Research Topics
| A R NissensonSummaryAffiliation: University of California Country: USA Publications
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Publications
The human nephron filter: toward a continuously functioning, implantable artificial nephron systemAllen R Nissenson
Department of Medicine, Division of Nephrology, David Geffen School of Medicine, Los Angeles, CA 90095, USA
Blood Purif 23:269-74. 2005..The enhanced solute removal and wearable design should substantially improve patient outcomes and quality of life...
Continuously functioning artificial nephron system: the promise of nanotechnologyAllen R Nissenson
Department of Medicine, Division of Nephrology, David Geffen School of Medicine, Los Angeles, California 90095, USA
Hemodial Int 9:210-7. 2005..The enhanced solute removal and wearable design should substantially improve patient outcomes and quality of life...
Restructuring the ESRD payment system in the United StatesAllen R Nissenson
David Geffen School of Medicine and UCLA Medical Center, Los Angeles, California, USA
Kidney Int 66:466-76. 2004
Randomized, controlled trial of darbepoetin alfa for the treatment of anemia in hemodialysis patientsAllen R Nissenson
University of California at Los Angeles Medical Center, Los Angeles, CA 90095, USA
Am J Kidney Dis 40:110-8. 2002..The purpose of this randomized, double-blind, noninferiority study is to determine whether darbepoetin alfa is as effective as epoetin for the treatment of anemia in hemodialysis patients when administered at a reduced dosing frequency...
Septicemia in patients with ESRD is associated with decreased hematocrit and increased use of erythropoietinAllen R Nissenson
David Geffen School of Medicine, University of California Los Angeles, 200 UCLA Medical Plaza, Suite 565 57, Los Angeles, CA 90095, USA
Clin J Am Soc Nephrol 1:505-10. 2006..Strategies to prevent septicemia are important not only to decrease clinical morbidity but also to conserve EPO usage and thus contain the costs of care for this complex patient population...
The National Anaemia Action Council, Inc.: the primary North American resource for anaemia education and researchA R Nissenson
Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, and The National Anaemia Action Council, Inc, Milwaukee, Wisconsin, USA
Eur J Clin Invest 35:100-6. 2005..This editorial illustrates the goals and objectives of NAAC, and depicts past, present and future educational and research projects and findings. NAAC resources in anaemia-related education and research are described in detail...
Influence of industry on renal guideline development commentary: keeping our eye on the ball and improving chronic kidney disease patient outcomesAllen R Nissenson
Department of Medicine, Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Clin J Am Soc Nephrol 2:205-6. 2007
Novel erythropoiesis stimulating protein for managing the anemia of chronic kidney diseaseA R Nissenson
Department of Medicine, and Division of Nephrology, University of California, Los Angeles, School of Medicine, and UCLA Medical Center, Los Angeles, CA 90095, USA
Am J Kidney Dis 38:1390-7. 2001..There have been no reports of antibody formation associated with NESP. NESP is an important new tool for physicians to use in the treatment of anemia of chronic kidney disease...
Improving outcomes in CKD and ESRD patients: carrying the torch from training to practiceAllen R Nissenson
Department of Medicine, Division of Nephrology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
Semin Dial 17:380-97. 2004..If nephrologists are to take their appropriate place as leaders of the care delivery team, nephrology fellowships must be restructured with appropriate emphasis placed on the comprehensive care of ESRD and CKD patients...
Opportunities for improving the care of patients with chronic renal insufficiency: current practice patternsA R Nissenson
Department of Medicine, University of California Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
J Am Soc Nephrol 12:1713-20. 2001..Providers, policy-makers, and payers should view CKD as a major public health problem and initiate innovative programs to address this growing patient population...
Prevalence and characteristics of individuals with chronic kidney disease in a large health maintenance organizationA R Nissenson
University of California at Los Angeles School of Medicine, Los Angeles, CA, USA
Am J Kidney Dis 37:1177-83. 2001..The time has come for a structured public and professional educational program to address this serious condition...
Evaluation of disease-state management of dialysis patientsA R Nissenson
University of California at Los Angeles School of Medicine, Los Angeles, CA, USA
Am J Kidney Dis 37:938-44. 2001....
Economic burden of anemia in an insured populationAllen R Nissenson
Division of Nephrology, David Geffen School of Medicine, University of California, Los Angeles, 90095 6945, USA
J Manag Care Pharm 11:565-74. 2005..This study examines anemia prevalence and associated medical costs and utilization, using administrative claims for adults newly diagnosed with anemia, including up to 12 months of follow-up...
Anemia: not just an innocent bystander?Allen R Nissenson
Arch Intern Med 163:1400-4. 2003
What common practices in dialysis units can be altered to improve patient care?Allen R Nissenson
Division of Nephrology, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
Semin Dial 17:12-3. 2004
Bottom-up nanotechnology: the human nephron filterAllen R Nissenson
Division of Nephrology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Semin Dial 22:661-4. 2009..The enhanced solute removal and wearable design should substantially improve patient outcomes and quality of life...
Associations of pretransplant serum albumin with post-transplant outcomes in kidney transplant recipientsM Z Molnar
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
Am J Transplant 11:1006-15. 2011..Clinical trials to examine interventions to improve nutritional status in transplant-waitlisted hemodialysis patients and their impacts on post-transplant outcomes are indicated...
Achieving target hematocrit in dialysis patients: new concepts in iron managementA R Nissenson
Department of Medicine, UCLA School of Medicine, USA
Am J Kidney Dis 30:907-11. 1997....
Optimal hematocrit in patients on dialysis therapyA R Nissenson
Department of Medicine, University of California at Los Angeles, USA
Am J Kidney Dis 32:S142-6. 1998....
Costs of managing anemia with erythropoiesis-stimulating agents during hemodialysis: a time and motion studyBrigitte Schiller
Satellite Healthcare Inc, Mountain View, California, USA
Hemodial Int 12:441-9. 2008..The patient questionnaire reported insufficient education on CKD. Use of a once-monthly ESA to correct anemia in dialysis patients may provide substantial time, resource, and cost savings compared with current treatment practices...
Sodium ferric gluconate complex in sucrose is safe and effective in hemodialysis patients: North American Clinical TrialA R Nissenson
University of California at Los Angeles Medical Center, 90095, USA
Am J Kidney Dis 33:471-82. 1999..0 g to achieve optimal response in hemoglobin and hematocrit levels...
Clinical evaluation of heme iron polypeptide: sustaining a response to rHuEPO in hemodialysis patientsAllen R Nissenson
University of California, Los Angeles, CA, USA
Am J Kidney Dis 42:325-30. 2003..This treatment was associated with a significant increase in rHuEPO efficiency (P = 0.04)...
Iron deficiency in patients with renal failureA R Nissenson
Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
Kidney Int Suppl 69:S18-21. 1999..It is essential, therefore, for renal health professionals to understand iron metabolism in dialysis patients in order to properly balance the therapy of renal anemia with rHuEPO and supplemental iron...
Prevalence, treatment, and control of hypertension in chronic hemodialysis patients in the United StatesRajiv Agarwal
Division of Nephrology, Department of Medicine, Indiana University School of Medicine, and RLR VA Medical Center, Indianapolis 46202, USA
Am J Med 115:291-7. 2003..Hypertension is common in chronic hemodialysis patients, yet there are limited data on the epidemiology of hypertension in these patients in the United States...
The new FDA label for erythropoietin treatment: how does it affect hemoglobin target?S Fishbane
Division of Nephrology, Winthrop University Hospital, Mineola, New York 11501, USA
Kidney Int 72:806-13. 2007..In this review, we consider the recent literature, the change in FDA warnings, and new National Kidney Foundation Anemia Guidelines. Suggestions for new Hb targets during erythropoiesis-stimulating agent treatment are presented...
Intravenous iron versus erythropoiesis-stimulating agents: friends or foes in treating chronic kidney disease anemia?Kamyar Kalantar-Zadeh
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Adv Chronic Kidney Dis 16:143-51. 2009....
Renal replacement therapy in the elderlyXiaoyi Ye
Division of Nephrology, Department of Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Room 7 155 Factor Building, Los Angeles, CA 90095, USA
Clin Geriatr Med 25:529-42. 2009..As the United States population ages, physicians will have to face many challenges associated with aging, whether medical, psychosocial, or ethical. This article discusses issues specific to the geriatric dialysis population...
The obesity paradox and mortality associated with surrogates of body size and muscle mass in patients receiving hemodialysisKamyar Kalantar-Zadeh
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Mayo Clin Proc 85:991-1001. 2010..To determine whether dry weight gain accompanied by an increase in muscle mass is associated with a survival benefit in patients receiving maintenance hemodialysis (HD)...
Mid-arm muscle circumference and quality of life and survival in maintenance hemodialysis patientsNazanin Noori
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Clin J Am Soc Nephrol 5:2258-68. 2010..We hypothesized that mid-arm muscle circumference (MAMC), a conveniently measured surrogate of lean body mass (LBM), has stronger association with clinical outcomes than triceps skinfold (TSF), a surrogate of fat mass...
Impact of race on hyperparathyroidism, mineral disarrays, administered vitamin D mimetic, and survival in hemodialysis patientsKamyar Kalantar-Zadeh
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, CA, USA
J Bone Miner Res 25:2724-34. 2010..Survival advantages of blacks appear restricted to those receiving higher doses of active vitamin D. Examining the effect of MBD modulation on racial survival disparities of hemodialysis patients is warranted...
Understanding sources of dietary phosphorus in the treatment of patients with chronic kidney diseaseKamyar Kalantar-Zadeh
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, C1 Annex, Torrance, CA 90509 2910, USA
Clin J Am Soc Nephrol 5:519-30. 2010..Provision of in-center and monitored meals during hemodialysis treatment sessions in the dialysis clinic may facilitate the achievement of these goals...
Technological advances in renal replacement therapy: five years and beyondAnjay Rastogi
Department of Medicine, University of California, Los Angeles, CA 90095, USA
Clin J Am Soc Nephrol 4:S132-6. 2009..In summary, nephrology is at an exciting crossroad with the application of innovative and novel technologies to RRT that hold considerable promise for the near future...
Disease management in chronic kidney diseaseAnjay Rastogi
David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1689, USA
Adv Chronic Kidney Dis 15:19-28. 2008..Recent experience suggests that these barriers can be overcome, with DM becoming a promising approach for improving outcomes for this vulnerable population...
Hepcidin--a potential novel biomarker for iron status in chronic kidney diseaseJoshua Zaritsky
Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
Clin J Am Soc Nephrol 4:1051-6. 2009..Hepcidin is a key regulator of iron homeostasis, but its study in the setting of chronic kidney disease (CKD) has been hampered by the lack of validated serum assays...
High prevalence of stage 3 chronic kidney disease in older adults despite normal serum creatinineO Kenrik Duru
Division of General Internal Medicine, University of California, Los Angeles, CA 90095, USA
J Gen Intern Med 24:86-92. 2009..Serum creatinine is commonly used to diagnose chronic kidney disease (CKD), but may underestimate CKD in older adults when compared with using glomerular filtration rates (eGFR). The magnitude of this underestimation is not clearly defined...
Effect of malnutrition-inflammation complex syndrome on EPO hyporesponsiveness in maintenance hemodialysis patientsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Harbor Mailbox 406, 1000 West Carson St, Torrance, CA 90509 2910, USA
Am J Kidney Dis 42:761-73. 2003..Elements of malnutrition-inflammation complex syndrome (MICS) may blunt the responsiveness of anemia of end-stage renal disease (ESRD) to recombinant human erythropoietin (EPO)...
Clinical and economic outcomes of Staphylococcus aureus septicemia in ESRD patients receiving hemodialysisAllen R Nissenson
David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Am J Kidney Dis 46:301-8. 2005..CONCLUSION: Patients with septicemia caused by S aureus had costly and lengthy hospitalizations, which frequently were associated with clinically and economically important complications, including hospital readmissions...
Associations of body mass index and weight loss with mortality in transplant-waitlisted maintenance hemodialysis patientsM Z Molnar
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
Am J Transplant 11:725-36. 2011..Transplant-waitlisted hemodialysis patients with lower BMI or muscle mass and/or unintentional weight or muscle loss have higher mortality in this observational study. Impact of intentional weight change remains unclear...
Daily hemodialysis: challenges and opportunities in the delivery and financing of end-stage renal disease patient careA R Nissenson
Division of Nephrology, Department of Medicine, UCLA School of Medicine, Los Angeles, CA, USA
Adv Ren Replace Ther 8:286-92. 2001....
Erythropoietin and anemiaE M Tong
Division of Nephrology, Department of Medicine, UCLA School of Medicine, Los Angeles, CA, USA
Semin Nephrol 21:190-203. 2001....
The future of renal replacement therapyAnjay Rastogi
UCLA Medical Center, Los Angeles, CA 90095, USA
Adv Chronic Kidney Dis 14:249-55. 2007..In summary, nephrology is at an exciting crossroad with the application of innovative and novel technologies to RRT that hold considerable promise for the near future...
Epoetin-associated pure red cell aplasia: past, present, and future considerationsJune M McKoy
Division of Hematology Oncology and Geriatric Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Transfusion 48:1754-62. 2008..In 1998, epoetin-associated pure red cell aplasia (PRCA) was first reported and causation was attributed to formulations without human serum albumin (HSA), subcutaneous administration, and uncoated rubber stoppers...
Chronic kidney disease in the United States: a public policy imperativeRichard A Rettig
RAND Corporation, Santa Monica, California, USA
Clin J Am Soc Nephrol 3:1902-10. 2008..In 2003, the Council of American Kidney Societies (CAKS) identified 19 barriers to improved patient outcomes in chronic kidney disease (CKD)...
Emphasizing patient choice: the modality selection project in ESRD Network 18Rajnish Mehrotra
Division of Nephrology, Research and Education Institute, Harbor-UCLA Medical Center, School of Medicine, USA
Nephrol News Issues 17:30-6. 2003..This in turn, would lead to better preparation of patients for RRT and hopefully, have a positive impact on the morbidity and mortality of maintenance dialysis patients...
Dialysis in nursing homesEric M Tong
Division of Nephrology, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095, USA
Semin Dial 15:103-6. 2002..Although another approach could be to more fully utilize the services of adult day care centers, this has proven logistically difficult and has not been reported to be successful since it was first suggested more than a decade ago...
The case for disease management in chronic kidney diseaseRandolph A Chen
Division of Nephrology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Dis Manag 9:86-92. 2006..Considering the magnitude of the opportunity, DM applied to CKD is a promising approach to the care of this vulnerable population...
Disease management improves outcomes in patients with CKDAllen R Nissenson
Dialysis Program, David Geffen School of Medicine, Department of Medicine, Division of Nephrology, UCLA Medical Center, Los Angeles, Calif, USA
Nephrol News Issues 17:15-9. 2003
Dialysis outcomes as a measure of adequacy of dialysisMichael Butman
Division of Nephrology, Department of Medicine, David Geffen School of Medicine at UCLA, USA
Semin Nephrol 25:70-5. 2005..Optimal dialysis will be accomplished only when normal kidney functions are mimicked by artificial devices to a much greater extent than is currently the case...
Determinants in APD selectionJimmy Wilson
Division of Nephrology, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095, USA
Semin Dial 15:388-92. 2002....
Race, gender, and socioeconomic disparities in CKD in the United StatesKeith Norris
Charles Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
J Am Soc Nephrol 19:1261-70. 2008..By so doing, we could become global leaders not only in medical technology, as we currently are, but also in health promotion and disease prevention, truly leaving no patient behind...
Vascular access for hemodialysisRick Hayashi
UCLA Medical Center, Los Angeles, CA, USA
Nat Clin Pract Nephrol 2:504-13. 2006..This paper reviews the 2000 K/DOQI dialysis access guideline as well as updated information published subsequently...
Utilizing a disease management approach to improve ESRD patient outcomesShaan Anand
Division of Nephrology, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095, USA
Semin Dial 15:38-40. 2002..Early data suggest a disease management approach may improve both the morbidity and mortality of CKD patients...
Role of sodium and volume in the pathogenesis of hypertension in hemodialysisJimmy Wilson
Division of Nephrology, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095, USA
Semin Dial 17:260-4. 2004..Aggressive control of extracellular volume and dietary sodium intake can normalize BP in chronic HD patients and reduce the morbidity associated with hypertension-related CV disease...
Epoetin dosing and dialysis facility ownershipAlan S Kliger
JAMA 298:861-2; author reply 862-3. 2007
Mortality differences among organisms causing septicemia in hemodialysis patientsMark D Danese
Outcomes Insights Inc, Newbury Park, California 91320, USA
Hemodial Int 10:56-62. 2006..Meningitis, stroke, and endocarditis represent particularly serious complications. Overall, septicemia hospitalizations (especially for S. aureus) are serious events, and patients would benefit from better treatment and prevention...
Dosing darbepoetin alfaAllen R Nissenson
Am J Kidney Dis 40:872. 2002
Sodium ferric gluconate complex in hemodialysis patients: adverse reactions compared to placebo and iron dextranBeckie Michael
Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Kidney Int 61:1830-9. 2002..S. under FDA's priority drug review. This Phase IV study was designed to evaluate the safety of a single dose of intravenous SFGC as compared to placebo and a historical iron dextran control...
Pure red-cell aplasia and epoetin therapyCharles L Bennett
MidWest Center for Health Services Research and Policy Studies, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60611, USA
N Engl J Med 351:1403-8. 2004....
Serum ferritin in chronic kidney disease: reconsidering the upper limit for iron treatmentSteven Fishbane
Semin Dial 17:336-41. 2004..Clinical judgment is critical to properly weigh the risks and benefits of intravenous iron treatment in the context of the individual patient...
Sodium ferric gluconate complex in hemodialysis patients. II. Adverse reactions in iron dextran-sensitive and dextran-tolerant patientsDaniel W Coyne
Washington University School of Medicine, St Louis, Missouri 63110, USA
Kidney Int 63:217-24. 2003....
L-carnitine use in dialysis patients: is national coverage for supplementation justified? What were CMS regulators thinking--or were they?Theodore I Steinman
Nephrol News Issues 17:28-30, 32-4, 36 passim. 2003..Until there is scientific evidence to support use of L-carnitine supplementation, and it proves to be cost-effective, reimbursement is not justified. Therefore, the current CMS reimbursement decision for L-carnitine appears to be flawed...
Anemia and its clinical consequences in patients with chronic diseasesLawrence Tim Goodnough
Division of Laboratory Medicine, Washington University Medical Center, St. Louis, Missouri 63130, USA
Am J Med 116:1S-2S. 2004
Erythropoietin, iron depletion, and relative thrombocytosis: a possible explanation for hemoglobin-survival paradox in hemodialysisElani Streja
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Am J Kidney Dis 52:727-36. 2008..High doses of human recombinant erythropoietin (rHuEPO) to achieve hemoglobin levels greater than 13 g/dL in patients with chronic kidney disease appear to be associated with increased mortality...
Economics of clinical nephrology practiceRobert Provenzano
Department of Nephrology, St. John Hospital and Medical Center, Detroit, MI 48230, USA
Am J Kidney Dis 44:168-78. 2004
Prevalence and outcomes of anemia in rheumatoid arthritis: a systematic review of the literatureAlisa Wilson
Zynx Health, Beverly Hills, California 90212, USA
Am J Med 116:50S-57S. 2004..Whether improvements in QOL and/or joint symptoms occur with improvement of anemia, independent of other signs of an overall response to RA therapy, remains to be determined...
The normal hematocrit study--follow-upAnatole Besarab
N Engl J Med 358:433-4. 2008
Identification, diagnosis, and management of anemia in adult ambulatory patients treated by primary care physicians: evidence-based and consensus recommendationsRobert W Dubois
Cerner Health Insights, Beverly Hills, CA 90212, USA
Curr Med Res Opin 22:385-95. 2006..Provide recommendations for the identification, diagnosis, and management of ambulatory patients with anemia...
Pure red-cell aplasia: an emerging epidemic in dialysis patients?Shaan Anand
Perit Dial Int 23:317-9. 2003
The chronic kidney disease initiativeThomas F Parker
Dallas Nephrology Associates, University of Texas Southwestern Medical School, Dallas, TX 75235, USA
J Am Soc Nephrol 15:708-16. 2004..This article describes the process, the barriers encountered, and the solutions required to fully identify and manage this large and complicated population of patients...
Racial differences in mortality and ESRDKeith Norris
Am J Kidney Dis 52:205-8. 2008
