Kathleen E McGrath

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Circulation is established in a stepwise pattern in the mammalian embryo
    Kathleen E McGrath
    Center for Human Genetics and Molecular Pediatric Diseases, Department of Pediatrics, University of Rochester, NY, USA
    Blood 101:1669-76. 2003
  2. ncbi A transient definitive erythroid lineage with unique regulation of the ?-globin locus in the mammalian embryo
    Kathleen E McGrath
    Department of Pediatrics, Center for Pediatric Biomedical Research, University of Rochester Medical Center, Rochester, NY, USA
    Blood 117:4600-8. 2011
  3. ncbi Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus
    Samantha J England
    Department of Pediatrics, Center for Pediatric Biomedical Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    Blood 117:2708-17. 2011
  4. ncbi Enucleation of primitive erythroid cells generates a transient population of "pyrenocytes" in the mammalian fetus
    Kathleen E McGrath
    University of Rochester Medical Center, Department of Pediatrics, Center for Pediatric Biomedical Research, Rochester, NY 14642, USA
    Blood 111:2409-17. 2008
  5. ncbi Primitive erythropoiesis and megakaryopoiesis in the yolk sac are independent of c-myb
    Joanna Tober
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Blood 111:2636-9. 2008
  6. ncbi An embryonic stage-specific enhancer within the murine ?-globin locus mediates domain-wide histone hyperacetylation
    George Fromm
    Department of Pediatrics, University of Rochester Medical Center, Center for Pediatric Biomedical Research, Rochester, NY, USA
    Blood 117:5207-14. 2011
  7. ncbi Sublethal radiation injury uncovers a functional transition during erythroid maturation
    Scott A Peslak
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Exp Hematol 39:434-45. 2011
  8. ncbi Primitive erythropoiesis in the mammalian embryo
    James Palis
    University of Rochester Medical Center, Department of Pediatrics, Center for Pediatric Biomedical Research, New York 14642, USA
    Int J Dev Biol 54:1011-8. 2010
  9. ncbi "Maturational" globin switching in primary primitive erythroid cells
    Paul D Kingsley
    Department of Pediatrics, University of Rochester Medical Center, Center for Pediatric Biomedical Research, Box 703, 601 Elmwood Ave, Rochester, NY 14642, USA
    Blood 107:1665-72. 2006
  10. ncbi The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis
    Joanna Tober
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, NY 14642, USA
    Blood 109:1433-41. 2007

Collaborators

  • Stephen D Dertinger
  • Yuhchyau Chen
  • Daniel H Turnbull
  • J Palis
  • COLIN K PHOON
  • Paul D Kingsley
  • Joanna Tober
  • Scott A Peslak
  • Samantha J England
  • Jenna M Frame
  • George Fromm
  • Michael Bulger
  • Rui Ping Ji
  • Michael Getman
  • Jeffrey C Bemis
  • Anne D Koniski
  • Jesse Wenger
  • Jacqueline P Williams
  • Brenda Cadiz-Rivera
  • Jennifer Fields
  • Christina de Vries
  • Steven Fiering
  • Anne Koniski
  • Karen K L de Mesy Bentley
  • Rachael Emerson
  • Richard Waugh
  • Radhika Vemishetti
  • Karen K L de Mesy-Bentley
  • Rachel L Emerson
  • Timothy P Bushnell
  • Laura A Bloedorn
  • Jeffrey Malik

Detail Information

Publications13

  1. ncbi Circulation is established in a stepwise pattern in the mammalian embryo
    Kathleen E McGrath
    Center for Human Genetics and Molecular Pediatric Diseases, Department of Pediatrics, University of Rochester, NY, USA
    Blood 101:1669-76. 2003
    ..We conclude that a functional vascular system develops gradually and that specialized vascular-hematopoietic environments exist after circulation becomes fully established...
  2. ncbi A transient definitive erythroid lineage with unique regulation of the ?-globin locus in the mammalian embryo
    Kathleen E McGrath
    Department of Pediatrics, Center for Pediatric Biomedical Research, University of Rochester Medical Center, Rochester, NY, USA
    Blood 117:4600-8. 2011
    ..We conclude that yolk sac-derived EMPs, the first of 2 origins of definitive erythropoiesis, express a unique pattern of globin genes as they generate the first definitive erythrocytes in the liver of the mammalian embryo...
  3. ncbi Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus
    Samantha J England
    Department of Pediatrics, Center for Pediatric Biomedical Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    Blood 117:2708-17. 2011
    ..Extensively self-renewing erythroblasts, despite their near complete maturity within the hematopoietic hierarchy, may ultimately serve as a renewable source of red cells for transfusion therapy...
  4. ncbi Enucleation of primitive erythroid cells generates a transient population of "pyrenocytes" in the mammalian fetus
    Kathleen E McGrath
    University of Rochester Medical Center, Department of Pediatrics, Center for Pediatric Biomedical Research, Rochester, NY 14642, USA
    Blood 111:2409-17. 2008
    ..Continued studies comparing primitive and definitive erythropoiesis will lead to an improved understanding of terminal erythroid maturation...
  5. ncbi Primitive erythropoiesis and megakaryopoiesis in the yolk sac are independent of c-myb
    Joanna Tober
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Blood 111:2636-9. 2008
    ..5 yolk sac and E11.5 liver. Despite this impaired megakaryocyte potential, c-myb-null fetuses had normal platelet numbers at E12.5 but became thrombocytopenic by E15.5, suggesting that c-myb is required for sustained thrombopoiesis...
  6. ncbi An embryonic stage-specific enhancer within the murine ?-globin locus mediates domain-wide histone hyperacetylation
    George Fromm
    Department of Pediatrics, University of Rochester Medical Center, Center for Pediatric Biomedical Research, Rochester, NY, USA
    Blood 117:5207-14. 2011
    ....
  7. ncbi Sublethal radiation injury uncovers a functional transition during erythroid maturation
    Scott A Peslak
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Exp Hematol 39:434-45. 2011
    ..To better understand this phenomenon, we investigated the kinetics and apoptotic response of the erythron to sublethal radiation injury...
  8. ncbi Primitive erythropoiesis in the mammalian embryo
    James Palis
    University of Rochester Medical Center, Department of Pediatrics, Center for Pediatric Biomedical Research, New York 14642, USA
    Int J Dev Biol 54:1011-8. 2010
    ..This surprising finding indicates that the primitive erythroid lineage is indeed mammalian, rather than non-mammalian, in character...
  9. ncbi "Maturational" globin switching in primary primitive erythroid cells
    Paul D Kingsley
    Department of Pediatrics, University of Rochester Medical Center, Center for Pediatric Biomedical Research, Box 703, 601 Elmwood Ave, Rochester, NY 14642, USA
    Blood 107:1665-72. 2006
    ..Globin switching during ontogeny is due not only to the sequential appearance of primitive and definitive lineages but also to changes in globin expression as primitive erythroblasts mature in the bloodstream...
  10. ncbi The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis
    Joanna Tober
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, NY 14642, USA
    Blood 109:1433-41. 2007
    ....
  11. ncbi Multispectral imaging of hematopoietic cells: where flow meets morphology
    Kathleen E McGrath
    University of Rochester Medical Center, Department of Pediatrics, Center for Pediatric Biomedical Research, Box 703, 601 Elmwood Ave, Rochester, NY 14642, United States
    J Immunol Methods 336:91-7. 2008
    ....
  12. ncbi Onset of cardiac function during early mouse embryogenesis coincides with entry of primitive erythroblasts into the embryo proper
    Rui Ping Ji
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY, USA
    Circ Res 92:133-5. 2003
    ..In situ hybridization revealed an onset of the heartbeat coincident with the appearance of yolk sac-derived erythroblasts in the embryo proper at 5 S. Early maturation of the circulation follows a tightly coordinated program...
  13. ncbi Hematopoiesis in the yolk sac: more than meets the eye
    Kathleen E McGrath
    Department of Pediatrics and the Center for Pediatric Biomedical Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    Exp Hematol 33:1021-8. 2005
    ....