Research Topics
| Andrzej MycSummaryAffiliation: University of Michigan Country: USA Publications
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Detail Information
Publications
Dendrimer-based BH3 conjugate that targets human carcinoma cellsAndrzej Myc
Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan Medical School, BSRB, Ann Arbor, MI 48109 0648, USA
Biomacromolecules 8:2986-9. 2007..The results show, for the first time, the therapeutic potential of targeted BH3 peptides as a means of inducing apoptosis by interfering with anti-apoptotic proteins within specific cells...- Targeting the efficacy of a dendrimer-based nanotherapeutic in heterogeneous xenograft tumors in vivoAndrzej Myc
Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan Medical School, BSRB, Ann Arbor, MI 48109, USA
Anticancer Drugs 21:186-92. 2010..The animal model of the artificial heterogeneous xenograft tumor showed that the nanotherapeutic was preferentially cytotoxic to KB cells... - Preclinical antitumor efficacy evaluation of dendrimer-based methotrexate conjugatesAndrzej Myc
Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan Medical School, BSRB, Ann Arbor, Michigan 48109, USA
Anticancer Drugs 19:143-9. 2008..Further in-vivo studies are, however, necessary to prove the clinical potential of this targeted therapeutic nanodevice... - PAMAM dendrimer-based multifunctional conjugate for cancer therapy: synthesis, characterization, and functionalityIstvan J Majoros
Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, 200 Zina Pitcher Place, 4027 Kresge II, Ann Arbor, 48109 0533, USA
Biomacromolecules 7:572-9. 2006..We present here the synthesis, characterization, and functionality of these dendrimer conjugates... - Targeting and inhibition of cell growth by an engineered dendritic nanodeviceThommey P Thomas
Center for Biologic Nanotechnology, University of Michigan Medical School, 9220 MSRB III, Ann Arbor, Michigan 48109 0648, USA
J Med Chem 48:3729-35. 2005..These studies show the potential of G5-FI-FA-MTX or G5-FA-MTX for targeting and growth suppression of tumor cells that overexpress FA-receptors... - In vitro targeting of synthesized antibody-conjugated dendrimer nanoparticlesThommey P Thomas
Center for Biologic Nanotechnology, 9220 MSRB III, University of Michigan Medical School, Ann Arbor, Michigan 48109-0648, USA
Biomacromolecules 5:2269-74. 2004..Confocal microscopic analysis suggested at least some cellular internalization of the dendrimer conjugate. Dendrimer-antibody conjugates are a suitable platform for targeted molecule delivery into antigen-expressing cells... - Extended cavity laser enhanced two-photon flow cytometryEric R Tkaczyk
University of Michigan, Center for Ultrafast Optical Science, Electrical Engineering and Computer Science Department, Ann Arbor, Michigan 48109 2099, USA
J Biomed Opt 13:041319. 2008.... - Quantitative two-photon flow cytometry--in vitro and in vivoCheng Frank Zhong
University of Michigan, Electrical Engineering and Computer Science Department, Center for Ultrafast Optical Science, 2200 Bonisteel Boulevard, Ann Arbor, Michigan 48109 2099, USA
J Biomed Opt 13:034008. 2008..The technique also enables us to monitor the fluorescent dye labeling dynamics in vivo. In addition, we present a unique two-beam scanning method to conduct cell size measurement in nonuniform flow... - Synthesis, characterization, and in vitro testing of superparamagnetic iron oxide nanoparticles targeted using folic Acid-conjugated dendrimersKevin J Landmark
Programs in Applied Physics, University of Michigan, Ann Arbor, Michigan 48109, USA
ACS Nano 2:773-83. 2008..The results were consistent between the uptake distribution quantified by flow cytometry using 6-TAMRA UV-visible fluorescence intensity and the cellular iron content determined using X-ray fluorescence microscopy... - Efficacy, immunogenicity and stability of a novel intranasal nanoemulsion-adjuvanted influenza vaccine in a murine modelTarek Hamouda
NanoBio Corp, Ann Arbor, MI, USA
Hum Vaccin 6:585-94. 2010..The nanoemulsion adjuvant can result in antigen sparing and cross-protection. The potential exists for a nasally administered influenza vaccine that may require little or no refrigerated storage... - Dendrimer-based targeted delivery of an apoptotic sensor in cancer cellsAndrzej Myc
Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA
Biomacromolecules 8:13-8. 2007..These results show, for the first time, the potential applicability of a targeted apoptosis-measuring nanodevice, which could be used for simultaneously monitoring the apoptotic potential of a delivered drug... - Development of immune response that protects mice from viral pneumonitis after a single intranasal immunization with influenza A virus and nanoemulsionAndrzej Myc
Department of Internal Medicine, Division of Allergy, Center of Biologic Nanotechnology, University of Michigan, 9240 MSRB III, Ann Arbor, MI 48109-0666, USA
Vaccine 21:3801-14. 2003..This paper demonstrates that nanoemulsion can be employed as a non-toxic mucosal adjuvant for influenza virus vaccine... - Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folate receptorAntonio Quintana
Center for Biologic Nanotechnology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109-0648, USA
Pharm Res 19:1310-6. 2002..CONCLUSIONS: These results demonstrate the ability to design and produce polymer-based nanodevices for the intracellular targeting of drugs, imaging agents, and other materials... - Synthesis and in vitro testing of J591 antibody-dendrimer conjugates for targeted prostate cancer therapyAnil K Patri
Center for Biologic Nanotechnology, Department of Internal Medicine, Division of Allergy, University of Michigan, 9220 MSRB III, Box 0648, Ann Arbor, Michigan 48109, USA
Bioconjug Chem 15:1174-81. 2004..Confocal microscopy experiments document the binding and internalization of these conjugates. This research encourages the further study of antibody-dendrimer-drug conjugates for use in targeted therapeutics... - Sensitive molecular binding assay using a photonic crystal structure in total internal reflectionYunbo Guo
Center for Ultrafast Optical Science, University of Michigan, Ann Arbor, MI 48109 2099, USA
Opt Express 16:11741-9. 2008..06 pg/mm(2) or a refractive index resolution of 3 x 10(-8) RIU; this represents a significant improvement relative to state-of-the-art surface-plasmon-resonance-based systems... - Characterization of stability and nasal delivery systems for immunization with nanoemulsion-based vaccinesPaul E Makidon
Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109 5648, USA
J Aerosol Med Pulm Drug Deliv 23:77-89. 2010.... - Activation of human and mouse Kupffer cells by lipopolysaccharide is mediated by CD14Grace L Su
Department of Veterans Affairs Medical Center, Ann Arbor, Michigan 48109, USA
Am J Physiol Gastrointest Liver Physiol 283:G640-5. 2002..Kupffer cells from CD14 knockout mice produced significantly less TNF-alpha in response to the same amount of LPS. Together, these data strongly support a critical role for CD14 in Kupffer cell responses to LPS... - The fungicidal activity of novel nanoemulsion (X8W60PC) against clinically important yeast and filamentous fungiAndrzej Myc
Department of Internal Medicine, Division of Allergy, Center for Biologic Nanotechnology, University of Michigan, Ann Arbor, MI, USA
Mycopathologia 155:195-201. 2002..This shows that the nanoemulsion structure is an important factor in the anti-fungal activity. The X8W60PC has great potential as a topical anti-fungal agent and further investigation into the mechanism of fungicidal action is warranted... - Prevention of influenza pneumonitis by sialic Acid-conjugated dendritic polymersJeffrey J Landers
Center for Biologic Nanotechnology, Department of Internal Medicine, Division of Allergy, University of Michigan, Ann Arbor, Michigan 48109, USA
J Infect Dis 186:1222-30. 2002..Polyvalent binding inhibitors have potential as antiviral therapeutics, but issues related to strain specificity must be resolved...