John P Norman

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neurons
    John P Norman
    Department of Neurology Child Neurology Division, Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Immunol 178:869-76. 2007
  2. ncbi HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization
    John P Norman
    Center for Neural Development and Disease, The University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    PLoS ONE 3:e3731. 2008
  3. ncbi HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis
    Seth W Perry
    Center for Aging and Developmental Biology, Interdepartmental Program in Neuroscience, Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 174:4333-44. 2005
  4. ncbi Antioxidants are required during the early critical period, but not later, for neuronal survival
    Seth W Perry
    Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci Res 78:485-92. 2004
  5. ncbi Mitochondrial membrane potential probes and the proton gradient: a practical usage guide
    Seth W Perry
    Department of Biomedical Engineering, University of Rochester School of Medicine and Dentistry, Rochester, NY 14627, USA
    Biotechniques 50:98-115. 2011

Detail Information

Publications5

  1. ncbi HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neurons
    John P Norman
    Department of Neurology Child Neurology Division, Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Immunol 178:869-76. 2007
    ..Based on these findings, we suggest that decreased NADPH and calcium concentration contribute to subsequent respiratory decline after exposure to Tat, with detrimental effects on neuronal signaling...
  2. ncbi HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization
    John P Norman
    Center for Neural Development and Disease, The University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    PLoS ONE 3:e3731. 2008
    ..Collectively, these data suggest that abnormal RyR signaling mediates the neuronal UPR with failure of mitochondrial energy metabolism, and is a critical locus for the neuropathogenesis of HIV-1 in the CNS...
  3. ncbi HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis
    Seth W Perry
    Center for Aging and Developmental Biology, Interdepartmental Program in Neuroscience, Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 174:4333-44. 2005
    ..Finally, Tat and platelet-activating factor also increased neuronal vesicular release, which may be related to increased mitochondrial bioenergetics and serve as a biomarker for early damage to neurons...
  4. ncbi Antioxidants are required during the early critical period, but not later, for neuronal survival
    Seth W Perry
    Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci Res 78:485-92. 2004
    ..Together, these findings suggest a brief window of high vulnerability to reactive oxygen species, and have important implications for studies of oxidative stress and developmental neuroscience...
  5. ncbi Mitochondrial membrane potential probes and the proton gradient: a practical usage guide
    Seth W Perry
    Department of Biomedical Engineering, University of Rochester School of Medicine and Dentistry, Rochester, NY 14627, USA
    Biotechniques 50:98-115. 2011
    ..In total, this review will help illustrate both the strengths and potential pitfalls of common mitochondrial membrane potential dyes, and highlight best-usage approaches for their efficacious application in life sciences research...