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Genomes and GenesSpecies | Po H LuSummaryAffiliation: University of California Country: USA Publications
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Publications
Age-related slowing in cognitive processing speed is associated with myelin integrity in a very healthy elderly samplePo H Lu
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
J Clin Exp Neuropsychol 33:1059-68. 2011..These results have implications for the neurobiology of the cognitive changes associated with brain aging...- Apolipoprotein E genotype is associated with temporal and hippocampal atrophy rates in healthy elderly adults: a tensor-based morphometry studyPo H Lu
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7226, USA
J Alzheimers Dis 23:433-42. 2011..Possession of the ?4 allele is associated with greater temporal and hippocampal volume reduction well before the onset of cognitive deficits... - Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly menPo H Lu
Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, USA
Arch Neurol 63:177-85. 2006..There is a compelling need for therapies that prevent, defer the onset, slow the progression, or improve the symptoms of Alzheimer disease (AD)... - Donepezil delays progression to AD in MCI subjects with depressive symptomsP H Lu
Departments of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Neurology 72:2115-21. 2009..To determine whether the presence of depression predicts higher rate of progression to Alzheimer disease (AD) in patients with amnestic mild cognitive impairment (aMCI) and whether donepezil treatment beneficially affect this relationship... - Gender and iron genes may modify associations between brain iron and memory in healthy agingGeorge Bartzokis
Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
Neuropsychopharmacology 36:1375-84. 2011..Combining genetic and MRI biomarkers may provide opportunities to design primary prevention clinical trials that target high-risk groups... - Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: implications for cognitive decline and dementiaGeorge Bartzokis
Department of Neurology, The David Geffen School of Medicine at UCLA, USA
Arch Gen Psychiatry 63:63-72. 2006..This may result in a progressive "disconnection" of widely distributed neural networks that may underlie the age risk factor for AD... - Apolipoprotein E affects both myelin breakdown and cognition: implications for age-related trajectories of decline into dementiaGeorge Bartzokis
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Biol Psychiatry 62:1380-7. 2007..Apolipoprotein E (ApoE) 4 allele is the second most important AD risk factor. We tested the hypothesis that ApoE4 accelerates age-related slowing in CPS through the process of myelin breakdown... - Differential effects of typical and atypical antipsychotics on brain myelination in schizophreniaGeorge Bartzokis
Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, United States
Schizophr Res 93:13-22. 2007..Atypical antipsychotics have been shown to have a wide spectrum of efficacy across multiple psychiatric diseases and to be particularly efficacious in treatment resistant cases of disorders such as schizophrenia... - In vivo evidence of differential impact of typical and atypical antipsychotics on intracortical myelin in adults with schizophreniaGeorge Bartzokis
Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
Schizophr Res 113:322-31. 2009..Increased white matter (WM) volume suggestive of increased myelination was detected in the patient group treated with an atypical antipsychotic compared to a typical one... - A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderlyApril J Ho
Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 107:8404-9. 2010..These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly... - Time-lapse mapping of cortical changes in schizophrenia with different treatmentsPaul M Thompson
Laboratory of Neuro Imaging, Department of Neurology, University of California Los Anges, School of Medicine, Los Angeles, CA 90095 7332, USA
Cereb Cortex 19:1107-23. 2009..These maps revise current models of schizophrenia progression; due to power limitations, the findings require confirmation in a sample large enough to model group x time interactions... - Lifespan trajectory of myelin integrity and maximum motor speedGeorge Bartzokis
Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA
Neurobiol Aging 31:1554-62. 2010..We tested the hypothesis that the age-related trajectory of FTS is related to brain myelin integrity... - Prevalent iron metabolism gene variants associated with increased brain ferritin iron in healthy older menGeorge Bartzokis
Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
J Alzheimers Dis 20:333-41. 2010..Clarifying mechanisms of brain iron accumulation may help identify novel interventions for age-related neurodegenerative diseases... - Heterogeneous age-related breakdown of white matter structural integrity: implications for cortical "disconnection" in aging and Alzheimer's diseaseGeorge Bartzokis
Department of Neurology, Univeristy of California School of Medicine, Los Angeles, CA 90095, USA
Neurobiol Aging 25:843-51. 2004..In AD this process is globally exacerbated, consistent with an extracellular deleterious process such as amyloid beta-peptide toxicity. Non-invasive measures such as R2 may be useful in primary prevention studies of AD... - Depressive symptoms in mild cognitive impairment predict greater atrophy in Alzheimer's disease-related regionsGrace J Lee
Department of Neurology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California
Biol Psychiatry 71:814-21. 2012..Thus, we examined the neuroanatomical changes associated with depressive symptoms in MCI... - Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjectsE C Mormino
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
Brain 132:1310-23. 2009..This pattern suggests that declining EM in older individuals may be caused by Abeta-induced hippocampus atrophy... - Myelin breakdown and iron changes in Huntington's disease: pathogenesis and treatment implicationsGeorge Bartzokis
Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Neurochem Res 32:1655-64. 2007..A unique combination of in vivo tissue integrity and iron level assessments was used to examine the hypothesis... - Subtle deficits in instrumental activities of daily living in subtypes of mild cognitive impairmentEdmond Teng
Neurobehavior Unit, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Dement Geriatr Cogn Disord 30:189-97. 2010..We explored the relationship between these factors by comparing instrumental activities of daily living (IADLs) among cognitive subtypes of MCI and examining associations between IADL and neuropsychological indices... - Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's diseaseDavid A Wolk
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 107:10256-61. 2010.... - Neuropsychiatric symptoms are associated with progression from mild cognitive impairment to Alzheimer's diseaseEdmond Teng
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7226, USA
Dement Geriatr Cogn Disord 24:253-9. 2007..Depression and apathy may identify a subset of MCI subjects at higher risk of progression to Alzheimer's disease (AD). However, it remains uncertain whether a broader spectrum of psychopathology is associated with progression to AD... - Longitudinal change of biomarkers in cognitive declineRaymond Y Lo
Division of Epidemiology, University of California, Berkeley, 94720 3190, USA
Arch Neurol 68:1257-66. 2011.... - Persistence of neuropsychological testing deficits in mild cognitive impairmentEdmond Teng
Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, Calif, USA
Dement Geriatr Cogn Disord 28:168-78. 2009.... - Quantifying age-related myelin breakdown with MRI: novel therapeutic targets for preventing cognitive decline and Alzheimer's diseaseGeorge Bartzokis
Department of Neurology, The David Gheffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
J Alzheimers Dis 6:S53-9. 2004.... - Identifying cognitively healthy elderly individuals with subsequent memory decline by using automated MR temporoparietal volumesGloria C Chiang
Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, Room M391, San Francisco, CA, 94143, USA
Radiology 259:844-51. 2011..To determine whether automated temporoparietal brain volumes can be used to accurately predict future memory decline among a multicenter cohort of cognitively healthy elderly individuals... - Deficits in facial emotion processing in mild cognitive impairmentEdmond Teng
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7226, USA
Dement Geriatr Cogn Disord 23:271-9. 2007..Patients with Alzheimer disease consistently demonstrate impaired performance on tests of facial emotion processing. However, it remains unclear how early in the neurodegenerative process these deficits emerge... - Brain ferritin iron may influence age- and gender-related risks of neurodegenerationGeorge Bartzokis
Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Neurobiol Aging 28:414-23. 2007..We hypothesized that brain iron may influence both the age- and gender-related risks of developing these diseases... - 3D mapping of mini-mental state examination performance in clinical and preclinical Alzheimer diseaseLiana G Apostolova
Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Alzheimer Dis Assoc Disord 20:224-31. 2006..As a global cognitive measure, MMSE depends on the integrity of widely distributed cortical areas in both brain hemispheres with left-sided predominance... - Dysregulated brain development in adult men with schizophrenia: a magnetic resonance imaging studyGeorge Bartzokis
Department of Neurology, University of California School of Medicine, Los Angeles 90095-1769, USA
Biol Psychiatry 53:412-21. 2003..The importance of myelination to the continued maturation and normal functioning of the brain has implications for the diagnosis, treatment, and prognosis of schizophrenia... - Adjunctive risperidone in the treatment of chronic combat-related posttraumatic stress disorderGeorge Bartzokis
Department of Neurology, University of California School of Medicine, Los Angeles, California, USA
Biol Psychiatry 57:474-9. 2005..The efficacy and safety of risperidone was evaluated in veteran patients with chronic combat-related posttraumatic stress disorder (PTSD) who were referred to a residential treatment program... - Brain ferritin iron as a risk factor for age at onset in neurodegenerative diseasesGeorge Bartzokis
Department of Neurology, UCLA, Los Angeles, California, USA
Ann N Y Acad Sci 1012:224-36. 2004..In vivo MRI can measure and track brain ferritin iron levels and provides an opportunity to design therapeutic interventions that target high-risk populations early in the course of illness, possibly even before symptoms appear... - Voxelwise genome-wide association study (vGWAS)Jason L Stein
Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles School of Medicine, Neuroscience Research Building 225E, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
Neuroimage 53:1160-74. 2010..These genes have high relevance to brain structure. This is the first voxelwise genome wide association study to our knowledge, and offers a novel method to discover genetic influences on brain structure... - Cortical gray matter volumes are associated with subjective responses to cocaine infusionGeorge Bartzokis
Department of Neurology, University of California Los Angeles School of Medicine, UCLA Alzheimer s Disease Center, 710 Westwood Plaza, Room 2 238, Los Angeles, CA 90095 1769, USA
Am J Addict 13:64-73. 2004..Given the well-established negative linear relationship between cortical gray matter volume and age, cortical gray matter volume may be a marker for the neurobiological substrate of the age-related reduction in addiction rates... - Human brain myelination and amyloid beta deposition in Alzheimer's diseaseGeorge Bartzokis
Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Alzheimers Dement 3:122-5. 2007.... - Mosaicism for trisomy 21 in a patient with young-onset dementia: a case report and brief literature reviewJohn M Ringman
Alzheimer s Disease Research Center, Department of Neurology, University of California, Los Angeles, 10911 Weyburn Ave, Ste 200, Los Angeles, CA 90095 7226, USA
Arch Neurol 65:412-5. 2008..To describe a case of young-onset Alzheimer disease (AD) due to mosaicism for trisomy 21... - Effectiveness of the Rey-Osterrieth Complex Figure Test and the Meyers and Meyers recognition trial in the detection of suspect effortPo H Lu
Harbor-UCLA Medical Center, Torrance, CA 90509-2910, USA
Clin Neuropsychol 17:426-40. 2003..Thus, the ROCFT+recognition trial show considerable potential for detecting noncredible effort... - Suspect cognitive symptoms in a 9-year-old child: malingering by proxy?Po H Lu
Department of Psychiatry, Harbor-UCLA Medical Center, Torrance, CA 90509-2910, USA
Clin Neuropsychol 16:90-6. 2002..Results demonstrate that children as young as 9 years of age are capable of feigning cognitive impairment, which highlights the need for routine evaluation of effort, irrespective of the age of the patient... - Brain maturation may be arrested in chronic cocaine addictsGeorge Bartzokis
Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA
Biol Psychiatry 51:605-11. 2002..The findings suggest that in adults, cocaine dependence may arrest normal white matter maturation in the frontal and temporal lobes of addicts who continue using cocaine... - Failure to inhibit the reading response on the Stroop Test: a pathognomonic indicator of suspect effortPo H Lu
Harbor-UCLA Medical Center, Torrance, CA 90509-2910, USA
J Clin Exp Neuropsychol 26:180-9. 2004....