Research Topics
| MAHIN MAINESSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
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Detail Information
Publications
Spin trap (N-t-butyl-alpha-phenylnitrone)-mediated suprainduction of heme oxygenase-1 in kidney ischemia/reperfusion model: role of the oxygenase in protection against oxidative injuryM D Maines
Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14642 0001, USA
J Pharmacol Exp Ther 291:911-9. 1999..We also suggest spin trap-mediated protection against ischemia/reperfusion injury is likely due to a sustained elevation of HO-1 gene expression by formation of stable radicals...- Potential application of biliverdin reductase and its fragments to modulate insulin/IGF-1/MAPK/PI3-K signaling pathways in therapeutic settingsMahin D Maines
Department of Biochemistry and Biophysics, University of Rochester School of Medicine, Rochester, New York 14642, USA
Curr Drug Targets 11:1586-94. 2010..This, points to a realistic prospect of their use in clinical settings. The present review will briefly update cytoprotective activity and cytotoxicity of bile pigments and will focus on findings that link hBVR to cell signaling... - Biliverdin reductase: PKC interaction at the cross-talk of MAPK and PI3K signaling pathwaysMahin D Maines
Department of Biochemistry and Biophysics, University of Rochester School of Medicine, Rochester, New York 14642, USA
Antioxid Redox Signal 9:2187-95. 2007..Structural features of BVR and recent findings relevant to its function in cell-signaling pathways are reviewed here and are intended to complement a recent commentary on the role of BVR in linking heme metabolism and cell signaling... - Human biliverdin reductase, a previously unknown activator of protein kinase C betaIIMahin D Maines
Department of Biochemistry and Biophysics, University of Rochester School of Medicine, Rochester, New York 14624, USA
J Biol Chem 282:8110-22. 2007..hBVR activation of PKC betaII underscores its potential function in propagation of signals relayed through PKCs... - The heme oxygenase system: update 2005Mahin D Maines
Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14624, USA
Antioxid Redox Signal 7:1761-6. 2005 - New insights into biliverdin reductase functions: linking heme metabolism to cell signalingMahin D Maines
Department of Biochemistry and Biophysics, University of Rochester Medical Center, New York, USA
Physiology (Bethesda) 20:382-9. 2005..These, together with the protein's primary and secondary features, intimately link BVR to the entire spectrum of cell-signaling cascades... - 30 some years of heme oxygenase: from a "molecular wrecking ball" to a "mesmerizing" trigger of cellular eventsMahin D Maines
University of Rochester Medical Center, Department of Biochemistry and Biophysics, 601 Elmwood Avenue Rochester, NY 14624, USA
Biochem Biophys Res Commun 338:568-77. 2005..This review is a compilation of certain older findings and recent events that together ensure placement of the HO system in the mainstream research for decades to come... - Bile pigments: newcomers to the cell signaling arenaMahin D Maines
University of Rochester Medical Center, Department of Biochemistry and Biophysics, 601 Elmwood Ave, Box 712, Rochester, NY 14620 2945, USA
Toxicol Sci 71:9-10. 2003..Tuomisto, Seppo Auriola, Raimo Pohjanvirta, Paula Syrjälä, Ulla Simanainen, Matti Viluksela, and Jouko Tuomisto (pp. 112-123)... - The heme oxygenase system and its functions in the brainM D Maines
University of Rochester Medical Center, Department of Biochemistry Biophysics, New York 14642, USA
Cell Mol Biol (Noisy-le-grand) 46:573-85. 2000..The present review is intended to highlight molecular properties of HO isozymes and their likely functions in the brain. Extended reviews of the system are found in Maines (1992, 1997)... - Nuclear localization of biliverdin reductase in the rat kidney: response to nephrotoxins that induce heme oxygenase-1M D Maines
Department of Biochemistry and Biophysics, University of Rochester School of Medicine, Rochester, New York 14642, USA
J Pharmacol Exp Ther 296:1091-7. 2001.... - Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cellsTihomir Miralem
Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, New York 14624, USA
J Biol Chem 280:17084-92. 2005..The findings describe the function of BVR in HO-1 oxidative response and, demonstrate, for the first time, not only that BVR advances the role of HO-1 in cytoprotection but also affords cytoprotection independent of heme degradation... - Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signalingNicole Lerner-Marmarosh
University of Rochester School of Medicine, Department of Biochemistry and Biophysics, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 105:6870-5. 2008.... - Biliverdin inhibits activation of NF-kappaB: reversal of inhibition by human biliverdin reductasePeter E M Gibbs
Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
Int J Cancer 121:2567-74. 2007..On the other hand, by increasing BVR levels beneficial functions of NF-kappaB might be augmented... - Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1Anatoliy Kravets
Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Biol Chem 279:19916-23. 2004..We propose that increased expression of the protein can be used to alter the gene expression profile in the cell... - Characterization of the human biliverdin reductase gene structure and regulatory elements: promoter activity is enhanced by hypoxia and suppressed by TNF-alpha-activated NF-kappaBPeter E M Gibbs
Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
FASEB J 24:3239-54. 2010.... - Human biliverdin reductase: a member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activityNicole Lerner-Marmarosh
Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14624, USA
Proc Natl Acad Sci U S A 102:7109-14. 2005.... - Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductaseNicole Lerner Marmarosh
University of Rochester School of Medicine and Dentistry, Department of Biochemistry and Biophysics, 601 Elmwood Avenue, Rochester, NY 14642, USA
FASEB J 21:3949-62. 2007..The findings are of potential significance for development of modulators of PKC-zeta activity and cellular response to cytokines... - Human biliverdin reductase suppresses Goodpasture antigen-binding protein (GPBP) kinase activity: the reductase regulates tumor necrosis factor-alpha-NF-kappaB-dependent GPBP expressionTihomir Miralem
Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Biol Chem 285:12551-8. 2010..Collectively, our data reveal that hBVR is a regulator of the TNF-alpha-GPBP-collagen type IV signaling cascade and uncover a novel biological interaction that may be of relevance in autoimmune pathogenesis... - Human biliverdin reductase is a leucine zipper-like DNA-binding protein and functions in transcriptional activation of heme oxygenase-1 by oxidative stressZulfiqar Ahmad
Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Biol Chem 277:9226-32. 2002..We propose a role for BVR in the signaling cascade for AP-1 complex activation necessary for HO-1 oxidative stress response... - The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters ?-adrenergic receptor ligand-mediated cardiac dysfunctionBo Ding
University of Rochester School of Medicine and Dentistry, Department of Biochemistry and Biophysics, Rochester, NY 14642, USA
FASEB J 25:301-13. 2011..Finding that BVR and HO-2 levels, myocyte apoptosis, and contractile function of the heart can be modulated by small human BVR-based peptides offers a promising therapeutic approach for treatment of cardiac dysfunctions... - Nitric oxide inhibitor N omega -nitro-l-arginine methyl ester potentiates induction of heme oxygenase-1 in kidney ischemia/reperfusion model: a novel mechanism for regulation of the oxygenaseRobert D Mayer
Department of Urology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Pharmacol Exp Ther 306:43-50. 2003..Inhibition of NOS is potentially useful for sustained induction of HO-1 in organs that will be subjected to oxidative-stress insult... - Biliverdin reductase is a transporter of haem into the nucleus and is essential for regulation of HO-1 gene expression by haematinCicerone Tudor
Laboratory of Biomolecular Dynamics, Katholieke Universiteit Leuven, Leuven, Belgium
Biochem J 413:405-16. 2008..Because gene regulation is energy-dependent and haematin regulates gene expression, our data suggest that hBVR functions as an essential component of the regulatory mechanisms for haem-responsive transcriptional activation... - Crystal structure of a biliverdin IXalpha reductase enzyme-cofactor complexFrank G Whitby
Department of Biochemistry, University of Utah School of Medicine, 50 N Medical Drive, Salt Lake City 84132, USA
J Mol Biol 319:1199-210. 2002..This finding suggests that the dominant role in catalysis may be performed by hydride transfer from the cofactor, a process that may be promoted by proximity of the invariant residues Glu96, Glu123, and Glu126, to the nicotinamide ring... - Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: relevance to brain aging, neurodegenerative disorders, and longevityVittorio Calabrese
Section of Biochemistry and Molecular Biology, Department of Chemistry, Faculty of Medicine, University of Catania, Catania, Italy
Antioxid Redox Signal 8:444-77. 2006.... - Antiaging medicine: antioxidants and agingVittorio Calabrese
Antioxid Redox Signal 8:362-4. 2006 - The heme oxygenase system: past, present, and futureMahin D Maines
Antioxid Redox Signal 6:797-801. 2004
Research Grants
- Regulation of Cell Signaling by Human Biliverdin ReductaseMahin D Maines; Fiscal Year: 2011..In addition, the enzyme activity is necessary for protection against the fatal "green jaundice". Our work has revealed a novel approach for development of therapeutic interventions in a range of human diseases. ..
- Protective Role of Heme Oxygenase in Ischemic BrainMAHIN MAINES; Fiscal Year: 2005..Genes will be delivered by CSF or by intracarotid route and the same indeces will be evaluated. ..
- ACTIVITIES OF BILIVERDIN REDUCTASE-EFFECT OF NEPHROTOXINMAHIN MAINES; Fiscal Year: 2004..4) To isolate the human BVR gene, characterize its promoter region and analyze its regulation by various toxins and effector agents. ..
- Regulation of heme oxygenase-1 by biliverdin reductaseMAHIN MAINES; Fiscal Year: 2006..H202 will be utilized as the generator of 02 radicals. COS cells transfected with adenoviral vectors of effectors or their mutated counterparts will be used as the experimental model. ..
- Regulation of Cell Signaling by Human Biliverdin ReductaseMahin D Maines; Fiscal Year: 2011..In addition, the enzyme activity is necessary for protection against the fatal "green jaundice". Our work has revealed a novel approach for development of therapeutic interventions in a range of human diseases. ..
- Regulation of heme oxygenase-1 by biliverdin reductaseMAHIN MAINES; Fiscal Year: 2009..Liver will serve as the non-target organ as control for the expression of the transgene. ..
- Regulation of heme oxygenase-1 by biliverdin reductaseMahin D Maines; Fiscal Year: 2010..Liver will serve as the non-target organ as control for the expression of the transgene. ..
- Regulation of Cell Signaling by Human Biliverdin ReductaseMahin D Maines; Fiscal Year: 2010..For this, mice null for BVR gene will be generated to examine effects of phenylhydrazine and As (III), which are diabetogenic and promote cell death, on glucose metabolism and apoptosis. ..
- Regulation of heme oxygenase-1 by biliverdin reductaseMAHIN MAINES; Fiscal Year: 2009..Liver will serve as the non-target organ as control for the expression of the transgene. ..
- Regulation of Cell Signaling by Human Biliverdin ReductaseMAHIN MAINES; Fiscal Year: 2009..For this, mice null for BVR gene will be generated to examine effects of phenylhydrazine and As (III), which are diabetogenic and promote cell death, on glucose metabolism and apoptosis. ..
- Heme Oxygenase-Regulation, Function&Clinical ApplicationMAHIN MAINES; Fiscal Year: 2003....
- MULTIPLE FORMS OF HEME OXYGENASE--REGULATION BY TOXINSMAHIN MAINES; Fiscal Year: 2001..The nature of the second HO-2 immunoreactive protein in GC-treated rat testis also will be investigated. ..
- BILIVERDIN REDUCTASE--MULTIPLICITY AND CONTROL BY TOXINMAHIN MAINES; Fiscal Year: 1999..Isolated protein, macrophages, hippocampal slices, and intact rats will be used. ..
- BILIVERDIN REDUCTASE: MULTIPLICITY & CONTROL BY TOXINSMAHIN MAINES; Fiscal Year: 1993..6) To examine whether the phenomenon of multiplicity extends to human tissues and other rat organs (brain and testes)...