Research Topics
| LESLIE PARISESummaryAffiliation: University of North Carolina Country: USA Publications
Research Grants
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Detail Information
Publications
Big science for small cells: systems approaches for plateletsStephen P Holly
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7260, USA
Curr Drug Targets 12:1859-70. 2011..Here we provide an overview of some of these exciting systems approaches ranging from genomics to aptamer discovery and emphasize the importance of identifying and exploiting novel platelet targets for therapeutic benefit...- Tumor growth and angiogenesis is impaired in CIB1 knockout miceMohamed A Zayed
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
J Angiogenes Res 2:17. 2010..Since pathological angiogenesis is highly dependent on many of these same processes, we hypothesized that CIB1 may also regulate tumor-induced angiogenesis... - Cytokines and plasma factors in sickle cell diseaseJulia E Brittain
Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Curr Opin Hematol 14:438-43. 2007..We also consider the putative role for those cytokines implicated by genetic analysis in sickle cell disease, but where the pathogenic, or ameliorative, role has yet to be determined... - Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertensionKenneth I Ataga
Division of Hematology Oncology, Department of Medicine, University of North Carolina at Chapel Hill, CB 7305, 3009 Old Clinic Bldg Chapel Hill, NC 27599 7305, USA
Haematologica 93:20-6. 2008..Pulmonary hypertension (PHT) is common in sickle cell disease (SCD). The purpose of this study was to determine whether markers of coagulation activation and inflammation are associated with PHT in SCD... - Phase I study of eptifibatide in patients with sickle cell anaemiaSheritha P Lee
Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7365, USA
Br J Haematol 139:612-20. 2007..Based on these phase I results, eptifibatide may benefit SCA patients by inhibiting platelet aggregation, decreasing sCD40L levels and favourably altering plasma levels of inflammatory mediators... - Biologically active CD40 ligand is elevated in sickle cell anemia: potential role for platelet-mediated inflammationSheritha P Lee
Department of Pharmacology, University of North Carolina, CB#7365, Chapel Hill, NC 27599-7365, USA
Arterioscler Thromb Vasc Biol 26:1626-31. 2006..The participation of sCD40L in SCA plasma-induced production of B cells, tissue factor, and ICAM-1 suggests that CD40L may contribute to the chronic inflammation and increased thrombotic activity known to occur in SCA... - Mechanism of CD47-induced alpha4beta1 integrin activation and adhesion in sickle reticulocytesJulia E Brittain
Department of Pharmacology, University of North Carolina at Chapel Hill, 27599 7365, USA
J Biol Chem 279:42393-402. 2004..These studies therefore identify the alpha4beta1 integrin on SS RBCs as a CD47-activated receptor for TSP, VCAM-1, and plasma fibronectin, revealing novel binding characteristics of this integrin... - Fibronectin bridges monocytes and reticulocytes via integrin alpha4beta1Julia E Brittain
Departments of Pharmacology, and Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, NC, USA
Br J Haematol 141:872-81. 2008.... - Characterization of calcium- and integrin-binding protein 1 (CIB1) knockout platelets: potential compensation by CIB family membersJan C DeNofrio
Curriculum in Genetics and Molecular Biology, The University of North Carolina, Chapel Hill, NC 27599, USA
Thromb Haemost 100:847-56. 2008..Therefore, the potential exists for compensation for the loss of CIB1 by these CIB family members, thereby preventing pathologic thrombus formation in Cib1(-/-) mice... - CIB1 regulates endothelial cells and ischemia-induced pathological and adaptive angiogenesisMohamed A Zayed
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Circ Res 101:1185-93. 2007..These data therefore reveal a critical role for CIB1 in ischemia-induced pathological and adaptive angiogenesis... - CIB1 is an endogenous inhibitor of agonist-induced integrin alphaIIbbeta3 activationWeiping Yuan
Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA
J Cell Biol 172:169-75. 2006..CIB1 appears to inhibit integrin activation by competing with talin for binding to alphaIIbbeta3, thus providing a model for tightly controlled regulation of alphaIIbbeta3 activation... - Essential role of CIB1 in regulating PAK1 activation and cell migrationTina M Leisner
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Cell Biol 170:465-76. 2005..These results point to CIB1 as a key regulator of PAK1 activation and signaling... - Identification of P2Y12-dependent and -independent mechanisms of glycoprotein VI-mediated Rap1 activation in plateletsMark K Larson
Department of Pharmacology, Center for Thrombosis and Hemostasis and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599, USA
Blood 101:1409-15. 2003..These results define mechanisms of GPVI-mediated platelet activation and implicate Rap1 as a key signaling protein in GPVI-induced platelet signaling... - Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesionPatrick C Hines
Department of Pharmacology, University of North Carolina at Chapel Hill, 27599, USA
Blood 101:3281-7. 2003.... - Platelet alpha2beta1 integrin activation: contribution of ligand internalization and the alpha2-cytoplasmic domainZhengyan Wang
Department of Pharmacology, Center for Thrombosis and Hemostasis, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 27599, USA
Blood 102:1307-15. 2003..Thus, collagen binding to stimulated platelets is increased due to alpha2beta1 activation, in addition to internalization, and the GFFKR motif appears to play an important role in the activation process... - Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domainWilliam T Barry
Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 277:28877-83. 2002..The identification of essential interacting regions within alpha(IIb) and CIB provides tools for further probing potential interrelated functions of these proteins... - Role of Rap1 in promoting sickle red blood cell adhesion to laminin via BCAM/LUMeghan M Murphy
Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Blood 105:3322-9. 2005..These results demonstrate that Epac-induced Rap1 activation in SS RBCs promotes BCAM/LU-mediated adhesion to laminin. Thus, Epac-mediated Rap1 activation may represent an important signaling pathway for promoting SS RBC adhesion... - JAM-1 regulation of endothelial cell migration: implications for angiogenesisLeslie V Parise
Arterioscler Thromb Vasc Biol 23:2119-20. 2003 - Genetic manipulation of megakaryocytes to study platelet functionJun Liu
Department of Biochemistry and Biophysics, University of North Carolina Chapel Hill, North Carolina 27599, USA
Curr Top Dev Biol 80:311-35. 2008.... - Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW-alphavbeta3 interactionsRahima Zennadi
Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Blood 104:3774-81. 2004..These data suggest that adrenergic hormones such as epinephrine may initiate or exacerbate vaso-occlusion and thus contribute to the association of vaso-occlusive events with physiologic stress... - Erythrocyte adhesion in sickle cell diseaseLeslie V Parise
DUMC Box 2615, 333 Medical Research Building, Duke University Medical Center, Durham, NC 27710, USA
Curr Hematol Rep 2:102-8. 2003..An understanding of these mechanisms at the molecular level should ultimately allow development of new preventive and treatment strategies to abrogate vaso-occlusive events...
Research Grants
- Signaling pathways activating adhesion in sickle cellsLESLIE PARISE; Fiscal Year: 2005..abstract_text> ..
- Target discovery in platelets by in situ proteome reactivity profilingLESLIE PARISE; Fiscal Year: 2007....
- CIB1 regulation of endothelial functionLeslie V Parise; Fiscal Year: 2010..In this proposal we seek to better understand how endothelial cells, which line all blood vessels, control blood vessel growth, by studying a protein called CIB1, which appears to regulate endothelial cell function. ..