W M Mendenhall

..Those with advanced recurrences are unlikely to benefit from re-irradiation and should be considered for either a prospective clinical trial or for palliative chemotherapy or supportive care...

..The purpose of this study was to analyze the results of radiotherapy (RT) alone or combined with surgery for adenoid cystic carcinoma...

..Postoperative radiotherapy also is indicated in the rare event that a patient has unresectable macroscopic disease. Experience with the use of radiotherapy alone to treat macroscopic disease is limited...

..Treatment outcomes were analyzed for retromolar trigone squamous cell carcinoma...

..The purpose of this study was to evaluate voice rehabilitation after laryngectomy and postoperative irradiation for patients with squamous cell carcinoma of the larynx and hypopharynx...

..The authors analyzed the outcomes of patients treated with radiotherapy (RT) alone or combined with surgery for carcinoma of the salivary glands...

..Patients with ulcerative tumors may have a lower likelihood of cause-specific survival...

..The current study was performed to investigate the efficacy of carbogen (95% oxygen [O(2)] and 5% carbon dioxide [CO(2)]) breathing during definitive radiotherapy (RT) to enhance local control...

..The purpose of this study is to review the role of radiation therapy in the treatment of resectable rectal adenocarcinoma. Selection criteria, treatment techniques, and results are discussed...

..To discuss the treatment and outcomes of inverted papilloma of the nasal cavity and paranasal sinuses...

..The objective of this report was to review the role of adjuvant postoperative radiotherapy (RT) for patients with adenocarcinoma of the colon...

..Preoperative chemoradiation probably results in improved downstaging and survival compared with preoperative irradiation alone...

..To define the role of planned neck dissection after definitive radiotherapy for patients with node-positive squamous cell carcinoma of the head and neck...

..To define the optimal treatment and outcomes for patients with solitary plasmacytoma of bone and soft tissue...

..The objective of the current study was to analyze the long-term local control and complications in a series of patients who were treated with radiotherapy for benign skull base meningiomas...

..To analyze parameters that may influence the likelihood of local control after definitive radiotherapy for head and neck cancer...

..To discuss the optimal management for patients with acoustic schwannoma...

..To review the roles of altered fractionation and adjuvant chemotherapy in the treatment of patients with squamous cell carcinomas of the head and neck...

..The remaining patients were optimally treated with radiotherapy. Open partial laryngectomy was reserved for patients with locally recurrent tumors...

..To determine the natural history and treatment outcomes for patients with Merkel cell carcinoma...

..This article reviews treatment techniques and results and discusses the pertinent literature...

..Most patients experienced recurrent disease after surgery, and the most common site of failure was local. Adjuvant RT reduced the risk of local recurrence, but its impact on survival was questionable...

..The purpose of this study was to evaluate the results of RT alone and RT combined with a planned neck dissection for carcinoma of the tonsillar area and to compare these data with the results of treatment with primary surgery...

..To evaluate irradiation alone for treatment of base-of-tongue cancer...

..The purpose of this article is to discuss the natural history, treatment, and outcomes for patients with aneurysmal bone cysts (ABC)...

..Additional standards pertaining to a variety of issues, including target definitions and dose specification, need to be developed. Phase III trials will better define the role of IMRT in coming years...

..We sought to report the outcomes after definitive radiotherapy (RT) for nasopharyngeal carcinoma...

..Adjuvant cisplatin-based chemotherapy also appears to improve the probability of cure in high-risk patients...

..The probability of complications after moderate-dose radiotherapy (RT) is low...

..To discuss the treatment and outcomes for cutaneous angiosarcoma...

..Data suggest that altered fractionation schedules may improve local control (and to a lesser extent, survival) compared with conventional irradiation...

..To discuss the treatment and outcomes for giant cell tumor (GCT) of bone...

..The purpose of this study is to update our experience with definitive radiotherapy (RT) for carcinoma of the tonsillar area...

..Patients with suspicious findings on computed tomography might benefit from fluorodeoxyglucose positron emission tomography to differentiate post-radiotherapy changes from tumor...

..The end results after radiation therapy for T1-T2N0 glottic carcinoma vary considerably. We analyze patient-related and treatment-related parameters that may influence the likelihood of cure...

..This article reviews the role of radiation therapy in the treatment of patients with paragangliomas of the head and neck...

..The purpose was to determine the optimal treatment for adult patients with head and neck soft tissue sarcomas...

..The purpose of this paper is to discuss the treatment and outcomes for patients with sinonasal undifferentiated carcinoma...

..To evaluate definitive radiotherapy (RT) for treatment of base of tongue cancer...

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..The purpose of this paper is to discuss lethal midline granuloma (LMG)-nasal natural killer (NK) T-cell lymphoma (LMG-NTL)...

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..CONCLUSION: Radiotherapy alone results in a relatively high probability of cure for selected patients with T4 skin cancers...

..To report long-term results using radiotherapy with or without a planned neck dissection for T1-T2 carcinoma of the pyriform sinus...

..The likelihood of severe complications after simultaneous (as opposed to staged) neck dissection was not significantly different (P =.24)...

..Elective neck irradiation is probably unnecessary for patients with early-stage disease...

..Postoperative RT improves local-regional control but may not impact survival. Definitive RT may occasionally cure patients with unresectable local-regional disease or at least provide long-term palliation...

..The purpose of this study was to examine the potential benefit of using intensity-modulated conformal therapy for a variety of lesions currently treated with stereotactic radiosurgery or conventional radiotherapy...

..To evaluate the role of endocavitary irradiation and wide local excision followed by irradiation in the treatment of early-stage rectal adenocarcinoma...

..This retrospective review describes a 27-year experience of treating these tumors at the University of Florida...

..The purpose of this study was to investigate the incidence of radiotherapy-induced primary and secondary hypopituitarism...

..Elective neck RT seems to correlate with improved nodal control and should be considered in the treatment of esthesioneuroblastoma...

..With the addition of chemotherapy to radiation, there is an increased risk of acute toxicity and about 1-2% incidence of toxic death. Smaller tumors (T1 and early T2) probably do not require the addition of chemotherapy...

..To report the results of radiotherapy alone for stage T3 squamous cell carcinoma of the true vocal cord and compare these data with those obtained with other treatment modalities...

..To define the role of elective neck dissection during salvage surgery for locally recurrent head and neck squamous cell carcinoma (SCCA) initially treated with elective nodal irradiation (ENI)...

..The remainder are treated with RT. Adjuvant CTX is indicated for those with T3-T4 tumors and/or involved regional nodes...

..Serum TSH should be checked every 6 months for the first 5 years and yearly thereafter. Thyroid hormone replacement should be initiated in any patient with a TSH of more than 4.5 mIU/L...

..CONCLUSIONS: Radiotherapy is an effective treatment for advanced JNA. Tumor regression usually occurs slowly over several months. JNAs that are slow to regress (greater than 2 years) may have an increased risk of recurrence...

..CONCLUSIONS: Irradiation offers a high probability of tumor control with relatively minimal risks for patients with chemodectomas of the temporal bone and neck. There were no severe treatment complications...

..Auditory and vestibular dysfunction following RT for VS may be limited by limiting the total dose of cranial nerve VIII irradiation and by fractionation...

..Patients who had imaging-positive minimal or moderate peripheral disease had a better local control rate but a similar survival rate compared with patients who had central and/or macroscopic disease...

..The 5-year survival rate is approximately 50% after treatment and is influenced by the extent of neck disease. In this article, we review the pertinent literature...

..To report the treatment outcomes of definitive radiotherapy (RT) for early-stage squamous cell carcinoma (SCCA) of the glottic larynx...

..The purpose of this study was to evaluate the prognostic significance of paraglottic space invasion determined with pretreatment computed tomography (CT) for patients with T2N0 glottic carcinoma treated with radiotherapy (RT)...

..Our aim was to report the outcomes of treatment for sinonasal undifferentiated carcinoma (SNUC)...

..Furthermore, available data on the functional consequences of treatment suggest the superiority of RT +/- ND. The authors conclude that RT +/- ND is preferable for the majority of patients with SCC of the oropharynx...

..To determine if pre-radiotherapy (RT) and/or post-radiotherapy computed tomography (CT) can predict local failure in patients with laryngeal carcinoma treated with definitive RT...

..To report long-term rates of tumor control after radiotherapy (RT) for carcinoma in situ (CIS) of the true vocal cords (TVC)...

..0174). Older patients had twice as many second malignancies. CONCLUSION.: Young age does not confer a worse prognosis in patients treated with definitive radiotherapy for squamous cell carcinoma of the oropharynx and larynx...

..CONCLUSIONS: The risk of distant metastases after definitive radiotherapy is 14% at 5 years and is significantly influenced by gender, T stage, N stage, nodal level, and locoregional control...

..Local recurrence is a significant mode of treatment failure. Outcome is influenced by tumor extent, histologic grade, and resectability...

..CONCLUSION: CT findings on post-RT neck studies can help predict the likelihood of residual disease and, thereby, the necessity of planned post-RT neck dissection...

..The likelihood of cure is inversely related to the proximal extent of the cancer and is lower for symptomatic compared with asymptomatic patients...

..CONCLUSION: EBRT increases the likelihood of local-regional control for patients with locally advanced differentiated thyroid carcinoma...

..CONCLUSION: Patients who have a high likelihood of local-regional recurrence after surgery have improved disease control and survival after postoperative RT...

..There were no severe complications. CONCLUSION: Postoperative RT may reduce the risk of local recurrence in patients with DFSP who have a high risk of residual disease after surgery...

..The role of salvage neck dissection for isolated regional recurrences after definitive radiotherapy (RT) is ill-defined...

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..To compare radiation doses to carotid arteries among various radiotherapy techniques for treatment of early-stage squamous cell carcinoma (SCC) of the true vocal cords...

..To investigate the incidence of postradiation therapy (postRT) hypopituitarism (hp-pit) in pediatric patients treated for extracranial head and neck tumors...

..The authors' purpose was to report efficacy and toxicity after weekly cisplatin (30 mg/m2/wk) concurrent with altered fractionation RT...

..We report the University of Florida experience with soft-palate carcinoma treated with radiotherapy alone or combined with adjuvant chemotherapy and/or neck dissection for residual disease in the neck...

..CONCLUSION: Patients with rCR 4 weeks after RT can be spared from a post-RT neck dissection regardless of initial node stage...

..Hyperfractionated radiotherapy is associated with a significant reduction in the incidence of radiation retinopathy, especially when the retina receives more than 50 Gy...

..Whether this represents a more aggressive variant is unknown. Regardless, this pattern of spread is likely a rare event...

..CONCLUSIONS: Review of the literature indicates that the optimal first line of treatment is high-dose corticosteroids. Surgery is indicated if the lesion fails to respond. Radiotherapy is indicated if complete resection is not feasible...

..CONCLUSIONS: Radiotherapy alone or combined with surgery may provide relatively long-term local control in patients who have neurotropic melanoma with clinical perineural invasion...

..Most investigators have observed no significant increased risk of late complications with the dose-fractionation schedules described...

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..Outcomes after radiotherapy for head and neck mucosal melanoma (MMHN)...

..To discuss our experience with the diagnostic evaluation in patients with squamous cell carcinomas (SCCAs) of the head and neck metastatic to the cervical lymph nodes from an unknown primary site...

..To report the long-term results after definitive radiotherapy (RT) for T1-T2 pyriform sinus squamous cell carcinoma...

..CONCLUSIONS: Although surgery and adjuvant RT provides excellent locoregional control, distant metastases remain the major cause of mortality. Hypofractionation and conventional fractionation are equally efficacious...

..This study was done to determine if pre-radiotherapy (pre-RT) dental extractions reduce the risk of osteoradionecrosis (ORN)...

..Retrospective review describing the 40-year University of Florida experience treating Ewing tumors of the head-and-neck region with a summary of the pertinent literature...

..The purpose was to determine if postradiotherapy (RT) neck dissection can be limited to the neck levels of residual adenopathy on post-RT computed tomography (CT)...

..CONCLUSION: The likelihood of developing RION is primarily influenced by the total dose. Hyperfractionation may reduce the risk of experiencing this complication...

..Each treatment results in distinct patterns of adverse changes in quality of life that are worsened by factors including obesity, large prostate size, high prostate-specific antigen (PSA), and older age...

..Following radiotherapy, the early use of phosphodiesterase inhibitors probably reduces the risk of ED...

..To discuss the role of radiotherapy (RT) in the treatment of cutaneous squamous and basal cell carcinomas of the head and neck...

..Limited lesions may be successfully resected. A small subset of patients may experience inexorable progression to a fixed, painful, sightless eye and require orbital exenteration...