John Olschowka

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice
    Stephanos Kyrkanides
    Department of Children s Dentistry, Stony Brook University Health Science Center, Stony Brook, NY 11794, USA
    J Neuroinflammation 8:112. 2011
  2. ncbi Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS
    John A Olschowka
    Departments of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Mol Ther 7:218-27. 2003
  3. ncbi Intraperitoneal inoculation of Sandhoff mouse neonates with an HIV-1 based lentiviral vector exacerbates the attendant neuroinflammation and disease phenotype
    Stephanos Kyrkanides
    Eastman Dental Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States
    J Neuroimmunol 188:39-47. 2007
  4. ncbi Peripheral blood mononuclear cell infiltration and neuroinflammation in the HexB-/- mouse model of neurodegeneration
    Stephanos Kyrkanides
    Department of Neurobiology and Anatomy, School of Medicine and Dentistry, University of Rochester Rochester NY 14642, USA
    J Neuroimmunol 203:50-7. 2008
  5. ncbi beta-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration
    Stephanos Kyrkanides
    Department of Dentistry, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester NY 14642, United States
    Brain Res Mol Brain Res 133:286-98. 2005
  6. ncbi COX-3: a splice variant of cyclooxygenase-1 in mouse neural tissue and cells
    Solomon S Shaftel
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Brain Res Mol Brain Res 119:213-5. 2003
  7. ncbi Temporomandibular joint nociception: effects of capsaicin on substance P-like immunoreactivity in the rabbit brain stem
    Stephanos Kyrkanides
    Craniofacial Research Core, University of Rochester Eastman Dental Center, 625 Elmwood Ave, Rochester, NY 14620, USA
    J Orofac Pain 16:229-36. 2002
  8. ncbi Intraparenchymal administration of interleukin-1beta induces cyclooxygenase-2-mediated expression of membrane- and cytosolic-associated prostaglandin E synthases in mouse brain
    Amy H Moore
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 603, Rochester, NY 14642, USA
    J Neuroimmunol 148:32-40. 2004
  9. ncbi Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury
    Stephanos Kyrkanides
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Brain Res Mol Brain Res 104:159-69. 2002
  10. ncbi Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration
    Solomon S Shaftel
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurosci 27:9301-9. 2007

Research Grants

  1. PERKIN ELMER 7700 SEQUENCE DETECTOR
    John Olschowka; Fiscal Year: 2001
  2. MOLECULAR MODULATION OF HSV VECTOR CNS INTERACTIONS
    John Olschowka; Fiscal Year: 2003

Collaborators

Detail Information

Publications18

  1. ncbi Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice
    Stephanos Kyrkanides
    Department of Children s Dentistry, Stony Brook University Health Science Center, Stony Brook, NY 11794, USA
    J Neuroinflammation 8:112. 2011
    ..The purpose of this study was to investigate whether localized peripheral inflammation, such as osteoarthritis, contributes to neuroinflammation and neurodegenerative disease in vivo...
  2. ncbi Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS
    John A Olschowka
    Departments of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Mol Ther 7:218-27. 2003
    ....
  3. ncbi Intraperitoneal inoculation of Sandhoff mouse neonates with an HIV-1 based lentiviral vector exacerbates the attendant neuroinflammation and disease phenotype
    Stephanos Kyrkanides
    Eastman Dental Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States
    J Neuroimmunol 188:39-47. 2007
    ..We observed an increase and acceleration in the presence of MHC-II and CD45+ cells in their brains, along with neuroinflammation, but not in control heterozygous or wild type littermates that also received the same treatment...
  4. ncbi Peripheral blood mononuclear cell infiltration and neuroinflammation in the HexB-/- mouse model of neurodegeneration
    Stephanos Kyrkanides
    Department of Neurobiology and Anatomy, School of Medicine and Dentistry, University of Rochester Rochester NY 14642, USA
    J Neuroimmunol 203:50-7. 2008
    ..There was no change in the level of GM2 storage and pro-apoptotic activity or astrocyte activation in HexB-/-; Ccr2-/- double knockout mice, which eventually succumbed secondary to GM2 gangliosidosis...
  5. ncbi beta-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration
    Stephanos Kyrkanides
    Department of Dentistry, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester NY 14642, United States
    Brain Res Mol Brain Res 133:286-98. 2005
    ..In conclusion, these results demonstrate the effective transfer of a beta-hexosaminidase lentiviral vector to the brain of Sandhoff mice and resolution of the GM2 gangliosidosis after neonatal intraperitoneal administration...
  6. ncbi COX-3: a splice variant of cyclooxygenase-1 in mouse neural tissue and cells
    Solomon S Shaftel
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Brain Res Mol Brain Res 119:213-5. 2003
    ..This isoform, referred to as COX-3, is identical in sequence to COX-1 except for the in-frame retention of intron 1. Like its counterpart COX-1, COX-3 does not generally appear to be induced by acute inflammatory stimulation...
  7. ncbi Temporomandibular joint nociception: effects of capsaicin on substance P-like immunoreactivity in the rabbit brain stem
    Stephanos Kyrkanides
    Craniofacial Research Core, University of Rochester Eastman Dental Center, 625 Elmwood Ave, Rochester, NY 14620, USA
    J Orofac Pain 16:229-36. 2002
    ....
  8. ncbi Intraparenchymal administration of interleukin-1beta induces cyclooxygenase-2-mediated expression of membrane- and cytosolic-associated prostaglandin E synthases in mouse brain
    Amy H Moore
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 603, Rochester, NY 14642, USA
    J Neuroimmunol 148:32-40. 2004
    ..In addition, IL-1beta stimulated protein expression of cytosolic PGES. Finally, we showed attenuation of these IL-1beta-inductions by COX-2 inhibition, suggesting in vivo regulation of both PGE synthase isoforms in the brain...
  9. ncbi Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury
    Stephanos Kyrkanides
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Brain Res Mol Brain Res 104:159-69. 2002
    ..These results indicate that COX-2 modulates the inflammatory response in brain following radiation injury, and suggest the use of COX-2 selective inhibitors for the management of CNS inflammation...
  10. ncbi Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration
    Solomon S Shaftel
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurosci 27:9301-9. 2007
    ..Knock-out of their sole receptor CXCR2 abrogated neutrophil infiltration but failed to reduce leakage of the blood-brain barrier...
  11. ncbi Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice
    Amy M Hein
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Brain Behav Immun 24:243-53. 2010
    ..Sustained neuroinflammation also reduced basal and conditioning-induced levels of the plasticity-related gene Arc...
  12. ncbi Interleukin 1beta (IL1B) signaling is a critical component of radiation-induced skin fibrosis
    Weimin Liu
    Department of Radiation Oncology, James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York 14642, USA
    Radiat Res 165:181-91. 2006
    ..In conclusion, these data suggest that IL1B plays a critical role in radiation-induced fibrosis and that the increased MMPs fail to block the IL1-related collagen accumulation...
  13. ncbi Intraarticular induction of interleukin-1beta expression in the adult mouse, with resultant temporomandibular joint pathologic changes, dysfunction, and pain
    Yu Ching Lai
    University of Rochester School of Medicine and Dentistry, Rochester, New York
    Arthritis Rheum 54:1184-97. 2006
    ..To examine the effects of intraarticular induction of interleukin-1beta (IL-1beta) expression in adult mice...
  14. ncbi Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology
    Solomon S Shaftel
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Clin Invest 117:1595-604. 2007
    ..These results demonstrate a possible adaptive role for IL-1 beta-driven neuroinflammation in AD and may help explain recent failures of antiinflammatory therapeutics for this disease...
  15. ncbi Radiation-induced edema is dependent on cyclooxygenase 2 activity in mouse brain
    Amy H Moore
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Radiat Res 161:153-60. 2004
    ....
  16. ncbi Regulation of prostaglandin E2 synthesis after brain irradiation
    Amy H Moore
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 62:267-72. 2005
    ..CONCLUSIONS: Taken together, these data indicate that both cyclooxygenases contribute to PGE2 production in irradiated brain and reveal dependence of PGES isoforms expression on specific cyclooxygenase activities...
  17. ncbi Acute morphine exposure potentiates the development of HSV-1-induced encephalitis
    Daniel T Lioy
    Department of Microbiology and Immunology, 575 Elmwood Ave, University of Rochester, Rochester, NY 14621, United States
    J Neuroimmunol 172:9-17. 2006
    ..Acute morphine exposure was observed to potentiate the development of HSVE in HSV-1 infected mice. The present data implicate a potential role for the blood-brain barrier in the development of HSVE in morphine-treated mice...
  18. ncbi Expression of tumor necrosis factor alpha and its mRNA in the spinal cord following a weight-drop injury
    Chen Xu Wang
    Room 533 HMRC, Department of Medicine, University of Alberta, Edmonton, AB T6G 2S2, Canada
    Neuroreport 13:1391-3. 2002
    ..The present results demonstrate that TNFalpha is rapidly induced in the spinal cord after the injury, and it may play a significant role in secondary events in SCI...

Research Grants5

  1. PERKIN ELMER 7700 SEQUENCE DETECTOR
    John Olschowka; Fiscal Year: 2001
    ..The institution will provide a room of approximately 350 sq feet to house the instrument, ancillary equipment required for PCR, and cost-sharing of service contracts. ..
  2. MOLECULAR MODULATION OF HSV VECTOR CNS INTERACTIONS
    John Olschowka; Fiscal Year: 2003
    ..The effectiveness of each manipulation will be assayed with the same methods used in Specific Aim 1. ..