Research Topics
Genomes and Genes | Xinrong MaSummaryAffiliation: University of Maryland Country: USA Publications
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Publications
Promoter methylation regulates cyclooxygenase expression in breast cancerXinrong Ma
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA
Breast Cancer Res 6:R316-21. 2004..Aberrant CpG island methylation, and subsequent silencing of the COX-2 promoter, has been observed in human cancer cell lines and in some human tumors of the gastrointestinal tract...
Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancerTonya C Walser
Department of Pathology, University of Maryland School of Medicine, 10 South Pine Street, Baltimore, MD 21201, USA
Cancer Res 66:7701-7. 2006..These studies also indicate for the first time that a small molecular weight antagonist of CXCR3 has the potential to inhibit tumor metastasis...
CXCR3 expression is associated with poor survival in breast cancer and promotes metastasis in a murine modelXinrong Ma
University of Maryland Greenebaum Cancer Center, Department of Pathology, School of Medicine, 9th Floor, 655 West Baltimore Street, Baltimore, MD 21201, USA
Mol Cancer Ther 8:490-8. 2009..These studies support the continued examination of CXCR3 as a potential therapeutic target in patients with breast cancer...
Immune-mediated modulation of breast cancer growth and metastasis by the chemokine Mig (CXCL9) in a murine modelTonya C Walser
Department of Pathology, University of Maryland School of Medicine, 10 South Pine Street, Baltimore, MD 21201, USA
J Immunother 30:490-8. 2007..These studies also implicate host NK cells as an additional effector cell critical for Mig-mediated control of metastasis...
Antagonism of the prostaglandin E receptor EP4 inhibits metastasis and enhances NK functionNamita Kundu
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Breast Cancer Res Treat 117:235-42. 2009....
Prostaglandin E receptor EP4 antagonism inhibits breast cancer metastasisXinrong Ma
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Cancer Res 66:2923-7. 2006..These studies support the hypothesis that EP receptor antagonists may be an alternative approach to the use of COX inhibitors to prevent tumor metastasis...
Prostaglandin E receptor EP1 suppresses breast cancer metastasis and is linked to survival differences and cancer disparitiesXinrong Ma
University of Maryland, Greenebaum Cancer Center, Baltimore, MD 21201, USA
Mol Cancer Res 8:1310-8. 2010..04). These studies support the hypothesis that EP1 functions as a metastasis suppressor and that loss of nuclear EP1 is associated with poorer overall survival and may contribute to disparities in outcome in different populations...
Targeting prostaglandin E EP receptors to inhibit metastasisAmy M Fulton
Department of Pathology and Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Cancer Res 66:9794-7. 2006..These initial results indicate that selective targeting of individual EP receptors should be investigated as an approach to exploit the high COX-2 activity in many epithelial malignancies...
Antimetastatic activity isolated from Colocasia esculenta (taro)Namita Kundu
Marlene and Stewart Greenebaum Cancer Center, Baltimore, Maryland 21201, USA
Anticancer Drugs 23:200-11. 2012..This is the first report describing compound(s) derived from taro that potently and specifically inhibits tumor metastasis...
Prostaglandin E(2) (PGE (2)) suppresses natural killer cell function primarily through the PGE(2) receptor EP4Dawn Holt
Department of Pathology, School of Medicine, University of Maryland, Baltimore, USA
Cancer Immunol Immunother 60:1577-86. 2011....
Cyclooxygenase inhibitors modulate NK activities that control metastatic diseaseNamita Kundu
Department of Pathology, University of Maryland, 10 S. Pine St, Baltimore, MD 21201, USA
Cancer Immunol Immunother 54:981-7. 2005..Taken together, these findings are consistent with a mechanism not previously described, whereby COX inhibitors may relieve MHC-mediated inhibition of NK cytotoxicity leading to recognition and lysis of metastatic tumor cells...
