Research Topics
| Istvan J MajorosSummaryAffiliation: University of Michigan Country: USA Publications
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Detail Information
Publications
Current dendrimer applications in cancer diagnosis and therapyIstvan J Majoros
Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109 1055, USA
Curr Top Med Chem 8:1165-79. 2008..An objective review of these new technologies will detail how dendrimer-based nanodevices are advantageous over conventional medicine...- PAMAM dendrimer-based multifunctional conjugate for cancer therapy: synthesis, characterization, and functionalityIstvan J Majoros
Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, 200 Zina Pitcher Place, 4027 Kresge II, Ann Arbor, 48109 0533, USA
Biomacromolecules 7:572-9. 2006..We present here the synthesis, characterization, and functionality of these dendrimer conjugates... - Poly(amidoamine) dendrimer-based multifunctional engineered nanodevice for cancer therapyIstvan J Majoros
Center for Biologic Nanotechnology, University of Michigan, 200 Zina Pitcher Place, 4027 Kresge II, Ann Arbor, Michigan 48109 0533, USA
J Med Chem 48:5892-9. 2005..Here, we present a more extensive investigation of our previously reported synthesis of this material with improvements directed toward scale-up synthesis and clinical trials (Pharm. Res. 2002, 19 (9), 1310-1316)... - Methotrexate delivery via folate targeted dendrimer-based nanotherapeutic platformIstvan J Majoros
Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109 0533, USA
Wiley Interdiscip Rev Nanomed Nanobiotechnol 1:502-10. 2009..Throughout this paper, we will stress that the unique collaboration that facilitated the evolution of this technology is vital to the success of future developments in nanomedicine... - Targeting and inhibition of cell growth by an engineered dendritic nanodeviceThommey P Thomas
Center for Biologic Nanotechnology, University of Michigan Medical School, 9220 MSRB III, Ann Arbor, Michigan 48109 0648, USA
J Med Chem 48:3729-35. 2005..These studies show the potential of G5-FI-FA-MTX or G5-FA-MTX for targeting and growth suppression of tumor cells that overexpress FA-receptors... - Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancerJolanta F Kukowska-Latallo
University of Michigan Center for Biologic Nanotechnology, Ann Arbor, Michigan, USA
Cancer Res 65:5317-24. 2005..Targeting methotrexate increased its antitumor activity and markedly decreased its toxicity, allowing therapeutic responses not possible with a free drug... - Investigation of tumor cell targeting of a dendrimer nanoparticle using a double-clad optical fiber probeThommey P Thomas
University of Michigan, Michigan Nanotechnology Institute for Medicine and Biological Sciences, Department of Internal Medicine, Division of Allergy, 9220 MSRB III, Box 0648, Ann Arbor, Michigan 48109, USA
J Biomed Opt 13:014024. 2008..These results indicate that the TPOFF technique using the DCF probe is an appropriate tool to quantify low nanomolar concentrations of targeted fluorescent probes from deep tissue... - Folate-targeted nanoparticles show efficacy in the treatment of inflammatory arthritisThommey P Thomas
Michigan Nanotechnology Institute for Medicine and Biological Sciences, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Arthritis Rheum 63:2671-80. 2011.... - The binding avidity of a nanoparticle-based multivalent targeted drug delivery platformSeungpyo Hong
Program in Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA
Chem Biol 14:107-15. 2007..These data support the hypothesis that multivalent enhancement of K(D), not an enhanced rate of endocytosis, is the key factor resulting in the improved biological targeting by these drug delivery platforms... - The implications of stochastic synthesis for the conjugation of functional groups to nanoparticlesDouglas G Mullen
Program in Macromolecular Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
Bioconjug Chem 19:1748-52. 2008..Two statistical models were employed to confirm that the observed heterogeneity is consistent with theoretical expectations... - Dendrimer-based targeted delivery of an apoptotic sensor in cancer cellsAndrzej Myc
Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA
Biomacromolecules 8:13-8. 2007..These results show, for the first time, the potential applicability of a targeted apoptosis-measuring nanodevice, which could be used for simultaneously monitoring the apoptotic potential of a delivered drug... - The role of ganglioside GM1 in cellular internalization mechanisms of poly(amidoamine) dendrimersSeungpyo Hong
Program in Macromolecular Science and Engineering and Biophysics, University of Michigan, Ann Arbor, Michigan 48109 1055, USA
Bioconjug Chem 20:1503-13. 2009..The presence of GM(1) in the membrane also had no effect upon XTT assays of cell viability or lactate dehydrogenase (LDH) assays of membrane permeability... - HPLC analysis of PAMAM dendrimer based multifunctional devicesMohammad T Islam
University of Michigan, Center for Biologic Nanotechnology, 200 Zina Pitcher Place, 4027 Kresge II, Ann Arbor, MI 48109, USA
J Chromatogr B Analyt Technol Biomed Life Sci 822:21-6. 2005..The benchmark data can be used to optimize the physicochemical properties of the conjugates to improve drug delivery to cancer cells... - Targeted dendrimer chemotherapy in an animal model for head and neck squamous cell carcinomaBrent B Ward
Michigan Nanotechnology Institute for Medicine and Biological Sciences, and Department of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor, MI 48109, USA
J Oral Maxillofac Surg 69:2452-9. 2011.... - Diffusion of Alexa Fluor 488-conjugated dendrimers in rat aortic tissueBrenda S Cho
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA
Ann N Y Acad Sci 1085:294-305. 2006..These preliminary data provide a novel mechanism whereby local inhibitory therapy may be delivered locally to aortic tissue... - Molecular heterogeneity analysis of poly(amidoamine) dendrimer-based mono- and multifunctional nanodevices by capillary electrophoresisXiangyang Shi
Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109, USA
Analyst 131:374-81. 2006..The applied CE analysis of mono- and multifunctional PAMAM-based nanodevices provides a powerful tool to evaluate the molecular heterogeneity of complex dendrimer conjugate nanodevices for targeted cancer therapeutics... - Dendritic polymer macromolecular carriers for drug deliveryAnil K Patri
Center for Biologic Nanotechnology, Department of Internal Medicine, 9220C MSRB III, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109-0648, USA
Curr Opin Chem Biol 6:466-71. 2002..Properties associated with these dendrimers such as uniform size, water solubility, modifiable surface functionality and available internal cavities make them attractive for biological and drug-delivery applications... - Capillary electrophoresis of poly(amidoamine) dendrimers: from simple derivatives to complex multifunctional medical nanodevicesXiangyang Shi
Center for Biologic Nanotechnology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
Mol Pharm 2:278-94. 2005....