Research Topics
Species | William M ManiscalcoSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
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Detail Information
Publications
Angiogenic factors and alveolar vasculature: development and alterations by injury in very premature baboonsWilliam M Maniscalco
Division of Neonatology, Strong Children s Research Center, Department of Pediatrics, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 282:L811-23. 2002..These data suggest that CLD impairs lung microvascular development and that a possible mechanism is disruption of VEGF and Flt-1 expression...- Hyperoxic ventilated premature baboons have increased p53, oxidant DNA damage and decreased VEGF expressionWilliam M Maniscalco
Division of Neonatology, Children s Research Center, Pulmonary Biology and Disease Program, University of Rochester School of Medicine, Rochester, NY 14642, USA
Pediatr Res 58:549-56. 2005..The findings suggest that oxidant DNA damage may be a mechanism of increased p53 in hyperoxic fetal lung... - Increased epithelial cell proliferation in very premature baboons with chronic lung diseaseWilliam M Maniscalco
Division of Neonatology, Strong Children s Research Center, Department of Pediatrics, University of Rochester, Rochester, New York 14642, USA
Am J Physiol Lung Cell Mol Physiol 283:L991-L1001. 2002..These data show that the development of chronic lung disease is associated with major alterations in normal patterns of lung-cell proliferation... - Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung developmentMin Yee
Department of Pediatrics, Box 850, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Ave, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 291:L1101-11. 2006..These data suggest that perinatal hyperoxia adversely affects alveolar development by disrupting the proper timing of type II cell proliferation and differentiation into type I cells... - Pathogenesis of bronchopulmonary dysplasiaPatricia R Chess
Department of Pediatrics, University of Rochester, Rochester, NY 14642, USA
Semin Perinatol 30:171-8. 2006..The contribution of hyperoxia and hypoxia, mechanical forces, vascular maldevelopment, inflammation, fluid management, patent ductus arteriosus (PDA), nutrition, and genetics will be discussed... - Murine mechanical ventilation stimulates alveolar epithelial cell proliferationPatricia Rose Chess
Departments of Pediatrics and Biomedical Engineering, University of Rochester, Rochester, New York 14642, USA patricia
Exp Lung Res 36:331-41. 2010..Ventilation did not increase apoptosis in alveolar type II cells, as measured by TUNEL staining. Ventilation at low tidal volumes leads to a mild inflammatory response and alveolar epithelial cell proliferation... - Induced p21Cip1 in premature baboons with CLD: implications for alveolar hypoplasiaMICHAEL A O'REILLY
Dept of Pediatrics, Box 850, Univ of Rochester, 601 Elm wood Ave, Rochester, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 285:L964-71. 2003..These data suggest that p21 may play a role in disorganized proliferation and alveolar hypoplasia seen in newborn chronic lung disease... - In vivo exposure to hyperoxia induces DNA damage in a population of alveolar type II epithelial cellsJason M Roper
Dept. of Pediatrics, Box 850, School of Medicine and Dentistry, Univ. of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 286:L1045-54. 2004..These data reveal that type II cells exposed to in vivo hyperoxia have oxidized and fragmented DNA. Because type II cells are essential for lung remodeling, our findings raise the possibility that they are proficient in DNA repair... - Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1)Rhonda J Staversky
Department of Pediatrics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA
Am J Pathol 161:1383-93. 2002..This observation has important implications for therapeutic strategies designed to attenuate long-term chronic lung disease after oxidant injury... - The role of vascular growth factors in hyperoxia-induced injury to the developing lungCARL T D'ANGIO
Strong Children s Research Center, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester NY, USA
Front Biosci 7:d1609-23. 2002..Strategies that enhance microvascular integrity, whether through attenuating alterations in vascular growth factors or by other means, also improve the outcome of lung injury. Such therapies may eventually offer hope in human BPD... - Bronchopulmonary dysplasia in preterm infants: pathophysiology and management strategiesCARL T D'ANGIO
Strong Children s Research Center, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Paediatr Drugs 6:303-30. 2004..Future research in BPD will most probably focus on continued incremental improvements in outcome, which are likely to be achieved through the combined effects of many therapeutic modalities... - Survival in early- and late-term infants with congenital diaphragmatic hernia treated with extracorporeal membrane oxygenationTimothy P Stevens
Division of Neonatology, Department of Pediatrics, Strong Children s Research Center, Golisano Children s Hospital at Strong, Rochester, New York 14642, USA
Pediatrics 110:590-6. 2002..Changes in survival rates of term infants and the factors associated with these changes were assessed over the 25 years that ECMO has been available...
Research Grants
- Regulation of Microvascular Development in BPDWilliam Maniscalco; Fiscal Year: 2006..New data from this proposal will be essential for developing novel therapies for BPD. ..