DEREK MOLLIVERSummaryAffiliation: University of Pittsburgh Country: USA Publications
Research Grants
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Detail Information
Publications
ATP and UTP excite sensory neurons and induce CREB phosphorylation through the metabotropic receptor, P2Y2Derek C Molliver
Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
Eur J Neurosci 16:1850-60. 2002..These findings suggest that P2Y2 contributes to the transduction of ATP-mediated sensory signalling, and may be involved in the activity-dependent regulation of nociceptor phenotype...- The ADP receptor P2Y1 is necessary for normal thermal sensitivity in cutaneous polymodal nociceptorsDerek C Molliver
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Mol Pain 7:13. 2011..These neurons represent the majority of epidermal afferents in hairy skin, and are predominantly C-fiber polymodal nociceptors (CPMs), responding to mechanical stimulation, heat and in some cases cold... - Gi- and Gq-coupled ADP (P2Y) receptors act in opposition to modulate nociceptive signaling and inflammatory pain behaviorSacha A Malin
Dept Medicine Dept Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA
Mol Pain 6:21. 2010..In this study, we examined the expression and function of P2Y1 and the Gi-coupled receptors P2Y12, P2Y13 and P2Y14 in sensory neurons to determine their contribution to nociception... - ASIC3, an acid-sensing ion channel, is expressed in metaboreceptive sensory neuronsDerek C Molliver
Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
Mol Pain 1:35. 2005..Here, we used immunocytochemistry, retrograde labelling, and electrophysiology to ask whether the distribution of ASIC3 in rat sensory neurons is consistent with either of these hypotheses... - Production of dissociated sensory neuron cultures and considerations for their use in studying neuronal function and plasticitySacha A Malin
Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, 3350 Terrace Street, Pittsburgh, Pennsylvania 15261, USA
Nat Protoc 2:152-60. 2007..Ease of production and the ability to control growth conditions make sensory neuron culture a powerful model system for studying basic neurobiology of central and peripheral nervous systems... - The P2Y agonist UTP activates cutaneous afferent fibersCheryl L Stucky
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 0509, USA
Pain 109:36-44. 2004..Furthermore, P2Y signaling may contribute to mechanotransduction in low threshold Abeta fibers under normal or pathological conditions... - Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and coldChristopher M Elitt
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Neurosci 26:8578-87. 2006..These results indicate that the level of artemin in the skin modulates gene expression and response properties of afferents that project to the skin and that these changes lead to behavioral sensitivity to both hot and cold stimuli... - Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivoSacha A Malin
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Neurosci 26:8588-99. 2006..These results indicate that GDNF family members regulate the sensitivity of thermal nociceptors and implicate artemin in particular as an important effector in inflammatory hyperalgesia...
Research Grants
- Pro- and Anti-Nociceptive Actions of P2y Nucleotide Receptors in Sensory NeuronsDEREK MOLLIVER; Fiscal Year: 2007....
- Pro- and Anti-Nociceptive Actions of P2y Nucleotide Receptors in Sensory NeuronsDEREK MOLLIVER; Fiscal Year: 2009....
- Pro- and Anti-Nociceptive Actions of P2y Nucleotide Receptors in Sensory NeuronsDerek C Molliver; Fiscal Year: 2010....