Research Topics
Genomes and GenesSpecies | MICHAEL NACHMANSummaryAffiliation: University of Arizona Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Recombination rate variation and speciation: theoretical predictions and empirical results from rabbits and miceMichael W Nachman
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Philos Trans R Soc Lond B Biol Sci 367:409-21. 2012..We suggest fruitful areas of research that might help distinguish between different models...- Ecological character displacement in the face of gene flow: evidence from two species of nightingalesRadka Reifová
Department of Zoology, Faculty of Science, Charles University, Prague, Czech Republic
BMC Evol Biol 11:138. 2011..Here we studied patterns of morphological variation in sympatric and allopatric populations of two hybridizing species of birds, the Common Nightingale (Luscinia megarhynchos) and the Thrush Nightingale (L. luscinia)... - The genetic basis of adaptation: lessons from concealing coloration in pocket miceMichael W Nachman
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Genetica 123:125-36. 2005.... - Variation in recombination rate across the genome: evidence and implicationsMichael W Nachman
Department of Ecology and Evolutionary Biology, Biosciences West Bldg, University of Arizona, Tucson, Arizona 85721, USA
Curr Opin Genet Dev 12:657-63. 2002.... - Estimate of the mutation rate per nucleotide in humansM W Nachman
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
Genetics 156:297-304. 2000..This high rate is difficult to reconcile with multiplicative fitness effects of individual mutations and suggests that synergistic epistasis among harmful mutations may be common... - Contrasting evolutionary histories of two introns of the duchenne muscular dystrophy gene, Dmd, in humansM W Nachman
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
Genetics 155:1855-64. 2000..These results are best explained by positive directional selection acting at or near intron 7 and demonstrate that even genes in regions of high recombination may be influenced by selection at linked sites... - Y chromosome variation of mice and menM W Nachman
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson 85721, USA
Mol Biol Evol 15:1744-50. 1998..There is at most only a modest reduction in variability that may be attributed to natural selection (either genetic hitchhiking or background selection)... - DNA variability and recombination rates at X-linked loci in humansM W Nachman
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
Genetics 150:1133-41. 1998..However, there was a positive correlation between heterozygosity and rate of recombination, suggesting that the joint effects of selection and linkage are important in shaping patterns of nucleotide variation in humans... - The genetic basis of adaptive melanism in pocket miceMichael W Nachman
Department of Ecology and Evolutionary Biology, Biosciences West Building, University of Arizona, Tucson, AZ 85721, USA
Proc Natl Acad Sci U S A 100:5268-73. 2003..Interestingly, another melanic population of these mice on a different lava flow shows no association with Mc1r mutations, indicating that adaptive dark color has evolved independently in this species through changes at different genes... - Haldane and the first estimates of the human mutation rateMichael W Nachman
Department of Ecology and Evolutionary Biology, P. O. Box 210088, Biosciences West Building, University of Arizona, Tucson, AZ 85721, USA
J Genet 83:231-3. 2004 - Nucleotide variation at Msn and Alas2, two genes flanking the centromere of the X chromosome in humansMichael W Nachman
Department of Ecology and Evolutionary Biology, Division of Biotechnology, University of Arizona, Tucson, Arizona 85721, USA
Genetics 167:423-37. 2004..These observations are difficult to reconcile with a simple demographic model but may be consistent with positive and/or purifying selection acting on loci within this large region of low recombination... - Local adaptation in the rock pocket mouse (Chaetodipus intermedius): natural selection and phylogenetic history of populationsH E Hoekstra
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Heredity 94:217-28. 2005..Together, the results suggest that color variation can evolve very rapidly over small geographic scales and that gene flow can both hinder and promote local adaptation... - Reduced introgression of the Y chromosome between subspecies of the European rabbit (Oryctolagus cuniculus) in the Iberian PeninsulaA Geraldes
CIBIO, Centro de Investigacao em Biodiversidade e Recursos Geneticos, Universidade do Porto, Campus Agrário de Vairão, 4485 661 Vairão, Portugal
Mol Ecol 17:4489-99. 2008..Taken together, these data indicate that there is a clear dichotomy in the rabbit genome and that some loci remain highly differentiated despite extensive gene flow following secondary contact... - Single nucleotide polymorphisms and recombination rate in humansM W Nachman
Dept of Ecology and Evolutionary Biology, University of Arizona, Tuscon 85721, USA
Trends Genet 17:481-5. 2001..Regional differences in the rate of recombination explain a substantial fraction of the variation in levels of nucleotide polymorphism, consistent with the widespread action of natural selection at the molecular level... - The frequency of multiple paternity suggests that sperm competition is common in house mice (Mus domesticus)M D Dean
University of Arizona, Ecology and Evolution, 333 Biosciences West, Tucson, AZ 85721, USA
Mol Ecol 15:4141-51. 2006..This study suggests that sperm competition is an important aspect of postcopulatory sexual selection in house mice... - Microsatellite variation and recombination rate in the human genomeB A Payseur
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
Genetics 156:1285-98. 2000..Together, these results indicate that background selection is not a major determinant of microsatellite variation in humans... - The origin of a Robertsonian chromosomal translocation in house mice inferred from linked microsatellite markersC Riginos
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson 85721, USA
Mol Biol Evol 16:1763-73. 1999..15 metacentric chromosomes found in the three Rb populations. These results suggest that cytologically indistinguishable mutations have arisen independently in natural populations of house mice... - Deleterious mutations at the mitochondrial ND3 gene in South American marsh rats (Holochilus)P Kennedy
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
Genetics 150:359-68. 1998..In general, an excess of rare sites was observed, consistent with either a recent selective sweep or with populations not at mutation-drift equilibrium... - Deleterious mutations in animal mitochondrial DNAM W Nachman
Department of Ecology and Evolutionary Biology, Biosciences, University of Arizona, Tucson 85721, USA
Genetica 102:61-9. 1998..These observations are best explained by a substantial number of mildly deleterious amino acid mutations that contribute to heterozygosity but rarely become fixed... - Patterns of DNA variability at X-linked loci in Mus domesticusM W Nachman
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson 85721, USA
Genetics 147:1303-16. 1997.... - Different genes underlie adaptive melanism in different populations of rock pocket miceH E Hoekstra
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Mol Ecol 12:1185-94. 2003..These results indicate that adaptive melanism has arisen at least twice in C. intermedius and that these similar phenotypic changes have a different genetic basis... - Population subdivision in marine environments: the contributions of biogeography, geographical distance and discontinuous habitat to genetic differentiation in a blennioid fish, Axoclinus nigricaudusC Riginos
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson 85721, USA
Mol Ecol 10:1439-53. 2001..nigricaudus cannot be explained by a single factor, but are due to the combined influences of biogeography, geographical distance and availability of suitable habitat... - The molecular basis of high-altitude adaptation in deer miceJay F Storz
School of Biological Sciences, University of Nebraska, Lincoln, Nebraska, United States of America
PLoS Genet 3:e45. 2007.... - Human adaptive evolution at Myostatin (GDF8), a regulator of muscle growthMatthew A Saunders
Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
Am J Hum Genet 79:1089-97. 2006..Both mutations are rare among non-Africans yet are at frequencies of up to 31% in sub-Saharan Africans. These signatures of selection at the molecular level suggest that human variation at GDF8 is associated with functional differences... - A complex genetic basis to X-linked hybrid male sterility between two species of house miceJeffrey M Good
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
Genetics 179:2213-28. 2008..musculus X chromosome involved in hybrid male sterility. Only a handful of spermatogenic genes are within this region, including one of the most rapidly evolving genes on the mouse X chromosome... - Nucleotide variation in wild and inbred miceTovah Salcedo
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
Genetics 177:2277-91. 2007..Together these results suggest that wild mice will be a valuable complement to laboratory strains for studying the genetics of complex traits... - The genetics of adaptive coat color in gophers: coding variation at Mc1r is not responsible for dorsal color differencesGabriela Wlasiuk
The Department of Ecology and Evolutionary Biology, Biosciences West Building, The University of Arizona, Tucson, AZ 85721, USA
J Hered 98:567-74. 2007..bottae. These results demonstrate that similar phenotypic variation may have a different genetic basis among different mammalian species... - Linkage disequilibrium in wild miceCathy C Laurie
Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
PLoS Genet 3:e144. 2007.... - Asymmetry and polymorphism of hybrid male sterility during the early stages of speciation in house miceJeffrey M Good
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Evolution 62:50-65. 2008..These data build on previous studies of speciation in house mice and show that the genetic basis of hybrid male sterility is fairly complex, even at this early stage of divergence... - Genome-wide patterns of gene flow across a house mouse hybrid zoneKatherine C Teeter
Museum of Zoology, University of Michigan, Ann Arbor, Michigan 48109 1079, USA
Genome Res 18:67-76. 2008..These data highlight the complex genetic architecture underlying speciation even at early stages of divergence and point to some of the biological processes that may govern this architecture... - Adaptive evolution of proteins secreted during sperm maturation: an analysis of the mouse epididymal transcriptomeMatthew D Dean
Department of Ecology and Evolutionary Biology, University of Arizona, USA
Mol Biol Evol 25:383-92. 2008..Immunity and protein modification functions were significantly overrepresented among epididymis-specialized, secreted genes. These analyses identified a group of genes likely to be important in male reproductive success... - Contrasting patterns of introgression at X-linked loci across the hybrid zone between subspecies of the European rabbit (Oryctolagus cuniculus)Armando Geraldes
CIBIO, Centro de Investigacao em Biodiversidade e Recursos Geneticos, Vairao, Spain
Genetics 173:919-33. 2006..These observations support a view of speciation where genomic incompatibilities at different loci in the genome create localized differences in levels of gene flow between nascent species... - The beta -globin recombinational hotspot reduces the effects of strong selection around HbC, a recently arisen mutation providing resistance to malariaElizabeth T Wood
Division of Biotechnology, University of Arizona, Tucson, AZ 85721, USA
Am J Hum Genet 77:637-42. 2005..The rapid decay in LD upstream of the HbC allele demonstrates the large effect the ss-globin hotspot has in mitigating the effects of positive selection on linked variation... - Searching for evidence of positive selection in the human genome using patterns of microsatellite variabilityBret A Payseur
Department of Ecology and Evolutionary Biology, Biosciences West Building, University of Arizona, Tucson, Arizona 85721, USA
Mol Biol Evol 19:1143-53. 2002..These results also suggest that the effects of positive selection may be more pronounced on the X chromosome than on the autosomes in humans... - Natural selection at linked sites in humansBret A Payseur
Department of Ecology and Evolutionary Biology, Biosciences West Building, University of Arizona, Tucson, AZ 85721, USA
Gene 300:31-42. 2002..These results contrast with those obtained for Drosophila, where the signals of positive selection are stronger... - Nucleotide variability at G6pd and the signature of malarial selection in humansMatthew A Saunders
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
Genetics 162:1849-61. 2002.... - Natural selection on protein polymorphism in the rodent genus Peromyscus: evidence from interlocus contrastsJay F Storz
Department of Ecology and Evolutionary Biology, University of Arizona, Biosciences West, Tucson, Arizona 85721, USA
Evolution 57:2628-35. 2003..Interestingly, the albumin locus was implicated as a candidate gene for local adaptation in four different species of Peromyscus. The results also demonstrate that selection can severely bias marker-based estimates of neutral parameters... - Genome scans of DNA variability in humans reveal evidence for selective sweeps outside of AfricaJay F Storz
Department of Ecology and Evolutionary Biology, Biosciences West, University of Arizona, AZ, USA
Mol Biol Evol 21:1800-11. 2004..A disproportionate number of these loci exhibited reduced levels of relative variability in non-African populations alone, suggesting that recent episodes of positive selection have been more prevalent outside of sub-Saharan Africa... - Ecological genetics of adaptive color polymorphism in pocket mice: geographic variation in selected and neutral genesHopi E Hoekstra
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
Evolution 58:1329-41. 2004..Together these results suggest that natural selection acts to match pocket mouse coat color to substrate color, despite high levels of gene flow between light and melanic populations... - Heterogeneous patterns of variation among multiple human x-linked Loci: the possible role of diversity-reducing selection in non-africansMichael F Hammer
Genomic Analysis and Technology Core, Division of Biotechnology, University of Arizona, Tucson, Arizona 85721, USA
Genetics 167:1841-53. 2004.... - Adaptive reptile color variation and the evolution of the Mc1r geneErica Bree Rosenblum
Museum of Vertebrate Zoology, University of California, Berkeley, California 94720, USA
Evolution 58:1794-808. 2004..This study provides comparative data on a nuclear gene in reptiles and highlights the utility of a candidate-gene approach for understanding the evolution of genes involved in vertebrate adaptation... - Differential patterns of introgression across the X chromosome in a hybrid zone between two species of house miceBret A Payseur
Department of Ecology and Evolutionary Biology, Biosciences West Building, University of Arizona, Tucson, Arizona 85721, USA
Evolution 58:2064-78. 2004..This study highlights the utility of natural populations of hybrids for mapping speciation genes and suggests that the middle of the X chromosome may be important for reproductive isolation between species of house mice... - Rates of protein evolution are positively correlated with developmental timing of expression during mouse spermatogenesisJeffrey M Good
Department of Ecology and Evolutionary Biology, University of Arizona, USA
Mol Biol Evol 22:1044-52. 2005..Overall, these data suggest that the intensity of positive selection associated with the evolution of male gametes varies considerably across development and acts primarily on phenotypes that develop late in spermatogenesis... - Human population structure and its effects on sampling Y chromosome sequence variationMichael F Hammer
Genomic Analysis and Technology Core, Division of Biotechnology, Biosciences West Building, University of Arizona, Tucson, AZ 85721, USA
Genetics 164:1495-509. 2003.... - The extent of linkage disequilibrium caused by selection on G6PD in humansMatthew A Saunders
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
Genetics 171:1219-29. 2005..1 < s < 0.2). These results also show that selection can lead to nonrandom associations among SNPs over great physical and genetic distances, even in African populations... - Gene density and human nucleotide polymorphismBret A Payseur
Mol Biol Evol 19:336-40. 2002
Research Grants
- Natural selection and DNA sequence variation in MusMICHAEL NACHMAN; Fiscal Year: 2009..domesticus and M. musculus and will provide a clear picture of the relationship between variation among commonly used inbred strains and variation in natural populations. ..
- Natural selection and DNA sequence variation in MusMichael W Nachman; Fiscal Year: 2010..domesticus and M. musculus and will provide a clear picture of the relationship between variation among commonly used inbred strains and variation in natural populations. ..