Guangjin Pan

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi Nanog and transcriptional networks in embryonic stem cell pluripotency
    Guangjin Pan
    The Wisconsin National Primate Research Center, University of Wisconsin Madison, 1220 Capitol Court, Madison, WI 53715 1299, USA
    Cell Res 17:42-9. 2007
  2. ncbi FGF2 sustains NANOG and switches the outcome of BMP4-induced human embryonic stem cell differentiation
    Pengzhi Yu
    Morgridge Institute for Research, Madison, WI 53715 7365, USA
    Cell Stem Cell 8:326-34. 2011
  3. ncbi The stem cell pluripotency factor NANOG activates transcription with two unusually potent subdomains at its C terminus
    Guangjin Pan
    Institute of Pharmacology, Department of Biological Sciences and Biotechnology, Institutes of Biomedicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, 100084 Beijing, China
    J Biol Chem 280:1401-7. 2005
  4. ncbi Regulation of the pluripotency marker Rex-1 by Nanog and Sox2
    Wenjing Shi
    Institute of Pharmacology, Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institutes of Biomedicine, School of Medicine, Tsinghua University, Beijing 100084, China
    J Biol Chem 281:23319-25. 2006
  5. ncbi A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal
    Guangjin Pan
    Institute of Pharmacology, Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institutes of Biomedicine, School of Medicine, Tsinghua University, Beijing, China
    FASEB J 20:1730-2. 2006
  6. ncbi Identification of a nuclear localization signal in OCT4 and generation of a dominant negative mutant by its ablation
    Guangjin Pan
    Institute of Pharmacology and State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing, China
    J Biol Chem 279:37013-20. 2004
  7. ncbi A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells
    Jun Li
    Institute of Pharmacology, Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institutes of Biomedicine, School of Medicine, Tsinghua University, Beijing 100084, China
    J Biol Chem 282:19481-92. 2007

Collaborators

Detail Information

Publications7

  1. ncbi Nanog and transcriptional networks in embryonic stem cell pluripotency
    Guangjin Pan
    The Wisconsin National Primate Research Center, University of Wisconsin Madison, 1220 Capitol Court, Madison, WI 53715 1299, USA
    Cell Res 17:42-9. 2007
    ..These key factors form a regulatory network to support or limit each other's expression level, which maintains the properties of ES cells...
  2. ncbi FGF2 sustains NANOG and switches the outcome of BMP4-induced human embryonic stem cell differentiation
    Pengzhi Yu
    Morgridge Institute for Research, Madison, WI 53715 7365, USA
    Cell Stem Cell 8:326-34. 2011
    ..Together, our results demonstrate that FGF2 signaling switches the outcome of BMP4-induced differentiation of human ESCs by maintaining NANOG levels through the MEK-ERK pathway...
  3. ncbi The stem cell pluripotency factor NANOG activates transcription with two unusually potent subdomains at its C terminus
    Guangjin Pan
    Institute of Pharmacology, Department of Biological Sciences and Biotechnology, Institutes of Biomedicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, 100084 Beijing, China
    J Biol Chem 280:1401-7. 2005
    ..These data suggest that either WR or CD2 is sufficient for NANOG to function as a transactivator...
  4. ncbi Regulation of the pluripotency marker Rex-1 by Nanog and Sox2
    Wenjing Shi
    Institute of Pharmacology, Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institutes of Biomedicine, School of Medicine, Tsinghua University, Beijing 100084, China
    J Biol Chem 281:23319-25. 2006
    ..Taking these findings together, we conclude that Rex-1 is a direct target of Nanog, which is augmented by Sox2 and Oct-3/4...
  5. ncbi A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal
    Guangjin Pan
    Institute of Pharmacology, Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institutes of Biomedicine, School of Medicine, Tsinghua University, Beijing, China
    FASEB J 20:1730-2. 2006
    ..Our results suggest the FoxD3-Nanog-Oct4 loop anchors an interdependent network of transcription factors that regulate stem cell pluripotency...
  6. ncbi Identification of a nuclear localization signal in OCT4 and generation of a dominant negative mutant by its ablation
    Guangjin Pan
    Institute of Pharmacology and State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing, China
    J Biol Chem 279:37013-20. 2004
    ..These data suggest that this dominant negative form of OCT4 may be a useful tool for modulating the activity of OCT4 in pluripotent cells such as embryonic stem cells to achieve the desired cell types for therapeutic applications...
  7. ncbi A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells
    Jun Li
    Institute of Pharmacology, Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institutes of Biomedicine, School of Medicine, Tsinghua University, Beijing 100084, China
    J Biol Chem 282:19481-92. 2007
    ..These results suggest that SOX2 maintains stem cell pluripotency by shuttling between the nucleus and cytoplasm in cooperation with OCT4 to prevent trophectoderm differentiation and polyploid formation in ES cells...