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Genomes and Genes | D O MorganSummaryAffiliation: University of California Country: USA Publications
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Publications
Cyclin-dependent kinases: engines, clocks, and microprocessorsD O Morgan
Department of Physiology, University of California, San Francisco 94143 0444, USA
Annu Rev Cell Dev Biol 13:261-91. 1997..In the cell, these regulatory mechanisms generate an interlinked series of Cdk oscillators that trigger the events of cell division...- The dynamics of cyclin dependent kinase structureD O Morgan
Department of Physiology, Box 0444, University of California, 513 Parnassus Ave, San Francisco, CA 94143, USA
Curr Opin Cell Biol 8:767-72. 1996.... - Cak1 is required for Kin28 phosphorylation and activation in vivoF H Espinoza
Departments of Physiology and Biochemistry and Biophysics, University of California, San Francisco, California 94143 0444, USA
Mol Cell Biol 18:6365-73. 1998..We conclude that Cak1 is required for the activating phosphorylation of Kin28 as well as that of Cdc28... - A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiaeS L Jaspersen
Department of Physiology, University of California, San Francisco, California 94143 0444, USA
Mol Biol Cell 9:2803-17. 1998..Mutant cells arrested in G1 contain normal APC activity. We conclude that Cdc15, Cdc5, Cdc14, Dbf2, and Tem1 cooperate in the activation of the APC in late mitosis but are not required for maintenance of that activity in G1... - Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14S L Jaspersen
Department of Physiology, University of California, San Francisco, California 94143 0444, USA
Curr Biol 9:227-36. 1999..Here, we explore the molecular function and regulation of the APC regulatory subunit Hct1 in Saccharomyces cerevisiae... - Cdc14 activates cdc15 to promote mitotic exit in budding yeastS L Jaspersen
Department of Physiology, University of California, San Francisco, CA 94143 0444, USA
Curr Biol 10:615-8. 2000..Instead, Cdc15 dephosphorylation may promote some additional function of Cdc15 that is independent of its effects on Cdc14 activation... - A cyclin-dependent kinase-activating kinase (CAK) in budding yeast unrelated to vertebrate CAKF H Espinoza
Department of Physiology, University of California, San Francisco, 94143 0444, USA
Science 273:1714-7. 1996..The CAK1 gene was essential for cell viability. Thus, the major CAK in S. cerevisiae is distinct from the vertebrate enzyme, suggesting that budding yeast and vertebrates may have evolved different mechanisms of CDK activation... - Cdc37 promotes the stability of protein kinases Cdc28 and Cak1A Farrell
Department of Physiology, University of California, San Francisco, California 94143 0444, USA
Mol Cell Biol 20:749-54. 2000..We conclude that budding yeast Cdc37, like its higher eukaryotic homologs, promotes the physical integrity of multiple protein kinases, perhaps by virtue of a cotranslational role in protein folding... - Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitorsN S Gray
Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA
Science 281:533-8. 1998..Purine libraries could provide useful tools for analyzing a variety of signaling and regulatory pathways and may lead to the development of new therapeutics... - Ran-independent nuclear import of cyclin B1-Cdc2 by importin betaC G Takizawa
Department of Physiology, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 96:7938-43. 1999..We conclude that cyclin B1 import is mediated by an unusual importin beta-dependent mechanism that does not require Ran... - Nuclear localization of cyclin B1 controls mitotic entry after DNA damageP Jin
Department of Physiology, University of California, San Francisco, California 94143 0444, USA
J Cell Biol 141:875-85. 1998..Thus, nuclear targeting of cyclin B1 and dephosphorylation of Cdc2 both contribute to the control of mitotic entry and exit in human cells... - A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinaseR P Fisher
Department of Physiology, University of California, San Francisco 94143 0444
Cell 78:713-24. 1994..Thus, CAK is a CDK-cyclin complex implicated in the control of multiple cell cycle transitions... - Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2D Desai
Department of Physiology, University of California, San Francisco 94143 0444
Mol Cell Biol 15:345-50. 1995..CDC2 does not bind with high affinity to cyclin E in vitro, even after phosphorylation of the CDC2 subunit. Thus, phosphorylation is of varying importance in the formation of high-affinity CDK-cyclin complexes... - The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiaeJ F Charles
Department of Physiology, University of California San Francisco, California, 94143, USA
Curr Biol 8:497-507. 1998..The Polo-related protein kinase Cdc5 in Saccharomyces cerevisiae might encode a regulator of the APC, because cdc5 mutant cells arrest with a late mitotic phenotype similar to that observed in cells with defective cyclin destruction... - Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinaseK K Kim
Department of Chemistry, University of California, Berkeley 94720, USA
Nat Struct Biol 3:849-55. 1996..Outside of the core domains, the N- and C-terminal regions of the three structures are completely different. The conformational differences between cyclin H and A structures may reflect functional differences between the two cyclins... - Cell cycle control by a complex of the cyclin HCS26 (PCL1) and the kinase PHO85F H Espinoza
Department of Physiology, University of California, San Francisco 94143
Science 266:1388-91. 1994..HCS26 does not associate with CDC28, but instead associates with PHO85, a closely related protein kinase. Thus, budding yeast, like higher eukaryotes, use multiple cdk's in the regulation of cell cycle progression... - Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25CC G Takizawa
Department of Physiology, University of California, San Francisco, CA 94143 0444, USA
Curr Opin Cell Biol 12:658-65. 2000..Phosphorylation-dependent changes in the rate of nuclear import and export of these proteins help to control the onset of mitosis both in normal cells and in cells delayed before mitosis by DNA damage... - Regulation of the APC and the exit from mitosisD O Morgan
Department of Physiology, University of California, San Francisco 94143 0444, USA
Nat Cell Biol 1:E47-53. 1999..An intricate regulatory network governs APC activity and helps to ensure that late mitotic events are properly timed and coordinated... - Kaposi's sarcoma-associated herpesvirus K-bZIP protein is phosphorylated by cyclin-dependent kinasesA G Polson
Departments of Microbiology and Immunology, University of California San Francisco, San Francisco, California 94143, USA
J Virol 75:3175-84. 2001..These studies indicate that K-bZIP is a substrate for CDKs and should inform further functional analyses of the protein... - Cdc37 is required for association of the protein kinase Cdc28 with G1 and mitotic cyclinsM R Gerber
Department of Physiology, University of California, San Francisco 94143 0444, USA
Proc Natl Acad Sci U S A 92:4651-5. 1995..cdc37-1 mutants also exhibit a defect in the binding and activation of Cdc28 by the mitotic cyclin Clb2. Thus Cdc37 may be a regulator that is required for the association of Cdc28 with multiple cyclins... - Alternative mechanisms of CAK assembly require an assembly factor or an activating kinaseR P Fisher
Department of Physiology, University of California, San Francisco 94143 0444, USA
Cell 83:47-57. 1995..Thus, CDK7-cyclin H complex formation can be achieved by multiple mechanisms... - Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15Y Gu
Department of Physiology, University of California, San Francisco 94143 0444
EMBO J 11:3995-4005. 1992..Phosphorylation on the inhibitory sites T14 and Y15 is also maximal during S phase and G2. Thus, the activity of a subpopulation of CDK2 molecules is inhibited at a time in the cell cycle when overall CDK2 activity is increased...