Sean P McBurney

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Viral sequence diversity: challenges for AIDS vaccine designs
    Sean P McBurney
    University of Pittsburgh, School of Medicine, Center for Vaccine Research, Program in Molecular Virology and Microbiology, Pittsburgh, PA 15261, USA
    Expert Rev Vaccines 7:1405-17. 2008
  2. ncbi Lentivirus-like particles without reverse transcriptase elicit efficient immune responses
    Sean P McBurney
    Department of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Curr HIV Res 4:475-84. 2006
  3. ncbi Membrane embedded HIV-1 envelope on the surface of a virus-like particle elicits broader immune responses than soluble envelopes
    Sean P McBurney
    Center for Vaccine Research for Emerging Diseases and Biodefense, University of Pittsburgh School of Medicine, 9047 Biomedical Sciences Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA
    Virology 358:334-46. 2007
  4. ncbi Human immunodeficiency virus-like particles with consensus envelopes elicited broader cell-mediated peripheral and mucosal immune responses than polyvalent and monovalent Env vaccines
    Sean P McBurney
    Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Vaccine 27:4337-49. 2009
  5. ncbi Developing broadly reactive HIV-1/AIDS vaccines: a review of polyvalent and centralized HIV-1 vaccines
    Sean P McBurney
    Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Curr Pharm Des 13:1957-64. 2007
  6. ncbi Virus-like particles: designing an effective AIDS vaccine
    Kelly R Young
    Department of Medicine, Division of Infectious Diseases, University of Pittsburgh School of Medicine, PA 15261, USA
    Methods 40:98-117. 2006

Collaborators

Detail Information

Publications6

  1. ncbi Viral sequence diversity: challenges for AIDS vaccine designs
    Sean P McBurney
    University of Pittsburgh, School of Medicine, Center for Vaccine Research, Program in Molecular Virology and Microbiology, Pittsburgh, PA 15261, USA
    Expert Rev Vaccines 7:1405-17. 2008
    ..In this review, the state of vaccine development to address envelope diversity will be presented, focusing on the use of centralized and polyvalent sequence design as mechanisms to elicit broadly reactive immune responses...
  2. ncbi Lentivirus-like particles without reverse transcriptase elicit efficient immune responses
    Sean P McBurney
    Department of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Curr HIV Res 4:475-84. 2006
    ..Therefore, the lack of RT enhances the safety of these VLPs for use in future human clinical trials without a significant reduction in the overall immunogenicity of these VLP immunogens...
  3. ncbi Membrane embedded HIV-1 envelope on the surface of a virus-like particle elicits broader immune responses than soluble envelopes
    Sean P McBurney
    Center for Vaccine Research for Emerging Diseases and Biodefense, University of Pittsburgh School of Medicine, 9047 Biomedical Sciences Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA
    Virology 358:334-46. 2007
    ..These lentiviral VLPs are effective mucosal immunogens that elicit broader immunity against Env determinants in both the systemic and mucosal immune compartments than soluble forms of Env...
  4. ncbi Human immunodeficiency virus-like particles with consensus envelopes elicited broader cell-mediated peripheral and mucosal immune responses than polyvalent and monovalent Env vaccines
    Sean P McBurney
    Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Vaccine 27:4337-49. 2009
    ..This is the first study to directly compare the breadth of cell-mediated immune responses elicited by consensus and polyvalent Env vaccines...
  5. ncbi Developing broadly reactive HIV-1/AIDS vaccines: a review of polyvalent and centralized HIV-1 vaccines
    Sean P McBurney
    Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Curr Pharm Des 13:1957-64. 2007
    ..This review will summarize the current uses of polyvalent and centralized vaccines to increase immune breadth that may determine future directions for HIV-1 vaccine development...
  6. ncbi Virus-like particles: designing an effective AIDS vaccine
    Kelly R Young
    Department of Medicine, Division of Infectious Diseases, University of Pittsburgh School of Medicine, PA 15261, USA
    Methods 40:98-117. 2006
    ..A variety of VLPs for lentiviruses are currently in preclinical and clinical trials. This review focuses on our current status of VLP-based AIDS vaccines, regarding issues of purification and immune design for animal and clinical trials...