Research Topics
Species | ROBERT ORLANDOSummaryAffiliation: University of New Mexico Country: USA Publications
Research Grants
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Detail Information
Publications
A chemical analog of curcumin as an improved inhibitor of amyloid Abeta oligomerizationRobert A Orlando
Department of Biochemistry and Molecular Biology, University of New Mexico, School of Medicine, Albuquerque, New Mexico, United States of America
PLoS ONE 7:e31869. 2012..The simple substitution of the para-hydroxy group on curcumin with a methoxy substitution improved inhibitor function by 6-7-fold over that measured for curcumin...- Syndecan-1 mediates internalization of apoE-VLDL through a low density lipoprotein receptor-related protein (LRP)-independent, non-clathrin-mediated pathwayLarissa C Wilsie
Department of Biochemistry and Molecular Biology, University of New Mexico, School of Medicine, MSC08 4670 1 University of New Mexico, Albuquerque, New Mexico, 87131, USA
Lipids Health Dis 5:23. 2006..For this study, we used a human fibroblast cell line (GM00701) that expresses large amounts of LRP, but possesses no LDL receptor activity to eliminate its contributions toward apoE-VLDL uptake... - Cell surface heparan sulfate proteoglycans contribute to intracellular lipid accumulation in adipocytesLarissa C Wilsie
Department of Biochemistry and Molecular Biology, University of New Mexico, Health Sciences Center, 915 Camino de Salud, Albuquerque, New Mexico 87131, USA
Lipids Health Dis 4:2. 2005.... - Substituted trans-stilbenes can inhibit or enhance the TPA-induced up-regulation of activator protein-1Lorraine M Deck
Department of Chemistry, University of New Mexico, Albuquerque, NM 87131, USA
BMC Pharmacol 8:19. 2008..Numerous plant polyphenols have been shown to inhibit the activation of AP-1, which often is ascribed to the anti-oxidant properties of these natural products... - Inhibition of nuclear factor kappaB activation and cyclooxygenase-2 expression by aqueous extracts of Hispanic medicinal herbsRobert A Orlando
Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, University of New Mexico, Albuquerque, New Mexico 87131, USA
J Med Food 13:888-95. 2010..Based on these results, laurel may represent a new, safe therapeutic agent for managing chronic inflammation... - Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytesAmanda M Gonzales
Department of Biochemistry and Molecular Biology, University of New Mexico, School of Medicine, MSC08 4670, 1 University of New Mexico, Albuquerque, New Mexico, 87131, USA
Nutr Metab (Lond) 5:17. 2008..In the present study, we examined if these natural products can inhibit NF-kappaB activation in adipocytes and in doing so reduce cytokine expression... - Role of adipocyte-derived lipoprotein lipase in adipocyte hypertrophyAmanda M Gonzales
Department of Biochemistry and Molecular Biology, University of New Mexico, School of Medicine, MSC08 4670, 1 University of New Mexico, Albuquerque, New Mexico, 87131, USA
Nutr Metab (Lond) 4:22. 2007..To address this gap in knowledge, we have measured the effect of reducing adipocyte LPL expression on intracellular lipid accumulation using a well-established cultured model of adipocyte differentiation... - The low-density lipoprotein receptor-related protein associates with calnexin, calreticulin, and protein disulfide isomerase in receptor-associated-protein-deficient fibroblastsRobert A Orlando
Department of Biochemistry and Molecular Biology, School of Medicine, University of New Mexico, Health Sciences Center, Albuquerque, NM 87131 5221, USA
Exp Cell Res 294:244-53. 2004..In RAP -/- cells, three well-known ER chaperones, calnexin, calreticulin, and protein disulfide isomerase (PDI), associate with LRP and likely compensate for the absence of RAP... - TPA-induced up-regulation of activator protein-1 can be inhibited or enhanced by analogs of the natural product curcuminWaylon M Weber
Department of Chemistry, University of New Mexico, Albuquerque, NM 87131, USA
Biochem Pharmacol 72:928-40. 2006.... - Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaBJustin J Heynekamp
Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131, USA
J Med Chem 49:7182-9. 2006..The results from screening were confirmed using BV-2 microglial cells where resveratrol and analogues were shown to inhibit LPS-induced COX-2 expression... - The low density lipoprotein receptor-related protein complexes with cell surface heparan sulfate proteoglycans to regulate proteoglycan-mediated lipoprotein catabolismLarissa C Wilsie
Department of Biochemistry and Molecular Biology, Health Sciences Center, University of New Mexico, Albuquerque, NM 87131 0001, USA
J Biol Chem 278:15758-64. 2003..Once HSPG dissociates from LRP, it is then able to bind and internalize VLDL independent of LRP endocytic activity. We conclude that HSPG and LRP together participate in VLDL clearance by means of a synergistic relationship... - A Jurkat transcriptional reporter cell line for high-throughput analysis of the nuclear factor-kappaB signaling pathwayAmanda M Gonzales
Department of Biochemistry and Molecular Biology, University of New Mexico, School of Medicine, Albuquerque, NM 87131, United States
N Biotechnol 26:244-50. 2009..The inhibition of NF-kappaB activation by analog 6q (IC(50) = 19 microm) showed a 3.7-fold improvement over that of resveratrol (IC(50) approximately 70 microm)...
Research Grants
- CELL SURFACE ACTIVITIES IN LIPOPROTEIN CATABOLISMROBERT ORLANDO; Fiscal Year: 2003....
- Curcumin-based analogs as improved inhibitors of Abeta aggregationROBERT ORLANDO; Fiscal Year: 2007....