Research Topics
Species | BARBARA ANNE OSBORNESummaryAffiliation: University of Massachusetts Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Notch and the immune systemB Osborne
Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst 01003, USA
Immunity 11:653-63. 1999- Transcriptional control of T cell developmentB A Osborne
Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA
Curr Opin Immunol 12:301-6. 2000..Additionally, a unique function of Ikaros in chromatin remodeling reveals a novel mechanism by which transcriptional control may be exerted... - Notch signalling during peripheral T-cell activation and differentiationBarbara A Osborne
Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA
Nat Rev Immunol 7:64-75. 2007..As interest in this issue grows, it is becoming increasingly clear that the main role of Notch signalling, to regulate cell-fate decisions, might also be influential in peripheral T cells... - Lymphoid development: it's not 'all Greek to us' any moreBarbara A Osborne
Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA
Nat Immunol 6:119-23. 2005 - Notch1 augments NF-kappaB activity by facilitating its nuclear retentionHyun Mu Shin
Molecular and Cellular Biology Program, University of Massachusetts Amherst, Amherst, MA 01003, USA
EMBO J 25:129-38. 2006..Taken together, these data suggest that there are two 'waves' of NF-kappaB activation: an initial, Notch-independent phase, and a later, sustained activation of NF-kappaB, which is Notch dependent... - TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cellsTanapat Palaga
Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA
J Immunol 171:3019-24. 2003..Our data reveal a new, nondevelopmental function of Notch as a previously unknown key link in peripheral T cell activation and cytokine secretion... - p53 regulates thymic Notch1 activationAmy M Laws
Department of Molecular and Cellular Biology, University of Massachusetts, Amherst 01003, USA
Eur J Immunol 34:726-34. 2004..Skewing of T cell development toward CD8+SP T cells in Trp53(-/-) mice is reminiscent of the phenotype of NIC-overexpressing mice. Thus, we suggest that p53 plays a role in T cell development, in part by regulating Notch1 activation... - Cell death in the thymus--it' s all a matter of contactsLisa M Minter
Program in Molecular and Cellular Immunology, Department of Animal Biotechnology and Biomedical Sciences, University of Massachusetts, 311 Paige Laboratory, Amherst, MA 01003, USA
Semin Immunol 15:135-44. 2003..We hypothesize that the immunological synapse (IS) may be critical to transducing survival signals during thymocyte development, and suggest that factors affecting IS assembly may also influence T cell selection... - Defects of immune regulation in the presenilin-1 mutant knockin mouseGrant A Morgan
Department of Veterinary and Animal Sciences, University of Massachusetts, 311 Paige Lab, Amherst, MA 01003, USA
Neuromolecular Med 9:35-45. 2007..These findings suggest that abnormalities in immune function might play major roles in the pathogenesis of AD... - c-Jun N-terminal kinase 1 is required for Toll-like receptor 1 gene expression in macrophagesHooman Izadi
Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, MA 01003, USA
Infect Immun 75:5027-34. 2007..These results demonstrate that JNK1 regulates the response to TLR1/2 ligands and suggest a positive feedback loop that may serve to increase the innate immune response to the spirochete... - Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cellsJeremy B Samon
Program in Animal Biotechnology and Biomedical Science, University of Massachusetts Amherst, MA 01003, USA
Blood 112:1813-21. 2008..Together, these findings indicate that the Notch and TGFbeta signaling pathways cooperatively regulate Foxp3 expression and regulatory T-cell maintenance both in vitro and in vivo... - Notch regulates cytolytic effector function in CD8+ T cellsOk Hyun Cho
Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA
J Immunol 182:3380-9. 2009..By abrogating Notch signaling, both biochemically as well as genetically, we conclude that Notch activity mediates CTL activity through direct regulation of EOMES, perforin, and granzyme B... - Phosphorylation of Nur77 by the MEK-ERK-RSK cascade induces mitochondrial translocation and apoptosis in T cellsAibo Wang
Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA
J Immunol 183:3268-77. 2009..Our data reveal that Nur77 phosphorylation and mitochondrial targeting, regulated by RSK, defines a role for the MEK1/2-ERK1/2 cascade in T cell apoptosis...
Research Grants
- The role of Notch signaling in T cell functionBarbara Osborne; Fiscal Year: 2007..Aim II asks how Notch regulates NF-kB. Aim III examines the functional consequences of Notch activation in peripheral T cells and Aim IV asks how Notch regulates cell cycle progression in T cells. ..
- Polyclonal human antibody in cloned HAC-transgenic cowsBarbara Osborne; Fiscal Year: 2006..Third, it would provide a new enabling technology for producing clinically important human antibody reagents against other bacterial and viral pathogens. ..
- MOLECULAR ANALYSIS OF APOPTOSIS IN T CELLSBarbara Osborne; Fiscal Year: 2002..Experiments also are presented to examine how the expression of these genes are regulated during cell death in both T cells and non-immune cells. ..