Andrew Newberg

..We used the selective DAT radiopharmaceutical Tc-TRODAT-1 and SPECT brain imaging, to examine differences in DAT levels in healthy subjects with and without depressive affect...

..The observed changes associated with long-term meditation appear in structures that underlie the attention network and also those that relate to emotion and autonomic function...

..While the findings are encouraging, there are a number of limitations that can be addressed in future studies with more participants and more detailed analyses...

..Although initially validated using a brief, non-quantitative protocol, this approach can provide quantitative CBF and CMRGlc, with a broad range of potential applications in functional physiology and pathophysiology...

..The pharmacologic safety profile of the compound was simultaneously assessed...

..This study determined whether healthy current smokers and nonsmokers exhibit differences in dopamine transporter (DAT) binding measured by Tc-99m TRODAT SPECT...

..The present study was an examination of the availability of brain dopamine transporter sites in patients with major depression and in healthy comparison subjects...

..DAT levels were unrelated to craving, severity of cocaine use, or duration of cocaine use, but DAT levels in the caudate and anterior putamen were significantly (p<0.05) negatively correlated with days since last use of cocaine...

..4% total accuracy, 97.5% specificity and 91.4% sensitivity). However, it should be stressed that, as with all applications of an ANN, it was difficult to interpret precisely what triggers in the images were being detected by the network...

..LEVEL OF EVIDENCE: Level II, diagnostic study. See Guidelines for Authors for a complete description of levels of evidence...

..This may reflect different pathophysiological processes of the two neurodegenerative diseases...

..89, best ROI AUC = 0.90). This suggested that the human observers are visually acquiring similar information from the images that are contained in the semi-quantitative striatal uptake...

..This study was designed to validate a simple scoring system for evaluating fluorodeoxyglucose (FDG) positron emission tomographic (PET) scans that can be used routinely in patients undergoing the clinical assessment of cognitive impairment...

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..CONCLUSION: This study led to the routine use of 3-D RAMLA reconstruction on the CPET scanner at our institution...

..We studied the correlation of striatal dopamine transporter (DAT) imaging with anxiety and depression symptoms in Parkinson's disease (PD)...

..We hypothesized that DAT levels might be higher in bipolar versus unipolar patients...

..We hypothesized that SERT binding activity may be altered in patients with MDD. This study compared SERT binding in patients with MDD with that in healthy controls...

..The study was conducted within a regulatory framework that required its pharmacologic safety to be assessed simultaneously...

..The study was conducted within a regulatory framework that required its pharmacological safety to be assessed simultaneously...

..The purpose of this study was to investigate the cerebral blood flow changes associated with the analgesic effect of acupuncture in patients with chronic pain...

..As such applications become more widely tested, their introduction into the clinical arena will further advance the use of PET imaging in the evaluation and management of CNS disorders...

..PET will continue to play a major role, not only in the clinical arena, but also in investigating the pathogenesis and treatment of various seizure disorders...

..Such a paradigm is frequently used in the clinical and research setting to assess various brain states...

..This article will also explore what FDG-PET imaging has revealed in these neuropsychiatric disorders and how these findings relate to both research and clinical applications...

..Future translational investigations can elucidate the role of MORs in nicotine addiction, which may lead to development of novel therapeutics...

..These findings, in conjunction with the therapeutic response of NES to sertraline, indicate that the serotonin system is involved in the pathophysiology of NES...

..Experienced practitioners of yoga have been shown to alter brain function, but this case series measured cerebral blood flow before and after a 12-week training program in Iyengar yoga (IY) for naïve subjects...

..This article will review the current uses of neuroimaging techniques in head trauma and delineate future applications...

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..Defining normal alterations in brain function and structure allows early detection of disorders such as Alzheimer's and Parkinson's diseases, which are commonly associated with normal aging...

..g. osteomyelitis and hence, increasingly is being used for detecting infection/inflammation in soft tissues...

..The positive correlation of arterial FDG uptake with the atherogenic risk factors suggested a promising role for FDG-PET imaging in the diagnosis of atherosclerosis and follow-up after treatment intervention...

..We chronicled the evolving relationship of blood flow and metabolism with concomitant single photon emission CT and positron emission tomography from the subacute to chronic phase following bilateral thalamic infarction...

..Neuroimaging also can be important in the chronic therapy of TBI, identifying chronic sequelae, determining prognosis, and guiding rehabilitation...

..However, many rituals have multiple components that can account for such effects. Few studies have distinguished between the effects of ritual and those related specifically to religious content and teachings...

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..This is the first functional neuroimaging study to demonstrate changes in cerebral activity during glossolalia. The frontal lobes, parietal lobes, and left caudate were most affected...

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..However, few studies have investigated the neural substrates of psychotherapy-related symptom changes...

..This study will provide that data while pursuing a long-term goal of developing a more effective and economical method for objectively assessing the outcome of an new treatment. ..

..Overall, this scanner will become a major tool for our present and future research programs with a focus on brain SPECT imaging, but also the potential to include many other types of studies. ..

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