Yuan Luo

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans
    Astrid Gutierrez-Zepeda
    Department of Biological Sciences, University of Southern Mississippi, Hattiesburg, MS 39406, USA
    BMC Neurosci 6:54. 2005
  2. ncbi Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans
    Marishka K Brown
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA
    BMC Neurosci 10:62. 2009
  3. ncbi Antidepressants are a rational complementary therapy for the treatment of Alzheimer's disease
    Marwa Aboukhatwa
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 N Pine St, Baltimore, MD 21201, USA
    Mol Neurodegener 5:10. 2010
  4. ncbi Behavioral phenotyping of a transgenic Caenorhabditis elegans expressing neuronal amyloid-beta
    Laura E Dosanjh
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    J Alzheimers Dis 19:681-90. 2010
  5. ncbi Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans
    Yanjue Wu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 26:13102-13. 2006
  6. ncbi Heat shock treatment reduces beta amyloid toxicity in vivo by diminishing oligomers
    Yanjue Wu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    Neurobiol Aging 31:1055-8. 2010
  7. ncbi Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathways
    Young Beob Yu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, United States of America
    PLoS ONE 5:e9339. 2010
  8. ncbi Intestinal and blood-brain barrier permeability of ginkgolides and bilobalide: in vitro and in vivo approaches
    Vamsi L M Madgula
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Planta Med 76:599-606. 2010
  9. ncbi Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons
    Flaubert Tchantchou
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA
    J Alzheimers Dis 18:787-98. 2009
  10. ncbi Beneficial effects of natural antioxidants EGCG and alpha-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans
    Marishka K Brown
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 N. Pine St, PH501, Baltimore, MD 21201, USA
    Pharmacol Biochem Behav 85:620-8. 2006

Research Grants

  1. Mechanisms of Ginkgo biloba Neuropotection
    Yuan Luo; Fiscal Year: 2004
  2. In vivo Studies of Ginkgo biloba Neuroprotection
    Yuan Luo; Fiscal Year: 2007
  3. In vivo Studies of Ginkgo biloba Neuroprotection
    Yuan Luo; Fiscal Year: 2007

Collaborators

  • Marishka K Brown
  • WILLIAM KLEIN
  • CHRISTOPHER LINK
  • Yanjue Wu
  • Zhiming Cao
  • Yanan Xu
  • Young Beob Yu
  • Flaubert Tchantchou
  • Yves Christen
  • Zhixin Wu
  • Laura Dosanjh
  • Vamsi L M Madgula
  • Laura E Dosanjh
  • Marwa Aboukhatwa
  • Lixing Lao
  • Changhai Cui
  • Ikhlas Khan
  • Astrid Gutierrez-Zepeda
  • Scott Fisher
  • Bharathi Avula
  • Shabana I Khan
  • Gautam Rao
  • Bum Sang Shim
  • Ming Tan
  • Ikhlas A Khan
  • Yan Hong Wang
  • Yan Hou
  • Pascale N Lacor
  • Kenneth Curry
  • Cheuk Pang
  • Peter Butko
  • Mary P Lambert
  • Baolu Zhao
  • Ross Santell

Detail Information

Publications13

  1. ncbi Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans
    Astrid Gutierrez-Zepeda
    Department of Biological Sciences, University of Southern Mississippi, Hattiesburg, MS 39406, USA
    BMC Neurosci 6:54. 2005
    ..elegans, that express human beta amyloid (Abeta), were fed with soy derived isoflavones genistein, daidzein and glycitein (100 microg/ml) and then examined for Abeta-induced paralysis and the levels of reactive oxygen species...
  2. ncbi Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans
    Marishka K Brown
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA
    BMC Neurosci 10:62. 2009
    ..elegans. The wild type worms, as well as well-characterized 5-HT mutants, were fed with bilobalide in a range of concentrations, and several 5-HT controlled behaviors were tested...
  3. ncbi Antidepressants are a rational complementary therapy for the treatment of Alzheimer's disease
    Marwa Aboukhatwa
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 N Pine St, Baltimore, MD 21201, USA
    Mol Neurodegener 5:10. 2010
    ..Based on this preclinical and clinical evidence, antidepressants represent a rational complimentary strategy for the treatment of AD patients with depression comorbidity...
  4. ncbi Behavioral phenotyping of a transgenic Caenorhabditis elegans expressing neuronal amyloid-beta
    Laura E Dosanjh
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    J Alzheimers Dis 19:681-90. 2010
    ..elegans suggest that the model may be used to elucidate underlying pathological events related to development of AD and for pharmaceutical intervention...
  5. ncbi Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans
    Yanjue Wu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 26:13102-13. 2006
    ....
  6. ncbi Heat shock treatment reduces beta amyloid toxicity in vivo by diminishing oligomers
    Yanjue Wu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    Neurobiol Aging 31:1055-8. 2010
    ....
  7. ncbi Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathways
    Young Beob Yu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, United States of America
    PLoS ONE 5:e9339. 2010
    ..This issue may be addressed through the use of contemporary methodology and validated animal models...
  8. ncbi Intestinal and blood-brain barrier permeability of ginkgolides and bilobalide: in vitro and in vivo approaches
    Vamsi L M Madgula
    National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Planta Med 76:599-606. 2010
    ..A brain-to-plasma partition coefficient of 0.56 at 120 min indicated its possibility of brain uptake...
  9. ncbi Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons
    Flaubert Tchantchou
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA
    J Alzheimers Dis 18:787-98. 2009
    ..Despite a recent report showing that EGb 761 was insufficient in prevent dementia, its constituents still warrant future investigation...
  10. ncbi Beneficial effects of natural antioxidants EGCG and alpha-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans
    Marishka K Brown
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 N. Pine St, PH501, Baltimore, MD 21201, USA
    Pharmacol Biochem Behav 85:620-8. 2006
    ..Other protective mechanisms, in addition to their antioxidant properties, may underlie their differential beneficial effects on aging and physiological behaviors...
  11. ncbi Ginkgo biloba extract EGb 761 and Wisconsin Ginseng delay sarcopenia in Caenorhabditis elegans
    Zhiming Cao
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    J Gerontol A Biol Sci Med Sci 62:1337-45. 2007
    ..elegans is a valid model system for testing therapeutic intervention for delaying the progress of sarcopenia...
  12. ncbi Gotu Kola (Centella Asiatica) extract enhances phosphorylation of cyclic AMP response element binding protein in neuroblastoma cells expressing amyloid beta peptide
    Yanan Xu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    J Alzheimers Dis 13:341-9. 2008
    ..Taken together, we provide a possible molecular mechanism for memory enhancing property of Gotu Kola extract for the first time...
  13. ncbi Restoration of impaired phosphorylation of cyclic AMP response element-binding protein (CREB) by EGb 761 and its constituents in Abeta-expressing neuroblastoma cells
    Yanan Xu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Baltimore, MD 21201, USA
    Eur J Neurosci 26:2931-9. 2007
    ..Actions of individual EGb 761 components provide further insights into direct mechanisms underlying the effect of EGb 761 on enhancing the cognitive performance of patients with AD...

Research Grants7

  1. Mechanisms of Ginkgo biloba Neuropotection
    Yuan Luo; Fiscal Year: 2004
    ....
  2. In vivo Studies of Ginkgo biloba Neuroprotection
    Yuan Luo; Fiscal Year: 2007
    ..A better understanding of the 'mechanisms of EGb 761 neuroprotection will be important for understanding of the underlying neurodegenerative processes and for designing therapeutic strategies that target neurodegenerative disorders ..
  3. In vivo Studies of Ginkgo biloba Neuroprotection
    Yuan Luo; Fiscal Year: 2007
    ..abstract_text> ..