Research Topics
Genomes and Genes | Ru Liu-BryanSummaryAffiliation: University of California Country: USA Publications
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Publications
Chondrocyte innate immune myeloid differentiation factor 88-dependent signaling drives procatabolic effects of the endogenous Toll-like receptor 2/Toll-like receptor 4 ligands low molecular weight hyaluronan and high mobility group box chromosomal proteinRu Liu-Bryan
VA Medical Center, San Diego, California 92161, USA
Arthritis Rheum 62:2004-12. 2010....- Monosodium urate and calcium pyrophosphate dihydrate (CPPD) crystals, inflammation, and cellular signalingRu Liu-Bryan
Veteran Affairs Medical Center, University of California, MC111K, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
Joint Bone Spine 72:295-302. 2005..This review will also focus on potential therapeutic targets related to cellular signalling in MSU and CPPD crystal-induced inflammation... - Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammationRu Liu-Bryan
VA Medical Center, University of California, San Diego 92161, USA
Arthritis Rheum 52:2936-46. 2005.... - Intracellular innate immunity in gouty arthritis: role of NALP3 inflammasomeRu Liu-Bryan
Department of Medicine, VA Medical Center, University of California, San Diego, CA, USA
Immunol Cell Biol 88:20-3. 2010..This review focuses on the critical role of intracellular NALP3 inflammasome in MSU crystal-induced inflammation... - TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generationRu Liu-Bryan
Veterans Affairs Medical Center, San Diego, CA 92161, USA
J Immunol 174:5016-23. 2005..Our results indicate the potential for innate immunity at the level of the articular chondrocyte to directly contribute to inflammatory and degenerative tissue reactions associated with both gout and pseudogout... - Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in miceHal M Hoffman
University of California, San Diego, USA
Arthritis Rheum 62:2170-9. 2010..The aim of this study was to use a mouse molecular genetics-based approach to test whether the leucine-rich repeat (LRR) domain of cryopyrin is required for MSU crystal-induced inflammation... - Engagement of CD14 mediates the inflammatory potential of monosodium urate crystalsPeter Scott
Veterans Affairs Medical Center, Department of Medicine, University of California San Diego, San Diego, CA 92161, USA
J Immunol 177:6370-8. 2006..c. air pouches in vivo. We conclude that engagement of CD14 is a central determinant of the inflammatory potential of MSU crystals... - Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytesDenise L Cecil
Veterans Affairs Medical Center, University of California San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
Arthritis Rheum 52:144-54. 2005..This study was undertaken to test the hypothesis that IL-8 promotes chondrocyte hypertrophy by modulating chondrocyte PiT-1 expression and sodium-dependent Pi uptake, and to assess differential roles in this activity... - A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathwaysM T Audrey Nguyen
Division of Endocrinology Metabolism, University of California, San Diego, La Jolla, California 92093, USA
J Biol Chem 282:35279-92. 2007..Together our results show that FFAs can activate CD11c(+) myeloid proinflammatory cells via TLR2/4 and JNK signaling pathways, thereby promoting inflammation and subsequent cellular insulin resistance... - Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1? and tumor necrosis factor ?Robert Terkeltaub
VA San Diego Medical Center and University of California, San Diego, CA, USA
Arthritis Rheum 63:1928-37. 2011..This study was undertaken to test the hypothesis that AMPK activity limits chondrocyte matrix catabolic responses to IL-1? and TNF?... - The CXCR1 tail mediates beta1 integrin-dependent cell migration via MAP kinase signalingRu Liu-Bryan
Department of Medicine, Veterans Affairs Medical Center, University of California, San Diego, CA, USA
Biochem Biophys Res Commun 332:117-25. 2005..We conclude that IL-8 stimulated beta1 integrin-mediated leukocyte migration on fibronectin through CXCR1 is dependent on the C-terminal cytoplasmic domain of CXCR1 and subsequent p38 and JNK MAPK signaling...
Research Grants
- IL-8 in chondrocalcinosisRU BRYAN; Fiscal Year: 2005..The completion of this study has the potential to provide a foundation for novel chemokine and signal transduction-based therapeutic strategies for treatment of chondrocalcinosis in OA and aging. ..
- Innate Immunity in gouty InflammationRU BRYAN; Fiscal Year: 2007..Completion of this work will help further understanding the mechanisms of acute gouty inflammation, how to control gouty arthritis and potentially other forms of crystal-induced inflammation. ..
- Cartilage Innate Immunity in OsteoarthritisRU BRYAN; Fiscal Year: 2010..Progression of OA is promoted by low-grade inflammation in cartilage. There is a pressing need to develop effective disease modifying treatment for OA. TLR2/4 innate immune signaling in the joint represents a novel target for OA. ..