W W Nichols

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi Clinical measurement of arterial stiffness obtained from noninvasive pressure waveforms
    Wilmer W Nichols
    Department of Medicine Cardiology, University of Florida College of Medicine, Gainesville, Florida, USA
    Am J Hypertens 18:3S-10S. 2005
  2. ncbi Enhanced external counterpulsation treatment improves arterial wall properties and wave reflection characteristics in patients with refractory angina
    Wilmer W Nichols
    Department of Medicine Cardiology, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Am Coll Cardiol 48:1208-14. 2006
  3. ncbi Effects of arterial stiffness, pulse wave velocity, and wave reflections on the central aortic pressure waveform
    Wilmer W Nichols
    Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Clin Hypertens (Greenwich) 10:295-303. 2008
  4. ncbi Actions of selected cardiovascular hormones on arterial stiffness and wave reflections
    Wilmer W Nichols
    Division of Cardiovascular Medicine and Department of Pharmacy Practice, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Curr Pharm Des 15:304-20. 2009
  5. ncbi Synergistic effects of LTC4 and TxA2 on coronary flow and myocardial function
    W W Nichols
    Department of Medicine, University of Florida College of Medicine, Gainesville 32610
    Am J Physiol 255:H153-9. 1988
  6. ncbi Attenuated coronary relaxation after reperfusion: effects of superoxide dismutase and TxA2 inhibitor U 63557A
    J L Mehta
    Department of Medicine, University of Florida College of Medicine
    Am J Physiol 257:H1240-6. 1989
  7. ncbi Arterial elastance and wave reflection augmentation of systolic blood pressure: deleterious effects and implications for therapy
    W W Nichols
    Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Cardiovasc Pharmacol Ther 6:5-21. 2001
  8. ncbi Leukotriene D4 potentiates the contractile effects of epinephrine and norepinephrine on rat aortic rings
    D L Lawson
    Veterans Administration Medical Center, Gainesville, Florida
    J Pharmacol Exp Ther 247:953-7. 1988
  9. ncbi Cardiac effects of acetylcholine in rat hearts: role of endothelium-derived relaxing factor and prostaglandins
    B C Yang
    Department of Medicine, University of Florida College of Medicine, Gainesville
    Am J Physiol 264:H1388-93. 1993
  10. ncbi Impact of aging on central pressure wave reflection characteristics during exercise
    Darren P Casey
    Center for Exercise Science, Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA
    Am J Hypertens 21:419-24. 2008

Detail Information

Publications45

  1. ncbi Clinical measurement of arterial stiffness obtained from noninvasive pressure waveforms
    Wilmer W Nichols
    Department of Medicine Cardiology, University of Florida College of Medicine, Gainesville, Florida, USA
    Am J Hypertens 18:3S-10S. 2005
    ..Therefore, optimal treatment of high BP and its complications should include consideration of arterial stiffness, augmentation of aortic pressure, and LV wasted energy, all of which should be reduced to the lowest possible level...
  2. ncbi Enhanced external counterpulsation treatment improves arterial wall properties and wave reflection characteristics in patients with refractory angina
    Wilmer W Nichols
    Department of Medicine Cardiology, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Am Coll Cardiol 48:1208-14. 2006
    ..To determine if arterial properties and wave reflection characteristics are favorably altered after enhanced external counterpulsation (EECP) treatment in patients with refractory angina...
  3. ncbi Effects of arterial stiffness, pulse wave velocity, and wave reflections on the central aortic pressure waveform
    Wilmer W Nichols
    Division of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Clin Hypertens (Greenwich) 10:295-303. 2008
    ..The decrease in systolic BP brought about by this mechanism is grossly underestimated when systolic BP is measured in the brachial artery...
  4. ncbi Actions of selected cardiovascular hormones on arterial stiffness and wave reflections
    Wilmer W Nichols
    Division of Cardiovascular Medicine and Department of Pharmacy Practice, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Curr Pharm Des 15:304-20. 2009
    ..This decrease in amplitude and increase in travel time (or delay) of the reflected wave causes a generalized decrease in systolic BP, arterial wall stress, wasted LV energy and TTI...
  5. ncbi Synergistic effects of LTC4 and TxA2 on coronary flow and myocardial function
    W W Nichols
    Department of Medicine, University of Florida College of Medicine, Gainesville 32610
    Am J Physiol 255:H153-9. 1988
    ....
  6. ncbi Attenuated coronary relaxation after reperfusion: effects of superoxide dismutase and TxA2 inhibitor U 63557A
    J L Mehta
    Department of Medicine, University of Florida College of Medicine
    Am J Physiol 257:H1240-6. 1989
    ..Thus SOD and U 63557A protect against loss of endothelium-mediated vascular relaxation by LTD4 and ACh after coronary occlusion and reperfusion...
  7. ncbi Arterial elastance and wave reflection augmentation of systolic blood pressure: deleterious effects and implications for therapy
    W W Nichols
    Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Cardiovasc Pharmacol Ther 6:5-21. 2001
    ..The decrease in systolic pressure brought about by this mechanism is grossly underestimated when systolic pressure is measured in the brachial artery...
  8. ncbi Leukotriene D4 potentiates the contractile effects of epinephrine and norepinephrine on rat aortic rings
    D L Lawson
    Veterans Administration Medical Center, Gainesville, Florida
    J Pharmacol Exp Ther 247:953-7. 1988
    ..This LTD4 potentiation of vascular contraction is mediated through LT-receptor stimulation and not through release of cyclooxygenase metabolites...
  9. ncbi Cardiac effects of acetylcholine in rat hearts: role of endothelium-derived relaxing factor and prostaglandins
    B C Yang
    Department of Medicine, University of Florida College of Medicine, Gainesville
    Am J Physiol 264:H1388-93. 1993
    ..Thus the cardiac effects of ACh are related to muscarinic receptor activation, and the release of prostaglandins and EDRF modulates the effects of ACh in isolated rat heart...
  10. ncbi Impact of aging on central pressure wave reflection characteristics during exercise
    Darren P Casey
    Center for Exercise Science, Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA
    Am J Hypertens 21:419-24. 2008
    ..We examined the impact of aging on the central blood pressure (BP) waveform and wave reflection responses during exercise...
  11. ncbi Endothelium-dependent relaxation of rat aortic rings by leukotriene D4: importance of the magnitude of preload
    D L Lawson
    Department of Medicine, University of Florida College of Medicine, Gainesville
    Eicosanoids 2:175-81. 1989
    ..These observations suggest that the rat aortic ring relaxation by LTD4 is endothelium-dependent and is probably related to the release of EDRF...
  12. ncbi Arterial-wave reflections are increased in heart failure patients with a left-ventricular assist device
    Richard S Schofield
    Department of Veterans Affairs Medical Center, Gainesville, Florida, USA
    Am J Hypertens 20:622-8. 2007
    ..Although the treatment of HF via left-ventricular assist device (LVAD) placement has recently become widespread, the effects of LVAD therapy on central arterial pulse-wave reflections are unknown...
  13. ncbi Enhanced external counterpulsation improves peripheral artery flow-mediated dilation in patients with chronic angina: a randomized sham-controlled study
    Randy W Braith
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Circulation 122:1612-20. 2010
    ..This was the first randomized sham-controlled study to investigate the extracardiac effects of EECP on peripheral artery flow-mediated dilation...
  14. ncbi Radial artery tonometry demonstrates arterial stiffness in children with type 1 diabetes
    Michael J Haller
    Pediatric Endocrinology, P O Box 100296, Gainesville, FL 32610, USA
    Diabetes Care 27:2911-7. 2004
    ..To determine if children with type 1 diabetes have increased arterial stiffness by estimating augmentation index with the simple noninvasive technique of radial artery tonometry...
  15. ncbi The pathophysiology of chronic ischemic heart disease
    Carl J Pepine
    Division of Cardiovascular Medicine, Gainesville, FL 32610 0277, USA
    Clin Cardiol 30:I4-9. 2007
    ..Where possible, targets for novel therapeutic approaches are highlighted...
  16. ncbi Blood pressure and outcomes in very old hypertensive coronary artery disease patients: an INVEST substudy
    Scott J Denardo
    Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Am J Med 123:719-26. 2010
    ..Our understanding of the growing population of very old patients (aged >or=80 years) with coronary artery disease and hypertension is limited, particularly the relationship between blood pressure and adverse outcomes...
  17. ncbi Vascular effects of sildenafil in hypertensive cardiac transplant recipients
    Richard S Schofield
    Division of Cardiovascular Medicine and Shands Transplant Center, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Am J Hypertens 16:874-7. 2003
    ..Sildenafil is commonly used in the treatment of erectile dysfunction in hypertensive male cardiac transplant recipients (CTR); however, little is known about the vascular effects of sildenafil in these patients...
  18. ncbi Augmentation index as a measure of peripheral vascular disease state
    Wilmer W Nichols
    Department of Medicine Cardiology, University of Florida College of Medicine, Gainesville, 32610, USA
    Curr Opin Cardiol 17:543-51. 2002
    ..This change in amplitude and timing of the reflected wave causes a generalized change in central arterial systolic and pulse pressure that is not detected by cuff pressure measurements in the brachial artery...
  19. ncbi Amplitude and timing of central aortic pressure wave reflections in heart transplant recipients
    Richard S Schofield
    Division of Cardiovascular Medicine and Shands Transplant Center, University of Florida, College of Medicine, Gainesville, USA
    Am J Hypertens 15:809-15. 2002
    ..The aim of this study was to measure the central aortic pressure wave in HTR on antihypertensive therapy and determine the effects of amplitude and timing of wave reflection on the various components of the wave...
  20. ncbi Pulse wave analysis of the aortic pressure waveform in severe left ventricular systolic dysfunction
    Scott J Denardo
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Circ Heart Fail 3:149-56. 2010
    ..The effect of moderate left ventricular systolic dysfunction (LVSD) on ventricular/vascular coupling and the aortic pressure waveform (AoPW) has been well described, but the effect of severe LVSD has not...
  21. ncbi Hemodynamics and arterial properties in response to mental stress in individuals with mild hypertension
    Pei Shan Tsai
    College of Nursing, University of Florida, Gainesville, Florida 32610 0187, USA
    Psychosom Med 65:613-9. 2003
    ..The role of tonic sympathetic stimulation on the properties of large arteries is largely unknown. The purpose of this study was to determine the effect of mental stress on hemodynamics and arterial properties in mild hypertensives...
  22. ncbi Relationship between endogenous concentrations of vasoactive substances and measures of peripheral vasodilator function in patients with coronary artery disease
    Darren P Casey
    Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Center for Exercise Science, Gainesville, Florida, USA
    Clin Exp Pharmacol Physiol 37:24-8. 2010
    ..Therefore, measurement of plasma NO(x) may serve as a reliable marker for peripheral vasodilator dysfunction in patients with CAD...
  23. ncbi Attenuation of coronary flow reserve and myocardial function after temporary subtotal coronary artery occlusion and increased myocardial oxygen demand in dogs
    W W Nichols
    Department of Medicine, University of Florida College of Medicine, Gainesville 32610 0277
    J Am Coll Cardiol 24:795-803. 1994
    ..However, the reduction in coronary flow reserve appears to be unrelated to leukocyte accumulation in the reperfused region...
  24. ncbi Effect of enhanced external counterpulsation on inflammatory cytokines and adhesion molecules in patients with angina pectoris and angiographic coronary artery disease
    Darren P Casey
    Center for Exercise Science, Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA
    Am J Cardiol 101:300-2. 2008
    ..Changes in soluble vascular cell adhesion molecule-1 were not observed in either group. In conclusion, 35 sessions of EECP decreased circulating levels of proinflammatory biomarkers in patients with symptomatic coronary artery disease...
  25. ncbi Pulse pressure and adverse outcomes in women: a report from the Women's Ischemia Syndrome Evaluation (WISE)
    R David Anderson
    Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
    Am J Hypertens 21:1224-30. 2008
    ..We sought to investigate the relative contributions of these indices to risk for adverse outcomes in women with suspected coronary artery disease (CAD) and myocardial ischemia...
  26. ncbi Aortic diameter, aortic stiffness, and wave reflection increase with age and isolated systolic hypertension
    Wilmer W Nichols
    VCCRI/University of New South Wales/St. Vincent's Clinic, Sydney, Australia
    Hypertension 45:652-8. 2005
  27. ncbi Potential for use of pulse wave analysis in determining the interaction between sildenafil and glyceryl trinitrate
    Michael F O'Rourke
    Department of Medicine, St Vincent s Hospital, University of New South Wales, Sydney, Australia
    Clin Cardiol 25:295-9. 2002
    ..The effects of arterial vasodilator agents, especially nitrates, on central aortic systolic blood pressure are grossly underestimated by sphygmomanometric measurements of brachial artery pressure...
  28. ncbi Ramipril and cardiovascular risk reduction
    Wilmer W Nichols
    Circulation 105:e194-5; author reply e194-5. 2002
  29. ncbi Use of arterial transfer function for the derivation of aortic waveform characteristics
    Miok Kim
    J Hypertens 22:431-2; author reply 433-4. 2004
  30. ncbi Use of arterial transfer function for the derivation of aortic waveform characteristics
    Wilmer W Nichols
    J Hypertens 21:2195-7; author reply 2197-9. 2003
  31. ncbi Proximal aortic diameter and aortic pressure-flow relationship in systolic hypertension
    Michel E Safar
    Circulation 109:e227-8; author reply e227-8. 2004
  32. ncbi Effect of exercise training on central aortic pressure wave reflection in coronary artery disease
    David G Edwards
    Department of Kinesiology, University of New Hampshire, Durham, NH 03824, USA
    Am J Hypertens 17:540-3. 2004
    ..Arterial stiffness is an important factor for cardiovascular performance and a predictor of cardiovascular risk. We investigated the effect of exercise training on arterial stiffness in coronary artery disease (CAD)...
  33. ncbi Shear stress and flow-mediated dilation
    Wilmer W Nichols
    Hypertension 44:119-20. 2004
  34. ncbi Role of heart failure etiology on arterial wave reflection in heart transplant recipients: relation with C-reactive protein
    Gary L Pierce
    Department of Applied Physiology and Kinesiology, USA
    J Hypertens 25:2273-9. 2007
    ....
  35. ncbi Effects of angiotensin-converting enzyme inhibitors on central blood pressure
    Wilmer W Nichols
    Hypertension 50:e63; author reply e64. 2007
  36. ncbi Effects of ramipril on arterial stiffness
    Wilmer W Nichols
    Hypertension 46:e14; author reply e14-5. 2005
  37. ncbi Brachial and central arterial pressure
    Wilmer W Nichols
    Hypertension 48:e1; author reply e2. 2006
  38. ncbi Association between wasted pressure effort and left ventricular hypertrophy in hypertension: influence of arterial wave reflection
    Junichiro Hashimoto
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Am J Hypertens 21:329-33. 2008
    ..The purpose of this study was to extract that component of extra myocardial oxygen requirement that is due to early systolic wave reflection, define it as wasted effort (DeltaE(w)), and examine its relationship to LV hypertrophy (LVH)...
  39. ncbi Timing and amplitude of wave reflection
    Wilmer W Nichols
    Hypertension 49:E3; author reply E4. 2007
  40. ncbi Changes in wave reflection with advancing age in normal subjects
    Wilmer W Nichols
    Hypertension 44:e10-1. 2004
  41. ncbi Noninvasive input impedance of the human systemic circulation
    Wilmer W Nichols
    Hypertension 50:e16; author reply e17. 2007
  42. ncbi Effect of exercise training on endothelial function in men with coronary artery disease
    David G Edwards
    Department of Kinesiology, University of New Hampshire, Durham, New Hampshire 03824, USA
    Am J Cardiol 93:617-20. 2004
    ..9% at baseline vs 11.1% at 12 weeks). Exercise training resulted in increased plasma nitrite and nitrate levels, increased plasma superoxide dismutase activity, and decreased oxidative stress...
  43. ncbi Carotid artery augmentation index as a marker of cardiovascular risk
    Wilmer W Nichols
    J Hypertens 21:1773-4; author reply 1774. 2003
  44. ncbi Does reduced vascular stiffening fully explain preserved cardiovagal baroreflex function in older physically active men?
    Wilmer W Nichols
    Circulation 105:E11. 2002
  45. ncbi Estrogen and different aspects of vascular disease in women and men
    Carl J Pepine
    Circ Res 99:459-61. 2006