Andrew W Norris

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi Effect of insulin and dexamethasone on fetal assimilation of maternal glucose
    Andrew W Norris
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Endocrinology 152:255-62. 2011
  2. ncbi Complications and comorbidities of type 2 diabetes
    Andrew W Norris
    Joslin Diabetes Center, Boston, MA, USA
    Pediatr Ann 34:710-8. 2005
  3. ncbi Analysis of gene expression in pathophysiological states: balancing false discovery and false negative rates
    Andrew W Norris
    Joslin Diabetes Center, Children s Hospital, and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 103:649-53. 2006
  4. ncbi Endogenous peroxisome proliferator-activated receptor-gamma augments fatty acid uptake in oxidative muscle
    Andrew W Norris
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Endocrinology 149:5374-83. 2008
  5. ncbi Localized fetomaternal hyperglycemia: spatial and kinetic definition by positron emission tomography
    Jianrong Yao
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
    PLoS ONE 5:e12027. 2010
  6. ncbi Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones
    Andrew W Norris
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
    J Clin Invest 112:608-18. 2003
  7. ncbi Programming of growth, insulin resistance and vascular dysfunction in offspring of late gestation diabetic rats
    Emily M Segar
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Clin Sci (Lond) 117:129-38. 2009
  8. ncbi Evidence for a role of developmental genes in the origin of obesity and body fat distribution
    Stephane Gesta
    Joslin Diabetes Center and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 103:6676-81. 2006
  9. ncbi Action of epoxyeicosatrienoic acids on cellular function
    Arthur A Spector
    Dept of Biochemistry, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Cell Physiol 292:C996-1012. 2007
  10. ncbi Fatty acid-binding proteins inhibit hydration of epoxyeicosatrienoic acids by soluble epoxide hydrolase
    Richard L Widstrom
    Department of Biochemistry, University of Iowa, College of Medicine, Iowa City, Iowa 52242, USA
    Biochemistry 42:11762-7. 2003

Research Grants

  1. Muscle PPARgamma and Metabolic Regulation
    Andrew Norris; Fiscal Year: 2007
  2. Regulatory Control of Metabolic Flexibility in Skeletal Muscle.
    Andrew Norris; Fiscal Year: 2009
  3. Regulatory Control of Metabolic Flexibility in Skeletal Muscle.
    Andrew W Norris; Fiscal Year: 2010

Collaborators

Detail Information

Publications13

  1. ncbi Effect of insulin and dexamethasone on fetal assimilation of maternal glucose
    Andrew W Norris
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Endocrinology 152:255-62. 2011
    ..Maternal insulin action has little effect on the inherent avidity of the fetal-placental unit for glucose but increases glucose utilization by maternal tissues, thus indirectly reducing the glucose available to the fetus...
  2. ncbi Complications and comorbidities of type 2 diabetes
    Andrew W Norris
    Joslin Diabetes Center, Boston, MA, USA
    Pediatr Ann 34:710-8. 2005
    ..The pediatrician should be aware of screening and interventions to lessen the effect of these risks on their patients. Societal-wide lifestyle changes are needed desperately to reduce the prevalence of these largely preventable diseases...
  3. ncbi Analysis of gene expression in pathophysiological states: balancing false discovery and false negative rates
    Andrew W Norris
    Joslin Diabetes Center, Children s Hospital, and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 103:649-53. 2006
    ..To this end, we have developed a unique, model-based procedure for the estimation of false negative rates, which allows application of BPA to real data in which changes are modest...
  4. ncbi Endogenous peroxisome proliferator-activated receptor-gamma augments fatty acid uptake in oxidative muscle
    Andrew W Norris
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Endocrinology 149:5374-83. 2008
    ..Thus, when PPARgamma activity in muscle is absent or reduced, there will be decreased fatty acid disposal leading to diminished energy utilization and ultimately adiposity...
  5. ncbi Localized fetomaternal hyperglycemia: spatial and kinetic definition by positron emission tomography
    Jianrong Yao
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
    PLoS ONE 5:e12027. 2010
    ..We approached this problem in the context of maternal diabetes and sought an approach to expose the developing fetus in vivo to isolated hyperglycemia in the pregnant rat...
  6. ncbi Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones
    Andrew W Norris
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
    J Clin Invest 112:608-18. 2003
    ..The tissue crosstalk mediating these effects is perhaps due to altered lipid metabolism in muscle...
  7. ncbi Programming of growth, insulin resistance and vascular dysfunction in offspring of late gestation diabetic rats
    Emily M Segar
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Clin Sci (Lond) 117:129-38. 2009
    ..Thus the development of diabetes during pregnancy programmes gender-specific insulin resistance and vascular dysfunction in adult offspring...
  8. ncbi Evidence for a role of developmental genes in the origin of obesity and body fat distribution
    Stephane Gesta
    Joslin Diabetes Center and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 103:6676-81. 2006
    ....
  9. ncbi Action of epoxyeicosatrienoic acids on cellular function
    Arthur A Spector
    Dept of Biochemistry, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Cell Physiol 292:C996-1012. 2007
    ..Therefore, sEH is considered a potential therapeutic target for enhancing the beneficial functions of EETs...
  10. ncbi Fatty acid-binding proteins inhibit hydration of epoxyeicosatrienoic acids by soluble epoxide hydrolase
    Richard L Widstrom
    Department of Biochemistry, University of Iowa, College of Medicine, Iowa City, Iowa 52242, USA
    Biochemistry 42:11762-7. 2003
    ..However, the effectiveness of this process may depend on metabolic conditions that regulate the levels of competing FABP ligands...
  11. ncbi Very long chain n-3 and n-6 polyunsaturated fatty acids bind strongly to liver fatty acid-binding protein
    Andrew W Norris
    Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Lipid Res 43:646-53. 2002
    ....
  12. ncbi New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
    Yu Hua Tseng
    Section on Obesity and Hormone Action, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 454:1000-4. 2008
    ..These data reveal an important role of BMP7 in promoting brown adipocyte differentiation and thermogenesis in vivo and in vitro, and provide a potential new therapeutic approach for the treatment of obesity...
  13. ncbi Avoiding nocturnal hypoglycemia: consideration of an extra injection at bedtime
    Andrew W Norris
    Ann Intern Med 136:547-9. 2002

Research Grants4

  1. Muscle PPARgamma and Metabolic Regulation
    Andrew Norris; Fiscal Year: 2007
    ..abstract_text> ..
  2. Regulatory Control of Metabolic Flexibility in Skeletal Muscle.
    Andrew Norris; Fiscal Year: 2009
    ..The knowledge gained from the successful completion of this project will help design new strategies to prevent and treat type 2 diabetes onset and progression. ..
  3. Regulatory Control of Metabolic Flexibility in Skeletal Muscle.
    Andrew W Norris; Fiscal Year: 2010
    ..The knowledge gained from the successful completion of this project will help design new strategies to prevent and treat type 2 diabetes onset and progression. ..