions the overall survival after treatment for intracranial chordoma... - Surgical resection and adjuvant radiotherapy for a large pineal hemangiopericytomaBrian J Jian
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
J Clin Neurosci 17:1209-11. 2010..The patient remains recurrence free 4 years after treatment... - TGF-beta downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patientsCourtney A Crane
Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143, USA
Neuro Oncol 12:7-13. 2010.... - Mapping clinical outcomes expectations to treatment decisions: an application to vestibular schwannoma managementSteven W Cheung
Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, California 94115, USA
Otol Neurotol 31:284-93. 2010..We aimed to demonstrate methodology and feasibility of adapting conjoint analysis for mapping clinical outcomes expectations to treatment decisions in vestibular schwannoma (VS) management... - Ubiquitin-specific protease 8 links the PTEN-Akt-AIP4 pathway to the control of FLIPS stability and TRAIL sensitivity in glioblastoma multiformeAmith Panner
Brain Tumor Research Center, Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA
Cancer Res 70:5046-53. 2010..These results show that USP8, a downstream target of Akt, regulates the ability of AIP4 to control FLIP(S) stability and TRAIL sensitivity... - Intramedullary spinal cord tumors: molecular insights and surgical innovationAndrew T Parsa
Department of Neurological Surgery, University of California, San Francisco, USA
Clin Neurosurg 52:76-84. 2005 - EMR-3: a potential mediator of invasive phenotypic variation in glioblastoma and novel therapeutic targetAri J Kane
Department of Neurological Surgery, Division of Neuropathology, University of California at San Francisco, San Francisco, California 94143, USA
Neuroreport 21:1018-22. 2010..EMR-3 is a potential mediator of cellular invasion in GBM. Given the poor survival associated with high levels of EMR-3 expression in glioma patients, our results provide impetus to explore EMR-3 as a potential therapeutic target... - Intratumoral hemorrhage and fibrosis in vestibular schwannoma: a possible mechanism for hearing lossMichael E Sughrue
Department of Neurological Surgery, University of California, San Francisco, 94143, USA
J Neurosurg 114:386-93. 2011..In this case-control study, the authors investigated the relationship between preoperative hearing loss and histological changes such as intratumoral microhemorrhage and extensive fibrosis... - Pathologic and epidemiologic findings of intramedullary spinal cord tumorsTarik Tihan
Department of Pathology, University of California, San Francisco, CA 94143, USA
Neurosurg Clin N Am 17:7-11. 2006 - Preservation of facial nerve function after resection of vestibular schwannomaMichael E Sughrue
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA
Br J Neurosurg 24:666-71. 2010..The objective of this study was to provide a comprehensive assessment of reported outcomes for facial nerve preservation after VS surgery... - Early surgical intervention in adult patients with ganglioglioma is associated with improved clinical seizure outcomesIsaac Yang
Department of Neurological Surgery, University of California at Los Angeles, Los Angeles, California, USA
J Clin Neurosci 18:29-33. 2011..Our findings also support that an early surgical intervention is significantly associated with improved clinical seizure control... - Treatment decision making based on the published natural history and growth rate of small meningiomasMichael E Sughrue
Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
J Neurosurg 113:1036-42. 2010..To address this need, the authors systematically reviewed the published literature regarding the natural history of small, untreated meningiomas... - Serial diffusion-weighted magnetic resonance imaging in cases of glioma: distinguishing tumor recurrence from postresection injuryJustin S Smith
Department of Neurological Surgery, Brain Tumor Research Center, University of California, San Francisco School of Medicine, San Francisco, California 94143 0112, USA
J Neurosurg 103:428-38. 2005..The purpose of this study was to investigate prospectively the incidence, time course, and ultimate outcome of these abnormalities... - Posttreatment prognosis of patients with esthesioneuroblastomaAri J Kane
Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
J Neurosurg 113:340-51. 2010..The objective was to ascertain what variables predict prognosis in these patients and to determine the relative effect of different therapies... - Complement and the central nervous system: emerging roles in development, protection and regenerationMartin J Rutkowski
Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94143, USA
Immunol Cell Biol 88:781-6. 2010.... - Distinguishing glioma recurrence from treatment effect after radiochemotherapy and immunotherapyIsaac Yang
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
Neurosurg Clin N Am 21:181-6. 2010..Further investigations are necessary to assess the imaging algorithms and accuracy of these modalities to differentiate true glioma recurrence from radiotherapy or immunotherapy treatment effect... - Glioblastoma multiforme regional genetic and cellular expression patterns: influence on anatomic and physiologic MR imagingRamon F Barajas
Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, Long L200B, Box 0628, San Francisco, CA 94143, USA
Radiology 254:564-76. 2010..To determine whether magnetic resonance (MR) imaging is influenced by genetic and cellular features of glioblastoma multiforme (GBM) aggressiveness... - Defective receptor expression and dendritic cell differentiation of monocytes in glioblastomasAlfred T Ogden
Department of Neurological Surgery, The Neurological Institute, Columbia University, New York, New York 10032, USA
Neurosurgery 59:902-9; discussion 909-10. 2006..This study seeks to develop understanding of the phenotypic changes that occur in circulating monocytes of patients with intracranial cancer and to assess the ability of these cells to differentiate into mature dendritic cells... - Radiobiology of vestibular schwannomas: mechanisms of radioresistance and potential targets for therapeutic sensitizationAndrea H Yeung
Departments of Otolaryngology Head and Neck Surgery, University of California at San Francisco, San Francisco, California, USA
Neurosurg Focus 27:E2. 2009..An improved understanding of the radiobiological behavior of VS may help guide appropriate patient selection for SRS and potentially aid in the design of novel therapies to treat radioresistant tumors... - Honokiol-mediated inhibition of PI3K/mTOR pathway: a potential strategy to overcome immunoresistance in glioma, breast, and prostate carcinoma without impacting T cell functionCourtney Crane
Department of Neurological Surgery, University of California, San Francisco, CA, USA
J Immunother 32:585-92. 2009..Honokiol is clinically available for human testing and may serve to augment T cell-mediated cancer immunotherapy... - Extended bifrontal craniotomy for midline anterior fossa meningiomas: minimization of retraction-related edema and surgical outcomesJohn H Chi
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
Neurosurgery 59:ONS426-33; discussion ONS433-4. 2006..The authors have attempted to quantitate retraction-related edema occurring after surgery to determine whether the extra bone removal limits retraction and reduces the chance of brain injury... - Cranial chondrosarcoma and recurrenceOrin G Bloch
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California
Skull Base 20:149-56. 2010..Our systematic review closely reflects the actuarial recurrence rate and provides predictive factors in the recurrence of cranial chondrosarcoma... - Restoration of p53 function for selective Fas-mediated apoptosis in human and rat glioma cells in vitro and in vivo by a p53 COOH-terminal peptidePatrick B Senatus
Department of Neurological Surgery, Columbia University Medical Center, 650 West 168th Street, BB 20-05, New York, NY 10032, USA
Mol Cancer Ther 5:20-8. 2006.... - Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcomaMichael D Prados
University of California, San Francisco, CA 94143, USA
J Clin Oncol 27:579-84. 2009..The objectives were to determine efficacy of this treatment as measured by survival and to explore the relationship between molecular markers and treatment response... - The natural history of untreated sporadic vestibular schwannomas: a comprehensive review of hearing outcomesMichael E Sughrue
Department of Neurological Surgery, University of California at San Francisco, California 94143, USA
J Neurosurg 112:163-7. 2010..Their objective was to provide a comprehensive and unbiased description of outcomes in patients whose disease was managed conservatively... - Monitoring immune responses after glioma vaccine immunotherapyBrian Jian
Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, M779, San Francisco, CA 94143 0112, USA
Neurosurg Clin N Am 21:195-9. 2010..Improvements in immunomonitoring should lead to an increase in the efficiency of identifying viable avenues of therapeutic research, and assess the efficacy of those currently employed... - Heat shock proteins in glioblastomasIsaac Yang
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, Room M779, Campus 0112, San Francisco, CA 94143, USA
Neurosurg Clin N Am 21:111-23. 2010.... - The role of microglia in central nervous system immunity and glioma immunologyIsaac Yang
Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, San Francisco, California 94143, USA
J Clin Neurosci 17:6-10. 2010..The role of microglia in CNS immunity is reviewed, with a focus on key advances made in glioma immunology... - Serum IgE, tumor epidermal growth factor receptor expression, and inherited polymorphisms associated with glioma survivalMargaret Wrensch
Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94102, USA
Cancer Res 66:4531-41. 2006..3 region influence survival. We also suggest that tumor EGFR expression be incorporated into clinical evaluation of anaplastic astrocytoma patients... - Intramedullary spinal cord metastasis: clinical management and surgical considerationsJohn H Chi
Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
Neurosurg Clin N Am 17:45-50. 2006 - Genetics and molecular biology of intramedullary spinal cord tumorsJohn H Chi
Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
Neurosurg Clin N Am 17:1-5. 2006 - Neuromonitoring during surgery for metastatic tumors to the spine: intraoperative interpretation and management strategiesAlfredo Quinones-Hinojosa
Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, 505 Parnassus Avenue, M 779, San Francisco, CA 94143 0112, USA
Neurosurg Clin N Am 15:537-47. 2004..Further experience with these techniques should allow improved results follow-ing surgical procedures in functionally eloquent are as of the spinal cord during the surgical management of metastatic tumors... - Stereotactic radiosurgery and interstitial brachytherapy for glial neoplasmsM W McDermott
Department of Neurosurgery, University of California, San Francisco, CA, USA
J Neurooncol 69:83-100. 2004..This paper reviews the recent literature and results of the use of brachytherapy and radiosurgery in the management of newly diagnosed and recurrent malignant gliomas... - Use of APO2L/TRAIL with mTOR inhibitors in the treatment of glioblastoma multiformeAmith Panner
Brain Tumor Research Center, Department of Neurological Surgery and the Comprehensive Cancer Center, University of California, San Francisco, CA 94143 0875, USA
Expert Rev Anticancer Ther 6:1313-22. 2006..These studies suggest that mTOR inhibitors can be combined with APO2L/TRAIL as a potential tumor-selective therapy... - Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migrationNader Sanai
Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, San Francisco, California 94143, USA
Nature 427:740-4. 2004..Unexpectedly, we find no evidence of chains of migrating neuroblasts in the SVZ or in the pathway to the olfactory bulb. Our work identifies SVZ astrocytes as neural stem cells in a niche of unique organization in the adult human brain... - Heat-shock protein vaccines as active immunotherapy against human gliomasIsaac Yang
Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94143, USA
Expert Rev Anticancer Ther 9:1577-82. 2009..They are now being investigated as a potential modality and adjuvant to immunotherapy, and they represent a promising novel treatment for human glioblastomas... - Complications of lumboperitoneal shuntsVincent Y Wang
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
Neurosurgery 60:1045-8; discussion 1049. 2007..These shunts can be placed with or without valves. We sought to review the complications associated with the use of LP shunts with the increasing use of horizontal-vertical (HV) valve systems... - Temporal fossa hemangiopericytoma: a case seriesMarc A Heiser
Department of Otolaryngology Head and Neck Surgery, University of California at San Francisco, San Francisco, California 94143 0342, USA
Otol Neurotol 30:985-9. 2009..Review clinical experience with temporal fossa hemangiopericytomas (HPCs)... - Integration of preoperative anatomic and metabolic physiologic imaging of newly diagnosed gliomaSusan M Chang
Department of Neurological Surgery, UCSF, 505 Parnassus Ave, San Francisco, CA 94143, USA
J Neurooncol 92:401-15. 2009.... - A case of enteroviral meningoencephalitis presenting as rapidly progressive dementiaVictor Valcour
Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA94143, USA
Nat Clin Pract Neurol 4:399-403. 2008..He had hypophonic speech and had mildly increased axial tone. He scored 5 out of 30 on the Mini Mental State Examination and was admitted for expedited evaluation... - Fluctuating response of a cystic vestibular schwannoma to radiosurgery: case reportAmy R de Ipolyi
Department of Neurological Surgery, Brain Tumor Research Center, University of California at San Francisco, San Francisco, California, USA
Neurosurgery 62:E1164-5; discussion E1165. 2008..In this article, we report an atypical fluctuating course of a cystic VS after GKS, ultimately requiring surgical intervention... - Clinical management of intramedullary spinal ependymomas in adultsJanet Lee
Department of Neurological Surgery, University of Utah, Salt Lake City, 30 N, 1900 E, RM 3B409, UT 84112, USA
Neurosurg Clin N Am 17:21-7. 2006 - Cooperative translational control of gene expression by Ras and Akt in cancerAndrew T Parsa
Department of Neurological Surgery, University of California San Francisco, CA 94143, USA
Trends Mol Med 10:607-13. 2004..The downstream components of these pathways have provided therapeutic targets that are currently being tested in clinical trials... - Changes in the immunologic phenotype of human malignant glioma cells after passaging in vitroRichard C Anderson
Department of Neurological Surgery, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Clin Immunol 102:84-95. 2002..These changes in the immunological phenotype of glioblastomas after in vitro culturing may in part explain the limited success of immunotherapeutic strategies against glioblastomas in human clinical trials...
Research Grants
- Antigen specific modeling of glioma immunotherapyAndrew Parsa; Fiscal Year: 2007..The long-term goal of this proposal is to facilitate the development of Dr. Parsa into an independent investigator capable of making meaningful scientific contributions. ..