Research Topics
Genomes and GenesSpecies | KAMAL MOUDGILSummaryAffiliation: University of Maryland Country: USA Publications
Research Grants
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Publications
The gene expression profile of preclinical autoimmune arthritis and its modulation by a tolerogenic disease-protective antigenic challengeHua Yu
Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 West Baltimore Street, HSF 1, Suite 380, Baltimore, MD 21201, USA
Arthritis Res Ther 13:R143. 2011..Furthermore, considering the complex nature of the pathogenic immune events in arthritis, microarray analysis offers a versatile tool to define the dynamic patterns of gene expression during the disease course...- Celastrus aculeatus Merr. suppresses the induction and progression of autoimmune arthritis by modulating immune response to heat-shock protein 65Li Tong
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Arthritis Res Ther 9:R70. 2007..Celastrus feeding also reduced the levels of nitric oxide. On the basis of our results, we suggest further systematic exploration of Celastrus as an adjunct therapeutic modality for rheumatoid arthritis... - The determinants of susceptibility/resistance to adjuvant arthritis in ratsEugene Y Kim
Department of Microbiology and Immunology, University of Maryland School of Medicine, 660 West Redwood Street, Baltimore, MD 21201, USA
Arthritis Res Ther 11:239. 2009..In addition, neuroendocrine factors and the housing environment can further modulate arthritis susceptibility/severity in particular rat strains... - Environmental modulation of autoimmune arthritis involves the spontaneous microbial induction of T cell responses to regulatory determinants within heat shock protein 65K D Moudgil
Departments of Microbiology and Molecular Genetics, School of Medicine, University of California, Los Angeles, CA 90095, USA
J Immunol 166:4237-43. 2001..These results have important implications in broadening understanding of the host-microbe interaction in human autoimmune diseases... - Advances in rheumatoid arthritis animal modelsKamal D Moudgil
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Curr Rheumatol Rep 13:456-63. 2011..Furthermore, new therapeutic targets, including specific tyrosine kinases and proteasome subunits, have been explored. These advances offer renewed optimism for continued improvements in the management of rheumatoid arthritis... - Regulation of autoimmune arthritis by self-heat-shock proteinsKamal D Moudgil
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Trends Immunol 29:412-8. 2008..The regulatory properties of self-hsps need be fully explored and might be used for therapeutic purposes... - Exogenous tumour necrosis factor alpha induces suppression of autoimmune arthritisE Y Kim
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA
Arthritis Res Ther 10:R38. 2008.... - Cytokines in autoimmunity: role in induction, regulation, and treatmentKamal D Moudgil
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Interferon Cytokine Res 31:695-703. 2011..In this 2-volume special issue of the journal, leading experts have presented their research findings and viewpoints on the role of cytokines in the context of specific autoimmune diseases... - The self-directed T cell repertoire: its creation and activationK D Moudgil
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore 21201, USA
Rev Immunogenet 2:26-37. 2000..It is now evident that many tumor antigens are unmutated self antigens, and cryptic determinants within such tumor antigens could be used to recruit the anticryptic T cell repertoire for induction of anti-tumor immunity... - The dynamics of articular leukocyte trafficking and the immune response to self heat-shock protein 65 influence arthritis susceptibilityMd Y Mia
Department of Microbiology and Immunology, University of Maryland School of Medicine, Howard Hall 323C, 660 West Redwood Street, Baltimore, MD 21201, USA
J Clin Immunol 28:420-31. 2008..1(l)) by immunization with heat-killed Mycobacterium tuberculosis (Mtb). We set out to unravel the mechanisms underlying the differential susceptibility to AA of these MHC-compatible rat strains... - Self heat-shock protein 65-mediated regulation of autoimmune arthritisMalarvizhi Durai
Department of Microbiology and Immunology, University of Maryland School of Medicine, Howard Hall Room 323 C, 660 West Redwood St, Baltimore, MD 21201, USA
J Autoimmun 33:208-13. 2009..Thus, immune response against self hsp65 in autoimmune arthritis is protective rather than being pathogenic... - The T cells specific for the carboxyl-terminal determinants of self (rat) heat-shock protein 65 escape tolerance induction and are involved in regulation of autoimmune arthritisMalarvizhi Durai
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Immunol 172:2795-802. 2004..These novel first experimental insights into the self hsp65-directed regulatory T cell repertoire in AA would help develop better immunotherapeutic approaches for autoimmune arthritis... - Heat shock protein 65-reactive T cells are involved in the pathogenesis of non-antigenic dimethyl dioctadecyl ammonium bromide-induced arthritisMd Younus Mia
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Immunol 175:219-27. 2005..Like other animal models of RA involving hsp65, these first insights into the disease-associated Ags in the DIA model would pave the way for further understanding of the immunological aspects of induction and regulation of RA... - Regulation of autoimmune arthritis by the pro-inflammatory cytokine interferon-gammaEugene Y Kim
Department of Microbiology and Immunology, University of Maryland School of Medicine, HH 323C, 660 W Redwood St, Baltimore, MD 21201, USA
Clin Immunol 127:98-106. 2008..These results provide a novel perspective on the pathogenesis of autoimmune arthritis... - Mycobacterial Hsp65-IgG-expressing tolerogenic B cells confer protection against adjuvant-induced arthritis in Lewis ratsShailesh R Satpute
University of Maryland School of Medicine, Baltimore, MD 21201, USA
Arthritis Rheum 56:1490-6. 2007.... - Antibody responses to mycobacterial and self heat shock protein 65 in autoimmune arthritis: epitope specificity and implication in pathogenesisHong Ro Kim
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Immunol 177:6634-41. 2006..These results are of significance in further understanding of the role of humoral immunity in the pathogenesis of autoimmune arthritis... - The regulatory C-terminal determinants within mycobacterial heat shock protein 65 are cryptic and cross-reactive with the dominant self homologs: implications for the pathogenesis of autoimmune arthritisMalarvizhi Durai
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Immunol 173:181-8. 2004..The identification of disease-regulating cryptic determinants in Ags implicated in arthritis provides a novel approach for immunotherapy of rheumatoid arthritis... - T cells against the pathogenic and protective epitopes of heat-shock protein 65 are crossreactive and display functional similarity: novel aspect of regulation of autoimmune arthritisMalarvizhi Durai
Department of Microbiology and Immunology, University of Maryland School of Medicine, 660 W Redwood Street, Baltimore, MD 21201, USA
J Rheumatol 34:2134-43. 2007.... - Green tea protects rats against autoimmune arthritis by modulating disease-related immune eventsHong Ro Kim
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Nutr 138:2111-6. 2008..Thus, green tea induced changes in arthritis-related immune responses. We suggest further systematic exploration of dietary supplementation with PGT as an adjunct nutritional strategy for the management of RA... - Tolerization with Hsp65 induces protection against adjuvant-induced arthritis by modulating the antigen-directed interferon-gamma, interleukin-17, and antibody responsesShailesh R Satpute
University of Maryland School of Medicine, Baltimore, MD 21201, USA
Arthritis Rheum 60:103-13. 2009..This study was aimed at unraveling the mechanisms underlying mycobacterial Hsp65-induced protection against arthritis, using contemporary parameters of immunity... - Huo-Luo-Xiao-Ling Dan modulates antigen-directed immune response in adjuvant-induced inflammationRajesh Rajaiah
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Ethnopharmacol 123:40-4. 2009..However, the precise immunological mechanisms by which HLXL mediates its anti-inflammatory activity are not fully defined... - Extract of the Chinese herbal formula Huo Luo Xiao Ling Dan inhibited adjuvant arthritis in ratsRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Man, 2200 Kernan Drive, Baltimore, MD 21207, USA
J Ethnopharmacol 121:366-71. 2009..The herbal formula Huo Luo Xiao Ling Dan (HLXL) and its modifications have been used in traditional Chinese medicine for about one hundred years to alleviate pain and inflammation... - Strain-dependent effect of nasal instillation of antigen on the immune response in miceMarco E F Melo
Department of Microbiology and Molecular Genetics, University of California, Los Angeles, CA, USA
Isr Med Assoc J 4:902-7. 2002..Nasal instillation is an effective method for inducing antigen-specific immune tolerance. However, it is not clear how a tolerization scheme established in one mouse strain will perform when used in a mouse of a different haplotype... - Regulation of autoimmune inflammation by pro-inflammatory cytokinesEugene Y Kim
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Immunol Lett 120:1-5. 2008.... - Understanding crypticity is the key to revealing the pathogenesis of autoimmunityKamal D Moudgil
University of Maryland School of Medicine, Department of Microbiology and Immunology, BRB 13-019, 655 W. Baltimore St, Baltimore, MD 21201, USA
Trends Immunol 26:355-9. 2005.... - Heat-shock proteins can promote as well as regulate autoimmunityRajesh Rajaiah
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Autoimmun Rev 8:388-93. 2009..However, Hsps possess immunoregulatory attributes as well and therefore, are being exploited for immunomodulation of various immune-mediated disorders... - Antigen-specific tolerogenic and immunomodulatory strategies for the treatment of autoimmune arthritisShailesh R Satpute
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Semin Arthritis Rheum 38:195-207. 2008..To review various antigen-specific tolerogenic and immunomodulatory approaches for arthritis in animal models and patients in regard to their efficacy, mechanisms of action, and limitations... - Mouse lysozyme-M knockout mice reveal how the self-determinant hierarchy shapes the T cell repertoire against this circulating self antigen in wild-type micePratima Sinha
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Immunol 173:1763-71. 2004..These results reveal that the induction of self tolerance to a multideterminant protein follows the quantitative hierarchy of self-determinant expression and are of relevance in understanding the pathogenesis of autoimmunity...
Research Grants
- SELF-DETERMINANTS & INDIRECTION OF ANTI-SELF IMMUNITYKAMAL MOUDGIL; Fiscal Year: 2001..They believe that such predetermined, experimentally programmed control of the display hierarchy of cryptic self determinants would pave the way for novel immunotherapeutic strategies for prevention and treatment of cancer. ..
- PROFILING SYNOVIAL VASCULATURE IN ARTHRITIS-PRONE RATSKAMAL MOUDGIL; Fiscal Year: 2005..abstract_text> ..
- REGULATION OF AUTOIMMUNITY THROUGH EPITOPE SPREADINGKAMAL MOUDGIL; Fiscal Year: 2006..This in turn would contribute to developing novel therapeutic approaches for RA and other autoimmune diseases. ..
- Modulation of Autoimmunity by Green Tea PolyphenolsKAMAL MOUDGIL; Fiscal Year: 2006..The results of this study would help in establishing a reliable scientific basis for the use of PGT in autoimmune arthritis, and in developing better therapeutic approaches for RA. ..
- Immune Modulation of Autoimmunity by Herbal ProductsKamal D Moudgil; Fiscal Year: 2010..We will conduct these studies in an experimental model of autoimmunity. The results of our study would help developing rationally designed therapeutic approaches for autoimmunity using botanical products. ..