Research Topics
| K J MeadorSummaryAffiliation: University of Florida Country: USA Publications
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Publications
Rapid detection of major depression in epilepsy: a multicentre studyFrank G Gilliam
Department of Neurology, The Neurological Institute, Columbia University, New York, USA
Lancet Neurol 5:399-405. 2006..Depression is a common comorbid disorder in epilepsy but is not routinely assessed in neurology clinics. We aimed to create a rapid yet accurate screening instrument for major depression in people with epilepsy...
Cognitive and behavioral effects of lamotrigine and topiramate in healthy volunteersK J Meador
Department of Neurology, Georgetown University, Washington, DC, USA
Neurology 64:2108-14. 2005..The relative cognitive and behavioral effects of lamotrigine (LTG) and topiramate (TPM) are unclear...
Pregnancy outcomes in women with epilepsy: a systematic review and meta-analysis of published pregnancy registries and cohortsKimford Meador
Department of Neurology, University of Florida, Gainesville, FL 32610 0236, USA
Epilepsy Res 81:1-13. 2008..To conduct a systematic review and meta-analysis to quantify the incidence of congenital malformations (CMs) and other pregnancy outcomes as a function of in utero anti-epileptic drug (AED) exposure...
The basic science of memory as it applies to epilepsyKimford J Meador
Department of Neurology, University of Florida, McKnight Brain Institute, Gainesville, FL 32610, USA
Epilepsia 48:23-5. 2007..The hippocampus contributes to both through its role in memory formation and its low seizure threshold...
Neuropsychological and neurophysiologic effects of carbamazepine and levetiracetamK J Meador
Department of Neurology, University of Florida, McKnight Brain Institute L3 100, 100 South Newell Drive, Gainesville, FL 32610, USA
Neurology 69:2076-84. 2007..The relative effects of levetiracetam (LEV) and carbamazepine (CBZ) on cognitive and neurophysiologic measures are uncertain...
Cognitive/behavioral teratogenetic effects of antiepileptic drugsKimford J Meador
Department of Neurology, University of Florida, Gainesville, FL, USA
Epilepsy Behav 11:292-302. 2007..The risks of AEDs in humans are less clear, but recent studies raise concerns, especially for valproate. There is a critical need for well-designed systematic research to improve our understanding of AED effects on the fetal brain...
In utero antiepileptic drug exposure: fetal death and malformationsK J Meador
Department of Neurology, University of Florida, Gainesville 32610, USA
Neurology 67:407-12. 2006..Pregnancy outcomes following in utero exposure to antiepileptic drugs (AEDs) are uncertain, limiting an evidenced-based approach...
Practice parameter update: management issues for women with epilepsy--focus on pregnancy (an evidence-based review): teratogenesis and perinatal outcomes: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment SubcommitteeC L Harden
University of Miami, Miami, FL, USA
Neurology 73:133-41. 2009..To reassess the evidence for management issues related to the care of women with epilepsy (WWE) during pregnancy...
Effects of breastfeeding in children of women taking antiepileptic drugsK J Meador
Department of Neurology, Emory University, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Atlanta, GA 30322, USA
Neurology 75:1954-60. 2010..Animal and human studies have demonstrated that some AEDs can adversely affect the immature brain. However, no investigation has examined effects of breastfeeding during AED therapy on subsequent cognitive abilities in children...
Differential cognitive effects of carbamazepine and gabapentinK J Meador
Department of Neurology, Medical College of Georgia, Augusta 30912, USA
Epilepsia 40:1279-85. 1999..The cognitive effects of the newer antiepileptic drugs (AEDs) compared with the older standard AEDs are uncertain...
Differential cognitive and behavioral effects of topiramate and valproateK J Meador
Department of Neurology, Medical College of Georgia, Augusta, USA
Neurology 60:1483-8. 2003..Cognitive effects have been reported during topiramate (TPM) treatment, but effects relative to standard antiepileptic drugs are unclear...
Practice parameter update: management issues for women with epilepsy--focus on pregnancy (an evidence-based review): obstetrical complications and change in seizure frequency: report of the Quality Standards Subcommittee and Therapeutics and Technology AsC L Harden
University of Miami, Miami, FL, USA
Neurology 73:126-32. 2009....
Cognitive function at 3 years of age after fetal exposure to antiepileptic drugsKimford J Meador
Department of Neurology, Emory University, Woodruff Memorial Research Bldg, 101 Woodruff Cir, Suite 6000, Atlanta, GA 30322, USA
N Engl J Med 360:1597-605. 2009....
Differential cognitive and behavioral effects of carbamazepine and lamotrigineK J Meador
Department of Neurology, Medical College of Georgia, Augusta, 30912, USA
Neurology 56:1177-82. 2001..The relative cognitive and behavioral effects of lamotrigine compared with the older standard antiepileptic drugs (AED) are uncertain...
Pregnancy registries in epilepsy: a consensus statement on health outcomesK J Meador
Department of Neurology, Emory University, Atlanta, GA 30322, USA
Neurology 71:1109-17. 2008..There is a critical need for investigations to delineate the underlying mechanisms and explain the variance seen in outcomes across AEDs and within a single AED...
Gamma coherence and conscious perceptionK J Meador
Department of Neurology, Medical College of Georgia, Augusta, USA
Neurology 59:847-54. 2002..In addition, controversy exists as to whether the primary sensory cortices are involved directly in the mechanisms of conscious perception or just in processes prior to conscious awareness...
Practice parameter update: management issues for women with epilepsy--focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding: report of the Quality Standards Subcommittee and Therapeutics and Technology AssesC L Harden
University of Miami, Miami, FL, USA
Neurology 73:142-9. 2009....
Structural versus functional prediction of memory change following anterior temporal lobectomyDavid W Loring
Department of Neurology, Georgetown University Medical Center, Building D, Suite 207, 4000 Reservoir Road, NW, Washington, DC 22057, USA
Epilepsy Behav 5:264-8. 2004..In the present case, behavioral measures were superior to structural measures in predicting cognitive change following surgery...
Topiramate dose effects on cognition: a randomized double-blind studyD W Loring
Department of Neurology, Emory University, 101 Woodruff Circle, Suite 6000, Atlanta, GA 30322, USA
Neurology 76:131-7. 2011..Topiramate (TPM), a broad-spectrum antiepileptic drug, has been associated with neuropsychological impairment in patients with epilepsy and in healthy volunteers...
Limb and hemispatial hypometriaK J Meador
Department of Neurology, Medical College of Georgia, Augusta 30912 3280, USA
J Int Neuropsychol Soc 6:71-5. 2000..No effect was found for direction of sensory input. The results suggest that the directional hypometria is predominantly produced by hemispatial output deficits...
Time perception following unilateral amobarbital injection in patients with temporal lobe epilepsyD L Drane
Medical College of Georgia, Department of Neurology, Gainesville, USA
J Clin Exp Neuropsychol 21:385-96. 1999..These findings are discussed in the context of the growing evidence for a right-hemispheric attentional network...
A prospective study of cognitive fluency and originality in children exposed in utero to carbamazepine, lamotrigine, or valproate monotherapyKelly M McVearry
Department of Neurology, Georgetown University Medical Center, Washington, DC 20007, USA
Epilepsy Behav 16:609-16. 2009..To investigate the differential effects of fetal exposure to antiepileptic drugs (AEDs) on cognitive fluency and flexibility in a prospective sample of children...
Neurodevelopmental effects of antiepileptic drugsKimford J Meador
Department of Neurology, Medical College of Georgia, 1120 15th Street BA3410, Augusta, GA 30912, USA
Curr Neurol Neurosci Rep 2:373-8. 2002..Prenatal folate and multivitamins should also be given routinely to women of childbearing age who require AED therapy...
Is antiepileptic drug use related to depression and suicidal ideation among patients with epilepsy?X Wen
Department of Pharmaceutical Outcomes and Policy, University of Florida, Gainesville, FL, USA
Epilepsy Behav 19:494-500. 2010..Significant improvements in proportions of depression and suicidal ideation were seen only for the No AED Change group, which differed only with the AED Dose Increased group with respect to suicidal ideation...
Relationship of extinction to perceptual thresholds for single stimuliK J Meador
Section of Behavioral Neurology, Department of Neurology, Medical College of Georgia, Augusta 30912-3280, USA
Neurology 56:1044-7. 2001..Asymmetries in mask and target intensities (relative to single-stimulus perceptual thresholds) affect extinction in RBS patients less for left targets but more for right targets as compared with control subjects...
Differential neuropsychological test sensitivity to left temporal lobe epilepsyDavid W Loring
Department of Neurology, University of Florida, Gainesville, Florida 32610, USA
J Int Neuropsychol Soc 14:394-400. 2008....
Neuropsychological and behavioral effects of antiepilepsy drugsDavid W Loring
Department of Neurology, University of Florida, Gainesville, USA
Neuropsychol Rev 17:413-25. 2007..The present article serves to provide an overview of our current understanding regarding the risks of antiepilepsy drug use for both cognitive and behavioral side effects...
Antiepileptic drugs and neurodevelopmentGholam K Motamedi
Georgetown University Hospital, Department of Neurology, PHC 7, 3800 Reservoir Road, NW, Washington, DC 20007, USA
Curr Neurol Neurosci Rep 6:341-6. 2006..Prospective clinical studies seem necessary in order to better understand the long-term neurodevelopmental effects of in utero exposure to AEDs...
Subjective preference for lamotrigine or topiramate in healthy volunteers: relationship to cognitive and behavioral functioningMary Ann Werz
Department of Neurology, University Hospitals of Cleveland and Case Western Reserve University School of Medicine, Cleveland, OH, USA
Epilepsy Behav 8:181-91. 2006..Additionally, drug preference was related to effects of lamotrigine and topiramate on objective neuropsychological tests as well as self-perception on behavioral instruments...
Victoria Symptom Validity Test performance in a heterogenous clinical sampleDavid W Loring
Department of Neurology, University of Florida, Gainesville, FL 2610 0236, USA
Clin Neuropsychol 21:522-31. 2007..These data suggest that intentional response distortion in patients referred for non-forensic neuropsychological evaluation is rare. Performances by specific diagnosis using different classification criteria are also presented...
Dimensions of the epilepsy foundation concerns indexDavid W Loring
Department of Neurology, University of Florida, Gainesville, FL, USA
Epilepsy Behav 6:348-52. 2005..We conclude that the Epilepsy Foundation Concerns Index is multidimensional, and using a global score based on all items may mask specific concerns that may be relevant when applied to individual patients...
Determinants of quality of life in epilepsyDavid W Loring
Department of Neurology, University of Florida, Gainesville, FL 32610, USA
Epilepsy Behav 5:976-80. 2004..Although quality of life has multiple determinants, symptoms of depression and seizure worry are the most important factors affecting QOL in patients with intractable epilepsy...
Pre-surgical evaluation for epilepsy surgeryD W Loring
Department of Neurology, Medical College of Georgia, Augusta, Georgia 30912 3275, USA
Saudi Med J 21:609-16. 2000....
Pathophysiology of altered consciousness during seizures: Subtraction SPECT studyK H Lee
Department of Neurology, Medical College of Georgia, Augusta, GA, USA
Neurology 59:841-6. 2002..Variance in the results may be due to differences in timing of radioisotope injection, sensitivity of the subtraction SPECT technique, and the ability to clinically assess the conscious state...
Negative seizuresK J Meador
Department of Neurology, Medical College of Georgia, Augusta 30912, USA
J Int Neuropsychol Soc 6:731-3. 2000..One had repeated episodes with PLEDs but no parenchymal lesions. Clinicians should consider seizures in the setting of unexplained deficits, even if there are no positive ictal phenomena...
Cognitive side effects of antiepileptic drugs in childrenDavid W Loring
Department of Neurology, Georgetown University Medical Center, Washington, DC, USA
Neurology 62:872-7. 2004....
Cognitive side effects of antiepileptic drugsPavel Ortinski
Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC 20007, USA
Epilepsy Behav 5:S60-5. 2004..AEDs can have positive or negative effects on mood, providing another consideration in choosing the course of treatment...
Antiepileptic drug use in women of childbearing ageKimford J Meador
Department of Neurology, Emory University, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Mail Stop 1930 001 1AN, Atlanta, GA 30322, USA
Epilepsy Behav 15:339-43. 2009..Except for the top two AED monotherapies, there were marked differences in other monotherapies and in polytherapies between U.S. and UK centers. Future investigations are needed to examine reasons for drug choice...
Cognitive outcomes and predictive factors in epilepsyKimford J Meador
Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
Neurology 58:S21-6. 2002..Patients who are refractory or intolerant to AED therapy should be referred for video EEG monitoring to confirm the seizure diagnosis and determine if the patient is a candidate for epilepsy surgery...
Diagnostic utility of Wada Memory Asymmetries: sensitivity, specificity, and likelihood ratio characterizationDavid W Loring
Department of Neurology, Emory University, Atlanta, GA 30322, USA
Neuropsychology 23:687-93. 2009..9%) obtained a difference score of -8. Multiple level LRs indicate impressive diagnostic sensitivity for certain WMA ranges, greatly increasing the probability of undergoing either left or right TL surgery depending on WMA magnitude...
Victoria symptom validity test performance in non-litigating epilepsy surgery candidatesDavid W Loring
Department of Neurology, Georgetown University Medical Center, Washington, DC 20057, USA
J Clin Exp Neuropsychol 27:610-7. 2005....
A test of the mechanisms of sensory extinction to simultaneous stimulationB M Kluger
Department of Neurology, University of Florida College of Medicine, Box 100236, Gainesville, FL 32610-0236, USA
Neurology 70:1644-5. 2008
Teratogenicity of antiepileptic medicationsBenzi M Kluger
Department of Neurology, University of Florida, Gainesville, Florida 32610, USA
Semin Neurol 28:328-35. 2008..Management of women with epilepsy should include a discussion of these risks, prophylactic treatment with folic acid, and the minimal use of polypharmacy and valproate needed to maintain optimum seizure control...
Newer anticonvulsants: dosing strategies and cognition in treating patients with mood disorders and epilepsyKimford J Meador
Department of Neurology, Medical College of Georgia, Augusta, USA
J Clin Psychiatry 64:30-4. 2003..Since multiple new anticonvulsants have been introduced in recent years, the question arises as to the frequency and magnitude of their cognitive side effects...
Antiepileptic drugs and memoryGholam K Motamedi
Department of Neurology, Georgetown University School of Medicine, Washington, DC, USA
Epilepsy Behav 5:435-9. 2004..Well-controlled studies are needed to understand the underlying mechanisms and to further delineate the magnitude and relative effects of AEDs on memory...
Screening for major depression in epilepsy with common self-report depression inventoriesJana E Jones
Department of Neurology, University of Wisconsin Madison, 53792, USA
Epilepsia 46:731-5. 2005..The purpose of this study was to determine the ability of two common depressive symptom inventories to identify major depression in people with epilepsy...
Neurodevelopmental outcomes of children born to mothers with epilepsyKimford J Meador
Department of Neurology, Georgetown University Hospital, 1st Floor Bles, 3800 Reservoir Rd, NW, Washington, DC 20007, USA
Cleve Clin J Med 71:S38-41. 2004..Flaws in the methodology of some studies of these effects require that the results be interpreted cautiously and highlight the need for well-designed studies to explore this issue further...
Topography of somatosensory processing: cerebral lateralization and focused attentionK J Meador
Department of Neurology, Medical College of Georgia, Augusta 30912, USA
J Int Neuropsychol Soc 8:349-59. 2002..Unattended stimuli activate the contralateral primary somatosensory area. Left/right asymmetries were demonstrated consistent with cerebral lateralization...
Structured cueing on a semantic fluency task differentiates patients with temporal versus frontal lobe seizure onsetDaniel L Drane
Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA
Epilepsy Behav 9:339-44. 2006....
Afterdischarges during cortical stimulation at different frequencies and intensitiesGholam K Motamedi
Department of Neurology, PHC 7, Georgetown University Hospital, 3800 Reservior Rd, NW, Washington, DC 20007, USA
Epilepsy Res 77:65-9. 2007..The occurrence of unwanted afterdischarges (ADs) impedes cortical stimulation for mapping purposes. We investigated the safety of several stimulation paradigms...
Theta oscillations mediate interaction between prefrontal cortex and medial temporal lobe in human memoryKristopher L Anderson
The J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
Cereb Cortex 20:1604-12. 2010....
Lateralized changes in autonomic arousal during emotional processing in patients with unilateral temporal lobe seizure onsetGregory P Lee
Department of Occupational Therapy, School of Allied Health, Department of Neurology, School of Medicine, Medical College of Georgia, Augusta, Georgia, USA
Int J Neurosci 112:743-57. 2002..Dysfunction of left mesial temporal lobe structures may result in autonomic hyperarousal and a release of the unrestrained negative emotional tendencies of the right hemisphere...
Clinical assessment of Axis I psychiatric morbidity in chronic epilepsy: a multicenter investigationJana E Jones
Department of Neurology, University of Wisconsin Madison, 53792 6180, USA
J Neuropsychiatry Clin Neurosci 17:172-9. 2005..Issues regarding recognition and treatment of psychiatric morbidity in epilepsy are discussed...
Ambiguous language in Wada evaluationsKimford J Meador
Department of Neurology, Georgetown University Hospital, Washington, DC 20007, USA
Epilepsia 45:24-5. 2004..A case is presented with ambiguous cerebral language lateralization, as determined by the intracarotid amobarbital test. Reasons for ambiguous language findings for this test are discussed...
A brief computerized self-screen for dementiaBenzi M Kluger
University of Florida, Gainesville, FL 32610, USA
J Clin Exp Neuropsychol 31:234-44. 2009..We discuss its relative merits and limitations in comparison to other current instruments as well as suggesting future directions for this field...
Auditory responsive naming versus visual confrontation naming in dementiaKimberly M Miller
Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA
Clin Neuropsychol 24:103-18. 2010..We believe that this reflects more widespread topographical distribution of auditory naming sites within the temporal lobe, but may also reflect the contributions of working memory and cognitive flexibility to performance...
Loss of somatosensory-evoked potentials and the timing of perceptionBenzi M Kluger
Department of Neurology, University of Colorado, Aurora, CO, USA
Cogn Behav Neurol 22:173-9. 2009..To determine if patients with brain lesions who have a unilateral loss of their primary somatosensory-evoked potential (SSEP) have altered temporal perception...
Rates and risk factors for suicide, suicidal ideation, and suicide attempts in chronic epilepsyJana E Jones
Department of Neurology, University of Wisconsin Madison, Madison, WI, USA
Epilepsy Behav 4:S31-8. 2003..Assessing severity of risk helps to determine the appropriate level of intervention. The suicidality module of the Mini-International Neuropsychiatric Interview is a practical tool to help quantify current suicide risk...
Role of cerebral lateralization in control of immune processes in humansKimford J Meador
Department of Neurology, Georgetown University, Washington, DC 20007, USA
Ann Neurol 55:840-4. 2004..The findings demonstrate a differential role of the left and right cerebral hemispheres on immune functions in humans...
What is the risk of orofacial clefts from lamotrigine exposure during pregnancy?Kimford J Meador
Neurology 71:706-7. 2008
Lamotrigine therapy in patients requiring a change in antiepileptic drug regimenRobert P Kustra
Epilepsy Clinical Development, GlaxoSmithKline, P O Box 13398, Research Triangle Park, NC 27709, USA
Seizure 14:254-61. 2005..Open-label studies conducted in the clinic setting may provide additional drug tolerability and effectiveness information that may not be evident in pre-approval clinical trials...
Cognitive and memory effects of the new antiepileptic drugsKimford J Meador
Epilepsy Res 68:63-7. 2006..The available data suggest that some of the new AEDs have fewer effects on cognition and memory than the older AEDs, and these differences can have clinical impact...
Distinct cognitive neurophysiologic profiles for lamotrigine and topiramateMichael E Smith
San Francisco Brain Research Institute and SAM Technology, San Francisco, California 94108, USA
Epilepsia 47:695-703. 2006..It is unknown whether such effects would also be observed at lower doses, such as those that often are used in monotherapy for newly diagnosed patients...
The Wada test for language and memory lateralizationKimford J Meador
Neurology 65:659. 2005
Epilepsy and reproductive function in womenKimford J Meador
Ann Neurol 52:696-7. 2002
Part 2: history of 20th century neurology: decade by decadeKenneth Tyler
Ann Neurol 53:S27-45. 2003
To drive or not to drive: roles of the physician, patient, and stateKimford J Meador
Neurology 68:1170-1. 2007
The neuropsychology of epilepsy: what are the factors involved?Albert P Aldenkamp
Department of Behavioral Sciences, Epilepsy Center Kempenhaeghe, PO Box 61, NL-5590 A.B. Heeze, The Netherlands
Epilepsy Behav 5:S1-2. 2004
