Research Topics
Species | D Paddon-JonesSummaryAffiliation: University of Texas Medical Branch Country: USA Publications
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Publications
Role of dietary protein in the sarcopenia of agingDouglas Paddon-Jones
Department of Physical Therapy, The University of Texas Medical Branch, Galveston, TX 77555 1144, USA
Am J Clin Nutr 87:1562S-1566S. 2008..However, renal function decreases with age, and high protein intake is contraindicated in individuals with renal disease. Assessment of renal function is recommended for older individuals before they adopt a higher-protein diet...- Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey proteinDouglas Paddon-Jones
Department of Surgery, The University of Texas Medical Branch, and Shriners Hospitals for Children, Galveston, Texas 77550, USA
Exp Gerontol 41:215-9. 2006..088+/-0.011% h-1 (EAA) and 0.066+/-0.004% h-1 (WY), (P<0.05). While both EAA and WY supplements stimulated muscle protein synthesis, EAAs may provide a more energetically efficient nutritional supplement for elderly individuals... - Protein, weight management, and satietyDouglas Paddon-Jones
Department of Physical Therapy, The University of Texas Medical Branch, Galveston, TX 77555 1144, USA
Am J Clin Nutr 87:1558S-1561S. 2008..Nevertheless, any potential benefits associated with a moderately elevated protein intake must be evaluated in the light of customary dietary practices and individual variability... - Amino acid metabolism and inflammatory burden in ovarian cancer patients undergoing intense oncological therapyE L Dillon
Department of Internal Medicine, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1060, USA
Clin Nutr 26:736-43. 2007..Our considerable data showing the strong anabolic potential of amino acids (AA) led us to test whether AA can acutely stimulate muscle protein synthesis in cancer patients (CA) undergoing intense chemotherapy... - Aging does not impair the anabolic response to a protein-rich mealT Brock Symons
Division of Rehabilitation Sciences, The University of Texas Medical Branch, Galveston, TX 77555 1144, USA
Am J Clin Nutr 86:451-6. 2007..However, the ability of an actual protein-rich food to stimulate anabolism in the young and the elderly has not been explored... - Acute adaptation to low volume eccentric exerciseD Paddon-Jones
School of Human Movement Studies, The University of Queensland, Brisbane, Queensland, 4072, Australia
Med Sci Sports Exerc 33:1213-9. 2001..The purpose of this study was to determine whether a nondamaging, low repetition, low volume eccentric exercise bout could also provide a protective/adaptive effect... - The catabolic effects of prolonged inactivity and acute hypercortisolemia are offset by dietary supplementationDouglas Paddon-Jones
Metabolism Unit, 815 Market Street, Galveston, Texas
J Clin Endocrinol Metab 90:1453-9. 2005..04%.h(-1)) and post-BR (EXP, 0.111 +/- 0.015, and CON, 0.05 +/- 0.002%.h(-1)). Unlike a typical clinical meal, AA/CHO supplementation stimulated net muscle protein synthesis despite acute hypercortisolemia and prolonged inactivity... - Differential expression of muscle damage in humans following acute fast and slow velocity eccentric exerciseD Paddon-Jones
School of Human Movement Studies, The University of Queensland, Brisbane, Queensland, Australia
J Sci Med Sport 8:255-63. 2005..The contraction velocity of an acute bout of eccentric exercise differentially influences the magnitude and time course of several indirect markers of muscle damage... - Interplay of stress and physical inactivity on muscle loss: Nutritional countermeasuresDouglas Paddon-Jones
The University of Texas Medical Branch, Galveston, TX 77550, USA
J Nutr 136:2123-6. 2006..This review focuses on the role of amino acid supplementation in the maintenance of skeletal muscle mass during age-related and clinically mandated inactivity... - Atrophy and impaired muscle protein synthesis during prolonged inactivity and stressDouglas Paddon-Jones
Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77550, USA
J Clin Endocrinol Metab 91:4836-41. 2006..We recently demonstrated that 28-d bed rest in healthy volunteers results in a moderate loss of lean leg mass and strength... - Dietary protein recommendations and the prevention of sarcopeniaDouglas Paddon-Jones
Department of Physical Therapy, Division of Rehabilitation Sciences The University of Texas Medical Branch 301 University Blvd Galveston, Texas 77555 1144, USA
Curr Opin Clin Nutr Metab Care 12:86-90. 2009..To draw attention to recent work on the role of protein and the amount of protein needed with each meal to preserve skeletal muscle mass in ageing... - Exogenous amino acids stimulate human muscle anabolism without interfering with the response to mixed meal ingestionDouglas Paddon-Jones
Department of Surgery, The University of Texas Medical Branch, Galveston, TX 77550, USA
Am J Physiol Endocrinol Metab 288:E761-7. 2005..2 +/- 8.5 nmol x min(-1) x 100 ml leg volume(-1). These data indicate that CAA supplementation produces a greater anabolic effect than ingestion of intact protein but does not interfere with the normal metabolic response to a meal... - Amino acid ingestion improves muscle protein synthesis in the young and elderlyDouglas Paddon-Jones
Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77550, USA
Am J Physiol Endocrinol Metab 286:E321-8. 2004..Despite differences in the time course of plasma phenylalanine kinetics and a greater residual IC phenylalanine concentration, amino acid supplementation acutely stimulated muscle protein synthesis in both young and elderly individuals... - Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrestDouglas Paddon-Jones
Metabolism Unit, 815 Market Street, Galveston, Texas 77550, USA
J Clin Endocrinol Metab 89:4351-8. 2004..8 +/- 1.4 kg; CON, -17.8 +/- 4.4 kg). Essential amino acid and carbohydrate supplementation may represent a viable intervention for individuals at risk of sarcopenia due to immobility or prolonged bedrest... - Short-term beta-hydroxy-beta-methylbutyrate supplementation does not reduce symptoms of eccentric muscle damageD Paddon-Jones
School of Human Movement Studies at The University of Queensland, Brisbane, Australia
Int J Sport Nutr Exerc Metab 11:442-50. 2001..We examined the effects of short-term beta-hydroxy-beta-methylbutyrate (HMB) supplementation on symptoms of muscle damage following an acute bout of eccentric exercise... - Hypercortisolemia alters muscle protein anabolism following ingestion of essential amino acidsDouglas Paddon-Jones
Department of Surgery, University of Texas Medical Branch and Metabolism Unit, Shriners Burns Hospital, 815 Market Street, Galveston, TX 77550, USA
Am J Physiol Endocrinol Metab 284:E946-53. 2003..180 min) in the C + AA group. Thus, although differences in protein metabolism were evident, EAA ingestion improved muscle protein anabolism during acute hypercortisolemia and may help minimize muscle loss following debilitating injury... - Adaptation to chronic eccentric exercise in humans: the influence of contraction velocityD Paddon-Jones
Department of Surgery, University of Texas Medical Branch, Galveston 77550, USA
Eur J Appl Physiol 85:466-71. 2001..Possible mechanisms include greater cumulative damage to contractile tissues or stress induced by slow eccentric muscle contractions... - Postexercise protein metabolism in older and younger men following moderate-intensity aerobic exerciseM Sheffield-Moore
Department of Surgery, General Clinical Research Center, University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston 77550, USA
Am J Physiol Endocrinol Metab 287:E513-22. 2004..Aging per se does not diminish the protein metabolic capacity of the elderly to respond to acute aerobic exercise... - The anabolic response to resistance exercise and a protein-rich meal is not diminished by ageT B Symons
Division of Rehabilitation Sciences, The University of Texas Medical Branch, Galveston, Texas 77555 1144, USA
J Nutr Health Aging 15:376-81. 2011..To this end, we sought to determine if the synergistic response to a bout of resistance exercise and a protein-rich lean beef meal was altered by age... - Mixed muscle and hepatic derived plasma protein metabolism is differentially regulated in older and younger men following resistance exerciseM Sheffield-Moore
Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1060, USA
Am J Physiol Endocrinol Metab 288:E922-9. 2005..Moreover, our data suggest that with age may come a greater need to salvage or make available amino acids from exercise-induced muscle protein breakdown to mount an acute-phase response... - Artificial gravity maintains skeletal muscle protein synthesis during 21 days of simulated microgravityT B Symons
The Univ of Texas Medical Branch, 301 Univ Blvd, Galveston, TX 77555 1144, USA
J Appl Physiol 107:34-8. 2009.... - Differential anabolic effects of testosterone and amino acid feeding in older menArny A Ferrando
Departments of Surgery, University of Texas Medical Branch, Galveston, Texas 77550, USA
J Clin Endocrinol Metab 88:358-62. 2003..Taken together, however, these diverse stimulatory effects can increase lean body mass and muscle strength over time... - Bed rest and myopathiesArny A Ferrando
Department of Surgery, University of Texas Medical Branch, Shrine Hospital for Children, Galveston, Texas 77550, USA
Curr Opin Clin Nutr Metab Care 9:410-5. 2006..Changes in protein metabolism with bed rest alone and during physiological stress are discussed. Nutritional and hormonal interventions that ameliorate the loss of skeletal muscle are highlighted... - Androgen therapy induces muscle protein anabolism in older womenMelinda Sheffield-Moore
University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0569, USA
J Clin Endocrinol Metab 91:3844-9. 2006..No change was noted in IGF-I expression in either group. We conclude that the skeletal muscle of older women and men responds to androgen administration, although the time course of anabolism appears to be gender specific... - Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscleBlake B Rasmussen
Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA
J Clin Invest 110:1687-93. 2002..07 nmol/g during hyperglycemia with hyperinsulinemia. We conclude that hyperglycemia with hyperinsulinemia increases malonyl-CoA, inhibits functional CPT-1 activity, and shunts LCFA away from oxidation and toward storage in human muscle... - Plasma triglycerides are not related to tissue lipids and insulin sensitivity in elderly following PPAR-alpha agonist treatmentMelanie G Cree
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555, United States
Mech Ageing Dev 128:558-65. 2007..2+/-0.05, insulin resistant). Furthermore, there was no change in IMCL or LFAT. These results indicate that whereas fenofibrate significantly lowers plasma lipids it neither affects insulin sensitivity nor intracellular lipids in elderly... - Cytokine secretion and latent herpes virus reactivation with 28 days of horizontal hypokinesiaPeter N Uchakin
Department of Internal Medicine, Mercer University School of Medicine, 1550 College Street, Macon, GA, USA
Aviat Space Environ Med 78:608-12. 2007..Hypokinesia is associated with spaceflight and prolonged illnesses and may lead to secondary immune deficiency... - Amino acid supplementation for reversing bed rest and steroid myopathiesDouglas Paddon-Jones
U TX Med Branch, Galveston
J Nutr 135:1809S-1812S. 2005..It may be necessary to concomitantly reduce the catabolic influence of cortisol or provide another anabolic stimulus... - Potential ergogenic effects of arginine and creatine supplementationDouglas Paddon-Jones
U TX Med Br, Galveston
J Nutr 134:2888S-2894S; discussion 2895S. 2004..The purpose of this review is to summarize the role of arginine and its metabolite creatine in the context of a nutrition supplement for use in conjunction with an exercise stimulus in both healthy and patient populations...