Research Topics
Genomes and Genes | M LjungmanSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
Phenylbutyrate interferes with the Fanconi anemia and BRCA pathway and sensitizes head and neck cancer cells to cisplatinKyunghee Burkitt
Department of Radiation Oncology, Division of Radiation Cancer Biology, University of Michigan Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Mol Cancer 7:24. 2008..In this study we explored whether phenylbutyrate may sensitize head and neck cancer cells by interfering with the Fanconi anemia pathway...- The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancersMichelle T Paulsen
Department of Radiation Oncology, Division of Radiation and Cancer Biology, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
Mol Cancer 5:25. 2006..In this study we developed antibodies against hCdc14A to investigate the expression and regulation of hCdc14A in human tissues and cancer cells... - Membrane-elution analysis of content of cyclins A, B1, and E during the unperturbed mammalian cell cycleStephen Cooper
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0620, USA
Cell Div 2:28. 2007..The membrane-elution method is a method that allows the study of the cell cycle by producing a culture of unperturbed, synchronized cells... - Effect of differential gene expression on the chromatin structure of the DHFR gene domain in vivoM Ljungman
Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor 48109 0582, USA
Biochim Biophys Acta 1307:171-7. 1996..These results suggest that the accessible chromatin structure of the DHFR promoter is not dependent on serum-stimulated poising of the gene for transcription, but may reflect the ability of the RNA polymerase to clear the promoter... - The transcription stress responseMats Ljungman
Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, USA
Cell Cycle 6:2252-7. 2007..It is proposed that the transcription stress response activated by blockage of transcription may play an important role in safeguarding the genome from DNA damage and thus act to suppress tumorigenesis... - Activation of DNA damage signalingMats Ljungman
Department of Radiation Oncology, Division of Radiation and Cancer Biology, University of Michigan Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109 0936, USA
Mutat Res 577:203-16. 2005..This review will focus on the potential mechanisms of the activation of DNA damage-induced signal transduction pathways... - Transcription - guarding the genome by sensing DNA damageMats Ljungman
Department of Radiation Oncology, Division of Radiation and Cancer Biology, University of Michigan Comprehensive Cancer Center, University of Michigan Medical School, University of Michigan, Ann Arbor, Michigan 48109 0936, USA
Nat Rev Cancer 4:727-37. 2004..Transcription might also act as a DNA-damage dosimeter where the severity of blockage determines whether or not to induce cell death. Could transcription therefore be a potential therapeutic target for anticancer strategies?.. - Induction of ser15 and lys382 modifications of p53 by blockage of transcription elongationM Ljungman
Department of Radiation Oncology, Division of Cancer Biology, University of Michigan Comprehensive Cancer Center, 150 E Medical Center Drive, Ann Arbor, MI 48109 0936, USA
Oncogene 20:5964-71. 2001..We propose that the elongating RNA polymerase complex may act as a sensor of DNA damage and as an integrator of cellular stress signals... - The DNA damage response--repair or despair?Mats Ljungman
Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
Environ Mol Mutagen 51:879-89. 2010..This final fate is determined by intricate cellular dosimeters that are yet to be fully understood. Here, key findings leading to our current view of DDR are discussed as well as potential areas of importance for future studies... - Recovery of RNA synthesis from the DHFR gene following UV-irradiation precedes the removal of photolesions from the transcribed strandM Ljungman
Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor 48109 0936, USA
Carcinogenesis 20:395-9. 1999..Thus, although RNA synthesis was initially inhibited by UV-induced photolesions, the results suggest that RNA polymerase II was able to bypass these lesions prior to their removal... - Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stressM Ljungman
Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, USA
Neoplasia 2:208-25. 2000..This review will focus on recent findings about how the p53 response may be activated following cellular stress... - The cyclin-dependent kinase inhibitor roscovitine inhibits RNA synthesis and triggers nuclear accumulation of p53 that is unmodified at Ser15 and Lys382M Ljungman
Department of Radiation Oncology, Division of Cancer Biology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109 0936, USA
Mol Pharmacol 60:785-9. 2001..We conclude that roscovitine is a potent inhibitor of RNA synthesis and that this inhibition may be responsible for the accumulation of nuclear p53... - Accumulation of soluble and nucleolar-associated p53 proteins following cellular stressS A Klibanov
Dept of Radiation Oncology, Division of Cancer Biology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
J Cell Sci 114:1867-73. 2001..However, inhibition of proteasome activity may be a unique stress in that it leads to the sequestering of p53 proteins to the nucleolus, thereby blunting the p53-mediated transactivation of target genes... - Potential roles for p53 in nucleotide excision repairB C McKay
Department of Radiation Oncology, Division of Cancer Biology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0936, USA
Carcinogenesis 20:1389-96. 1999..Furthermore, we suggest that the role of p53 in the recovery of mRNA synthesis is important for resistance to UV-induced apoptosis... - RPA and ATR link transcriptional stress to p53Frederick A Derheimer
Department of Radiation Oncology, Division of Radiation and Cancer Biology, University of Michigan Comprehensive Cancer Center, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
Proc Natl Acad Sci U S A 104:12778-83. 2007..We propose that this transcription-based stress response involving RPA, ATR, and p53 has evolved as a DNA damage-sensing mechanism to safeguard cells against DNA damage-induced mutagenesis... - Potential role of MLH1 in the induction of p53 and apoptosis by blocking transcription on damaged DNA templatesSunitha Yanamadala
Department of Radiation Oncology, Division of Radiation and Cancer Biology, University of Michigan Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109 0936, USA
Mol Cancer Res 1:747-54. 2003..These findings suggest a novel mechanism of MLH1 in the induction p53 and apoptosis by inhibiting RNA polymerase II-dependent transcription on damaged DNA templates... - Role for p53 in the recovery of transcription and protection against apoptosis induced by ultraviolet lightB C McKay
Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor 48109 0936, USA
Neoplasia 1:276-84. 1999..Furthermore, we suggest that the capacity of cells to recover transcription after genotoxic damage is an important determinant of sensitivity to apoptosis... - Phenylbutyrate attenuates the expression of Bcl-X(L), DNA-PK, caveolin-1, and VEGF in prostate cancer cellsM Goh
Section of Urology, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0396, USA
Neoplasia 3:331-8. 2001..Taken together, our results point to the possibility that PB may be an effective anti-prostate cancer agent when used in combination with radiation or chemotherapy and for the inhibition of cancer progression... - Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiationMukesh K Nyati
Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Cancer Res 66:11554-9. 2006..These findings show a new function for ATM in the control of mitogenic pathways affecting cell signaling and emphasize the key role of ATM in coordinating the cellular response to DNA damage... - Advances in radiation oncologyMohamed Elshaikh
Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Annu Rev Med 57:19-31. 2006..Taken together, these advances have increased the effectiveness of radiation therapy and promise better treatment results in the future... - The natural toxin juglone causes degradation of p53 and induces rapid H2AX phosphorylation and cell death in human fibroblastsMichelle T Paulsen
Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109-0936, USA
Toxicol Appl Pharmacol 209:1-9. 2005..Our results show that juglone has multiple effects on cells such as the induction of DNA damage, inhibition of transcription, reduction of p53 protein levels and the induction of cell death... - Phenylbutyrate sensitizes human glioblastoma cells lacking wild-type p53 function to ionizing radiationCarlos A Lopez
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
Int J Radiat Oncol Biol Phys 69:214-20. 2007..Because of its low cytotoxicity, cerebrospinal fluid penetration, and high oral bioavailability, we investigated PB as a potential radiation sensitizer in human glioblastoma cell lines... - Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleusMario D Galigniana
Departments of Pharmacology and Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
J Biol Chem 279:22483-9. 2004..This is the first demonstration of the linkage between an hsp90-chaperoned transcription factor and the system for its retrograde movement to the nucleus both in vitro and in vivo... - Histone ubiquitination associates with BRCA1-dependent DNA damage responseJiaxue Wu
Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Mol Cell Biol 29:849-60. 2009..Taken together, our results suggest that ubiquitinated histones H2A and H2B may recruit the BRCA1 complex to DNA damage lesions on the chromatin... - Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocationPatrick J M Murphy
Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
J Biol Chem 279:30195-201. 2004.... - Celastrol potentiates radiotherapy by impairment of DNA damage processing in human prostate cancerYao Dai
Department of Radiation Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109 5637, USA
Int J Radiat Oncol Biol Phys 74:1217-25. 2009..In the present study, we evaluated the radiosensitizing potential of celastrol in the human prostate cancer PC-3 model... - H2AX phosphorylation after UV irradiation is triggered by DNA repair intermediates and is mediated by the ATR kinaseSheela Hanasoge
Department of Radiation Oncology, Division of Radiation and Cancer Biology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109 2200, USA
Carcinogenesis 28:2298-304. 2007..We suggest a model for UV light-induced phosphorylation of H2AX where in addition to replication blockage, DNA repair intermediates trigger H2AX phosphorylation via the ATR kinase... - Compromised Fanconi anemia response due to BRCA1 deficiency in cisplatin-sensitive head and neck cancer cell linesKyunghee Burkitt
Department of Radiation Oncology, University of Michigan Medical School, University of Michigan, Ann Arbor, MI 48109 2200, USA
Cancer Lett 253:131-7. 2007..These results suggest a possible role for BRCA1 in modulating cisplatin sensitivity in head and neck cancer cells... - Enhanced radiosensitization with gemcitabine in mismatch repair-deficient HCT116 cellsBlaine W Robinson
Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0504, USA
Cancer Res 63:6935-41. 2003..We suggest that dATP depletion produces errors of replication in MMR-deficient cells, which, if left unrepaired, enhances cell death by ionizing radiation... - Efficient NES-dependent protein nuclear export requires ongoing synthesis and export of mRNAsMats Ljungman
Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
Exp Cell Res 297:548-59. 2004..These results demonstrate a novel role for ongoing synthesis and export of mRNAs in NES-dependent protein nuclear export... - Phosphorylation and nuclear accumulation are distinct events contributing to the activation of p53Mats Ljungman
Department of Radiation Oncology, Program in Molecular and Cellular Biology, University of Michigan Medical School, Ann Arbor, MI 48109-0936, USA
Mutat Res 546:7-15. 2004.... - Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1M E Gonzalez
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Oncogene 28:843-53. 2009..Blockade of EZH2 may provide a prime target to prevent and/or halt ER-negative breast cancer progression... - Transcription inhibition: a potential strategy for cancer therapeuticsFrederick A Derheimer
Department of Radiation Oncology, Division of Radiation and Cancer Biology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
Eur J Cancer 41:2569-76. 2005..Future efforts should be directed towards exploring whether interference of transcription could be used as an anti-cancer therapeutic strategy... - Phenylbutyrate inhibits the invasive properties of prostate and breast cancer cell lines in the sea urchin embryo basement membrane invasion assayErica S Dyer
Department of Radiation Oncology, Division of Radiation and Cancer Biology, University of Michigan Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Int J Cancer 101:496-9. 2002..These results suggest that in addition to activating apoptosis in cancer cells, phenylbutyrate may be used in prevention of metastatic disease... - Cells from long-lived mutant mice exhibit enhanced repair of ultraviolet lesionsAdam B Salmon
Cellular and Molecular Biology Graduate Program, University of Michigan Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA
J Gerontol A Biol Sci Med Sci 63:219-31. 2008..Overall, these data suggest a mechanism for the UV resistance of Snell dwarf-derived fibroblasts that could contribute to the delay of aging and neoplasia in these mice... - Nuclear accumulation of p53 following inhibition of transcription is not due to diminished levels of MDM2Mats Ljungman
Program in Molecular and Cellular Biology, Department of Radiation Oncology, Division of Radiation and Cancer Biology, University of Michigan Medical School, Ann Arbor, MI 48109-0936, USA
Oncogene 23:5505-12. 2004..These findings suggest that blockage of transcription induce the nuclear accumulation of p53 without breaking the p53-MDM2 regulation loop... - Psoralen-induced DNA interstrand cross-links block transcription and induce p53 in an ataxia-telangiectasia and rad3-related-dependent mannerFrederick A Derheimer
Department of Radiation Oncology, Division of Radiation and Cancer Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Mol Pharmacol 75:599-607. 2009..Our finding that cells underwent apoptosis preferentially during S-phase suggests that the combined blockade of transcription and DNA replication by psoralen ICLs during S-phase elicits a strong apoptotic response... - Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilizationLidong Wang
Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
Cancer Cell 15:207-19. 2009..ATDC was found to stabilize beta-catenin via ATDC-induced effects on the Disheveled-2 protein, a negative regulator of glycogen synthase kinase 3beta in the Wnt/beta-catenin signaling pathway... - Ultraviolet light-induced apoptosis is associated with S-phase in primary human fibroblastsBruce C McKay
Centre for Cancer Therapeutics, Ottawa Regional Cancer Centre, ON, Canada
DNA Repair (Amst) 1:811-20. 2002..Taken together these results suggest that the induction of apoptosis requires S-phase progression following UV-irradiation...
Research Grants
- REGULATION OF P53 STABILITY BY SER315 PHOSPHORYLATIONMats Ljungman; Fiscal Year: 2002..We will express wild-type or mutant CDC14 in MCF7 cells and study what effect it will have on basal and induced levels of p53. ..