Research Topics
Species | Julio LicinioSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
The experience of bipolar disorder: a personal perspective on the impact of mood disorder symptomsJ Licinio
Center for Pharmacogenomics and Clinical Pharmacology, Semel Institute for Neuroscience and Human Behavior and David Geffen School of Medicine at University of California, Los Angeles, CA 90095 1761, USA
Mol Psychiatry 10:827-30. 2005..This could rapidly decrease the enormous burden of psychiatric disorders, which is eloquently described in this perspective article...- The neuroimmune-endocrine axis: pathophysiological implications for the central nervous system cytokines and hypothalamus-pituitary-adrenal hormone dynamicsJ Licinio
Department of Psychiatry and Neuropsychiatric Institute, School of Medicine, University of California, os Angeles, CA 90095 1761, USA
Braz J Med Biol Res 33:1141-8. 2000..The mechanisms by which cytokine signaling affects the function of stress-related neuroendocrine systems are reviewed in this article... - Depression, antidepressants and suicidality: a critical appraisalJulio Licinio
Center for Pharmacogenomics and Clinical Pharmacology, Neuropsychiatric Institute and David Geffen School of Medicine, University of California, Los Angeles, USA
Nat Rev Drug Discov 4:165-71. 2005.... - Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adultsJulio Licinio
Center for Pharmacogenomics, Neuropsychiatric Institute, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
Proc Natl Acad Sci U S A 101:4531-6. 2004..These results highlight the role of the leptin pathway in adults with key effects on the regulation of body weight, gonadal function, and behavior... - Informed consent in pharmacogenomicsJulio Licinio
UCLA Laboratory for Pharmacogenomics, Email
Pharmacogenomics J 2:343-4. 2002..The Pharmacogenomics Journal (2002) 2, 343. doi:10.1038/sj.tpj.6500151.. - Simultaneous and continuous 24-hour plasma and cerebrospinal fluid leptin measurements: dissociation of concentrations in central and peripheral compartmentsMa Li Wong
Center for Pharmacogenomics and Interdepartmental Clinical Pharmacology Center, Neuropsychiatric Institute and David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095, USA
J Clin Endocrinol Metab 89:258-65. 2004.... - Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesityBulent O Yildiz
Center for Pharmacogenomics and Clinical Pharmacology, Neuropsychiatric Institute, Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
Proc Natl Acad Sci U S A 101:10434-9. 2004..We suggest that the blunting of the nocturnal rise of ghrelin is a biological feature of human obesity... - Short-term plasticity of gray matter associated with leptin deficiency and replacementEdythe D London
Department of Psychiatry and Biobehavioral Sciences and Semel Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024, USA
J Clin Endocrinol Metab 96:E1212-20. 2011..We previously reported that leptin supplementation increased gray matter (GM) concentration in the anterior cingulate gyrus (ACG), cerebellum, and inferior parietal lobule, areas that are also involved in food intake... - The prototypic antidepressant drug, imipramine, but not Hypericum perforatum (St. John's Wort), reduces HPA-axis function in the ratP Frost
Laboratory of Pharmacogenomics, Neuropsychiatric Institute, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Horm Metab Res 35:602-6. 2003..However, our data does not support any role for H. perforatum in modulation of HPA axis function, suggesting that alternative pathways may be involved in mediating its antidepressant effects... - From monoamines to genomic targets: a paradigm shift for drug discovery in depressionMa Li Wong
Center for Pharmacogenomics, Neuropsychiatric Institute and David Geffen School of Medicine at UCLA, 695 Charles Young Drive South, Los Angeles, California 90095 1761, USA
Nat Rev Drug Discov 3:136-51. 2004..Yet such a drug is not on the horizon. Here, we cover the different phases of antidepressant drug discovery in the past, present and future, and comment on the challenges and opportunities for antidepressant research... - Modeling of the temporal patterns of fluoxetine prescriptions and suicide rates in the United StatesMichael S Milane
Center for Pharmacogenomics and Clinical Pharmacology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA
PLoS Med 3:e190. 2006.... - Leptin replacement improves cognitive developmentGilberto J Paz-Filho
Department of Psychiatry and Behavioral Sciences, Center for Pharmacogenomics, University of Miami Miller School of Medicine, Miami, Florida, USA
PLoS ONE 3:e3098. 2008..Leptin changes brain structure, neuron excitability and synaptic plasticity. It also regulates the development and function of feeding circuits. However, the effects of leptin on neurocognitive development are unknown... - St John's wort and imipramine-induced gene expression profiles identify cellular functions relevant to antidepressant action and novel pharmacogenetic candidates for the phenotype of antidepressant treatment responseM L Wong
Department of Psychiatry, Center for Pharmacogenomics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1761, USA
Mol Psychiatry 9:237-51. 2004..Our data support the hypothesis that chronic antidepressant treatment by drugs of various classes may result in a common, final pathway of changes in gene expression in a discrete brain region... - Research and treatment approaches to depressionM L Wong
Clinical Pharmacology Program, Laboratory of Pharmacogenomics, Neuropsychiatric Institute, Gonda Neuroscience and Genetics Research Center, University of California Los Angeles, School of Medicine, Los Angeles, CA 90095 1761, USA
Nat Rev Neurosci 2:343-51. 2001..The complexity of this field is best approached by rigorous explorations of known candidate systems in conjunction with the use of genomic tools to discover new targets for antidepressants and to predict therapeutic outcomes... - The evolution of signaling complexity suggests a mechanism for reducing the genomic search space in human association studiesK J L Irizarry
Center for Pharmacogenomics and Clinical Pharmacology, Neuropsychiatric Institute, David Geffen School of Medicine, University California, Los Angeles, CA 90095, USA
Mol Psychiatry 10:14-26. 2005.... - Leptin replacement alters brain response to food cues in genetically leptin-deficient adultsKate Baicy
Department of Psychiatry and Biobehavioral Sciences and Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
Proc Natl Acad Sci U S A 104:18276-9. 2007..Leptin appears to modulate feeding behavior through these circuits, suggesting therapeutic targets for human obesity... - Emergent oscillations in a mathematical model of the human menstrual cycleNatalie L Rasgon
Department of Psychiatry and Biobehavioral Sciences, Stanford School of Medicine, Palo Alto, California 94305, USA
CNS Spectr 8:805-14. 2003..The aim of this study was to develop a mathematical model of the hypothalamo-pituitary-gonadal axis that would reflect available data in humans... - Identification, characterization, and gene expression profiling of endotoxin-induced myocarditisMa Li Wong
Center for Pharmacogenomics, Neuropsychiatric Institute, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
Proc Natl Acad Sci U S A 100:14241-6. 2003..Our findings can help identify innate immune pathways that could become targets for immunotherapy in the treatment of disease caused by potential bioterrorism agents... - Relationship between increasing body weight, insulin resistance, inflammation, adipocytokine leptin, and coronary circulatory functionThomas H Schindler
Department of Molecular, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, California 90095-1735, USA
J Am Coll Cardiol 47:1188-95. 2006.... - Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-AmericansC Dong
Department of Psychiatry and Behavioral Sciences, Center for Pharmacogenomics, University of Miami Miller School of Medicine, Miami, FL, USA
Mol Psychiatry 14:1105-18. 2009..Moreover, these results highlight the importance of direct re-sequencing of key candidate genes in ethnic minority groups in order to discover novel genetic variants that cannot be simply inferred from existing databases... - Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: a possible link between inflammatory cytokines and atherogenesisM L Wong
Department of Psychiatry and Biobehavioral Sciences, University of California, School of Medicine, Los Angeles, CA 90095 1761, USA
Proc Natl Acad Sci U S A 97:8681-6. 2000..9-fold, respectively (P < 0.01). These data show regulation of S-SMase activity in vivo and they raise the possibility that local stimulation of S-SMase may contribute to the effects of inflammatory cytokines in atherosclerosis... - Single nucleotide polymorphism identification in candidate gene systems of obesityK Irizarry
Dept of Chemistry and Biochemistry, University of California, Los Angeles 90095-1570, USA
Pharmacogenomics J 1:193-203. 2001..bioinformat ics.ucla.edu/snp/obesity. We believe this panel can serve as a valuable new resource for genetic and pharmacogenomic studies of the causes of obesity... - Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-AmericansJ Licinio
Center for Pharmacogenomics and Clinical Pharmacology, Neuropsychiatric Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
Mol Psychiatry 9:1075-82. 2004..These findings also suggest that variations in the CRHR1 gene may affect response to CRHR1 agonists or antagonists. All data are deposited in www.pharmgkb.org... - Caspase 1 deficiency reduces inflammation-induced brain transcriptionClaudio Mastronardi
Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Proc Natl Acad Sci U S A 104:7205-10. 2007..Our results indicate that those genes may also play a role in several neuropsychiatric conditions in which inflammation has been implicated and indicate that casp1 might be a potential therapeutic target for such disorders... - Depression and obesity treatments are life savingJulio Licinio
Nat Med 8:1336; author reply 1336. 2002 - Ecological studies of antidepressant treatment and suicidal risksRoss J Baldessarini
Department of Psychiatry and Neuroscience Program, Harvard Medical School, and International Psychopharmacology Program, McLean Hospital, Belmont, MA 02478, USA
Harv Rev Psychiatry 15:133-45. 2007..Overall, as with findings from randomized trials and cohort or case-control studies, evidence of specific antisuicidal effects of antidepressant treatment from ecological analyses remains elusive... - The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-AmericansLuciana Ribeiro
Department of Psychiatry and Behavioral Sciences, Center on Pharmacogenomics, University of Miami Miller School of Medicine, Miami, Florida 33136 1013, USA
Neuroreport 18:1291-3. 2007..7 95% CI 1.17-2.47). Our findings support the association of BDNF single nucleotide polymorphism rs6265 and depression, suggesting that this polymorphism may increase susceptibility to major depression in Mexican-Americans... - Effects of leptin on intake of specific micro- and macronutrients in a woman with leptin gene deficiency studied off and on leptin at stable body weightJulio Licinio
Department of Psychiatry and Behavioral Sciences D 28, University of Miami, Miller School of Medicine, 1695 NW 9th Avenue, Suite 3100, Miami, FL 33136, USA
Appetite 49:594-9. 2007..The nutritional data from this study indicates a direct link between the effects of leptin and ingestion of several specific micronutrients. The mechanisms underlying these effects warrant further investigation and study... - Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapyDonald A Williamson
Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
Appetite 45:75-80. 2005..These results are discussed in the context of the scientific literature pertaining to leptin and its effects on appetite and obesity... - Suicidality scores during double-blind fluoxetine and desipramine treatment in Mexican AmericansAnil Sharma
J Clin Psychopharmacol 27:99-101. 2007 - Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment responseMa Li Wong
Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
Proc Natl Acad Sci U S A 103:15124-9. 2006..This study identifies a potential CNS role for the PDE11 family. The hypothesis that drugs affecting PDE function, particularly cGMP-related PDEs, represent a treatment strategy for major depression should therefore be tested... - Effect of leptin replacement on brain structure in genetically leptin-deficient adultsJohn A Matochik
Neuroimaging Research Branch, National Institute on Drug Abuse, Department of Health and Human Services/National Institutes of Health, Baltimore, Maryland 21224, USA
J Clin Endocrinol Metab 90:2851-4. 2005..Our findings suggest that leptin can have sustained effects on tissue composition in the human brain and broaden the potential spectrum of leptin's influence beyond feeding behavior and endocrine function... - Development of a PCR-based strategy for CYP2D6 genotyping including gene multiplication of worldwide potential usePedro Dorado
University of Beira Interior, Covilh, Portugal
Biotechniques 39:571-4. 2005.... - Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implicationsSalvatore Alesci
Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Building 10, Room 2D46, MSC 1284, Bethesda, Maryland 20892 1284, USA
J Clin Endocrinol Metab 90:2522-30. 2005..Given the activating role of IL-6 on the hypothalamic-pituitary-adrenal (HPA) axis, and the relevance of its dysregulation in MDD, we also analyzed the relations between IL-6 and cortisol levels...