Research Topics
| Alissa MyrickSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Short report: Dynamics of Plasmodium falciparum malaria after sub-optimal therapy in UgandaAlissa Myrick
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
Am J Trop Med Hyg 74:758-61. 2006..These results highlight the complexity of malaria in Africa and have implications for efficacy trials, because missing late reappearances of strains could lead to misclassification of outcomes...- Validation of microsatellite markers for use in genotyping polyclonal Plasmodium falciparum infectionsBryan Greenhouse
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94143, USA
Am J Trop Med Hyg 75:836-42. 2006..31 versus P = 0.03). Four microsatellite markers performed well on polyclonal samples and may provide a valuable addition to genotyping for clinical drug efficacy studies in high transmission areas... - Analysis of the genetic diversity of the Plasmodium falciparum multidrug resistance gene 5' upstream regionAlissa Myrick
Department of Medicine, San Francisco General Hospital, University of California at San Francisco, 94110, USA
Am J Trop Med Hyg 72:182-8. 2005..The SNP frequency of the pfmdr1 upstream region is lower than that found in the noncoding region of other genes... - Experimental malaria infection triggers early expansion of natural killer cellsCharles C Kim
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA
Infect Immun 76:5873-82. 2008..These data indicate that the early response to P. chabaudi infection of the blood is marked by a primary wave of interferon with a subsequent response by NK cells... - Mapping of the Plasmodium falciparum multidrug resistance gene 5'-upstream region, and evidence of induction of transcript levels by antimalarial drugs in chloroquine sensitive parasitesAlissa Myrick
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston MA, USA
Mol Microbiol 49:671-83. 2003..There was no evidence of transcript induction in pyrimethamine-treated parasites. This is the first evidence of induction of pfmdr1 expression in sensitive cells; and suggests a novel method of transcriptional control for this gene... - In vivo and in vitro analysis of chloroquine resistance in Plasmodium falciparum isolates from SenegalOusmane Sarr
Laboratory of Bacteriology and Virology, Hopital Aristide Le Dantec, Dakar, Senegal
Parasitol Res 97:136-40. 2005..The pfmdr1 N86Y polymorphism did not correlate with in vitro or in vivo CQ resistance. Our data suggest that the pfcrt T76 allele alone is required but not a sufficient predictor for in vivo CQ resistance... - Genomic heterogeneity in the density of noncoding single-nucleotide and microsatellite polymorphisms in Plasmodium falciparumSarah K Volkman
Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA, USA
Gene 387:1-6. 2007.... - Regulatory motifs uncovered among gene expression clusters in Plasmodium falciparumAnusha M Gunasekera
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Harvard University, Boston, MA, USA
Mol Biochem Parasitol 153:19-30. 2007..Together, both the bioinformatic and functional data reported here imply that multiple forms of gene regulation, including post-transcriptional control, may be important in the malarial system... - Plasmodium falciparum: genome wide perturbations in transcript profiles among mixed stage cultures after chloroquine treatmentAnusha M Gunasekera
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
Exp Parasitol 117:87-92. 2007..Molecular Microbiology 50, 1229-1239]. These findings are important to report, given the striking contrast to similar studies in other model eukaryotic organisms...