G A MacGowan

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Clinical overview of the novel inotropic agent toborinone
    G A MacGowan
    Cardiovascular Institute of the University of Pittsburgh Medical Center, S550 Scaife Hall, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Expert Opin Investig Drugs 9:1109-17. 2000
  2. ncbi Ischemic dysfunction in transgenic mice expressing troponin I lacking protein kinase C phosphorylation sites
    G A MacGowan
    Pittsburgh Nuclear Magnetic Resonance Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Heart Circ Physiol 280:H835-43. 2001
  3. ncbi Rhod-2 based measurements of intracellular calcium in the perfused mouse heart: cellular and subcellular localization and response to positive inotropy
    G A MacGowan
    University of Pittsburgh Medical Center, Cardiovascular Institute, NMR Institute for Biomedical Research, Pennsylvania 15213, USA
    J Biomed Opt 6:23-30. 2001
  4. ncbi New molecular insights into heart failure and cardiomyopathy: potential strategies and therapies
    G A MacGowan
    Cardiovascular Institute, University of Pittsburgh School of Medicine, PA 15213, USA
    Ir J Med Sci 171:99-104. 2002
  5. ncbi High calcium and dobutamine positive inotropy in the perfused mouse heart: myofilament calcium responsiveness, energetic economy, and effects of protein kinase C inhibition
    G A MacGowan
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    BMC Physiol 1:12. 2001
  6. ncbi Compensatory changes in Ca(2+) and myocardial O(2) consumption in beta-tropomyosin transgenic hearts
    G A MacGowan
    Cardiovascular Institute of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Heart Circ Physiol 281:H2539-48. 2001
  7. ncbi Calcium measurements in perfused mouse heart: quantitating fluorescence and absorbance of Rhod-2 by application of photon migration theory
    C Du
    Center for Light Microscope Imaging and Biotechnology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Biophys J 80:549-61. 2001
  8. ncbi Calibration of the calcium dissociation constant of Rhod(2)in the perfused mouse heart using manganese quenching
    C Du
    NSF Center for Light Microscope Imaging and Biotechnology, Carnegie Mellon University, Pittsburgh, PA, USA
    Cell Calcium 29:217-27. 2001
  9. ncbi Manganese-enhanced MRI of mouse heart during changes in inotropy
    T C Hu
    Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
    Magn Reson Med 46:884-90. 2001
  10. ncbi Exercise-related ventilatory abnormalities are more specific for functional impairment in chronic heart failure than reduction in peak exercise oxygen consumption
    G A MacGowan
    Cardiovascular Institute of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Heart Lung Transplant 20:1167-73. 2001

Research Grants

  1. MODULATING ENERGETIC EFFICIENCY OF THE INOTROPIC STATE
    Guy Macgowan; Fiscal Year: 2003

Collaborators

Detail Information

Publications25

  1. ncbi Clinical overview of the novel inotropic agent toborinone
    G A MacGowan
    Cardiovascular Institute of the University of Pittsburgh Medical Center, S550 Scaife Hall, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Expert Opin Investig Drugs 9:1109-17. 2000
    ..Data regarding safety in larger clinical trials, particularly regarding arrhythmias, is at present unavailable. This information will determine whether this agent becomes an accepted iv. therapeutic option for congestive heart failure...
  2. ncbi Ischemic dysfunction in transgenic mice expressing troponin I lacking protein kinase C phosphorylation sites
    G A MacGowan
    Pittsburgh Nuclear Magnetic Resonance Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Heart Circ Physiol 280:H835-43. 2001
    ..The reduced intracellular calcium and prolonged calcium transients suggests that a potent feedback mechanism exists between the myofilament and the processes controlling calcium homeostasis...
  3. ncbi Rhod-2 based measurements of intracellular calcium in the perfused mouse heart: cellular and subcellular localization and response to positive inotropy
    G A MacGowan
    University of Pittsburgh Medical Center, Cardiovascular Institute, NMR Institute for Biomedical Research, Pennsylvania 15213, USA
    J Biomed Opt 6:23-30. 2001
    ..Thus, this appears a valid method of measuring cytosolic calcium in the perfused mouse heart, which will help determine the mechanisms of altered contractility in genetically engineered mice...
  4. ncbi New molecular insights into heart failure and cardiomyopathy: potential strategies and therapies
    G A MacGowan
    Cardiovascular Institute, University of Pittsburgh School of Medicine, PA 15213, USA
    Ir J Med Sci 171:99-104. 2002
    ..While therapies are largely aimed at attenuating neurohumoral responses recent molecular insights reveal other potential targets for therapy...
  5. ncbi High calcium and dobutamine positive inotropy in the perfused mouse heart: myofilament calcium responsiveness, energetic economy, and effects of protein kinase C inhibition
    G A MacGowan
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    BMC Physiol 1:12. 2001
    ..Calcium handling is an important determinant of myocardial oxygen consumption. Therefore, we hypothesized that this phenomenon was due to reduced myofilament responsiveness to calcium, related to protein kinase C activation...
  6. ncbi Compensatory changes in Ca(2+) and myocardial O(2) consumption in beta-tropomyosin transgenic hearts
    G A MacGowan
    Cardiovascular Institute of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Heart Circ Physiol 281:H2539-48. 2001
    ..Because pressures are normal and intracellular Ca(2+) decreased and myocardial O(2) consumption increased, this suggests that these abnormalities are at least in part compensatory mechanisms to the altered myofilament function...
  7. ncbi Calcium measurements in perfused mouse heart: quantitating fluorescence and absorbance of Rhod-2 by application of photon migration theory
    C Du
    Center for Light Microscope Imaging and Biotechnology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Biophys J 80:549-61. 2001
    ..Methods to effectively minimize motion-induced artifacts and to monitor the oxygenation status of the whole perfused heart are also discussed...
  8. ncbi Calibration of the calcium dissociation constant of Rhod(2)in the perfused mouse heart using manganese quenching
    C Du
    NSF Center for Light Microscope Imaging and Biotechnology, Carnegie Mellon University, Pittsburgh, PA, USA
    Cell Calcium 29:217-27. 2001
    ..This is in good agreement with values obtained by calibration of fluorescence values with a calcium saturation tetanization procedure in the same perfused mouse heart model...
  9. ncbi Manganese-enhanced MRI of mouse heart during changes in inotropy
    T C Hu
    Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
    Magn Reson Med 46:884-90. 2001
    ..Thus, the simultaneous measurement of global function and calcium influx using MEMRI may provide a useful method of evaluating in vivo responses to inotropic therapy...
  10. ncbi Exercise-related ventilatory abnormalities are more specific for functional impairment in chronic heart failure than reduction in peak exercise oxygen consumption
    G A MacGowan
    Cardiovascular Institute of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Heart Lung Transplant 20:1167-73. 2001
    ..The purpose of this study was to test the hypothesis that ventilatory abnormalities during exercise, rather than functional capacity, are specific to congestive heart failure patients...
  11. ncbi Pharmacogenetic interactions between beta-blocker therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure
    D M McNamara
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Circulation 103:1644-8. 2001
    ....
  12. ncbi The myofilament force-calcium relationship as a target for positive inotropic therapy in congestive heart failure
    Guy A MacGowan
    Dept of Cardiology, Freeman Hospital and University of Newcastle upon Tyne, Newcastle upon Tyne NE7 7DN, United Kingdom
    Cardiovasc Drugs Ther 19:203-10. 2005
    ....
  13. ncbi In vivo alpha-adrenergic responses and troponin I phosphorylation: anesthesia interactions
    Guy A MacGowan
    Freeman Hospital, Dept of Cardiology, Newcastle upon Tyne NE7 7DN, UK
    J Appl Physiol 98:1163-70. 2005
    ..Thus choice of a negative inotropic anesthetic agent (avertin) with phenylephrine can lead to profound contractile dysfunction...
  14. ncbi Pharmacogenetic interactions between angiotensin-converting enzyme inhibitor therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure
    Dennis M McNamara
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Am Coll Cardiol 44:2019-26. 2004
    ..We evaluated the interaction of angiotensin-converting enzyme (ACE) inhibitor therapy with the effect of the ACE D/I polymorphism on heart failure survival...
  15. ncbi Interaction of implantable defibrillator therapy with angiotensin-converting enzyme deletion/insertion polymorphism
    Maninder S Bedi
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213-2582, USA
    J Cardiovasc Electrophysiol 15:1162-6. 2004
    ..This finding suggests that mortality in this high-risk genetic subset of patients is due to progression of heart failure rather than arrhythmic sudden death...
  16. ncbi Effect of the TNF-alpha-promoter polymorphism on cardiac allograft rejection
    Maninder Bedi
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Heart Lung Transplant 23:696-700. 2004
    ..We examined the effect of the TNFA2 allele on the risk of allograft rejection in adult cardiac transplant recipients...
  17. ncbi Troponin I protein kinase C phosphorylation sites and ventricular function
    Guy A MacGowan
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cardiovasc Res 63:245-55. 2004
    ..We postulated that there would be greater Ca2+-dependent changes in ventricular function in hearts of cTnI transgenic (TG) mice expressing mutant troponin I lacking PKC sites compared to wild-type (WT)...
  18. ncbi Selected patients listed for cardiac transplantation may benefit from defibrillator implantation regardless of an established indication
    Samir Saba
    Electrophysiology Division of the Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Heart Lung Transplant 22:411-8. 2003
    ..End-stage heart failure (HF) patients are at high risk of sudden cardiac death. This study evaluates the role of implantable cardiac defibrillators (ICDs) in HF patients awaiting cardiac transplantation...
  19. ncbi Effect of the Asp298 variant of endothelial nitric oxide synthase on survival for patients with congestive heart failure
    Dennis M McNamara
    Heart Failure Section, Cardiovascular Institute, University of Pittsburgh Medical Center, 558 Scaife Hall, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Circulation 107:1598-602. 2003
    ..Given the importance of nitric oxide in the heart failure syndrome, we evaluated the effect of this variant on event-free survival in a population with systolic dysfunction...
  20. ncbi Impact of beta-blocker therapy on functional capacity criteria for heart transplant listing
    Amar L Pohwani
    Cardiovascular Institute, Pittsburgh, Pennsylvania, USA
    J Heart Lung Transplant 22:78-86. 2003
    ..Alternatively, non-usage of beta-blockers may be a criterion to list for transplantation...
  21. ncbi Decreasing motion artifacts in calcium-dependent fluorescence transients from the perfused mouse heart using frequency filtering
    Congwu Du
    Medical Department, Brookhaven National Laboratory, Upton, NY 11794, USA
    Cell Calcium 35:141-53. 2004
    ....
  22. ncbi What is the in vivo mechanism of action of levosimendan?
    Guy A MacGowan
    J Card Fail 11:482; author reply 482-3. 2005
  23. ncbi Clinical importance of beta-adrenoceptor polymorphisms in cardiovascular disease
    Dennis M McNamara
    Department of Medicine, Heart Failure Section, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
    Am J Pharmacogenomics 2:73-8. 2002
    ..Importantly, the pharmacogenetic impact of these variants on the effectiveness of beta-adrenergic blockade remains unknown...
  24. ncbi Pressure-calcium relationships in perfused mouse hearts
    Guy A MacGowan
    Cardiovascular Institute, University of Pittsburgh, 749 Benedum Hall, Pittsburgh, PA 15261, USA
    Am J Physiol Heart Circ Physiol 290:H2614-24. 2006
    ..Additionally, unlike other mammalian species, load-dependent prolongation of pressure relaxation is absent in the mouse heart, and pressure relaxation is primarily governed by intracellular free calcium relaxation...
  25. ncbi Dynamic analysis of exercise oxygen consumption predicts outcomes in advanced heart failure
    Guy A MacGowan
    Freeman Hospital, Newcastle upon Tyne, UK
    Congest Heart Fail 13:313-8. 2007
    ....

Research Grants1

  1. MODULATING ENERGETIC EFFICIENCY OF THE INOTROPIC STATE
    Guy Macgowan; Fiscal Year: 2003
    ..In this submission, a program of didactic training, mentorship, and research development is proposed, structured to develop the candidate's research training to eventual full independent status. ..