Research Topics
Genomes and Genes | Valter LongoSummaryAffiliation: University of Southern California Country: USA Publications
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Publications
Growth factors, nutrient signaling, and cardiovascular agingLuigi Fontana
3715 McClintock Ave, Los Angeles, CA Email
Circ Res 110:1139-50. 2012..Here, we review the link between growth factors, cardiac function, and heart disease with focus on the cardioprotective and sensitizing effect of growth factors in both model organisms and humans...- Inference of transcription modification in long-live yeast strains from their expression profilesChao Cheng
Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 2910, USA
BMC Genomics 8:219. 2007..However, the mechanisms of longevity, especially the underlying transcription program have not been fully understood... - Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cellsV D Longo
Department of Biological Sciences, University of Southern Californiia, Los Angeles 90089 0191, USA
Neurobiol Aging 20:479-86. 1999..Taken together, the published studies suggest that survival may be regulated by similar fundamental mechanisms in many eukaryotes and that simple model systems will contribute to our understanding of the aging process in mammals... - Ras: the other pro-aging pathwayValter D Longo
Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
Sci Aging Knowledge Environ 2004:pe36. 2004..Here I review the data from experiments at both the organismal and cellular levels that support a role for Ras in the regulation of stress resistance and life span in eukaryotes... - Programmed and altruistic ageingValter D Longo
Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089, USA
Nat Rev Genet 6:866-72. 2005.... - Turning anti-ageing genes against cancerValter D Longo
Andrus Gerontology Center, Molecular and Computational Biology Department, University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089 0191, USA
Nat Rev Mol Cell Biol 9:903-10. 2008..This raises the possibility that cancer can be reduced by chronic downregulation of pro-ageing pathways... - Search for methuselah genes heats upValter D Longo
Leonard Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 0191, USA
Sci Aging Knowledge Environ 2004:pe6. 2004..The role of multiple transcription factors in extending life span in yeast and worms raises the possibility that many transcriptional regulators can contribute to longevity extension... - Calorie restriction and cancer prevention: metabolic and molecular mechanismsValter D Longo
The Andrus Gerontology Center, University of Southern California, Los Angeles, CA, USA
Trends Pharmacol Sci 31:89-98. 2010..Here, we discuss the link between nutritional interventions and cancer prevention with focus on the mechanisms that might be responsible for these effects in simple systems and mammals with a view to developing chemoprevention agents... - Oxygen? No thanks, I'm on a dietValter D Longo
Andrus Gerontology Center, Division of Biogerontology, and Department of Biological Sciences at the University of Southern California, Los Angeles, CA 90089 0191, USA
Sci Aging Knowledge Environ 2002:pe10. 2002..The implications of these results are discussed in this Perspective... - Sirtuins in aging and age-related diseaseValter D Longo
Department of Molecular and Computational Biology, Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089, USA
Cell 126:257-68. 2006..Here we examine the roles of Sirtuins in diverse eukaryotic species, with special emphasis on their links to aging and age-related diseases including cancer, diabetes, and neurodegenerative disorders... - The Ras and Sch9 pathways regulate stress resistance and longevityValter D Longo
Division of Biogerontology and Department of Biological Sciences, Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
Exp Gerontol 38:807-11. 2003..Although only one intracellular pathway that includes genes homologous to SCH9 and SOD2 has been identified in worms, our studies in yeast suggest that longevity in higher eukaryotes may also be negatively regulated by the Ras pathway... - Evolutionary medicine: from dwarf model systems to healthy centenarians?Valter D Longo
Andrus Gerontology Center, Division of Biogerontology, and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
Science 299:1342-6. 2003..This information suggests a new category of drugs that could prevent or postpone diseases of aging with few adverse effects... - Chronological Aging in Saccharomyces cerevisiaeValter D Longo
Department of Biological Sciences, Andrus Gerontology Center, University of Southern California, Los Angeles, CA, 90089 0191, USA
Subcell Biochem 57:101-21. 2012.... - Regulation of longevity and stress resistance: a molecular strategy conserved from yeast to humans?V D Longo
Division of Biogerontology, Andrus Gerontology Center, University of Southern California, Los Angeles 90089 0191, USA
Cell Mol Life Sci 59:903-8. 2002.... - Linking sirtuins, IGF-I signaling, and starvationValter D Longo
Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA
Exp Gerontol 44:70-4. 2009..Here, I review the studies linking SirT1, IGF-I signaling and starvation in various model organisms with a focus on the post-mitotic cells, which indicate that sirtuins can play both protective and pro-aging roles... - Reversible inactivation of superoxide-sensitive aconitase in Abeta1-42-treated neuronal cell linesV D Longo
Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 0191, USA
J Neurochem 75:1977-85. 2000..Abeta neurotoxicity was partially blocked by the iron chelator deferoxamine. These data suggest that increased superoxide generation and the release of iron from 4Fe-4S clusters are early events in Abeta1-42 neurotoxicity... - Sir2 blocks extreme life-span extensionPaola Fabrizio
Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA
Cell 123:655-67. 2005..Our results demonstrate that effects of SIR2 on chronological life span are opposite to replicatve life span and suggest that the relevant activities of Sir2-like deacetylases may also be complex in higher eukaryotes... - Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9Min Wei
Andrus Gerontology Center, University of Southern California, Los Angeles, California, United States of America
PLoS Genet 4:e13. 2008..Notably, the anti-aging effect caused by the inactivation of both pathways is much more potent than that caused by CR... - Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanismFederica Madia
Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
J Cell Biol 186:509-23. 2009.... - Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model systemFederica Madia
Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
J Cell Biol 180:67-81. 2008..The conserved function of Akt/S6k homologues in lifespan regulation raises the possibility that modulation of the IGF-I-Akt-56K pathway can protect against premature aging syndromes in mammals... - The chronological life span of Saccharomyces cerevisiaePaola Fabrizio
Andrus Gerontology Center, Division of Biogerontology and Department of Biological Sciences, University of Southern California, Los Angeles 90089-0191, USA
Aging Cell 2:73-81. 2003..We will review the yeast S. cerevisiae model system with emphasis on the chronological life span as a model system to study aging and the regulation of stress resistance in eukaryotes... - Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extensionMin Wei
Andrus Gerontology Center, University of Southern California, Los Angeles, CA, USA
PLoS Genet 5:e1000467. 2009.... - Significant and systematic expression differentiation in long-lived yeast strainsChao Cheng
Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America
PLoS ONE 2:e1095. 2007..The three yeast mutants sch9Delta, ras2Delta, tor1Delta show extended chronological life span up to three folds. Our aim is to dissect the mechanisms that lead to the yeast life span extension... - Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic indexChanghan Lee
Andrus Gerontology Center, Department of Biological Sciences and Norris Cancer Center, University of Southern California, Los Angeles, California 90089 0191, USA
Cancer Res 70:1564-72. 2010..We conclude that normal cells and mice can be protected against chemotherapy-dependent damage by reducing circulating IGF-I levels and by a mechanism that involves downregulation of proto-oncogene signals... - Comparative analyses of time-course gene expression profiles of the long-lived sch9Delta mutantHuanying Ge
Andrus Gerontology Center, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
Nucleic Acids Res 38:143-58. 2010.... - Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiaePaola Fabrizio
Andrus Gerontology Center and Dept. of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, USA
J Cell Biol 166:1055-67. 2004..The role of similar pathways in the regulation of longevity in organisms ranging from yeast to mice raises the possibility that mammals may also undergo programmed aging... - SOD2 functions downstream of Sch9 to extend longevity in yeastPaola Fabrizio
Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 0191, USA
Genetics 163:35-46. 2003..cerevisiae to superoxide dismutases and suggest that the induction of other stress-resistance genes regulated by Msn2/4 and Rim15 is required for maximum longevity extension... - Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brainEdoardo Parrella
Division of Neurogerontology Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA
ScientificWorldJournal 10:161-77. 2010..Taken together, these studies indicate that simple model systems will contribute to our comprehension of aging of the mammalian nervous system and will stimulate novel neurotherapeutic strategies in humans... - Chronological aging-induced apoptosis in yeastPaola Fabrizio
Andrus Gerontology Center, Division of Biogerontology, University of Southern California, Los Angeles, CA 90089 0191, USA
Biochim Biophys Acta 1783:1280-5. 2008..cerevisiae. We also describe the use of a genome-wide screening technique to gain further insights into the mechanisms of programmed death in populations of chronologically aging S. cerevisiae... - Cell resilience in species life spans: a link to inflammation?Caleb E Finch
University of Southern California, Los Angeles, CA 90089 0191, USA
Aging Cell 9:519-26. 2010..We suggest expanding the battery of stressors and markers used for comparative studies to additional cell types and additional parameters relevant to host defense and to their ecological specificities... - Analysis of gene expression profile in yeast aging chronologicallyPaola Fabrizio
Andrus Gerontology Center, Division of Biogerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, USA
Mech Ageing Dev 126:11-6. 2005..We also discuss a novel genomics method for the identification of chronologically long-lived yeast mutants... - Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulationPaola Fabrizio
Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America
PLoS Genet 6:e1001024. 2010..The high degree of conservation of these novel yeast longevity determinants in other species raises the possibility that their role in senescence might be conserved... - The chronological life span of Saccharomyces cerevisiaePaola Fabrizio
Adrus Gerontology Center, Division of Biogerentology and Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA
Methods Mol Biol 371:89-95. 2007..Here, we describe the standard procedures to measure the chronological life span, including both the normal and calorie restriction paradigms... - The chronological life span of Saccharomyces cerevisiae to study mitochondrial dysfunction and diseaseEdoardo Parrella
Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
Methods 46:256-62. 2008..Here, we describe the use of S. cerevisiae CLS in combination with three methods to quantify age-dependent mitochondrial damage and the accumulation of mitochondrial DNA mutations... - Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapyLizzia Raffaghello
Andrus Gerontology Center, Department of Biological Sciences and Norris Cancer Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
Proc Natl Acad Sci U S A 105:8215-20. 2008.... - Superoxide inhibits 4Fe-4S cluster enzymes involved in amino acid biosynthesis. Cross-compartment protection by CuZn-superoxide dismutaseMatthew Alan Wallace
Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095-1569, USA
J Biol Chem 279:32055-62. 2004..Thus, we conclude that when Sod1p is absent a lysine auxotrophy is induced because Lys4p is inactivated in the matrix by superoxide that originates in the intermembrane space and diffuses across the inner membrane... - SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neuronsYing Li
Neuroscience Program, University of Southern California, Los Angeles, CA 90089 2520, USA
Cell Metab 8:38-48. 2008..These results are consistent with findings in S. cerevisiae and other model systems, suggesting that mammalian sirtuins can play both protective and proaging roles... - Fasting and cancer treatment in humans: A case series reportFernando M Safdie
Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
Aging (Albany NY) 1:988-1007. 2009..Only controlled-randomized clinical trials will determine the effect of fasting on clinical outcomes including quality of life and therapeutic index... - Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microgliaZhong Xie
Division of Biogerontology, Andrus Gerontology Center, and Department of Biological Sciences, University of Southern California, Los Angeles, California 90089-0191, USA
J Neurosci 22:3484-92. 2002..These results implicate peroxynitrite as a mediator of the toxicity of activated microglia, which may play a major role in Abeta1-42 neurotoxicity and Alzheimer's disease... - Aging as a mitochondria-mediated atavistic program: can aging be switched off?Vladimir P Skulachev
Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow 119992, Russia
Ann N Y Acad Sci 1057:145-64. 2005..Aging of higher animals is accompanied by an increase in damage induced by mitochondrial ROS. Perhaps prevention of such damage by scavenging of mitochondrial ROS might slow down or even switch off the aging programs... - Biodemographic trajectories of age-specific reproliferation from stationary phase in the yeast Saccharomyces cerevisiae seem multiphasicChristi M Gendron
Max Planck Institute for Demographic Research, Konrad-Zuse Strasse 1, Rostock D-18057, Germany
Mech Ageing Dev 124:1059-63. 2003..Furthermore, we observed this pattern in different experiments and in different genotypes and established that this pattern was not due to genetic heterogeneity of the populations... - Genetics of aging and diseases: from rare mutations and model systems to disease preventionValter D Longo
Arch Neurol 59:1706-8. 2002
Research Grants
- Chronological Age-Dependent Genomic Instability in YeastValter Longo; Fiscal Year: 2007..Thus, chronologically aging S. cerevisiae can serve as a model to identify genes that regulate genomic instability and understand the mechanisms responsible for age-dependent DNA mutations and cancer in mammals. ..
- Mechanisms of Longevity Regulation in YeastValter D Longo; Fiscal Year: 2010..For example, mutations that cause activation of Akt or Ras accelerate aging in yeast but are also found in a major portion of human cancers. ..
- Mechanisms of Longevity Regulation in YeastValter Longo; Fiscal Year: 2007..abstract_text> ..
- 4 iron-4sulfur Clusters in Aging and Alzheimer's DiseaseValter Longo; Fiscal Year: 2004..abstract_text> ..
- Chronological Age-Dependent Genomic Instability in YeastValter D Longo; Fiscal Year: 2010..Thus, chronologically aging S. cerevisiae can serve as a model to identify genes that regulate genomic instability and understand the mechanisms responsible for age-dependent DNA mutations and cancer in mammals. ..