M MacKiewicz

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Activity of adenosine deaminase in the sleep regulatory areas of the rat CNS
    M MacKiewicz
    Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    Brain Res Mol Brain Res 80:252-5. 2000
  2. ncbi Analysis of the QTL for sleep homeostasis in mice: Homer1a is a likely candidate
    M MacKiewicz
    Department of Medicine, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Translational Research Laboratories, Philadelphia, PA 19104 3403, USA
    Physiol Genomics 33:91-9. 2008
  3. ncbi Macromolecule biosynthesis: a key function of sleep
    Miroslaw Mackiewicz
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 3403, USA
    Physiol Genomics 31:441-57. 2007
  4. ncbi Age-related changes in adenosine metabolic enzymes in sleep/wake regulatory areas of the brain
    Miroslaw Mackiewicz
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 991 Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104 4283, USA
    Neurobiol Aging 27:351-60. 2006
  5. ncbi Enzymes of adenosine metabolism in the brain: diurnal rhythm and the effect of sleep deprivation
    Miroslaw Mackiewicz
    Center for Sleep and Respiratory Neurobiology, Division of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurochem 85:348-57. 2003
  6. ncbi Simultaneous assessment of ecto- and cytosolic-5'-nucleotidase activities in brain micropunches
    M MacKiewicz
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 3600 Spruce Street, 991 Maloney Building, Philadelphia, PA 19104 4283, USA
    J Neurosci Methods 104:9-18. 2000
  7. ncbi Glycogen in the brain of Drosophila melanogaster: diurnal rhythm and the effect of rest deprivation
    John E Zimmerman
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    J Neurochem 88:32-40. 2004
  8. ncbi Multiple mechanisms limit the duration of wakefulness in Drosophila brain
    John E Zimmerman
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Physiol Genomics 27:337-50. 2006
  9. ncbi Molecular mechanisms of sleep and wakefulness
    Miroslaw Mackiewicz
    Center for Sleep and Respiratory Neurobiology, Division of Sleep Medicine Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann N Y Acad Sci 1129:335-49. 2008
  10. ncbi Alpha(1B) receptors are the main postsynaptic mediators of adrenergic excitation in brainstem motoneurons, a single-cell RT-PCR study
    D V Volgin
    Department of Animal Biology 205ED/VET, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104-6046, USA
    J Chem Neuroanat 22:157-66. 2001

Collaborators

Detail Information

Publications15

  1. ncbi Activity of adenosine deaminase in the sleep regulatory areas of the rat CNS
    M MacKiewicz
    Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    Brain Res Mol Brain Res 80:252-5. 2000
    ..We postulate that adenosine deaminase plays an important role in the mechanism that controls regional concentration of adenosine in the brain and thus, it is a part of the sleep-wake regulatory mechanism...
  2. ncbi Analysis of the QTL for sleep homeostasis in mice: Homer1a is a likely candidate
    M MacKiewicz
    Department of Medicine, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Translational Research Laboratories, Philadelphia, PA 19104 3403, USA
    Physiol Genomics 33:91-9. 2008
    ..The strongest candidate gene is Homer1a, which is supported by expression differences between sleep and wakefulness and the SNP polymorphism in the upstream regulatory regions...
  3. ncbi Macromolecule biosynthesis: a key function of sleep
    Miroslaw Mackiewicz
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 3403, USA
    Physiol Genomics 31:441-57. 2007
    ..We postulate that during sleep there is a rebuilding of multiple key cellular components in preparation for subsequent wakefulness...
  4. ncbi Age-related changes in adenosine metabolic enzymes in sleep/wake regulatory areas of the brain
    Miroslaw Mackiewicz
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 991 Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104 4283, USA
    Neurobiol Aging 27:351-60. 2006
    ..An increase in the activity of 5'-nucleotideases with age likely leads to an increase in adenosine levels in the brain...
  5. ncbi Enzymes of adenosine metabolism in the brain: diurnal rhythm and the effect of sleep deprivation
    Miroslaw Mackiewicz
    Center for Sleep and Respiratory Neurobiology, Division of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurochem 85:348-57. 2003
    ..In contrast, we found no changes specifically with sleep deprivation in the activity of any enzyme in any brain region. Thus, changes in adenosine with sleep deprivation are not a consequence of alterations in adenosine enzyme activity...
  6. ncbi Simultaneous assessment of ecto- and cytosolic-5'-nucleotidase activities in brain micropunches
    M MacKiewicz
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 3600 Spruce Street, 991 Maloney Building, Philadelphia, PA 19104 4283, USA
    J Neurosci Methods 104:9-18. 2000
    ..The level of both enzymes was significantly lower in the cerebral cortex than other brain regions tested...
  7. ncbi Glycogen in the brain of Drosophila melanogaster: diurnal rhythm and the effect of rest deprivation
    John E Zimmerman
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    J Neurochem 88:32-40. 2004
    ..0001 and p<0.0001, respectively). Glycogen in the fly brain changes in relationship to rest and activity and demonstrates a biphasic response to rest deprivation similar to that observed in mammalian astrocytes in culture...
  8. ncbi Multiple mechanisms limit the duration of wakefulness in Drosophila brain
    John E Zimmerman
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Physiol Genomics 27:337-50. 2006
    ....
  9. ncbi Molecular mechanisms of sleep and wakefulness
    Miroslaw Mackiewicz
    Center for Sleep and Respiratory Neurobiology, Division of Sleep Medicine Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann N Y Acad Sci 1129:335-49. 2008
    ..Identification of genes regulating sleep has the potential for translational studies to elucidate the genetics of sleep and response to sleep deprivation in humans...
  10. ncbi Alpha(1B) receptors are the main postsynaptic mediators of adrenergic excitation in brainstem motoneurons, a single-cell RT-PCR study
    D V Volgin
    Department of Animal Biology 205ED/VET, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104-6046, USA
    J Chem Neuroanat 22:157-66. 2001
    ..We conclude that postsynaptic effects of NE in XII motoneurons are primarily mediated by alpha(1B) receptors; the effects ascribed to alpha(2) and/or beta adrenoceptors may be exerted presynaptically...
  11. ncbi Molecular signatures of obstructive sleep apnea in adults: a review and perspective
    Erna S Arnardottir
    Center for Sleep and Respiratory Neurobiology, Division of Sleep Medicine Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Sleep 32:447-70. 2009
    ..Such changes will be at least partly a consequence of chronic intermittent hypoxia and sleep fragmentation that occurs during sleep...
  12. ncbi What are microarrays teaching us about sleep?
    Miroslaw Mackiewicz
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Trends Mol Med 15:79-87. 2009
    ..In human studies, microarrays are being applied to the identification of biomarkers for sleepiness and for the common debilitating condition of obstructive sleep apnea...
  13. ncbi Functional genomics of sleep
    Miroslaw Mackiewicz
    Department of Medicine, Division of Sleep Medicine, Center for Sleep and Respiratory Neurobiology, Hospital of the University of Pennsylvania, 991 Maloney Building, Philadelphia, PA 19104-4283, USA
    Respir Physiol Neurobiol 135:207-20. 2003
    ..The concepts outlined here for the functional genomics of sleep are applicable to respiration research...
  14. ncbi Single cell laser dissection with molecular beacon polymerase chain reaction identifies 2A as the predominant serotonin receptor subtype in hypoglossal motoneurons
    G Zhan
    Center for Sleep and Respiratory Neurobiology, 972 Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104, USA
    Neuroscience 113:145-54. 2002
    ..This information will allow a more complete understanding of serotonergic control of respiratory activity...
  15. ncbi AMP-activated protein kinase phosphorylation in brain is dependent on method of killing and tissue preparation
    Matthew T Scharf
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 3403, USA
    J Neurochem 105:833-41. 2008
    ..These results demonstrate that alpha-AMPK phosphorylation is dependent on method of killing and tissue preparation and that alpha-AMPK phosphorylation can increase in a manner that does not reflect biological alterations...