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Genomes and GenesSpecies | Thomas P NeufeldSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
Shrinkage control: regulation of insulin-mediated growth by FOXO transcription factorsThomas P Neufeld
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
J Biol 2:18. 2003..Recent studies in Drosophila have shown how transcriptional responses to reduced insulin and nutrient levels can act to inhibit growth...- Genetic analysis of TOR signaling in DrosophilaT P Neufeld
Department of Genetics, Cell Biology, and Development, University of Minnesota, 6 160 Jackson Hall, 321 Church Street S E, Minneapolis, MN 55455, USA
Curr Top Microbiol Immunol 279:139-52. 2004..Here we describe the use of mutations in dTOR to dissect its role in various signaling events, to gain insight into TOR protein structure, and to identify novel factors involved in TOR signaling... - Body building: regulation of shape and size by PI3K/TOR signaling during developmentThomas P Neufeld
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
Mech Dev 120:1283-96. 2003..This review focuses on the cellular activities regulated by PI3K and TOR during development, and discusses how changes in different aspects of cellular metabolism may interact to regulate growth... - Contribution of Atg1-dependent autophagy to TOR-mediated cell growth and survivalThomas P Neufeld
Department of Genetics, Cell Biology and Development, University of Minnesota, Mineapolis, Minnesota 55455, USA
Autophagy 3:477-9. 2007..Atg1 also has an inhibitory effect on TOR signaling, indicating the existence of a positive feedback mechanism that may amplify the nutrient-dependent signals that control autophagy... - The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in DrosophilaGabor Juhasz
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
J Cell Biol 181:655-66. 2008..Our results suggest that Vps34 is regulated by TOR-dependent nutrient signals directly at sites of autophagosome formation... - Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell deathRyan C Scott
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
Curr Biol 17:1-11. 2007..Here, we circumvent this difficulty by directly manipulating autophagy rates in Drosophila through the autophagy-specific protein kinase Atg1... - The phosphatase subunit tap42 functions independently of target of rapamycin to regulate cell division and survival in DrosophilaKatherine D Cygnar
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, 55455, USA
Genetics 170:733-40. 2005..Our results demonstrate that the role of Tap42 in TOR signaling has not been conserved in higher eukaryotes, indicating fundamental differences in the mechanisms of TOR signaling between yeast and higher eukaryotes... - An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulationYu Yun Chang
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
Mol Biol Cell 20:2004-14. 2009..Atg1-Atg13 complexes thus function at multiple levels to mediate and adjust nutrient-dependent autophagic signaling... - Role and regulation of starvation-induced autophagy in the Drosophila fat bodyRyan C Scott
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis 55455 USA
Dev Cell 7:167-78. 2004..Thus, in cells lacking TOR, autophagy plays a protective role that is dominant over its potential role as a growth suppressor... - TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growthKrista M Hennig
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
J Cell Biol 173:963-74. 2006..Our data indicate that endocytosis acts both as an effector function downstream of TOR and as a physiologically relevant regulator of TOR signaling... - Drosophila target of rapamycin kinase functions as a multimerYong Zhang
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
Genetics 172:355-62. 2006..TOR multimerization thus partially accounts for the high apparent molecular weight of TOR complexes and offers novel therapeutic strategies for pathologies stemming from TOR hyperactivity... - Drosophila Atg7: required for stress resistance, longevity and neuronal homeostasis, but not for metamorphosisGabor Juhasz
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
Autophagy 4:357-8. 2008..These results suggest that in Drosophila, normal levels of autophagy may play a more important role in the homeostasis of certain terminally differentiated cells and stress survival than during development... - Nutrient-dependent regulation of autophagy through the target of rapamycin pathwayYu Yun Chang
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
Biochem Soc Trans 37:232-6. 2009..Further insight into these TOR-dependent control mechanisms may support development of autophagy-based therapies for a number of pathological conditions... - A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathwayAndrew M Arsham
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, USA
PLoS ONE 4:e6068. 2009.... - Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in DrosophilaGabor Juhasz
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
Genes Dev 21:3061-6. 2007..Thus, normal levels of autophagy are crucial for stress survival and continuous cellular renewal, but not metamorphosis... - Autophagy takes flight in DrosophilaYu Yun Chang
University of Minnesota, Department of Genetics, Cell Biology, and Development, Minneapolis, MN 55455, USA
FEBS Lett 584:1342-9. 2010..This review summarizes key studies in Drosophila autophagy research and discusses potential questions that may lead to better understanding of the roles and regulation of autophagy in higher eukaryotes... - TOR regulation: sorting out the answersThomas P Neufeld
Department of Genetics, Cell Biology and Development, University of Minnesota, 6 160 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
Cell Metab 5:3-5. 2007..A recent report by now implicates Pmr1, a secretory pathway Ca(2+)/Mn(2+) ATPase located in the Golgi apparatus, as a novel regulator of TOR and its downstream targets in yeast... - Inhibition of cellular growth and proliferation by dTOR overexpression in DrosophilaKrista M Hennig
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
Genesis 34:107-10. 2002 - Eating on the fly: function and regulation of autophagy during cell growth, survival and death in DrosophilaThomas P Neufeld
University of Minnesota, Department of Genetics, Cell Biology and Development, Minneapolis, Minnesota 55455, USA
Autophagy 4:557-62. 2008..We discuss genetic screening approaches that are being used to identify novel regulators and effectors of autophagy, and speculate about areas of research in this system likely to bear fruit in future studies... - Genetic manipulation and monitoring of autophagy in DrosophilaThomas P Neufeld
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA
Methods Enzymol 451:653-67. 2008.... - Autophagy: a forty-year search for a missing membrane sourceGabor Juhasz
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota, USA
PLoS Biol 4:e36. 2006 - Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat bodyG Juhasz
Department of General Zoology, Eotvos Lorand University, Budapest, Hungary
Cell Death Differ 14:1181-90. 2007..Accordingly, we found that Foxo mutants cannot properly undergo autophagy in response to starvation, and that overexpression of Foxo induces autophagy... - Thinking globally and acting locally with TORAndrew M Arsham
Department of Genetics, Cell Biology, and Development, University of Minnesota, 6-160 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
Curr Opin Cell Biol 18:589-97. 2006..TOR thus functions to coordinate growth-permitting inputs with growth-promoting outputs on both a cellular and an organismal level... - TOR-dependent control of autophagy: biting the hand that feedsThomas P Neufeld
Department of Genetics, Cell Biology and Development, University of Minnesota, 6 160 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
Curr Opin Cell Biol 22:157-68. 2010.... - Regulation of TORC1 by Rag GTPases in nutrient responseEunjung Kim
Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093 081, USA
Nat Cell Biol 10:935-45. 2008..Genetic studies in Drosophila also show that Rag GTPases regulate cell growth, autophagy and animal viability during starvation. Our studies establish a function of Rag GTPases in TORC1 activation in response to amino acid signals... - The cell biology of autophagy in metazoans: a developing storyAlicia Melendez
Department of Biology, Queens College, Flushing, NY 11367, USA
Development 135:2347-60. 2008..Insights gained from investigating the functions of autophagy in normal development should increase our understanding of its roles in human disease and its potential as a target for therapeutic intervention... - Experimental control and characterization of autophagy in DrosophilaGabor Juhasz
Department of General Zoology, Eotvos Lorand University, Budapest, Hungary
Methods Mol Biol 445:125-33. 2008..We also describe methods for experimentally activating and inhibiting autophagy in this system and discuss the potential for genetic analysis in Drosophila to identify novel genes involved in autophagy... - Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotesDaniel J Klionsky
Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
Autophagy 4:151-75. 2008..In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to verify an autophagic response...